Marie-Louise Newell

Summary

Affiliation: Africa Centre for Health and Population Studies
Country: South Africa

Publications

  1. ncbi request reprint Within and between race differences in lymphocyte, CD4+, CD8+ and neutrophil levels in HIV-uninfected children with or without HIV exposure in Europe and Uganda
    Madeleine Bunders
    Centre for Paediatric Epidemiology, Institute of Child Health, University College, London, UK
    Ann Trop Paediatr 26:169-79. 2006
  2. doi request reprint Safety of antiretroviral drugs in pregnancy and breastfeeding for mother and child
    Marie Louise Newell
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, KwaZulu Natal, South Africa
    Curr Opin HIV AIDS 8:504-10. 2013
  3. ncbi request reprint Male circumcision to cut HIV risk in the general population
    Marie Louise Newell
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, KwaZulu Natal 3935, South Africa
    Lancet 369:617-9. 2007
  4. pmc Evaluation of the impact of immediate versus WHO recommendations-guided antiretroviral therapy initiation on HIV incidence: the ANRS 12249 TasP (Treatment as Prevention) trial in Hlabisa sub-district, KwaZulu-Natal, South Africa: study protocol for a clus
    Collins C Iwuji
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, KwaZulu Natal, South Africa
    Trials 14:230. 2013
  5. pmc Impact of a novel molecular TB diagnostic system in patients at high risk of TB mortality in rural South Africa (Uchwepheshe): study protocol for a cluster randomised trial
    Richard J Lessells
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trials 14:170. 2013
  6. pmc The social dynamics of consent and refusal in HIV surveillance in rural South Africa
    Lindsey Reynolds
    Department of Anthropology, Johns Hopkins University, 3400 N Charles St, 404 Macauley Hall, Baltimore, MD 21218, United States
    Soc Sci Med 77:118-25. 2013
  7. pmc Human resources needs for universal access to antiretroviral therapy in South Africa: a time and motion study
    Jan Ac Hontelez
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, South Africa
    Hum Resour Health 10:39. 2012
  8. pmc An investigation of factors associated with the health and well-being of HIV-infected or HIV-affected older people in rural South Africa
    Makandwe Nyirenda
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, R618 Enroute Somkhele, Mtubatuba 3935, South Africa
    BMC Public Health 12:259. 2012
  9. pmc A retrospective study of Human Immunodeficiency Virus transmission, mortality and loss to follow-up among infants in the first 18 months of life in a prevention of mother-to-child transmission programme in an urban hospital in KwaZulu-Natal, South Africa
    Terusha Chetty
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, South Africa
    BMC Pediatr 12:146. 2012
  10. pmc Using two on-going HIV studies to obtain clinical data from before, during and after pregnancy for HIV-positive women
    Susie E Huntington
    Research Department of Infection and Population Health, University College London, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    BMC Med Res Methodol 12:110. 2012

Detail Information

Publications80

  1. ncbi request reprint Within and between race differences in lymphocyte, CD4+, CD8+ and neutrophil levels in HIV-uninfected children with or without HIV exposure in Europe and Uganda
    Madeleine Bunders
    Centre for Paediatric Epidemiology, Institute of Child Health, University College, London, UK
    Ann Trop Paediatr 26:169-79. 2006
    ..Racial immuno-haematological differences have been reported in children but to date have not been well quantified...
  2. doi request reprint Safety of antiretroviral drugs in pregnancy and breastfeeding for mother and child
    Marie Louise Newell
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, KwaZulu Natal, South Africa
    Curr Opin HIV AIDS 8:504-10. 2013
    ..Changing MTCT prevention guidelines, with expanded eligibility, have led to a rapid increase of ART-treated women and exposed infants in high prevalence regions...
  3. ncbi request reprint Male circumcision to cut HIV risk in the general population
    Marie Louise Newell
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, KwaZulu Natal 3935, South Africa
    Lancet 369:617-9. 2007
  4. pmc Evaluation of the impact of immediate versus WHO recommendations-guided antiretroviral therapy initiation on HIV incidence: the ANRS 12249 TasP (Treatment as Prevention) trial in Hlabisa sub-district, KwaZulu-Natal, South Africa: study protocol for a clus
    Collins C Iwuji
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, KwaZulu Natal, South Africa
    Trials 14:230. 2013
    ..The first phase will specifically focus on the trial's secondary outcomes...
