Hilkka Soininen

Summary

Publications

  1. pmc Structural MRI in frontotemporal dementia: comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry
    Miguel Ángel Muñoz-Ruiz
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 7:e52531. 2012
  2. pmc Software tool for improved prediction of Alzheimer's disease
    Hilkka Soininen
    University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland
    Neurodegener Dis 10:149-52. 2012
  3. pmc Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer's disease
    Matej Oresic
    VTT Technical Research Centre of Finland, Espoo, FI 02044 VTT, Finland
    Genome Med 1:83. 2009
  4. doi request reprint Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study
    Yawu Liu
    Department of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 21:947-66. 2010
  5. doi request reprint APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus
    Okko T Pyykkö
    Neurosurgery of NeuroCentre, Kuopio University Hospital, P O Box 1777, 70211 Kuopio, Finland
    J Neurol Neurosurg Psychiatry 83:1119-24. 2012
  6. ncbi request reprint Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population
    Anne M Koivisto
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Dement Geriatr Cogn Disord 22:449-53. 2006
  7. doi request reprint Progression of Alzheimer's disease during a three-year follow-up using the CERAD-NB total score: Kuopio ALSOVA study
    Ilona Hallikainen
    School of Medicine, Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
    Int Psychogeriatr 25:1335-44. 2013
  8. doi request reprint Disease state fingerprint in frontotemporal degeneration with reference to Alzheimer's disease and mild cognitive impairment
    Miguel Ángel Muñoz-Ruiz
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 35:727-39. 2013
  9. doi request reprint Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups--the AddNeuroMed study
    Yawu Liu
    Department of Neurology, University of Kuopio, University Hospital, Kuopio, Finland
    Neurobiol Aging 32:1198-206. 2011
  10. ncbi request reprint Evolution of global and local grey matter atrophy on serial MRI scans during the progression from MCI to AD
    Gabriela Spulber
    University of Eastern Finland, Kuopio Campus, Institute of Clinical Medicine Neurology, Kuopio
    Curr Alzheimer Res 9:516-24. 2012

Collaborators

Detail Information

Publications85

  1. pmc Structural MRI in frontotemporal dementia: comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry
    Miguel Ángel Muñoz-Ruiz
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 7:e52531. 2012
    ..MRI is an important clinical tool for diagnosing dementia-like diseases such as Frontemporal Dementia (FTD). However there is a need to develop more accurate and standardized MRI analysis methods...
  2. pmc Software tool for improved prediction of Alzheimer's disease
    Hilkka Soininen
    University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland
    Neurodegener Dis 10:149-52. 2012
    ..Diagnostic criteria of Alzheimer's disease (AD) emphasize the integration of clinical data and biomarkers. In practice, collection and analysis of patient data vary greatly across different countries and clinics...
  3. pmc Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer's disease
    Matej Oresic
    VTT Technical Research Centre of Finland, Espoo, FI 02044 VTT, Finland
    Genome Med 1:83. 2009
    ..Given that data acquired at different levels can carry complementary information about early Alzheimer's disease pathology, it is expected that their integration will improve early detection as well as our understanding of the disease...
  4. doi request reprint Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study
    Yawu Liu
    Department of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 21:947-66. 2010
    ..We conclude that the APOE ε4 allele modulates regional cortical thickness and volume in relation to diagnostic group and gender. The ε4 allele has a dose-dependent and regionally specific effect on brain structures...
  5. doi request reprint APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus
    Okko T Pyykkö
    Neurosurgery of NeuroCentre, Kuopio University Hospital, P O Box 1777, 70211 Kuopio, Finland
    J Neurol Neurosurg Psychiatry 83:1119-24. 2012
    ....
  6. ncbi request reprint Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population
    Anne M Koivisto
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Dement Geriatr Cogn Disord 22:449-53. 2006
    ..026). These results suggest that the PPARgamma gene may modify the age of onset in LOAD...
  7. doi request reprint Progression of Alzheimer's disease during a three-year follow-up using the CERAD-NB total score: Kuopio ALSOVA study
    Ilona Hallikainen
    School of Medicine, Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
    Int Psychogeriatr 25:1335-44. 2013
    ..We also investigated possible differences in progression between patients with very mild or mild baseline AD...
