Ilia V Soloviev

Summary

Publications

  1. ncbi request reprint Evidence for high frequency of chromosomal mosaicism in spontaneous abortions revealed by interphase FISH analysis
    Svetlana G Vorsanova
    National Center of Mental Health, Russian Academy of Medical Sciences, Zagorodnoe sh 2, 119152 Moscow, Russia
    J Histochem Cytochem 53:375-80. 2005
  2. pmc Molecular cytogenetic diagnosis and somatic genome variations
    S G Vorsanova
    Institute of Pediatrics and Children Surgery, Rosmedtechnologii
    Curr Genomics 11:440-6. 2010
  3. pmc Somatic genome variations in health and disease
    I Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences
    Curr Genomics 11:387-96. 2010
  4. pmc Molecular cytogenetics and cytogenomics of brain diseases
    I Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences
    Curr Genomics 9:452-65. 2008
  5. pmc The DNA replication stress hypothesis of Alzheimer's disease
    Yuri B Yurov
    Laboratory of Cytogenetics and Genomics of Psychiatric Disorders, Mental Health Research Center, Russian Academy of Medical Sciences, Moscow 119152, Russia
    ScientificWorldJournal 11:2602-12. 2011
  6. pmc Single cell genomics of the brain: focus on neuronal diversity and neuropsychiatric diseases
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia Institute of Pediatrics and Children Surgery, Minzdravsotsrazvitia, Moscow, Russia
    Curr Genomics 13:477-88. 2012
  7. pmc GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny
    Yuri B Yurov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow 119152, Russia
    Mol Cytogenet 2:23. 2009
  8. pmc Partial monosomy 7q34-qter and 21pter-q22.13 due to cryptic unbalanced translocation t(7;21) but not monosomy of the whole chromosome 21: a case report plus review of the literature
    Svetlana G Vorsanova
    Institute of Human Genetics and Anthropology, Friedrich Schiller University, Jena, Germany
    Mol Cytogenet 1:13. 2008
  9. ncbi request reprint Interphase chromosome-specific multicolor banding (ICS-MCB): a new tool for analysis of interphase chromosomes in their integrity
    Ivan Y Iourov
    National Research Center of Mental Health, RAMS, Moscow, Russia
    Biomol Eng 24:415-7. 2007
  10. pmc Chromosomal mosaicism goes global
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, 119152, Russia
    Mol Cytogenet 1:26. 2008

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Evidence for high frequency of chromosomal mosaicism in spontaneous abortions revealed by interphase FISH analysis
    Svetlana G Vorsanova
    National Center of Mental Health, Russian Academy of Medical Sciences, Zagorodnoe sh 2, 119152 Moscow, Russia
    J Histochem Cytochem 53:375-80. 2005
    ..Chromosomal mosaicism may contribute significantly to both pregnancy complications and spontaneous fetal loss...
  2. pmc Molecular cytogenetic diagnosis and somatic genome variations
    S G Vorsanova
    Institute of Pediatrics and Children Surgery, Rosmedtechnologii
    Curr Genomics 11:440-6. 2010
    ....
  3. pmc Somatic genome variations in health and disease
    I Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences
    Curr Genomics 11:387-96. 2010
    ..Together, we suggest that detection and characterization of somatic genome behavior and variations can provide new opportunities for human genome research and genetics...
  4. pmc Molecular cytogenetics and cytogenomics of brain diseases
    I Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences
    Curr Genomics 9:452-65. 2008
    ..In this light, the present review considers perspectives of this dynamically developing field of neurogenetics and genomics...
  5. pmc The DNA replication stress hypothesis of Alzheimer's disease
    Yuri B Yurov
    Laboratory of Cytogenetics and Genomics of Psychiatric Disorders, Mental Health Research Center, Russian Academy of Medical Sciences, Moscow 119152, Russia
    ScientificWorldJournal 11:2602-12. 2011
    ..Abnormal cell cycle reentry and somatic genome variations can be used for updating the cell cycle theory introducing replication stress as a missing link between cell genetics and neurobiology of AD...
  6. pmc Single cell genomics of the brain: focus on neuronal diversity and neuropsychiatric diseases
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia Institute of Pediatrics and Children Surgery, Minzdravsotsrazvitia, Moscow, Russia
    Curr Genomics 13:477-88. 2012
    ....
  7. pmc GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny
    Yuri B Yurov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow 119152, Russia
    Mol Cytogenet 2:23. 2009
    ....
