Dan Qing Song

Summary

Publications

  1. pmc Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes
    Yi Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    J Transl Med 9:62. 2011
  2. doi request reprint Synthesis, structure-activity relationship and biological evaluation of anticancer activity for novel N-substituted sophoridinic acid derivatives
    Xin Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem Lett 21:5251-4. 2011
  3. doi request reprint Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor
    Yan Xiang Wang
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem Lett 19:6004-8. 2009
  4. doi request reprint Synthesis, structure-activity relationship and biological evaluation of novel N-substituted matrinic acid derivatives as host heat-stress cognate 70 (Hsc70) down-regulators
    Na Na Du
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem Lett 21:4732-5. 2011
  5. doi request reprint Protein kinase D activation stimulates the transcription of the insulin receptor gene
    Hao Zhang
    Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, 1 Tiantan Xili, Beijing 100050, China
    Mol Cell Endocrinol 330:25-32. 2010
  6. doi request reprint Small molecular compounds that inhibit hepatitis C virus replication through destabilizing heat shock cognate 70 messenger RNA
    Zong Gen Peng
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Hepatology 52:845-53. 2010
  7. doi request reprint Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents
    Dan Qing Song
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, 1 Tiantan Xili, Beijing 100050, China
    Bioorg Med Chem Lett 19:755-8. 2009
  8. doi request reprint Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression
    Hao Zhang
    Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, China
    Metabolism 59:285-92. 2010
  9. doi request reprint Synthesis and structure-activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators
    Peng Yang
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem Lett 18:4675-7. 2008
  10. doi request reprint Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine
    Ying Hong Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem 18:6422-8. 2010

