Yong Song



  1. Song Y, Shi Y, Ao L, Harken A, Meng X. TLR4 mediates LPS-induced HO-1 expression in mouse liver: role of TNF-alpha and IL-1beta. World J Gastroenterol. 2003;9:1799-803 pubmed
    ..This study demonstrates that TLR4 plays a dominant role in mediating HO-1 expression following LPS. LPS-induced HO-1 expression is mainly mediated by endogenous TNF-alpha, but only partially by endogenous IL-1beta. ..
  2. Wang Z, Huang C, Yang J, Song Y, Cheng Y, Chen G, et al. A randomised phase II clinical trial of nab-paclitaxel and carboplatin compared with gemcitabine and carboplatin as first-line therapy in advanced squamous cell lung carcinoma (C-TONG1002). Eur J Cancer. 2019;109:183-191 pubmed publisher
    ..05). The first-line nab-PC and GC had the same response, PFS, and OS in patients with advanced squamous cell lung carcinoma. Nab-PCM has advantage over GC in QoL improvement. NCT01236716. ..
  3. Jin J, Xu W, Wan B, Wang X, Zhou Z, Miao Y, et al. Topotecan Alleviates Lipopolysaccharide-Mediated Acute Lung Injury Via the NF-κB Signaling Pathway. J Surg Res. 2019;235:83-92 pubmed publisher
    ..In conclusion, TPT attenuates LPS-induced ALI through inhibiting the NF-κB signaling pathway, suggesting that TPT might serve as a useful therapeutic for ALI. Thus, our study has provided new insight for current ALI treatment. ..
  4. Wei Y, Shen K, Lv T, Wang X, Li C, Fan H, et al. Three new disease-progression modes in NSCLC patients after EGFR-TKI treatment by next-generation sequencing analysis. Lung Cancer. 2018;125:43-50 pubmed publisher
  5. Wu L, Xu W, Wang F, Lv T, Yin Z, Song Y. Plasma mtDNA Analysis Aids in Predicting Pancreatic Necrosis in Acute Pancreatitis Patients: A Pilot Study. Dig Dis Sci. 2018;63:2975-2982 pubmed publisher
    ..7 [IQR 307.00-1370.00] vs. 237.5 [IQR 117.20-464.80] pg/ml, P < 0.01). Elevated plasma mtDNA content in AP patients may be used as a more accurate early predictor of PNec in contrast to traditional CRP. ..
  6. Song Y, Zhou Q, Zhang X, Chen G, Zhong D, Yu Z, et al. Factors associated with gene aberration test status and treatment decision in patients with unresectable Stage IIIB/IV nonsquamous non-small cell lung cancer: A multicenter survey in China (CTONG 1506). Lung Cancer. 2018;123:7-13 pubmed publisher
  7. Wan B, Xu W, Zhan P, Jin J, Xi G, Chen M, et al. Topotecan alleviates ventilator-induced lung injury via NF-?B pathway inhibition. Cytokine. 2018;110:381-388 pubmed publisher
    ..Moreover, topotecan inhibited NF-?B expression and activation in the VILI model. Topotecan alleviates acute lung injury in the model of VILI through the inhibition of the NF-?B pathway. ..
  8. Zhang Q, Hu H, Liu H, Jin J, Zhu P, Wang S, et al. RNA sequencing enables systematic identification of platelet transcriptomic alterations in NSCLC patients. Biomed Pharmacother. 2018;105:204-214 pubmed publisher
    ..The outcomes from subgroup analysis between lung adenocarcinoma and lung squamous cell carcinoma demonstrated the diagnostic potential of platelet RNA-Seq on distinguishing tumor histological types. ..
  9. Gu X, Wu G, Yao Y, Zeng J, Shi D, Lv T, et al. Intratracheal administration of mitochondrial DNA directly provokes lung inflammation through the TLR9-p38 MAPK pathway. Free Radic Biol Med. 2015;83:149-58 pubmed publisher

