E G Solon

Summary

Publications

  1. ncbi Autoradiography: high-resolution molecular imaging in pharmaceutical discovery and development
    Eric G Solon
    Quest Pharmaceutical Services, 110 Executive Drive, Suite 7, Newark, Delaware, 19702, USA
    Expert Opin Drug Discov 2:503-14. 2007
  2. ncbi Whole-body autoradiography in drug discovery
    E G Solon
    Bristol Myers Squibb Company, Experimental Station, E353 204A, Rt 141 and Henry Clay Road, Wilmington, DE 19880, USA
    Curr Drug Metab 3:451-62. 2002
  3. ncbi Interaction of ritonavir on tissue distribution of a [(14)c]L-valinamide, a potent human immunodeficiency virus-1 protease inhibitor, in rats using quantitative whole-body autoradiography
    Eric G Solon
    Bristol Myers Squibb Company, Wilmington, Delaware, USA
    Drug Metab Dispos 30:1164-9. 2002
  4. ncbi Quantitative whole-body autoradiography in the pharmaceutical industry. Survey results on study design, methods, and regulatory compliance
    E G Solon
    Quest Pharmaceutical Services, Suite 240, Delaware Technology Park 3 Innovation Way, Newark DE 19711, USA
    J Pharmacol Toxicol Methods 46:73-81. 2001
  5. ncbi Methods determining phosphor imaging limits of quantitation in whole-body autoradiography rodent tissue distribution studies affect predictions of 14C human dosimetry
    E G Solon
    Autoradiography Labs, Quest Pharmaceutical Services, Inc, Delaware Technology Park 3 Innovation Way, Suite 240, Newark, DE 19711, USA
    J Pharmacol Toxicol Methods 46:83-91. 2001
  6. ncbi Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development
    Eric G Solon
    QPS, LLC, Newark, Delaware 19702, USA
    AAPS J 12:11-26. 2010
  7. ncbi Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats
    Harvey Wong
    Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492-7660, USA
    Toxicol Sci 84:232-42. 2005
  8. ncbi Distribution of radioactivity in bone and related structures following administration of [14C]dalbavancin to New Zealand white rabbits
    Eric G Solon
    Quest Pharmaceuticals Services, Newark, DE, USA
    Antimicrob Agents Chemother 51:3008-10. 2007

Collaborators

Detail Information

Publications8

  1. ncbi Autoradiography: high-resolution molecular imaging in pharmaceutical discovery and development
    Eric G Solon
    Quest Pharmaceutical Services, 110 Executive Drive, Suite 7, Newark, Delaware, 19702, USA
    Expert Opin Drug Discov 2:503-14. 2007
    ..In addition, this review comments on the integration of the ex vivo ARG and in vivo molecular imaging techniques to serve pharmaceutical discovery and development in the future...
  2. ncbi Whole-body autoradiography in drug discovery
    E G Solon
    Bristol Myers Squibb Company, Experimental Station, E353 204A, Rt 141 and Henry Clay Road, Wilmington, DE 19880, USA
    Curr Drug Metab 3:451-62. 2002
    ..Thus, WBA is quickly becoming part of the battery of studies conducted during the lead optimization process to select optimal drug candidates. Examples of the use of the WBA tool in early discovery are reviewed...
  3. ncbi Interaction of ritonavir on tissue distribution of a [(14)c]L-valinamide, a potent human immunodeficiency virus-1 protease inhibitor, in rats using quantitative whole-body autoradiography
    Eric G Solon
    Bristol Myers Squibb Company, Wilmington, Delaware, USA
    Drug Metab Dispos 30:1164-9. 2002
    ..The data above and the reported RTV concentrations suggested that both the Pgp and CYP3A4 inhibition by RTV may play a significant role in enhancing the systemic and tissue exposure to DPC in humans...
  4. ncbi Quantitative whole-body autoradiography in the pharmaceutical industry. Survey results on study design, methods, and regulatory compliance
    E G Solon
    Quest Pharmaceutical Services, Suite 240, Delaware Technology Park 3 Innovation Way, Newark DE 19711, USA
    J Pharmacol Toxicol Methods 46:73-81. 2001
    ....
  5. ncbi Methods determining phosphor imaging limits of quantitation in whole-body autoradiography rodent tissue distribution studies affect predictions of 14C human dosimetry
    E G Solon
    Autoradiography Labs, Quest Pharmaceutical Services, Inc, Delaware Technology Park 3 Innovation Way, Suite 240, Newark, DE 19711, USA
    J Pharmacol Toxicol Methods 46:83-91. 2001
    ..The objective of this study is to compare and evaluate the human dosimetry estimates obtained by applying those five LOQ methods to a single set of WBA data...
  6. ncbi Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development
    Eric G Solon
    QPS, LLC, Newark, Delaware 19702, USA
    AAPS J 12:11-26. 2010
    ....
  7. ncbi Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats
    Harvey Wong
    Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492-7660, USA
    Toxicol Sci 84:232-42. 2005
    ..However, DMP 904 is distinguished from other compounds associated with similar effects on thyroid hormone homeostasis because its effects were primarily related to increased biliary excretion of unconjugated T4...
  8. ncbi Distribution of radioactivity in bone and related structures following administration of [14C]dalbavancin to New Zealand white rabbits
    Eric G Solon
    Quest Pharmaceuticals Services, Newark, DE, USA
    Antimicrob Agents Chemother 51:3008-10. 2007
    ..Drug-derived radioactivity, determined over 14 days by either liquid scintillation counting or autoradiography, remained above the MIC for common gram-positive pathogens that cause bone and joint infections...