  5. pmc Impact of a novel molecular TB diagnostic system in patients at high risk of TB mortality in rural South Africa (Uchwepheshe): study protocol for a cluster randomised trial
    Richard J Lessells
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trials 14:170. 2013
    ..We present a cluster randomised trial designed to evaluate whether the positioning of this diagnostic system within the health system has an impact on important patient-level outcomes...
  6. pmc The social dynamics of consent and refusal in HIV surveillance in rural South Africa
    Lindsey Reynolds
    Department of Anthropology, Johns Hopkins University, 3400 N Charles St, 404 Macauley Hall, Baltimore, MD 21218, United States
    Soc Sci Med 77:118-25. 2013
    ....
  7. pmc Human resources needs for universal access to antiretroviral therapy in South Africa: a time and motion study
    Jan Ac Hontelez
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, South Africa
    Hum Resour Health 10:39. 2012
    ..abstract:..
  8. pmc An investigation of factors associated with the health and well-being of HIV-infected or HIV-affected older people in rural South Africa
    Makandwe Nyirenda
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, R618 Enroute Somkhele, Mtubatuba 3935, South Africa
    BMC Public Health 12:259. 2012
    ....
  9. pmc A retrospective study of Human Immunodeficiency Virus transmission, mortality and loss to follow-up among infants in the first 18 months of life in a prevention of mother-to-child transmission programme in an urban hospital in KwaZulu-Natal, South Africa
    Terusha Chetty
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, South Africa
    BMC Pediatr 12:146. 2012
    ..We determined HIV transmission, mortality and loss to follow-up (LTFU) of HIV-exposed infants attending a postnatal clinic in an urban hospital in Durban, South Africa...
  10. pmc Using two on-going HIV studies to obtain clinical data from before, during and after pregnancy for HIV-positive women
    Susie E Huntington
    Research Department of Infection and Population Health, University College London, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    BMC Med Res Methodol 12:110. 2012
    ..A methodology was developed to find and match records for women reported to both studies thereby obtaining clinical and treatment data on pregnant HIV-positive women not available from either dataset alone...
  11. pmc A cluster randomised controlled trial of the community effectiveness of two interventions in rural Malawi to improve health care and to reduce maternal, newborn and infant mortality
    Sonia Lewycka
    Centre for International Health and Development, UCL Institute of Child Health, London, UK
    Trials 11:88. 2010
    ..The MaiMwana Project aims to test community-based interventions that tackle maternal and child health problems through increasing awareness and local action...
  12. pmc Verbal autopsy-based cause-specific mortality trends in rural KwaZulu-Natal, South Africa, 2000-2009
    Abraham J Herbst
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, South Africa
    Popul Health Metr 9:47. 2011
    ..abstract:..
  13. pmc Validating child vaccination status in a demographic surveillance system using data from a clinical cohort study: evidence from rural South Africa
    James Ndirangu
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, South Africa
    BMC Public Health 11:372. 2011
    ..Childhood vaccination coverage can be estimated from a range of sources. This study aims to validate vaccination data from a longitudinal population-based demographic surveillance system (DSS) against data from a clinical cohort study...
  14. pmc Population uptake of antiretroviral treatment through primary care in rural South Africa
    Graham S Cooke
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, KwaZulu Natal, South Africa
    BMC Public Health 10:585. 2010
    ..We investigated the factors associated with uptake of antiretroviral treatment through a primary healthcare system in rural South Africa...
  15. pmc Design and methods of a longitudinal study investigating the impact of antiretroviral treatment on the partnerships and sexual behaviour of HIV-infected individuals in rural KwaZulu-Natal, South Africa
    Nuala McGrath
    London School of Hygiene and Tropical Medicine, London, UK
    BMC Public Health 11:121. 2011
    ..This includes improving the availability of longitudinal demographic and health data on HIV-infected individuals who have accessed ART services but who are not yet ART-eligible...
  16. pmc HIV prevention for South African youth: which interventions work? A systematic review of current evidence
    Abigail Harrison
    Brown University, Population Studies and Training Center, and Department of Medicine, Warren Alpert School of Medicine, Providence, RI, USA
    BMC Public Health 10:102. 2010
    ..In South Africa, HIV prevalence among youth aged 15-24 is among the world's highest. Given the urgent need to identify effective HIV prevention approaches, this review assesses the evidence base for youth HIV prevention in South Africa...
