Li Bing Song

Summary

Publications

  1. ncbi request reprint Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor
    Xi Wang
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Sun Yat sen University Cancer Center, Guangzhou, Guangdong 510060, China
    Mol Cancer 13:106. 2014
  2. pmc MACC1 as a prognostic biomarker for early-stage and AFP-normal hepatocellular carcinoma
    Chan Xie
    Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong Province, China
    PLoS ONE 8:e64235. 2013
  3. pmc Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway
    Lili Jiang
    Department of Pathophysiology, Guangzhou Medical University, Guangzhou, Guangdong 510182, China
    BMC Cancer 12:406. 2012
  4. pmc Astrocyte elevated gene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma
    Wen Ting Liao
    State Key Laboratory of Oncology in Southern China, Guangzhou 510060, P R China
    J Transl Med 9:205. 2011
  5. pmc Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy
    Guanglin Liu
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, China
    BMC Cancer 10:495. 2010
  6. doi request reprint Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-κB pathway in human non-small cell lung cancer
    Libing Song
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, PR China
    Clin Cancer Res 17:1839-49. 2011
  7. ncbi request reprint Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer
    Libing Song
    State Key Laboratory of Oncology in Southern China, Sun Yat Sen University Cancer Centre, Guangzhou, Guangdong 510060, People s Republic of China
    J Pathol 219:317-26. 2009
  8. doi request reprint Inhibition of centriole duplication by centrobin depletion leads to p38-p53 mediated cell-cycle arrest
    Libing Song
    Sun Yat sen University Cancer Center, Guangzhou, Guangdong, China
    Cell Signal 22:857-64. 2010
  9. doi request reprint Sam68 up-regulation correlates with, and its down-regulation inhibits, proliferation and tumourigenicity of breast cancer cells
    Libing Song
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, China
    J Pathol 222:227-37. 2010
  10. pmc The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
    Li Bing Song
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    J Clin Invest 119:3626-36. 2009

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor
    Xi Wang
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Sun Yat sen University Cancer Center, Guangzhou, Guangdong 510060, China
    Mol Cancer 13:106. 2014
    ..Acylglycerol kinase (AGK) is reported to be overexpressed in multiple cancers. The clinical significance and biological role of AGK in breast cancer, however, remain to be established...
  2. pmc MACC1 as a prognostic biomarker for early-stage and AFP-normal hepatocellular carcinoma
    Chan Xie
    Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong Province, China
    PLoS ONE 8:e64235. 2013
    ..The aim of this study was to investigate the prognostic value of MACC1 in early-stage and AFP-normal hepatocellular carcinoma (HCC)...
  3. pmc Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway
    Lili Jiang
    Department of Pathophysiology, Guangzhou Medical University, Guangzhou, Guangdong 510182, China
    BMC Cancer 12:406. 2012
    ....
  4. pmc Astrocyte elevated gene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma
    Wen Ting Liao
    State Key Laboratory of Oncology in Southern China, Guangzhou 510060, P R China
    J Transl Med 9:205. 2011
    ..Astrocyte elevated gene-1 (AEG-1) is associated with tumorigenesis and progression in diverse human cancers. The present study was aimed to investigate the clinical and prognostic significance of AEG-1 in salivary gland carcinomas (SGC)...
  5. pmc Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy
    Guanglin Liu
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, China
    BMC Cancer 10:495. 2010
    ..The current study was to characterize the expression of SPHK1 in salivary gland carcinomas (SGC) and to investigate the association between SPHK1 expression and progression of SGC...
  6. doi request reprint Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-κB pathway in human non-small cell lung cancer
    Libing Song
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, PR China
    Clin Cancer Res 17:1839-49. 2011
    ....
  7. ncbi request reprint Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer
    Libing Song
    State Key Laboratory of Oncology in Southern China, Sun Yat Sen University Cancer Centre, Guangzhou, Guangdong 510060, People s Republic of China
    J Pathol 219:317-26. 2009
    ..Taken together, our results suggest that elevated expression of AEG-1 plays an important role in the aggressiveness of NSCLC, leading to a poor clinical outcome...
  8. doi request reprint Inhibition of centriole duplication by centrobin depletion leads to p38-p53 mediated cell-cycle arrest
    Libing Song
    Sun Yat sen University Cancer Center, Guangzhou, Guangdong, China
    Cell Signal 22:857-64. 2010
    ....
  9. doi request reprint Sam68 up-regulation correlates with, and its down-regulation inhibits, proliferation and tumourigenicity of breast cancer cells
    Libing Song
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, China
    J Pathol 222:227-37. 2010
    ....
  10. pmc The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
    Li Bing Song
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    J Clin Invest 119:3626-36. 2009
    ..Our results provide functional and mechanistic links between the oncoprotein Bmi-1 and the tumor suppressor PTEN in the development and progression of cancer...
  11. pmc Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma
    Qing Li Kong
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    PLoS Pathog 6:e1000940. 2010
    ..Taken together, our data indicate that LMP2A induces EMT and stem-like cell self-renewal in NPC, suggesting a novel mechanism by which Epstein-Barr virus induces the initiation, metastasis and recurrence of NPC...
