Stereotactic body radiation therapy: a new paradigm in radiotherapy management of cancerTimothy D Solberg
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Am Coll Radiol 5:673-7. 2008
Quantifying the interplay effect in prostate IMRT delivery using a convolution-based methodHaisen S Li
Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska 68198 7521, USA
Med Phys 35:1703-10. 2008
..3%, in single fraction plans. For entire treatment courses delivered in either a hypofractionated (five fractions) or conventional (> 30 fractions) regimen, the discrepancy in total dose due to interplay effect was negligible...
- A methodology for verification of radiotherapy dose calculation
Nzhde Agazaryan
Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 6951, USA
J Neurosurg 101:356-61. 2004
..Dosimetric accuracy of clinically active intensity-modulated radiotherapy (IMRT) and intensity-modulated radiosurgery (IMRS) programs was assessed using this methodology...
- Degeneracy, frequency response and filtering in IMRT optimization
Jorge Llacer
EC Engineering Consultants LLC, 130 Forest Hill Drive, Los Gatos, CA 95032, USA
Phys Med Biol 49:2853-80. 2004
..Stopping points for the studied algorithms are discussed and the deterioration of DVH characteristics with filtering is shown to be partially recoverable by the use of space-variant filtering techniques...
- Segmental and dynamic intensity-modulated radiotherapy delivery techniques for micro-multileaf collimator
Nzhde Agazaryan
Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 6951, USA
Med Phys 30:1758-67. 2003
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- The effects of tumor motion on planning and delivery of respiratory-gated IMRT
Geoffrey D Hugo
Department of Radiation Oncology, UCLA School of Medicine, Los Angeles, California 90095, USA
Med Phys 30:1052-66. 2003
..The utilization of gating for IMRT treatment, including imaging, planning, and delivery, significantly reduces the errors introduced by object motion...
- Experimental verification and clinical implementation of a commercial Monte Carlo electron beam dose calculation algorithm
Margarida Fragoso
University of Nebraska Medical Center, Omaha, Nebraska 68198 7521, USA
Med Phys 35:1028-38. 2008
..3 cm. Timing values ranged from 2 min to 24.5 h, depending on the field size, beam energy, number, and thickness of computed tomography slices used to define the patient's anatomy for the overall uncertainty values mentioned above...
- Absence of multiple local minima effects in intensity modulated optimization with dose-volume constraints
Jorge Llacer
EC Engineering Consultants, LLC 130, Forest Hill Drive, Los Gatos, CA 95032, USA
Phys Med Biol 48:183-210. 2003
..The results of the latter two methods have only been discussed briefly, as they yielded the same conclusions as the NG method...
- A seed specific dose kernel method for low-energy brachytherapy dosimetry
John J DeMarco
Department of Radiation Oncology, UCLA School of Medicine, Los Angeles, California 90095, USA
J Appl Clin Med Phys 4:66-74. 2003
..Good agreement is achieved for a representative pre- and post-plan comparison versus a commercial implementation of the TG-43 brachytherapy dosimetry protocol...
- Targeting accuracy of an image guided gating system for stereotactic body radiotherapy
Stephen E Tenn
Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Phys Med Biol 50:5443-62. 2005
..5 +/- 0.2 mm for phantom rotations up to 5 degrees. We found and corrected a synchronization error caused by a faulty x-ray duration setting and detected a 60 +/- 20 ms time delay in our linear accelerator...
Quality assurance of immobilization and target localization systems for frameless stereotactic cranial and extracranial hypofractionated radiotherapyTimothy D Solberg
Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198 7521, USA
Int J Radiat Oncol Biol Phys 71:S131-5. 2008
..In this report, we reviewed the technologies for frameless localization of cranial and extracranial targets with emphasis on the quality assurance aspects...