Collaborators

Detail Information

Publications26

  1. pmc Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes
    Yi Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    J Transl Med 9:62. 2011
    ..The present study explored answers to the question of which CYP450 (Cytochrome P450) isoenzymes execute the phase-I transformation for BBR, and what are the bioactivities of its metabolites on energy pathways...
  2. doi request reprint Synthesis, structure-activity relationship and biological evaluation of anticancer activity for novel N-substituted sophoridinic acid derivatives
    Xin Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem Lett 21:5251-4. 2011
    ..We consider 6b promising for further anticancer investigation...
  3. doi request reprint Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor
    Yan Xiang Wang
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem Lett 19:6004-8. 2009
    ..The 10-hydroxyl of 13a could be an arm to connect proper chemical groups for optimizing drug-bioavailability in vivo. Thus, 13a could be considered to be a parent compound to make pro-drugs for either blood lipids or glucose...
  4. doi request reprint Synthesis, structure-activity relationship and biological evaluation of novel N-substituted matrinic acid derivatives as host heat-stress cognate 70 (Hsc70) down-regulators
    Na Na Du
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem Lett 21:4732-5. 2011
    ..Among these analogs, compound 9p possessing N-p-methoxylbenzyl afforded an increased anti-HBV effect in comparison with 1. We consider 9p a promising anti-HBV candidate...
  5. doi request reprint Protein kinase D activation stimulates the transcription of the insulin receptor gene
    Hao Zhang
    Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, 1 Tiantan Xili, Beijing 100050, China
    Mol Cell Endocrinol 330:25-32. 2010
    ..These results suggest that the PKD family is involved in the transcriptional regulation of the InsR gene; we consider it to be a potential new target to discover drugs for sugar-related disorders in the future...
  6. doi request reprint Small molecular compounds that inhibit hepatitis C virus replication through destabilizing heat shock cognate 70 messenger RNA
    Zong Gen Peng
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Hepatology 52:845-53. 2010
    ..IMB-DM122 showed considerable good safety in vitro as well as in vivo with no indication of harmful effect on liver and kidney functions. CONCLUSION: Hsc70 might be a new drug target and mechanism to inhibit HCV proliferation...
  7. doi request reprint Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents
    Dan Qing Song
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, 1 Tiantan Xili, Beijing 100050, China
    Bioorg Med Chem Lett 19:755-8. 2009
    ..Furthermore, 16c and 16g killed cancer cells with a mechanism independent of mitotic arrest, indicating a change of action mode...
  8. doi request reprint Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression
    Hao Zhang
    Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, China
    Metabolism 59:285-92. 2010
    ..Together with our previous report, we strongly suggest BBR as an ideal medicine for T2DM with a mechanism different from metformin and rosiglitazone...
  9. doi request reprint Synthesis and structure-activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators
    Peng Yang
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem Lett 18:4675-7. 2008
    ....
  10. doi request reprint Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine
    Ying Hong Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem 18:6422-8. 2010
    ..Therefore, the design of M1 prodrug appears to be an effective strategy to improve pharmacokinetic feature of BBR for its lipid-lowering efficacy in vivo...
  11. doi request reprint Synthesis and structure-activity relationship of N-(2-arylethyl) isoquinoline derivatives as human scavenger receptor CD36 antagonists
    Yan Xiang Wang
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Eur J Med Chem 46:1066-73. 2011
    ..We consider N-(2-arylethyl) isoquinoline analogs to be a family of novel CD36 antagonists...
  12. pmc Heat stress cognate 70 host protein as a potential drug target against drug resistance in hepatitis B virus
    Yu Ping Wang
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, China
    Antimicrob Agents Chemother 54:2070-7. 2010
    ..As the target is not a viral protein, OMTR is active for either wild-type HBV or strains resistant to reverse transcriptase (RT) inhibitors...
  13. doi request reprint Synthesis, structure-activity relationship and in vitro biological evaluation of N-arylethyl isoquinoline derivatives as Coxsackievirus B3 inhibitors
    Yan Xiang Wang
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem Lett 21:5787-90. 2011
    ..8); furthermore, 7f exhibited a moderate activity against enterovirus 71 (EV71) with SI value of 9.0. Thus it has been selected as an anti-enteroviral lead compound for further investigation...
  14. doi request reprint Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression
    Wei Jia Kong
    Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Metabolism 58:109-19. 2009
    ..Our results suggest that BBR is a unique natural medicine against insulin resistance in type 2 diabetes mellitus and metabolic syndrome...
  15. ncbi request reprint [Overexpression of synuclein-gamma confers resistance to antimicrotubule drugs against human hepatoma cells]
    Shi Xiang Cheng
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Yao Xue Xue Bao 45:724-9. 2010
    ....
  16. ncbi request reprint [Antitumor mechanism of 3-bromopropionylamino benzoylurea on leukemia and lymphoma]
    Jian Nong Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Yao Xue Xue Bao 39:491-5. 2004
    ..To study the antitumor mechanism of 3-bromopropionylamino benzoylurea (JIMB01) on leukemia and lymphoma...
  17. doi request reprint The benzoylurea derivative F13 inhibits cell growth, migration and invasion through inducing expression of ERK1/2-mediated RECK in fibrosarcoma HT-1080 cells
    Haixia Jin
    Departments of Oncology and Pharmacology, Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    Anticancer Drugs 21:372-80. 2010
    ..Our data suggested that F13 might act as a novel RECK inducer, inhibiting cancerous processes with the inactivation of MMP-2/9 by the induction of RECK through the inhibition of ERK1/2 signalling transduction...
  18. doi request reprint Combination of simvastatin with berberine improves the lipid-lowering efficacy
    Wei Jia Kong
    Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Metabolism 57:1029-37. 2008
    ..Our results display the rationale, effectiveness, and safety of the combination therapy for hyperlipidemia using BBR and SIMVA. It could be a new regimen for hypercholesterolemia...
  19. doi request reprint Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy
    Ying Hong Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    J Med Chem 52:492-501. 2009
    ..01 for both). The results were confirmed in the hyperlipidemic mice. LD(50) of 2 in mice was over 5000 mg/kg (oral). We consider compound 2 a promising cholesterol-lowering drug candidate...
  20. doi request reprint Benzoylurea derivatives as a novel class of antimitotic agents: synthesis, anticancer activity, and structure-activity relationships
    Dan Qing Song
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Med Chem 51:3094-103. 2008
    ..The mechanism of 14b is to inhibit microtubule assembly, followed by the M-phase arrest, bcl-2 inactivation, and then apoptosis. We consider 14b promising for further anticancer investigation...
  21. doi request reprint Synthesis and in vitro antitubercular evaluation of novel sansanmycin derivatives
    Yang Biao Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem Lett 21:6804-7. 2011
    ..tuberculosis strain isolated from patients in China. These promising results offer an opportunity for further exploration of this novel class of analogs as antitubercular agents...
  22. ncbi request reprint [Construction and application of pharmacophore model of benzoylurea derivatives as beta-tubulin inhibitors]
    Li Mei Gao
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Beijing Union Medical College, Beijing 100050, China
    Yao Xue Xue Bao 45:462-6. 2010
    ..43, Correl = 0.98, Weight = 2.06, Config = 15.97). This pharmacophore model is able to predict the activity of known beta-tubulin inhibitors and can be further used to identify structurally diverse compounds with higher activity...
  23. ncbi request reprint [Synthesis and structure-activity relationship of 13-hexylberberine analogues as CD36 antagonists]
    Ying Hong Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Yao Xue Xue Bao 45:1128-33. 2010
    ..7 micromol L(-1). Besides, its antagonistic activity was further verified with Sf9 insect cell HTS model. So berberine analogues are a new family of CD36 receptor antagonists and worthy to be studied further...
  24. pmc Zebrafish as a potential model organism for drug test against hepatitis C virus
    Cun Bao Ding
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 6:e22921. 2011
    ..Thus, zebrafish might be a model organism to host HCV, and this zebrafish/HCV (sub-replicon) system could be an animal model for anti-HCV drug screening and evaluation...
  25. pmc In vivo antibacterial activity of vertilmicin, a new aminoglycoside antibiotic
    Xue Fu You
    Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Antimicrob Agents Chemother 53:4525-8. 2009
    ..coli 9612 and E. faecalis HH22 infections. The therapeutic efficacy of vertilmicin was further confirmed in local infection models of rabbit skin burn infection and mouse ascending urinary tract infection...
  26. doi request reprint Synthesis and activity evaluation of phenylurea derivatives as potent antitumor agents
    Dan Qing Song
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem 17:3873-8. 2009
    ..38 and 4.07 microM. Interestingly, compound 16j killed cancer cells with a mechanism independent of the tubulin-based mechanism, indicating a significant change of the action mode after the structure modification...