A microarray analysis of the effects of moderate hypothermia and rewarming on gene expression by human hepatocytes (HepG2)Larry A Sonna
Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Cell Stress Chaperones 15:687-702. 2010
..Thus, while some overlap occurs (particularly after rewarming), moderate hypothermia produces extensive, time-dependent gene expression changes in HepG2 cells that differ in important ways from those induced by heat shock...
Exertional heat illness and human gene expressionLarry A Sonna
Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Prog Brain Res 162:321-46. 2007
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- Effect of moderate hypothermia on gene expression by THP-1 cells: a DNA microarray study
Larry A Sonna
Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
Physiol Genomics 26:91-8. 2006
..These in vitro findings suggest that prolonged hypothermia in vivo might be capable of producing physiologically relevant changes in gene expression by circulating leukocytes...
- Exertional heat injury and gene expression changes: a DNA microarray analysis study
Larry A Sonna
Thermal and Mountain Medicine Div, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
J Appl Physiol 96:1943-53. 2004
..The molecular evidence from these patients is thus consistent with the hypothesis that EHI can result from cumulative effects of multiple adverse interacting stimuli...
- Effect of acute heat shock on gene expression by human peripheral blood mononuclear cells
Larry A Sonna
Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760, USA
J Appl Physiol 92:2208-20. 2002
..We conclude that heat shock causes extensive gene expression changes in PBMCs, affecting all functional categories of the heat shock response...
- Effect of hypoxia on gene expression by human hepatocytes (HepG2)
Larry A Sonna
Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Physiol Genomics 12:195-207. 2003
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- Core temperature correlates with expression of selected stress and immunomodulatory genes in febrile patients with sepsis and noninfectious SIRS
Larry A Sonna
University of Maryland School of Medicine, Baltimore, MD 21201, USA
Cell Stress Chaperones 15:55-66. 2010
..For some genes, it appears that clinical condition can alter temperature-sensitive gene expression. Collectively, these data underscore the potential importance of body temperature in shaping the immune response to infection and injury...
- Ontogeny of the eotaxins in human lung
Kathleen J Haley
Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, 75 Francis Street, Boston, MA 02115, USA
Am J Physiol Lung Cell Mol Physiol 294:L214-24. 2008
..We conclude that developing lung expresses the eotaxins and functional CCR3 receptor. CCL11 may promote airway epithelial proliferation in the developing lung...
- Invited review: Effects of heat and cold stress on mammalian gene expression
Larry A Sonna
Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760, USA
J Appl Physiol 92:1725-42. 2002
..The similarities and differences between the cellular responses to heat and cold may yield key insights into how cells, and by extension tissues and organisms, survive and adapt to stress...
- Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice
Rebecca M Baron
Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
FASEB J 18:1276-8. 2004
..This study demonstrates that expression of NOS2 in lung epithelial cells is critical for the development of lung injury and mediates surfactant dysfunction independent of NOS2 inflammatory cell expression and cytokine production...
- DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line
Richard J Wood
Mineral Bioavailability Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston 02111, USA
Physiol Genomics 17:122-9. 2004
..The known function of these genes suggests that many of them could be involved in the antiproliferative effects of 1,25-dihydroxyvitamin D3...
Heat shock protein 90beta: a novel mediator of vitamin D actionGiana Angelo
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Mineral Bioavailability Laboratory, 711 Washington Street, Boston, MA 02111, USA
Biochem Biophys Res Commun 367:578-83. 2008
..These findings indicate that Hsp90beta is needed for optimal vitamin D responsiveness in the enterocyte and demonstrate a specific role for Hsp90beta in VDR signaling...
- Effects of allergen challenge on airway epithelial cell gene expression
Craig M Lilly
Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Thorn 826C, Boston, MA 02115, USA
Am J Respir Crit Care Med 171:579-86. 2005
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