  8. doi request reprint Disease state fingerprint in frontotemporal degeneration with reference to Alzheimer's disease and mild cognitive impairment
    Miguel Ángel Muñoz-Ruiz
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 35:727-39. 2013
    ..It has been demonstrated that it is applicable in the diagnosis of Alzheimer's disease (AD)...
  9. doi request reprint Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups--the AddNeuroMed study
    Yawu Liu
    Department of Neurology, University of Kuopio, University Hospital, Kuopio, Finland
    Neurobiol Aging 32:1198-206. 2011
    ..A combination of neuropsychological tests and regional volumes are important when discriminating AD from healthy controls and MCI...
  10. ncbi request reprint Evolution of global and local grey matter atrophy on serial MRI scans during the progression from MCI to AD
    Gabriela Spulber
    University of Eastern Finland, Kuopio Campus, Institute of Clinical Medicine Neurology, Kuopio
    Curr Alzheimer Res 9:516-24. 2012
    ..This accelerated atrophy may offer new insights into the understanding of neurodegenerative pathology and the clinical relevance of these changes remains to be verified by subsequent studies...
  11. ncbi request reprint The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study
    Corina Pennanen
    Department of Neuroscience and Neurology, University of Kuopio, Canthia, Kuopio, Finland
    Dement Geriatr Cogn Disord 22:60-6. 2006
    ..In cases homozygous for the epsilon4 allele (n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus...
  12. doi request reprint Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain
    Tero Tapiola
    Department of Neuroscience and Neurology, Clinical Research Center Mediteknia, Kuopio University Hospital, University of Kuopio, Finland
    Arch Neurol 66:382-9. 2009
    ....
  13. doi request reprint Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus
    Ville Leinonen
    Department of Neurosurgery, Neurocenter, Kuopio University Hospital, Kuopio, Finland
    Neurodegener Dis 10:166-9. 2012
    ..Brain biopsy did not predict survival but may open a novel research window to study the pathobiology of neurodegeneration...
  14. doi request reprint Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 28:553-9. 2012
    ....
  15. pmc Education increases reserve against Alzheimer's disease--evidence from structural MRI analysis
    Yawu Liu
    Department of Neurology, University of Eastern Finland, Kuopio University Hospital, P O Box 1627, 70211 Kuopio, Finland
    Neuroradiology 54:929-38. 2012
    ..The aim of this study was to determine whether years of schooling influences regional cortical thicknesses and volumes in Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy age-matched controls...
  16. ncbi request reprint Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort
    Anna Maija Tolppanen
    Department of Neurology, University of Eastern Finland, P O Kuopio, Finland
    J Alzheimers Dis 38:201-9. 2014
    ..Obesity has been consistently associated with dementia. The role of certain risk factors of dementia may change during life, and the importance of having a life-course perspective has been acknowledged...
  17. doi request reprint Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus
    Anne M Koivisto
    Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Neurosurgery 72:1-8;discussion 8. 2013
    ..Idiopathic normal pressure hydrocephalus (iNPH) causes cognitive decline that can be alleviated by shunting, but long-term outcome studies are scarce...
  18. doi request reprint Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease
    Yawu Liu
    Department of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland
    Neurobiol Aging 31:1375-85. 2010
    ..We conclude that regional cortical volume measures are more powerful than those common cognitive tests we used in identifying AD patients at the very earliest stage of the disease...
  19. ncbi request reprint Longitudinal changes of CSF biomarkers in Alzheimer's disease
    Toni T Seppälä
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 25:583-94. 2011
    ..More longitudinal studies of CSF biomarker dynamics are needed, especially in patients during the preclinical stage of the disease...
  20. doi request reprint An association study of 21 potential Alzheimer's disease risk genes in a Finnish population
    Timo Sarajärvi
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 21:763-7. 2010
    ..Risk analysis revealed a protective effect for the minor allele carriers of rs1800629. This suggests that genetic alteration in TNF gene may play a role in AD...
  21. doi request reprint Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment
    Anne M Jauhiainen
    Institute of Clinical Medicine, Unit of Neurology, University of Kuopio, Kuopio, Finland
    Hippocampus 19:166-75. 2009
    ..Future technical improvements may improve the utilization of hippocampal fMRI for early diagnostic purposes...