  8. pmc Partial monosomy 7q34-qter and 21pter-q22.13 due to cryptic unbalanced translocation t(7;21) but not monosomy of the whole chromosome 21: a case report plus review of the literature
    Svetlana G Vorsanova
    Institute of Human Genetics and Anthropology, Friedrich Schiller University, Jena, Germany
    Mol Cytogenet 1:13. 2008
    ..Here, we report a cytogenetically similar case associated with congenital malformation including mental retardation, motor development delay, craniofacial dysmorphism and skeletal abnormalities...
  9. ncbi request reprint Interphase chromosome-specific multicolor banding (ICS-MCB): a new tool for analysis of interphase chromosomes in their integrity
    Ivan Y Iourov
    National Research Center of Mental Health, RAMS, Moscow, Russia
    Biomol Eng 24:415-7. 2007
    ..We introduce a technology using microdissection-based engineering of DNA probes and fluorescence multicolor chromosome banding that allows studying interphase chromosome organization, numbers and rearrangements in somatic cells...
  10. pmc Chromosomal mosaicism goes global
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, 119152, Russia
    Mol Cytogenet 1:26. 2008
    ....
  11. doi request reprint Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: differential expression and pathological meaning
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia
    Neurobiol Dis 34:212-20. 2009
    ..These data indicate neural aneuploidy to be a newly identified feature of neurodegenerative diseases, similar to other devastative disorders hallmarked by aneuploidy such as chromosome syndromes and cancer...
  12. doi request reprint Dynamic mosaicism manifesting as loss, gain and rearrangement of an isodicentric Y chromosome in a male child with growth retardation and abnormal external genitalia
    I Y Iourov
    National Research Center of Mental Health, RAMS, Moscow, Russia
    Cytogenet Genome Res 121:302-6. 2008
    ..23). The present report indicates that cases of mosaicism involving isodicentric and isochromosome Ys can be more dynamic in terms of somatic intercellular variability that probably has an underappreciated effect on the phenotype...
  13. pmc Human interphase chromosomes: a review of available molecular cytogenetic technologies
    Svetlana G Vorsanova
    Institute of Pediatrics and Children Surgery, Rosmedtechnologii, Moscow, 127412, Russia
    Mol Cytogenet 3:1. 2010
    ....
  14. ncbi request reprint An approach for quantitative assessment of fluorescence in situ hybridization (FISH) signals for applied human molecular cytogenetics
    Ivan Y Iourov
    National Center of Mental Health, Russian Academy of Medical Sciences, Zagorodnoe sh 2, 119152 Moscow, Russia
    J Histochem Cytochem 53:401-8. 2005
    ..We propose this approach to be efficient and to be considered as a useful tool in addition to visual FISH signal analysis for applied molecular cytogenetic studies...
  15. ncbi request reprint Visualization of interphase chromosomes in postmitotic cells of the human brain by multicolour banding (MCB)
    I Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow 119152, Russia
    Chromosome Res 14:223-9. 2006
    ..Thus, cytogenetics is no longer limited in its application to dividing cells, which is a great step forward for brain research...
  16. pmc Aneuploidy and confined chromosomal mosaicism in the developing human brain
    Yuri B Yurov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia Institute of Pediatrics and Children Surgery, Roszdrav, Moscow, Russia
    PLoS ONE 2:e558. 2007
    ..However, the incidence of aneuploidy in the developing human brain and its impact on the brain development and function are obscure...
  17. ncbi request reprint Pericentric inversion inv(7)(p11q21.1): report on two cases and genotype-phenotype correlations
    S G Vorsanova
    Institute of Pediatrics and Children Surgery, Roszdrav, Moscow, Russia
    Tsitol Genet 40:45-8. 2006
    ..Our results reconfirm previous linkage analyses suggested 7q21-q22 as a locus of ectrodactily and propose inv (7)(p11q21.1) as a cause of recognizable pattern of malformations or a new chromosomal syndrome...
  18. ncbi request reprint Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus
    S G Vorsanova
    Institute of Pediatrics and Children Surgery, Roszdrav, Moscow, Russia
    Tsitol Genet 40:28-30. 2006
    ..The difficulties of chimerism identification in fetal tissues are discussed...