  17. pmc Coming home to die? The association between migration and mortality in rural South Africa
    Paul Welaga
    Navrongo Health Research Centre, Navrongo, Ghana
    BMC Public Health 9:193. 2009
    ..Several studies have shown migrants to be particularly susceptible to HIV infection. This paper investigates whether migrants to rural households have a higher risk of dying, especially from HIV, than non-migrants...
  18. pmc The tuberculosis challenge in a rural South African HIV programme
    Catherine F Houlihan
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, South Africa
    BMC Infect Dis 10:23. 2010
    ..Within South Africa, KwaZulu-Natal has one of the highest rates of TB incidence and an emerging epidemic of drug-resistant tuberculosis...
  19. pmc Renal impairment in a rural African antiretroviral programme
    Cara Franey
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, South Africa
    BMC Infect Dis 9:143. 2009
    ..With the increasing availability of the potentially nephrotixic drug, tenofovir, such information is important for the planning of antiretroviral programmes..
  20. ncbi request reprint High HIV incidence in a community with high HIV prevalence in rural South Africa: findings from a prospective population-based study
    Till Barnighausen
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, South Africa
    AIDS 22:139-44. 2008
    ..To measure HIV incidence in a rural area of South Africa with high HIV prevalence and to analyze risk factors for acquisition of HIV using a prospective population-based cohort study...
  21. pmc The socioeconomic determinants of HIV incidence: evidence from a longitudinal, population-based study in rural South Africa
    Till Barnighausen
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, South Africa
    AIDS 21:S29-38. 2007
    ..Both problems are avoided in longitudinal cohort studies...
  22. doi request reprint Intervention to promote exclusive breast-feeding for the first 6 months of life in a high HIV prevalence area
    Ruth M Bland
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, KwaZulu Natal, South Africa
    AIDS 22:883-91. 2008
    ..We report on a nonrandomized intervention cohort study to increase exclusive breast-feeding rates for 6 months after delivery in HIV-positive and HIV-negative women in KwaZulu-Natal, South Africa...
  23. pmc Population and antenatal-based HIV prevalence estimates in a high contracepting female population in rural South Africa
    Brian D Rice
    Africa Centre for Health and Population Studies, KwaZulu Natal, South Africa
    BMC Public Health 7:160. 2007
    ..There is particular emphasis on unrepresentative selection of ANC clinics and unrepresentative testing in the population...
  24. doi request reprint Mortality levels and trends by HIV serostatus in rural South Africa
    Makandwe Nyirenda
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, South Africa
    AIDS 21:S73-9. 2007
    ..To examine mortality differentials in HIV-infected and uninfected adults by demographic characteristics and the effect of non-testing on the level and pattern of age-sex specific mortality...
  25. pmc Cohort Profile: Africa Centre Demographic Information System (ACDIS) and population-based HIV survey
    Frank Tanser
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, South Africa
    Int J Epidemiol 37:956-62. 2008
  26. ncbi request reprint Short communication: CD4 counts of HIV-infected pregnant women and their infected children--implications for PMTCT and treatment programmes
    Ankie Lebon
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, South Africa
    Trop Med Int Health 12:1472-4. 2007
    ..The antenatal-postnatal divide needs to be bridged with respect to the follow-up of both HIV-infected women and their exposed infants...
  27. ncbi request reprint Continued very high prevalence of HIV infection in rural KwaZulu-Natal, South Africa: a population-based longitudinal study
    Tanya Welz
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Durban, South Africa
    AIDS 21:1467-72. 2007
    ..To estimate the prevalence of HIV and associated sociodemographic factors including mobility and migration in a rural population in KwaZulu-Natal, South Africa...
  28. pmc Preventing postnatal transmission of HIV-1 through breast-feeding: modifying infant feeding practices
    Nigel Rollins
    Africa Centre for Health and Population Studies, Mtubatuba, South Africa
    J Acquir Immune Defic Syndr 35:188-95. 2004
    ..This may inform policy, programming, and training options and may be especially valuable in the absence of conclusive data on the efficacy of the interventions to be applied during the breast-feeding period...