  22. ncbi request reprint Somatostatin genetic variants modify the risk for Alzheimer's disease among Finnish patients
    Saila Vepsäläinen
    Department of Neurology, University Hospital and University of Kuopio, 70211, Kuopio, Finland
    J Neurol 254:1504-8. 2007
    ..This first genetic association study between somatostatin and AD indicates that genetic variations in the somatostatin gene may modify the risk for AD among Finnish AD subjects...
  23. doi request reprint Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells
    Jayashree Viswanathan
    Institute of Clinical Medicine Neurology, University of Eastern Finland, and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Biochemistry 52:3899-912. 2013
    ..These data suggest that ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage and thus may play a role in regulating γ-secretase cleavage of various substrates...
  24. doi request reprint Cortical thickness analysis to detect progressive mild cognitive impairment: a reference to Alzheimer's disease
    Valtteri Julkunen
    Department of Neurology, Kuopio University Hospital, FI 70211 Kuopio, Finland
    Dement Geriatr Cogn Disord 28:404-12. 2009
    ..It would be advantageous to be able to distinguish the characteristics of those MCI patients with a high probability to progress to AD if one wishes to monitor the disease development and treatment...
  25. ncbi request reprint Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 37:217-32. 2013
    ..While the present study indicates that GGA3 is involved in the cellular processes relevant for AD pathogenesis, the genetic data do not support the idea that common GGA3 polymorphisms would contribute to AD risk. ..
  26. doi request reprint Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease
    Seppo Helisalmi
    Institute of Clinical Medicine, Unit of Neurology and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio University, Kuopio, Finland
    Neurosci Lett 441:233-6. 2008
    ..We conclude that PPARG gene does not play a major role in the genetic predisposition to AD in the Finnish population...
  27. ncbi request reprint Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment
    Anne Hämäläinen
    Department of Neurology, University of Kuopio and Brain Research Unit, Clinical Research Center, Mediteknia, and Kuopio University Hospital, Finland
    Neuroimage 37:1122-31. 2007
    ..We conclude that widespread cortical atrophy is present already two and a half years before a clinical diagnosis of dementia can be set...
  28. doi request reprint CERAD neuropsychological battery total score in multinational mild cognitive impairment and control populations: the AddNeuroMed study
    Teemu Paajanen
    Department of Neurology, University of Eastern Finland, University Hospital, Kuopio, Finland
    J Alzheimers Dis 22:1089-97. 2010
    ..We conclude that the CERAD total score is an accurate measure for detecting mild cognitive impairment, but implementing specific cut-off points needs to be based upon country specific normative data...
  29. doi request reprint Flanking markers of cystatin c (CST3) gene do not show association with Alzheimer's disease
    Seppo Helisalmi
    Institute of Clinical Medicine, Unit of Neurology and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio University, Kuopio, Finland
    Dement Geriatr Cogn Disord 27:318-21. 2009
    ..In the present study we determined whether the cystatin c gene (CST3) is genetically associated with late-onset Alzheimer's disease (AD)...
  30. doi request reprint APOE ε2 allele is associated with larger regional cortical thicknesses and volumes
    Yawu Liu
    Department of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland
    Dement Geriatr Cogn Disord 30:229-37. 2010
    ..The protective effect of the apolipoprotein E (APOE) ε2 allele against Alzheimer's disease (AD) is controversial...
  31. doi request reprint Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study
    Marjo H Eskelinen
    Department of Neurology, University of Kuopio, Kuopio, Finland
    Int J Geriatr Psychiatry 23:741-7. 2008
    ..To investigate the association of midlife dietary fat intake to cognitive performance, and to the occurrence of clinical mild cognitive impairment (MCI) later in life in a non-demented population...
  32. pmc Predicting AD conversion: comparison between prodromal AD guidelines and computer assisted PredictAD tool
    Yawu Liu
    Department of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 8:e55246. 2013
    ....
  33. doi request reprint GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer's disease patients
    Anna Kämäläinen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 33:23-7. 2013
    ..Our findings suggest that the A allele of rs5848 is functionally relevant by reducing the expression of granulin...
  34. doi request reprint Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats
    Timo Sarajärvi
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Cell Mol Med 16:2754-67. 2012
    ..These findings suggest that bepridil is a plausible therapeutic candidate in AD or stroke owing to its multifunctional role in key cellular events that are relevant for the pathogenesis of these diseases...
