Lirlândia Pires Sousa



  1. Vago J, Tavares L, Garcia C, Lima K, Perucci L, Vieira Ã, et al. The role and effects of glucocorticoid-induced leucine zipper in the context of inflammation resolution. J Immunol. 2015;194:4940-50 pubmed publisher
    ..Alternatively, a lack of endogenous GILZ during the resolution of inflammation is compensated by AnxA1 overexpression. ..
  2. Vago J, Tavares L, Sugimoto M, Lima G, Galvão I, de Caux T, et al. Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1. J Immunol. 2016;196:1922-32 pubmed publisher
  3. Carmo A, Costa B, Vago J, de Oliveira L, Tavares L, Nogueira C, et al. Plasmin induces in vivo monocyte recruitment through protease-activated receptor-1-, MEK/ERK-, and CCR2-mediated signaling. J Immunol. 2014;193:3654-63 pubmed publisher
    ..Therefore, Pla-induced mononuclear cell recruitment in vivo was dependent on protease-activated receptor-1 activation of the MEK/ERK/NF-κB pathway, which led to the release of CCL2 and activation of CCR2. ..
  4. Perucci L, Santos P, Ribeiro L, Souza D, Gomes K, Dusse L, et al. Lipoxin A4 Is Increased in the Plasma of Preeclamptic Women. Am J Hypertens. 2016;29:1179-85 pubmed publisher
    ..Further studies are necessary to clarify this issue and to evaluate the role of LXA4 and other proresolving mediators of inflammation in the pathogenesis of PE. ..
  5. Perucci L, Vieira E, Teixeira A, Gomes K, Dusse L, Sousa L. Decreased plasma concentrations of brain-derived neurotrophic factor in preeclampsia. Clin Chim Acta. 2017;464:142-147 pubmed publisher
    ..No correlation was significant in normotensive pregnant women. Lower BDNF plasma concentrations and cross-talk between BDNF and AnxA1 signaling pathways might be involved in PE pathogenesis. ..
  6. Perucci L, Corrêa M, Dusse L, Gomes K, Sousa L. Resolution of inflammation pathways in preeclampsia-a narrative review. Immunol Res. 2017;65:774-789 pubmed publisher
    ..In this narrative review, we discuss possible pro-resolution pathways that might be compromised in PE women, which could be targets to novel therapeutic strategies in this disease. ..
  7. Lima K, Vago J, Caux T, Negreiros Lima G, Sugimoto M, Tavares L, et al. The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1. J Biol Chem. 2017;292:13758-13773 pubmed publisher
    ..Our results show that AnxA1 is at least one of the endogenous determinants mediating the pro-resolving properties of cAMP-elevating agents and cAMP-mimetic drugs. ..
  8. Sugimoto M, de Jesus Amazonas da Silva M, Froede Brito L, Dos Santos Borges R, Amaral F, de Araújo Boleti A, et al. Anti-Inflammatory Potential of 1-Nitro-2-Phenylethylene. Molecules. 2017;22: pubmed publisher
    ..Taken together, the results suggest a potential anti-inflammatory activity for NPe via inhibition of ERK1/2 and NF-κB pathways on leukocytes. ..