  12. ncbi request reprint The clinical significance of twist expression in nasopharyngeal carcinoma
    Li Bing Song
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    Cancer Lett 242:258-65. 2006
    ..These findings demonstrate that the Twist may play an important role in the invasion and metastasis of NPC. Twist protein is valuable marker for assessing the prognosis of NPC...
  13. ncbi request reprint [Expression and significance of Bmi-1 in breast cancer]
    Yan Feng
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, PR China
    Ai Zheng 26:154-7. 2007
    ..Bmi-1, a putative oncogene, is a member of the polycomb group genes family. It is widely expressed in many kinds of tumors. This study was to investigate the expression and significance of Bmi-1 in breast cancer...
  14. pmc Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer
    Bao Hong Guo
    State Key Laboratory of Oncology in South China and Department of Experimental Research, Sun Yat sen University Cancer Center, Guangzhou, PR China
    Mol Cancer 10:10. 2011
    ..However, the underlying molecular mechanism of Bmi-1-mediated progression and the metastasis of breast cancer are not fully elucidated at this time...
  15. pmc Prognostic relevance of Bmi-1 expression and autoantibodies in esophageal squamous cell carcinoma
    Wan li Liu
    Department of Experimental Research, Sun Yat sen University Cancer Center, Guangzhou, China
    BMC Cancer 10:467. 2010
    ..The objective of this study was to determine the level of Bmi-1 expression or its autoantibodies in human esophageal squamous cell carcinoma (ESCC) and to correlate it with clinicopathologic data...
  16. doi request reprint Centromere protein H is a novel prognostic marker for human nonsmall cell lung cancer progression and overall patient survival
    Wen Ting Liao
    State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, China
    Cancer 115:1507-17. 2009
    ..The objective of the current study was to investigate the expression pattern and clinicopathologic significance of centromere protein H (CENP-H) in patients with nonsmall cell lung cancer (NSCLC)...
  17. pmc Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway
    Jun Li
    Departments of Biochemistry, Zhongshan School of Medicine, Sun Yat Sen University, 74 Zhongshan Road II, Guangzhou, Guangdong 510080, China
    Am J Pathol 176:699-709. 2010
    ..Together, our data demonstrate that Bmi-1 bestows apoptotic resistance to glioma cells through the IKK-NF-kappaB pathway and suggest Bmi-1 as a useful indicator for glioma prognosis...
  18. ncbi request reprint [Effect of EBV encoded BARF1 gene on malignant transformation of human epithelial cell line HBE]
    Li Bing Song
    Research Department, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, 510060, P R China
    Ai Zheng 23:1361-4. 2004
    ..This study was designed to evaluate effect of BARF(1) on cell transformation and tumorgenesis on human epithelia and its mechanisms...
  19. doi request reprint Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival
    Jun Li
    Key Laboratory of Tropical Disease Control Sun Yat sen University, Ministry of Education, Guangzhou, Guangdong, China
    Clin Cancer Res 14:3319-26. 2008
    ....
  20. ncbi request reprint [Establishment of three-dimensional culture models related to different stages of nasopharyngeal carcinogenesis]
    Wen Ting Liao
    State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, 510060, PR China
    Ai Zheng 24:1317-21. 2005
    ..This study was to establish three-dimensional culture models that represent different stages of nasopharyngeal caicinogenesis, and provide information to elucidate the related molecular events...
  21. ncbi request reprint Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival
    Wen Ting Liao
    State Key Laboratory of Oncology in Southern China and Department of Experimental Research, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, China
    Clin Cancer Res 13:508-14. 2007
    ....
  22. pmc Prognostic relevance of Centromere protein H expression in esophageal carcinoma
    Xian Zhi Guo
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, PR China
    BMC Cancer 8:233. 2008
    ....
  23. ncbi request reprint Overexpression of centromere protein H is significantly associated with breast cancer progression and overall patient survival
    Wen Ting Liao
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P R China
    Chin J Cancer 30:627-37. 2011
    ..Multivariate analysis showed that CENP-H expression was an independent prognostic indicator for patient survival. Our results suggest that CENP-H protein is a valuable marker of breast cancer progression and prognosis...
  24. pmc Expression of Bmi-1 is a prognostic marker in bladder cancer
    Zi Ke Qin
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, Guangdong, PR China
    BMC Cancer 9:61. 2009
    ..The molecular mechanisms of the development and progression of bladder cancer are poorly understood. The objective of this study was to analyze the expression of Bmi-1 protein and its clinical significance in human bladder cancer...
  25. ncbi request reprint Infection of Epstein-Barr virus in colorectal cancer in Chinese
    Li Bing Song
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P R China
    Ai Zheng 25:1356-60. 2006
    ..This study was to investigate the correlation of EBV to colorectal carcinoma in Chinese...