  35. ncbi request reprint Olfactory identification in non-demented elderly population and in mild cognitive impairment: a comparison of performance in clinical odor identification versus Boston Naming Test
    Mikko P Laakso
    Department of Neurology, Kuopio University Hospital, Bldg 5, P O Box 1777, Kuopio 70211, Finland
    J Neural Transm 116:891-5. 2009
    ..Standard assessment of olfactory nerve function is not sufficient to study cognitive impairment in MCI...
  36. pmc New insights into Alzheimer's disease progression: a combined TMS and structural MRI study
    Eini Niskanen
    Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 6:e26113. 2011
    ..Combination of structural and functional data of the human brain can provide detailed information of neurodegenerative diseases and the influence of the disease on various local cortical areas...
  37. doi request reprint Amyloid and tau proteins in cortical brain biopsy and Alzheimer's disease
    Ville Leinonen
    Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland
    Ann Neurol 68:446-53. 2010
    ..Amyloid-β(Aβ) aggregates are presumed to be found in the brain at an early stage of Alzheimer's disease (AD) but have seldom been assessed by brain biopsy during life in often elderly patients...
  38. ncbi request reprint Effect of cholinergic stimulation in early Alzheimer's disease - functional imaging during a recognition memory task
    Pekka S Miettinen
    Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Curr Alzheimer Res 8:753-64. 2011
    ..These findings also suggest the importance of early AChEI treatment in the course of AD, at the point when there is still some cognitive reserve available and the therapy has the highest potential efficacy...
  39. doi request reprint Changes in vascular factors 28 years from midlife and late-life cortical thickness
    Miika Vuorinen
    Department of Neurology, School of Medicine, University of Eastern Finland, Kuopio, Finland
    Neurobiol Aging 34:100-9. 2013
    ..No associations were found between body mass index, cholesterol, or apolipoprotein E ε4 allele and cortical thickness in this group of elderly at risk individuals...
  40. ncbi request reprint CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy
    Sanna Kaisa Herukka
    Department of Neurology, University of Kuopio, Kuopio, Finland
    J Alzheimers Dis 14:51-7. 2008
    ..However, the order of the changes in the CSF biomarkers and MTL atrophy remain unclear due to a small number of studied subjects and study design...
  41. doi request reprint Differential hypometabolism patterns according to mild cognitive impairment subtypes
    Anne M Jauhiainen
    Unit of Neurology, Institute of Clinical Medicine, Mediteknia, Kuopio, Finland
    Dement Geriatr Cogn Disord 26:490-8. 2008
    ..The present study investigated cerebral glucose metabolism and structural atrophy in controls and subjects with mild cognitive impairment (MCI)...
  42. pmc Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis
    Timo Sarajärvi
    Department of Neurology, University of Kuopio and Kuopio University Hospital, FIN 70211 Kuopio, Finland
    J Biol Chem 284:34433-43. 2009
    ..These mechanistic findings related to seladin-1 down-regulation are important in the context of AD as the oxidative stress-induced apoptosis plays a key role in the disease pathogenesis...
  43. doi request reprint Incidence of stroke in people with Alzheimer disease: a national register-based approach
    Anna Maija Tolppanen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Kuopio, Finland
    Neurology 80:353-8. 2013
    ..We investigated whether noninstitutionalized persons with AD were more likely to experience incident stroke than persons without AD and whether there are differences in the incidence of ischemic or hemorrhagic strokes...
  44. doi request reprint Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study
    Marjo H Eskelinen
    Department of Neurology, University of Kuopio, P O Kuopio, Finland
    J Alzheimers Dis 16:85-91. 2009
    ..Coffee drinking at midlife is associated with a decreased risk of dementia/AD later in life. This finding might open possibilities for prevention of dementia/AD...
  45. doi request reprint Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology
    Saila Vepsäläinen
    Department of Neurology, University Hospital and University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Neurosci Lett 438:216-20. 2008
    ..mRNA and protein levels of NEP were also nominally up-regulated in Tg mice compared to controls. These data may reflect up-regulation of the IDE and possibly of NEP expression in response to the Abeta accumulation...