  29. ncbi request reprint Refining the criteria for stalled fertility declines: an application to rural KwaZulu-Natal, South Africa, 1990-2005
    Tom A Moultrie
    Centre for Actuarial Research, University of Cape Town, South Africa
    Stud Fam Plann 39:39-48. 2008
    ..This identification of a stalled fertility decline provides the first evidence of such a stall in southern Africa, the region with the lowest fertility levels in sub-Saharan Africa...
  30. ncbi request reprint Higher rates of post-partum complications in HIV-infected than in uninfected women irrespective of mode of delivery
    Simona Fiore
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    AIDS 18:933-8. 2004
    ..To inform the debate on the use of elective caesarean section (CS) delivery in HIV-infected women, we investigated the occurrence of clinical events in the immediate post-partum period in women delivering in 13 European centres...
  31. ncbi request reprint Surveillance of mother-to-child transmission prevention programmes at immunization clinics: the case for universal screening
    Nigel Rollins
    Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Congella 4013, South Africa
    AIDS 21:1341-7. 2007
    ..Additionally, infected infants are often not identified early and only gain access to comprehensive HIV care and treatment late in their disease...
  32. pmc Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA
    Marie Louise Newell
    Centre of Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    BMC Infect Dis 7:60. 2007
    ....
  33. ncbi request reprint Pregnancy and HIV infection: A european consensus on management
    Oriol Coll
    Hospital Clinic, University of Barcelona, Spain
    AIDS 16:S1-18. 2002
  34. ncbi request reprint Current issues in the prevention of mother-to-child transmission of HIV-1 infection
    Marie Louise Newell
    Infectious Disease Group, Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK
    Trans R Soc Trop Med Hyg 100:1-5. 2006
    ..In light of the high mortality in all children of HIV-infected women, programmes for prevention of MTCT should be monitored not only in terms of HIV transmission avoided but also in terms of child survival...
  35. ncbi request reprint Prevalence of sexually transmitted infections in HIV-1 infected pregnant women in Europe
    Megan Landes
    Department of Family and Community Medicine, University of Toronto, Toronto, Canada
    Eur J Epidemiol 22:925-36. 2007
    ..HIV-infected women should receive adequate screening for STIs during pregnancy together with appropriate counseling and follow-up for treatment and prevention...
  36. ncbi request reprint Cohort profile: the paediatric antiretroviral treatment programmes in lower-income countries (KIDS-ART-LINC) collaboration
    Elise Arrive
    Unité INSERM 593, Institut de Santé Publique, Epidémiologie et Développement ISPED, Universite Victor Segalen, Bordeaux, France
    Int J Epidemiol 37:474-80. 2008
  37. ncbi request reprint Breastmilk RNA viral load in HIV-infected South African women: effects of subclinical mastitis and infant feeding
    Juana F Willumsen
    Centre for International Child Health, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    AIDS 17:407-14. 2003
    ..To investigate determinants of breastmilk RNA viral load among HIV-infected South African women, with particular attention to infant feeding mode and subclinical mastitis...
  38. ncbi request reprint Immunoprophylaxis to prevent mother-to-child transmission of HIV-1
    Jeffrey T Safrit
    Elizabeth Glaser Pediatric AIDS Foundation, David Geffen School of Medicine, University of California, Los Angeles, USA
    J Acquir Immune Defic Syndr 35:169-77. 2004
    ..Data regarding currently or imminently available passive and active immunoprophylaxis products are reviewed for their potential use in neonatal trials within the coming 1-2 years...
  39. pmc Breast-feeding and Transmission of HIV-1
    Grace John-Stewart
    Department of Medicine, University of Washington, USA
    J Acquir Immune Defic Syndr 35:196-202. 2004
    ..Innate and acquired immune factors may act most effectively in combination to prevent primary HIV-1 infection by breast milk...
  40. ncbi request reprint Mother-to-child transmission of HIV infection and its prevention
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    Curr HIV Res 1:447-62. 2003
    ..However, the key to prevention of paediatric HIV infections is adequate prevention of infection in women of reproductive age...
  41. doi request reprint Reproductive experience of HIV-infected women living in Europe
    Simona Fiore
    Department of Obstetrics and Gynaecology, DSC Sacco, University of Milan, Milan, Italy
    Hum Reprod 23:2140-4. 2008
    ..The aim of this study was to describe the experience of pregnant and non-pregnant HIV-infected women regarding fertility and childbearing, with a view to inform policies and practices to improve reproductive outcome...