  26. ncbi request reprint Bmi-1 expression predicts prognosis for patients with gastric carcinoma
    Jian Hua Liu
    Department of Gastroenterology, The Second Affiliated Hospital of Sun Yat sen University, Guangzhou, China
    J Surg Oncol 97:267-72. 2008
    ..The Bmi-1 gene is a transcriptional repressor involved in oncogenesis in various human cancers. Here, we examine Bmi-1 expression in gastric carcinoma (GC) and investigates whether its expression correlates with patient prognosis...
  27. pmc Upregulation of CENP-H in tongue cancer correlates with poor prognosis and progression
    Wen Ting Liao
    Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Sun Yat sen University, Guangzhou, PR China
    J Exp Clin Cancer Res 28:74. 2009
    ..Recently, CENP-H was identified to be associated with tumorigenesis. This study was aimed to investigate the clinicopathologic significance of CENP-H in tongue cancer...
  28. doi request reprint Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients
    Wen Li
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Guangzhou, China
    Clin Cancer Res 15:1393-9. 2009
    ..The present study was to investigate the clinical significance of sphingosine kinase 1 (SPHK1), an oncoenzyme, in the development and progression of gastric cancer...
  29. ncbi request reprint [Expression and clinical significance of DNA-PKcs in nasopharyngeal carcinoma]
    Shan Shan Yan
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China
    Ai Zheng 27:979-83. 2008
    ..This study was to investigate the expression of DNA-PKcs in nasopharyngeal carcinoma (NPC), and analyze its correlation to the clinicopathologic features and prognosis of NPC...
  30. pmc Upregulator of cell proliferation predicts poor prognosis in hepatocellular carcinoma and contributes to hepatocarcinogenesis by downregulating FOXO3a
    Chan Xie
    Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong Province, China
    PLoS ONE 7:e40607. 2012
    ....
  31. ncbi request reprint [Effects of MT1-MMP on the in vitro invasiveness of breast cancer cells]
    Guang Yu Yao
    Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Zhonghua Zhong Liu Za Zhi 28:650-3. 2006
    ..To investigate the effect of membrane type-1 matrix metalloproteinase (MTI-MMP) on the invasive potential of breast cancer cell and analyze its mechanisms...
  32. pmc High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis
    Jian Hua Wang
    Department of Chest, Second People s Hospital of Guangdong Province, Guangzhou, Guangdong, PR China
    PLoS ONE 7:e45622. 2012
    ..The aim of this study was to examine GOLPH3 expression in patients with esophageal squamous cell cancer (ESCC) and explore its clinical significance...
  33. pmc Genomic sequence analysis of Epstein-Barr virus strain GD1 from a nasopharyngeal carcinoma patient
    Mu Sheng Zeng
    State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China
    J Virol 79:15323-30. 2005
    ..Furthermore, these findings provide the second full-length sequence analysis of any EBV strain as well as the first full-length sequence analysis of an NPC-derived EBV strain...
  34. ncbi request reprint [Identification of differentially expressed genes in primary cultured nasopharyngeal carcinoma cells by cDNA microarray]
    Rui Ping Li
    State Key Laboratory of Oncology in South China and Department of Pathology, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:1156-60. 2007
    ..To analyze the global gene expression profile of primary cultured nasopharyngeal carcinoma (NPC) cells using cDNA microarray techniques to screen new candidate genes related to the occurrence and progression of NPC...
  35. ncbi request reprint Proteasome inhibitor MG-132 modifies coxsackie and adenovirus receptor expression in colon cancer cell line lovo
    Nian hua Zhang
    State Key Laboratory of Oncology in South China, Biotherapy Center, Sun Yat Sen University, Guangzhou, China
    Cell Cycle 7:925-33. 2008
    ..These data provide a rational basis for evaluation of CAR expression in tumors and pretreatment with CAR conditioner prior to adenovirus vector-based gene therapy...
  36. doi request reprint Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival
    Jun Li
    Department of Biochemistry, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
    Clin Cancer Res 14:6996-7003. 2008
    ..To characterize the expression of sphingosine kinase-1 (SPHK1) in human astrocytomas and to investigate the association between SPHK1 expression and progression of astrocytomas...
  37. doi request reprint Proteomics-based identification of autoantibody against CDC25B as a novel serum marker in esophageal squamous cell carcinoma
    Wan li Liu
    Department of Research, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    Biochem Biophys Res Commun 375:440-5. 2008
    ..29%) patients with ESCC, 13 of 150 (8.67%) patients with other types of cancer and 0 of 102 (0%) of healthy individuals. Thus, CDC25B autoantibodies may have clinical utility in ESCC screening and diagnosis...
  38. ncbi request reprint Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells
    Li Bing Song
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    Cancer Res 66:6225-32. 2006
    ....
  39. pmc GOLPH3 overexpression correlates with tumor progression and poor prognosis in patients with clinically N0 oral tongue cancer
    Huan Li
    State Key Laboratory of Oncology in South China, Guangzhou 510060, PR China
    J Transl Med 10:168. 2012
    ..We aimed to investigate the clinical significance of GOLPH3 expression in the development and progression of clinically N0 (cN0) oral tongue cancer...