  46. ncbi request reprint CERAD Neuropsychological Compound Scores are Accurate in Detecting Prodromal Alzheimer's Disease: A Prospective AddNeuroMed Study
    Teemu Paajanen
    Cognition and Work Team, Finnish Institute of Occupational Health, Helsinki, Finland Department of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 39:679-90. 2014
    ..08). CERAD total scores are a practical way of screening for prodromal AD and assessing cognitive progression in MCI. The new memory compound scores were more accurate than CERAD subtests in predicting AD conversion. ..
  47. ncbi request reprint Genetic variation in apolipoprotein D and Alzheimer's disease
    Seppo Helisalmi
    Dept of Neuroscience and Neurology, University Hospital and University of Kuopio, Kuopio, Finland
    J Neurol 251:951-7. 2004
    ..Each method suggested that the -352G allele frequency is higher for EOAD in the eastern Finnish population...
  48. doi request reprint An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population
    Jayashree Viswanathan
    Department of Neurology, Clinical Research Centre Mediteknia, University Hospital and University of Kuopio, Finland
    Am J Med Genet B Neuropsychiatr Genet 150:747-50. 2009
    ..These data suggest that genetic variability in the GRN gene may also increase the risk for developing AD in a gender-specific manner...
  49. ncbi request reprint Chronic obstructive pulmonary disease and asthma and the risk of mild cognitive impairment and dementia: a population based CAIDE study
    Minna Rusanen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Yliopistonranta 1, PL 1627, 70211 Kuopio, Finland
    Curr Alzheimer Res 10:549-55. 2013
    ..We examined the association between midlife and late-life self-reported COPD and asthma and the lifelong risk of cognitive impairment (MCI/dementia) in a population-based study with a follow-up of over 25 years...
  50. doi request reprint Cortical thickness in frontotemporal dementia, mild cognitive impairment, and Alzheimer's disease
    Päivi Hartikainen
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 30:857-74. 2012
    ..Cortical thickness might be a tool for detecting subtle changes in brain atrophy in screening of dementia prior to the development of diffuse or lobar atrophies...
  51. doi request reprint Diffusion tensor imaging and tract-based spatial statistics in Alzheimer's disease and mild cognitive impairment
    Yawu Liu
    Department of Clinical Radiology, Kuopio University Hospital, P O Box 1777, FI 70211 Kuopio, Finland
    Neurobiol Aging 32:1558-71. 2011
    ..We conclude that TBSS is a promising method in examining the degeneration of neurofiber tracts in MCI and AD patients...
  52. pmc Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer's Disease: Kuopio ALSOVA Study
    Ilona Hallikainen
    Institute of Clinical Medicine, Neurology, University of Eastern Finland, Mikkeli, Finland
    Dement Geriatr Cogn Dis Extra 2:209-18. 2012
    ..The aim of this study was to examine whether demographic variables, dementia severity, ADL and neuropsychiatric symptoms are associated with cognition in very mild or mild AD...
  53. doi request reprint AMP-activated protein kinase: a potential player in Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    J Neurochem 118:460-74. 2011
    ..We will outline the potential role of AMPK function in respect to various aspects affecting AD pathogenesis...
  54. doi request reprint Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B
    Ville Leinonen
    Department of Neurosurgery, Kuopio University Hospital, PO Box 1777, 70211 Kuopio, Finland
    Arch Neurol 65:1304-9. 2008
    ..To compare carbon 11-labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) findings in patients with and without Alzheimer disease lesions in frontal cortical biopsy specimens...
  55. pmc Increased γ-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with β-Amyloid Pathology
    Tiina Laiterä
    Institute of Clinical Medicine Neurosurgery, University of Eastern Finland, Kuopio, Finland Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 9:e93717. 2014
    ..Despite the resemblances in the Aβ pathology, iNPH and AD patients appear to have marked differences in the cellular mechanisms responsible for the production of Aβ. ..
  56. pmc History of medically treated diabetes and risk of Alzheimer disease in a nationwide case-control study
    Anna Maija Tolppanen
    Institute of Clinical Medicine, Neurology, University of Kuopio, Kuopio, Finland
    Diabetes Care 36:2015-9. 2013
    ..We investigated whether individuals with AD were more likely to have a history of diabetes than matched controls from the general aged population...