More Information


  1. Zhang F, Huang G, Hu B, Qian G, Song Y. Recombinant HMGB1 A box protein inhibits Th17 responses in mice with neutrophilic asthma by suppressing dendritic cell-mediated Th17 polarization. Int Immunopharmacol. 2015;24:110-8 pubmed publisher
    ..These data demonstrate that rHMGB1 A box may have therapeutic effects on controlling Th17 polarization and airway inflammation in neutrophilic asthma by blocking the HMGB1 pathway on DCs. ..
  2. Liu H, Wu Y, Zhu S, Liang W, Wang Z, Wang Y, et al. PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer. Cancer Lett. 2015;359:218-25 pubmed publisher
    ..Our study uncovered that PTP1B can promote NSCLC proliferation and metastasis by activating src and subsequently ERK1/2 and provides a theoretical basis for future applications of PTP1B inhibitors in the treatment of NSCLC. ..
  3. Yuan D, Zhang Q, Lv Y, Ma X, Zhang Y, Liu H, et al. Predictive and prognostic significance of circulating endothelial cells in advanced non-small cell lung cancer patients. Tumour Biol. 2015;36:9031-7 pubmed publisher
    ..And the reduction of CECs after treatment might be more ideal than the baseline CEC counts as a predictive or prognostic factor in patients treated with chemotherapy or anti-angiogenic therapy. ..
  4. Zhu Q, Ma C, Wang Q, Song Y, Lv T. The role of TWIST1 in epithelial-mesenchymal transition and cancers. Tumour Biol. 2016;37:185-97 pubmed publisher
    ..Therefore, it is important to provide a better understanding of the context-dependent regulation of TWIST1 in each individual epithelial tumor, which might reveal new therapeutic targets in cancer treatment. ..
  5. Zhang H, Liu H, Yuan D, Wang Z, Wang Y, Song Y. Prognostic value of secreted phosphoprotein-1 in pleural effusion associated with non-small cell lung cancer. BMC Cancer. 2014;14:280 pubmed publisher
    ..832, 95% confidence interval: 1.003-3.345; P = 0.049). SPP1 in pleural effusion can be used for the auxiliary diagnosis of MPE and used to determine the prognosis of patients with NSCLC. ..
  6. request reprint
    Li Q, Yuan D, Ma L, Ma C, Liu Y, Lv T, et al. Chloroquine inhibits tumor growth and angiogenesis in malignant pleural effusion. Tumour Biol. 2016;: pubmed
    ..In MPE mice, the volume of the pleural effusion, the number of pleural tumor foci, and the MVD were significantly reduced in the CQ group. Our work demonstrated that CQ played the role of an efficient treatment for MPE. ..
  7. request reprint
    Yuan D, Li Q, Zhang Q, Xiao X, Yao Y, Zhang Y, et al. Efficacy and Safety of Neurokinin-1 Receptor Antagonists for Prevention of Chemotherapy-Induced Nausea and Vomiting: Systematic Review and Meta-analysis of Randomized Controlled Trials. Asian Pac J Cancer Prev. 2016;17:1661-75 pubmed
    ..NK1-RAs improved the CR rate of CINV. They are effective for both adults and children. The use of NK1-RAs might be associated with the appearance of diarrhea and hiccups, while decreasing the possibility of constipation and insomnia. ..
  8. Pan X, Lv T, Zhang F, Fan H, Liu H, Song Y. Frequent genomic alterations and better prognosis among young patients with non-small-cell lung cancer aged 40 years or younger. Clin Transl Oncol. 2018;20:1168-1174 pubmed publisher
    ..9 months (n = 8). Young patients are associated with an increased likelihood of gene mutations and can receive a better prognosis when patients harboring gene mutations are treated with EGFR-TKIs or ALK inhibitors. ..
  9. Zhou L, Lv T, Zhang Q, Zhu Q, Zhan P, Zhu S, et al. The biology, function and clinical implications of exosomes in lung cancer. Cancer Lett. 2017;407:84-92 pubmed publisher
    ..In addition, we also discuss current challenges that might impede the clinical use of exosomes. Further studies on the functional roles of exosomes in lung cancer requires thorough research. ..
  10. Gao J, Qiu X, Li X, Fan H, Zhang F, Lv T, et al. Expression profiles and clinical value of plasma exosomal Tim-3 and Galectin-9 in non-small cell lung cancer. Biochem Biophys Res Commun. 2018;498:409-415 pubmed publisher
    ..Together, our data revealed that Exo-pro, especially Exo-T and Exo-G could be potential biomarkers for NSCLC. Further studies focusing on pure tumor-derived exosomes isolated from plasma were needed. ..
  11. Zhang Q, Liu H, Zhu Q, Zhan P, Zhu S, Zhang J, et al. Patterns and functional implications of platelets upon tumor "education". Int J Biochem Cell Biol. 2017;90:68-80 pubmed publisher
    ..Further studies with well-designed prospective multicenter trials may contribute to clinical "liquid biopsy" diagnosis by evaluating the global changes of platelets. ..
  12. Zhan P, Zhang B, Xi G, Wu Y, Liu H, Liu Y, et al. PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway. Mol Cancer. 2017;16:108 pubmed publisher
  13. Ma C, Shi X, Zhu Q, Li Q, Liu Y, Yao Y, et al. The growth arrest-specific transcript 5 (GAS5): a pivotal tumor suppressor long noncoding RNA in human cancers. Tumour Biol. 2016;37:1437-44 pubmed publisher
    ..In this review, we will summarize the current knowledge about this vital lncRNA, from its discovery, characteristics, and biological function to molecular mechanism in various neoplasms. ..
  14. Zhang F, Su X, Huang G, Xin X, Cao E, Shi Y, et al. sRAGE alleviates neutrophilic asthma by blocking HMGB1/RAGE signalling in airway dendritic cells. Sci Rep. 2017;7:14268 pubmed publisher
    ..Thus, sRAGE prevents Th17-mediated airway inflammation in neutrophilic asthma at least partly by blocking HMGB1/RAGE signalling in DCs. ..
  15. Miao L, Wang Y, Zhu S, Shi M, Li Y, Ding J, et al. Identification of novel driver mutations of the discoidin domain receptor 2 (DDR2) gene in squamous cell lung cancer of Chinese patients. BMC Cancer. 2014;14:369 pubmed publisher