- An evaluation of gating window size, delivery method, and composite field dosimetry of respiratory-gated IMRT
Geoffrey D Hugo
Department of Radiation Oncology, UCLA School of Medicine, Los Angeles, California 90095, USA
Med Phys 29:2517-25. 2002
..For multiple field IMRT delivery, the largest errors were generated in regions where high field modulation was present parallel to the axis of motion. Gating was found to reduce these large errors to clinically acceptable levels...
- A Monte Carlo based phase space model for quality assurance of intensity modulated radiotherapy incorporating leaf specific characteristics
Randi F Aaronson
Department of Radiation Oncology, University of California, Los Angeles, California 90095 6951, USA
Med Phys 29:2952-8. 2002
..53 criteria for all benchmark fields used. Film dosimetry was used to evaluate the model for IMRT sequences and plans, and the ability of the model to account for leaf sequencing effects is also demonstrated...
- Patient specific quality assurance for the delivery of intensity modulated radiotherapy
Nzhde Agazaryan
Department of Radiation Oncology, UCLA School of Medicine, 200 UCLA Medical Plaza, Suite B265, Los Angeles, California 90095 6951, USA
J Appl Clin Med Phys 4:40-50. 2003
..Absolute dosimetry for each composite plan is performed using an ionization chamber. To date, excellent agreement between measurements and calculations has been observed...
- Dosimetric consequences of intrafraction prostate motion
Haisen S Li
Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA
Int J Radiat Oncol Biol Phys 71:801-12. 2008
..To analyze characteristics of intrafraction prostate motion, monitored using the Calypso system, and investigate dosimetric consequences of the motion for different clinical target volume (CTV) to planning target volume (PTV) margins...
- An arteriovenous malformation model for stereotactic radiosurgery research
Reza Jahan
Division of Interventional Neuroradiology, Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
Neurosurgery 61:152-9; discussion 159. 2007
..To introduce the utilization of a swine arteriovenous malformation (AVM) model for stereotactic radiosurgery research and to describe the morphological changes in the vessels after radiation...
- Image-guided radiotherapy using a mobile kilovoltage x-ray device
Stephen P Sorensen
Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA
Med Dosim 31:40-50. 2006
..It was demonstrated that this could be improved by correlating the acquisition of individual 2D projections with respiration for retrospective reconstruction of phase-based volumetric datasets...
- Stereotactic radiosurgery of the rete mirabile in swine: a longitudinal study of histopathological changes
Reza Jahan
Division of Interventional Neuroradiology, Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Neurosurgery 58:551-8; discussion 551-8. 2006
..The mechanisms of vessel occlusion in arteriovenous malformations has not been extensively evaluated. To better understand these mechanisms, we report histopathological changes in the swine rete mirabile after stereotactic radiosurgery...
- Phase versus amplitude sorting of 4D-CT data
Nicole Wink
Department of Radiation Oncology, David Geffen School of Medicine at University of California, Los Angeles, Peter Morton Medical Building, Suite B265, Los Angeles, California 90095 USA
J Appl Clin Med Phys 7:77-85. 2006
..A 180 degrees interpolation was used for reconstruction after gating. Significant improvement using the amplitude-sorting technique was observed, particularly when testing nonperiodic motion functions...
- Optimization of multi-slice helical respiration-correlated CT: the effects of table speed and rotation time
Nicole M Wink
Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Phys Med Biol 50:5717-29. 2005
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- Use of the BrainLAB ExacTrac X-Ray 6D system in image-guided radiotherapy
Jian Yue Jin
Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202, USA
Med Dosim 33:124-34. 2008
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- Respiratory correlated cone-beam computed tomography on an isocentric C-arm
Sergey Kriminski
Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Phys Med Biol 50:5263-80. 2005
..Images reconstructed from the retrospectively gated projection sequences using the optimal gating window data showed a significant improvement compared to images reconstructed from the complete projection datasets...