  57. ncbi request reprint Distinct and overlapping fMRI activation networks for processing of novel identities and locations of objects
    Maija Pihlajamaki
    Department of Neurology, Kuopio University Hospital, PO Box 1777, 70211 Kuopio, Finland
    Eur J Neurosci 22:2095-105. 2005
    ..These findings offer new insights to the functional roles and intrinsic specialization of the cingulate/retrosplenial, and lateral temporal cortical areas in visuospatial cognition...
  58. ncbi request reprint Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population
    Anne M Koivisto
    Department of Medicine, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    J Neurogenet 19:155-61. 2005
    ..Interestingly, the G allele frequency was lower in our population in both AD patients and in controls compared to Southern European populations...
  59. ncbi request reprint Structural and functional MRI in mild cognitive impairment
    Maija Pihlajamaki
    Department of Neurology, Kuopio University Hospital Kuopio, Finland
    Curr Alzheimer Res 6:179-85. 2009
    ..It is suggested that both altered MTL and posteromedial cortical function may be indicative of future cognitive decline from MCI to clinical AD...
  60. doi request reprint Comparing predictors of conversion to Alzheimer's disease using the disease state index
    Miguel Ángel Muñoz-Ruiz
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Neurodegener Dis 13:200-2. 2014
    ..The Disease State Index (DSI) is a method which interprets data originating from multiple different sources, assisting the clinician in the diagnosis and follow-up of dementia diseases...
  61. doi request reprint Targeting ubiquilin-1 in Alzheimer's disease
    Mari Takalo
    Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Expert Opin Ther Targets 17:795-810. 2013
    ..These include the amyloid precursor protein and presenilins that are intimately involved in the mechanisms of AD...
  62. pmc Incident hip fractures among community dwelling persons with Alzheimer's disease in a Finnish nationwide register-based cohort
    Anna Maija Tolppanen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 8:e59124. 2013
    ..Previous cohort studies have shown that persons with Alzheimer's disease (AD) have a higher risk of hip fractures but recent data from large representative cohorts is scarce...
  63. doi request reprint Structure and function of medial temporal and posteromedial cortices in early Alzheimer's disease
    Pekka S Miettinen
    Department of Neurology, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, Kuopio, Finland
    Eur J Neurosci 34:320-30. 2011
    ..Disturbances in posteromedial cortical function are associated with morphological changes in the MTL across the continuum from normal aging to clinical AD...
  64. ncbi request reprint Whole brain atrophy rate predicts progression from MCI to Alzheimer's disease
    Gabriela Spulber
    Institute of Clinical Medicine, Unit of Neurology, Kuopio University, Kuopio, Finland
    Neurobiol Aging 31:1601-5. 2010
    ..These findings suggest that IPCA could be an effective brain-imaging marker of progression to AD and useful tool for the evaluation of disease-modifying treatments...
  65. ncbi request reprint Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients: a longitudinal study
    Valtteri Julkunen
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 21:1141-51. 2010
    ....
  66. pmc Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus
    Okko T Pyykkö
    Neurosurgery of Neurocenter, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 9:e91974. 2014
    ..The significance of amyloid precursor protein (APP) and neuroinflammation in idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) is unknown...
  67. ncbi request reprint High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status
    Mari Takalo
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Nutr Biochem 25:634-41. 2014
    ..Our study suggests that the high-fat diet independently of type 2 diabetes or Alzheimer's disease background induces the expression and exon 10 inclusion of tau in the brain of female mice. ..
  68. doi request reprint Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus
    Mikko Hiltunen
    Department of Neurology, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Neurobiol Dis 35:103-13. 2009
    ..These results demonstrate that focal cerebral ischemia leads to complex pathogenic events in the thalamus long after the initial insult...
  69. pmc Effects of NR1H3 genetic variation on the expression of liver X receptor α and the progression of Alzheimer's disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    PLoS ONE 8:e80700. 2013
    ..These results suggest that genetic variation in NR1H3 modulates the expression of LXRα and the levels of soluble Aβ42. ..
  70. doi request reprint Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 96:87-95. 2012
    ..We will review here the molecular and functional characteristics of p62 protein and outline its potential role in the regulation of Alzheimer's pathogenesis...
  71. doi request reprint Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions
    Päivi H Hartikainen
    Department of Neurology, Kuopio University Hospital, Finland
    Neuropathology 32:60-8. 2012
    ..We conclude that clinical phenotypes of FUS pathologies also include elderly patients and are more variable with motor and speech disorders than previously reported...