  42. ncbi request reprint Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study
    Hoosen M Coovadia
    Centre for HIV AIDS Networking, University of KwaZulu Natal, South Africa
    Lancet 369:1107-16. 2007
    ..We assessed the HIV-1 transmission risks and survival associated with exclusive breastfeeding and other types of infant feeding...
  43. ncbi request reprint Vaccines to prevent transmission of HIV-1 via breastmilk: scientific and logistical priorities
    Katherine Luzuriaga
    University of Massachusetts Medical School, Program in Molecular Medicine, 373 Plantation Street, Suite 318, Worcester, MA 01605, USA
    Lancet 368:511-21. 2006
    ..Here, we discuss the scientific and logistical challenges for the development of paediatric HIV vaccines; available vaccines and completed or planned paediatric vaccine trials are also discussed...
  44. ncbi request reprint Child mortality and HIV infection in Africa: a review
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    AIDS 18:S27-34. 2004
    ..To review the available data relating to child mortality in Africa by the HIV infection status of mothers and children...
  45. ncbi request reprint Does highly active antiretroviral therapy increase the risk of congenital abnormalities in HIV-infected women?
    Deven Patel
    J Acquir Immune Defic Syndr 40:116-8. 2005
  46. ncbi request reprint Pregnancy outcomes in HIV-infected and uninfected women in rural and urban South Africa
    Nigel C Rollins
    Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Congella 4013, South Africa
    J Acquir Immune Defic Syndr 44:321-8. 2007
    ..To describe pregnancy outcomes among clade C HIV-infected and uninfected women in South Africa...
  47. ncbi request reprint Antiretroviral therapy and mother-to-child transmission of HIV-1
    Marie Louise Newell
    University College London, Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Expert Rev Anti Infect Ther 2:717-32. 2004
    ..However, postnatal transmission of infection through breastfeeding significantly reduces the longer-term efficacy of these strategies. Ongoing research is focusing on the use of antiretroviral therapy in the breastfeeding period...
  48. ncbi request reprint Late postnatal transmission of HIV-1 in breast-fed children: an individual patient data meta-analysis
    Anna Coutsoudis
    J Infect Dis 189:2154-66. 2004
    ....
  49. ncbi request reprint Reply to 'Mode of infant feeding and HIV infection in children in a program for prevention of mother-to-child transmission in Uganda' by Magoni et al
    Anna Coutsoudis
    AIDS 19:1718-9; author reply 1720-1. 2005
  50. ncbi request reprint Treatment options for the prevention of mother-to-child transmission of HIV
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Curr Opin Investig Drugs 6:804-11. 2005
    ....
  51. ncbi request reprint Age-related standards for total lymphocyte, CD4+ and CD8+ T cell counts in children born in Europe
    Madeleine Bunders
    Institute of Child Health, University College London, United Kingdom
    Pediatr Infect Dis J 24:595-600. 2005
    ..Standards are essential for diagnosing and monitoring childhood diseases such as pediatric human immunodeficiency virus (HIV) infection...
  52. ncbi request reprint Maternal toxicity and pregnancy complications in human immunodeficiency virus-infected women receiving antiretroviral therapy: PACTG 316
    D Heather Watts
    National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Am J Obstet Gynecol 190:506-16. 2004
    ..The purpose of this study was to evaluate rates of maternal toxicity, pregnancy complications, and peripartum morbidity by type and duration of antiretroviral therapy (ART) during pregnancy...
  53. ncbi request reprint Disease progression in children with vertically-acquired HIV infection in sub-Saharan Africa: reviewing the need for HIV treatment
    Kirsty Little
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    Curr HIV Res 5:139-53. 2007
    ..Additionally, improvements in health infrastructures could improve care provision, not only through improved detection and monitoring but also through treatment of co-morbidities and nutritional support...
  54. ncbi request reprint Antenatal and neonatal antiretroviral therapy in HIV-infected women and their infants: a review of safety issues
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, 30 Guilford Street, WC1N 1EH London, UK
    Med Wieku Rozwoj 7:425-36. 2003
    ....
