Affiliation: Council for Scientific and Industrial Research
Country: South Africa
Pillay P, Maharaj V, Smith P. Investigating South African plants as a source of new antimalarial drugs. J Ethnopharmacol. 2008;119:438-54 pubmed publisher
Pillay P, Vleggaar R, Maharaj V, Smith P, Lategan C. Isolation and identification of antiplasmodial sesquiterpene lactones from Oncosiphon piluliferum. J Ethnopharmacol. 2007;112:71-6 pubmed
..Structure-activity relationships were assessed. ..
Pillay P, Vleggaar R, Maharaj V, Smith P, Lategan C, Chouteau F, et al. Antiplasmodial hirsutinolides from Vernonia staehelinoides and their utilization towards a simplified pharmacophore. Phytochemistry. 2007;68:1200-5 pubmed
..The antiplasmodial data obtained in respect of these two acids suggests that the 2(5H)-furanone substructure is a key pharmacophore in the observed antiplasmodial activity...