  19. ncbi request reprint Fluorescence intensity profiles of in situ hybridization signals depict genome architecture within human interphase nuclei
    I Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia
    Tsitol Genet 42:3-8. 2008
    ..We conclude the approach to be a powerful additional tool for analysis of interphase genome architecture and chromosome behavior in the nucleus of human somatic cells...
  20. ncbi request reprint The schizophrenia brain exhibits low-level aneuploidy involving chromosome 1
    Yuri B Yurov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow 119152, Russian Federation
    Schizophr Res 98:139-47. 2008
    ..To gain further insights into the relationship between aneuploidy in the brain and schizophrenia pathogenesis, a molecular-cytogenetic study of chromosome 1 aneuploidy was performed...
  21. ncbi request reprint The variation of aneuploidy frequency in the developing and adult human brain revealed by an interphase FISH study
    Yuri B Yurov
    National Center of Mental Health, Russian Academy of Medical Sciences, Zagorodnoe sh 2, 119152 Moscow, Russia
    J Histochem Cytochem 53:385-90. 2005
    ..6-3.0% and 0.1-0.8% in uncultured fetal and postmortem adult brain cells, respectively). The data obtained support the hypothesis regarding aneuploidy occurrence in normal developing and adult human brain...
  22. ncbi request reprint Molecular-cytogenetic investigation of skewed chromosome X inactivation in Rett syndrome
    Y B Yurov
    National Centre of Mental Health, Russian Academy of Medical Sciences, 113152, Zagorodnoe sh 2, Moscow, Russia
    Brain Dev 23:S214-7. 2001
    ..Therefore, non-random or skewed X inactivation with variable penetrance in blood cells could take place in RTT...
  23. ncbi request reprint Multicolor fluorescent in situ hybridization on post-mortem brain in schizophrenia as an approach for identification of low-level chromosomal aneuploidy in neuropsychiatric diseases
    Y B Yurov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, 113152, Zagorodnoe sh 2, Moscow, Russia
    Brain Dev 23:S186-90. 2001
    ....
  24. ncbi request reprint Non-disjunction of chromosome 21, alphoid DNA variation, and sociogenetic features of Down syndrome
    S G Vorsanova
    Institute of Pediatrics and Children Surgery, RF MH, Moscow, Russia
    Tsitol Genet 39:30-6. 2005
    ..The possible relevance of data obtained to the subsequent studies of chromosome 21 non-disjunction is discussed...
  25. ncbi request reprint Brain tissue preparations for chromosomal PRINS labeling
    Ivan Y Iourov
    Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia
    Methods Mol Biol 334:123-32. 2006
    ..Here, we propose the detailed brain tissue processing protocol that could be used for different molecular cytogenetic approaches to study chromosome complement in interphase nuclei...
  26. ncbi request reprint Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Zagorodnoe sh 2, Moscow 119152, Russia
    Hum Mol Genet 18:2656-69. 2009
    ..Our data suggest that mosaic instability of somatic genome in cells of the central nervous system is more significant genetic factor predisposing to the brain pathology than previously recognized...
  27. pmc Ontogenetic variation of the human genome
    Y B Yurov
    Institute of Pediatrics and Children Surgery, Rosmedtechnologii
    Curr Genomics 11:420-5. 2010
    ..Here, a review of these ontogenetic variations is given to propose a new "dynamic genome" model for pathological and natural genomic changes throughout life that mimic those of phylogenetic diversity...
  28. ncbi request reprint Recent patents on molecular cytogenetics
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, 119152, Russia
    Recent Pat DNA Gene Seq 2:6-15. 2008
    ..Here, we address world-wide patents on DNA sequences used as molecular cytogenetic probes and molecular cytogenetic techniques to define current state and perspectives of this biomedical direction...
  29. ncbi request reprint Chromosomal variation in mammalian neuronal cells: known facts and attractive hypotheses
    Ivan Y Iourov
    National Research Center of Mental Health, Russian Academy of Sciences, Moscow, Russia 119152
    Int Rev Cytol 249:143-91. 2006
    ..We propose to cover the term "molecular neurocytogenetics to cover all studies the aim of which is to reveal chromosome variations and organization in the mammalian brain...
  30. ncbi request reprint First case of del(1)(p36.2p33) in a fetus delivered stillborn
    Ivan Y Iourov
    Prenat Diagn 26:1092-3. 2006
  31. ncbi request reprint Mosaic X chromosome aneuploidy can help to explain the male-to-female ratio in autism
    Ivan Y Iourov
    Med Hypotheses 70:456. 2008