- Investigations of a minimally invasive method for treatment of spinal malignancies with LINAC stereotactic radiation therapy: accuracy and animal studies
Paul M Medin
Department of Radiation Oncology, University of California Los Angeles, Los Angeles, CA, USA
Int J Radiat Oncol Biol Phys 52:1111-22. 2002
..Phantom measurements suggest that localization accuracy similar to intracranial stereotactic radiotherapy techniques is achievable. Swine studies suggest that the implant technique is expedient and feasible for tumor targeting purposes...
- Contrast-enhanced brachytherapy for prostate cancer
Amos Norman
Department of Radiation Oncology, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, USA
Acad Radiol 9:S182-4. 2002
- Dosimetric parameters for three low-energy brachytherapy sources using the Monte Carlo N-particle code
John J DeMarco
Department of Radiation Oncology, UCLA School of Medicine, Los Angeles, California 90095 6951, USA
Med Phys 29:662-8. 2002
..Radial dose function, g(r), calculated to a distance of 10 cm, and an isotropy function, F(r, theta), calculated for radii from 0.5 to 7.0 cm, were found to be in close agreement with previously published data...
- Initial clinical results of stereotactic radiotherapy for the treatment of craniopharyngiomas
Michael T Selch
Department of Radiation Oncology, School of Medicine, University of California, Los Angeles CA 90095, USA
Technol Cancer Res Treat 1:51-9. 2002
..Further clinical experience is necessary to determine the clinical utility of beam shaping in the setting of SRT...
- Stereotactic radiotherapy for treatment of cavernous sinus meningiomas
Michael T Selch
Department of Radiation Oncology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA 90045 6951, USA
Int J Radiat Oncol Biol Phys 59:101-11. 2004
..To assess the safety and efficacy of stereotactic radiotherapy (SRT) using a linear accelerator equipped with a micromultileaf collimator for cavernous sinus meningiomas...
- Stereotactic radiotherapy for the treatment of acoustic neuromas
Michael T Selch
Department of Radiation Oncology and Division of Neurosurgery, David Geffen School of Medicine, University of California, 90045 6951, USA
J Neurosurg 101:362-72. 2004
..The authors sought to assess the safety and efficacy of stereotactic radiotherapy when using a linear accelerator equipped with a micromultileaf collimator for the treatment of patients with acoustic neuromas...
- Functional stereotactic radiosurgery involving a dedicated linear accelerator and gamma unit: a comparison study
Timothy D Solberg
Department of Radiation Oncology, University of California, Los Angeles School of Medicine, Los Angeles 90095 6951, USA
J Neurosurg 101:373-80. 2004
..The purpose of this work was to investigate the targeting and dosimetric characteristics of a linear accelerator (LINAC) system dedicated for stereotactic radiosurgery compared with those of a commercial gamma knife (GK) unit...
- A feasibility study of 18F-fluorodeoxyglucose positron emission tomography targeting and simultaneous integrated boost for intensity-modulated radiosurgery and radiotherapy
Timothy D Solberg
Department of Radiation Oncology, David Geffen School of Medicine, University of California, 90095 6951, USA
J Neurosurg 101:381-9. 2004
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- Three-dimensional fast imaging employing steady-state acquisition magnetic resonance imaging for stereotactic radiosurgery of trigeminal neuralgia
Gabriela del Rocío Chávez Chávez
Division of Neurosurgery, University of California at Los Angeles, Los Angeles, California, USA
Neurosurgery 56:E628; discussion E628. 2005
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- Intracranial stereotactic positioning systems: Report of the American Association of Physicists in Medicine Radiation Therapy Committee Task Group no. 68
A W Lightstone
Department of Medical Physics, Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario M4N 3M5, Canada
Med Phys 32:2380-98. 2005
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- Dosimetric parameters of three new solid core I-125 brachytherapy sources
Timothy D Solberg
Department of Radiation Oncology, UCLA School of Medicine, Los Angeles, California 98095 6951, USA
J Appl Clin Med Phys 3:119-34. 2002
..All dosimetric parameters were found to be in close agreement with previously published data for similar source configurations. The MCNP Monte Carlo code appears to be ideally suited to low energy dosimetry applications...