  55. ncbi request reprint Use of antiretroviral drugs to prevent HIV-1 transmission through breast-feeding: from animal studies to randomized clinical trials
    Philippe Gaillard
    World Health Organization, Reproductive Health and Research, Geneva, Switzerland
    J Acquir Immune Defic Syndr 35:178-87. 2004
    ..Laboratory studies nested within several of these trials will provide a better understanding of the pathogenesis of postnatal HIV transmission and its potential prevention using antiretroviral drugs...
  56. ncbi request reprint Older children and adolescents surviving with vertically acquired HIV infection
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    J Acquir Immune Defic Syndr 29:396-401. 2002
    ..As they enter adolescence, additional services are needed including support with disclosure to others, therapy, and sexual health...
  57. pmc Routine provision of nevirapine to women of unknown serostatus: at best a temporary solution to prevent MTCT
    Marie Louise Newell
    Institute of Child Health, University College London, London, England
    Bull World Health Organ 83:228-9. 2005
  58. ncbi request reprint Prevention of HIV transmission through breast-feeding: strengthening the research agenda
    Francois Dabis
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, London, UK
    J Acquir Immune Defic Syndr 35:167-8. 2004
    ..These papers summarize the current state of knowledge and highlight the outstanding issues that will need to be addressed in the very near future before research advances can be translated into public health practice...
  59. ncbi request reprint [A decade of child health research in developing countries]
    Joanna Orne-Gliemann
    Institut de Santé Publique, d Épidémiologie et de Développement, Universite Victor Segalen Bordeaux 2, Case 11, 33086 Bordeaux, France
    Sante 13:69-75. 2003
    ..Furthermore, it appears that descriptive epidemiology, evaluation and priority setting strategies are essential tools to guide adequate research activities and further improvement of child health...
  60. ncbi request reprint Estimating the efficacy of interventions to prevent mother-to-child transmission of human immunodeficiency virus in breastfeeding populations: comparing statistical methods
    Ahmadou Alioum
    INSERM U 593, Institut d Epidémiologie, Santé Publique et Développement, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Am J Epidemiol 158:596-605. 2003
    ..For estimation of this proportion at age 18 months, more sophisticated methods, such as the extension of the Kaplan-Meier procedure to interval-censored data and competing risks, would be preferred...
  61. ncbi request reprint Antenatal and perinatal strategies to prevent mother-to-child transmission of HIV infection
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Trans R Soc Trop Med Hyg 97:22-4. 2003
    ..Micronutrient supplementation, including vitamin A, does not reduce MTCT of HIV, but may improve pregnancy outcome generally...
  62. ncbi request reprint Effects of CCR5-delta32 and CCR2-64I alleles on disease progression of perinatally HIV-1-infected children: an international meta-analysis
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    AIDS 17:1631-8. 2003
    ..Among perinatally infected children, the effects of certain alleles of the CCR5 and CCR2 genes on the rate of disease progression remain unclear. We addressed the effects of CCR5-delta32 and CCR2-64I in an international meta-analysis...
  63. ncbi request reprint Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH, UK
    Lancet 364:1236-43. 2004
    ..With individual data from seven randomised mother-to-child transmission (MTCT) intervention trials, we estimate mortality in African children born to HIV-infected mothers and analyse selected risk factors...
  64. ncbi request reprint European participation in an international perinatal trial
    Simona Fiore
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, 30 Guilford Street, WC1N 1EH London, UK
    Med Wieku Rozwoj 7:449-58. 2003
    ..To compare the population enrolled in a Phase III trial to that enrolled during the same period in a parallel longitudinal cohort, and to assess the generalisability of the trial results...
  65. doi request reprint Response to combination antiretroviral therapy: variation by age
    Caroline A Sabin
    AIDS 22:1463-73. 2008
    ..To provide information on responses to combination antiretroviral therapy in children, adolescents and older HIV-infected persons...
  66. ncbi request reprint Prevention of mother-to-child transmission of HIV infection
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Curr Opin Infect Dis 17:247-52. 2004
    ..There is a need for alternative, easier and more effective interventions for population-based programmes...
  67. ncbi request reprint Estimating the number of vertically HIV-infected children eligible for antiretroviral treatment in resource-limited settings
    Kirsty Little
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health UCL, 30 Guilford Street, London, UK
    Int J Epidemiol 36:679-87. 2007
    ....