  72. ncbi request reprint Age-related macular degeneration (AMD): Alzheimer's disease in the eye?
    Kai Kaarniranta
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 24:615-31. 2011
    ..However, it seems that these diseases have a different genetic background. In this review, differences and similarities of AMD and AD are thoroughly discussed...
  73. doi request reprint Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice
    Mikko Hiltunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    J Cell Mol Med 16:1206-22. 2012
    ..These findings provide evidence for new regulatory mechanisms that link type-2 diabetes and Alzheimer pathology...
  74. doi request reprint Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Eur J Neurosci 34:3-11. 2011
    ..We will review the astroglial changes occurring during aging and emphasize that senescent astrocytes can have an important role in age-related neuroinflammation and neuronal degeneration...
  75. doi request reprint Neuropsychiatric symptoms and quality of life in patients with very mild and mild Alzheimer's disease
    Kristiina Karttunen
    Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Int J Geriatr Psychiatry 26:473-82. 2011
    ..Neuropsychiatric symptoms (NPS) are common manifestations of Alzheimer' s disease (AD)...
  76. pmc Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking
    Timo Sarajärvi
    Institute of Clinical Medicine Neurology, University of Eastern Finland, and Department of Neurology, Kuopio University Hospital, FI 70211 Kuopio, Finland
    Mol Cell Biol 31:2326-40. 2011
    ..These data suggest that an increased constitutive internalization and/or concurrent signaling of the δOR-Cys27 variant affects APP processing through altered endocytic trafficking of APP...
  77. doi request reprint Use of antiepileptic drugs among community-dwelling persons with Alzheimer's disease in Finland
    J Simon Bell
    Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 26:231-7. 2011
    ..83; 95% CI, 0.70 to 0.99). Use of older AEDs is more prevalent among persons with AD, despite persons with AD being particularly vulnerable to adverse drug reactions associated with many older AEDs...
  78. doi request reprint Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 106:33-54. 2013
    ....
  79. pmc Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation
    Jayashree Viswanathan
    Institute of Clinical Medicine Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Traffic 12:330-48. 2011
    ..Collectively, our results indicate that specific ubiquilin-1 TVs can cause PS1 accumulation and aggresome formation, which may impact AD pathogenesis or susceptibility...
  80. pmc Combining transcranial magnetic stimulation and electroencephalography may contribute to assess the severity of Alzheimer's disease
    Petro Julkunen
    Department of Clinical Neurophysiology, Kuopio University Hospital, POB 1777, 70211 Kuopio, Finland
    Int J Alzheimers Dis 2011:654794. 2011
    ..Given the small sample size, further studies may be needed to confirm the results...
  81. doi request reprint Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 93:99-110. 2011
    ..We will review the role of Hsp90 chaperone network in the regulation of tau biology and pathology in Alzheimer's disease...
  82. doi request reprint Prevention of Alzheimer's disease: moving backward through the lifespan
    Alina Solomon
    Department of Neurology, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 33:S465-9. 2013
    ....
  83. doi request reprint Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar ataxia as assessed by p62/sequestosome immunohistochemistry
    Maria Pikkarainen
    Department of Clinical Medicine, Unit of Neurology, University of Eastern Finland, Kuopio, Finland
    Cerebellum 10:720-31. 2011
    ..Based on a literature search, it is apparent that there is a need for clinico-pathologic-genetical studies of LOCA, especially to obtain a deeper understanding of the regional distribution and progression of pathology...
  84. pmc Midlife healthy-diet index and late-life dementia and Alzheimer's disease
    Marjo H Eskelinen
    Department of Neurology, University of Eastern Finland, Kuopio, Kuopio, Finland
    Dement Geriatr Cogn Disord Extra 1:103-12. 2011
    ..To study long-term effects of dietary patterns on dementia and Alzheimer's disease (AD)...
  85. doi request reprint Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease
    Henna Martiskainen
    Kuopio University Hospital, Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio, Finland
    Expert Opin Ther Targets 17:781-94. 2013
    ..Based on the prevailing amyloid cascade hypothesis, it is conceivable that lowering the β-amyloid (Aβ) levels is sufficient to slow down the disease process, if started early enough...