  68. ncbi request reprint Prevalence of resistance to nevirapine in mothers and children after single-dose exposure to prevent vertical transmission of HIV-1: a meta-analysis
    Elise Arrive
    Unité INSERM 593, Bordeaux, France
    Int J Epidemiol 36:1009-21. 2007
    ..This systematic review and meta-analysis of summarized data aimed to estimate the proportion of mothers and children with NVP resistance mutations detected in plasma samples 4-8 weeks postpartum after single-dose NVP use for PMTCT...
  69. pmc Monitoring the scale-up of antiretroviral therapy programmes: methods to estimate coverage
    J Ties Boerma
    The World Health Organization, Geneva, Switzerland
    Bull World Health Organ 84:145-50. 2006
    ..The mid-2005 estimate of 970,000 people receiving ART in low- and middle-income countries (with an uncertainty range 840,000-1,100,000) corresponds to a coverage of 15% of people in need of treatment...
  70. ncbi request reprint Response to Kourtis et al. 'Use of antiretroviral therapy in pregnant HIV-infected women and the risk of premature delivery: a meta-analysis'
    Deven Patel
    AIDS 21:1656-7; author reply1657-8. 2007
  71. ncbi request reprint Prevention of mother-to-child transmission of HIV infection: Ukraine experience to date
    Ruslan Malyuta
    World Health Organization Regional Office for Europe, Copenhagen, Denmark
    Eur J Public Health 16:123-7. 2006
    ..This article sets out to describe the first 2 years of the implementation of the national PMTCT programme in Ukraine...
  72. ncbi request reprint Vertically acquired paediatric coinfection with HIV and hepatitis C virus
    Kirsty England
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Lancet Infect Dis 6:83-90. 2006
    ..Future research must therefore focus on vertically acquired HIV/HCV coinfection to inform treatment trials addressing coinfection management...
  73. ncbi request reprint Antiretroviral therapy-associated modulation of Th1 and Th2 immune responses in HIV-infected pregnant women
    Simona Fiore
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London UCL, London, UK
    J Reprod Immunol 70:143-50. 2006
    ..0-1.17; p=0.005). HAART use in pregnancy provides significant benefits in delaying HIV disease progression and reducing the risk of mother-to-child-transmission, but may be counterproductive in terms of successful pregnancy outcome...
  74. ncbi request reprint Does exposure to antiretroviral therapy affect growth in the first 18 months of life in uninfected children born to HIV-infected women?
    Claire Hankin
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, United Kingdom
    J Acquir Immune Defic Syndr 40:364-70. 2005
    ..10 [P = 0.019]; height, -0.12 [P = 0.008]; and OFC, -0.14 [P = 0.001]). Although the effect of combination therapy exposure is minimal, long-term monitoring of these children is important...
  75. ncbi request reprint Is there a difference in the efficacy of peripartum antiretroviral regimens in reducing mother-to-child transmission of HIV in Africa?
    Valeriane Leroy
    INSERM U 593, Institut d Epidémiologie, Santé Publique et Développement ISPED, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    AIDS 19:1865-75. 2005
    ....
  76. ncbi request reprint Maternal viral load and rate of disease progression among vertically HIV-1-infected children: an international meta-analysis
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    AIDS 18:99-108. 2004
    ....
  77. ncbi request reprint Are girls more at risk of intrauterine-acquired HIV infection than boys?
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, London, UK
    AIDS 18:344-7. 2004
    ..Girls were at a 1.5 times increased risk of MTCT overall, but the sex effect was limited to elective caesarean section deliveries, suggesting that girls may have an increased risk of intrauterine transmission compared with boys...
  78. ncbi request reprint Time to undetectable viral load after highly active antiretroviral therapy initiation among HIV-infected pregnant women
    Deven Patel
    Clin Infect Dis 44:1647-56. 2007
    ....
  79. pmc Scaling-up exclusive breastfeeding support programmes: the example of KwaZulu-Natal
    Chris Desmond
    Human Sciences Research Council, Durban, South Africa
    PLoS ONE 3:e2454. 2008
    ..We present a costing and cost effectiveness analysis of a successful intervention to promote EBF in high HIV prevalence area in South Africa, and implications for scale-up in the province of KwaZulu-Natal...
  80. ncbi request reprint Modelling HIV-RNA viral load in vertically infected children
    Linsay Gray
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    Stat Med 23:769-81. 2004
    ..Although Hughes' methodology is the best approach, its implementation is not necessary for the identification of the optimal model...