Adherence to Mediterranean diet and health status: meta-analysisFrancesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
BMJ 337:a1344. 2008
..To systematically review all the prospective cohort studies that have analysed the relation between adherence to a Mediterranean diet, mortality, and incidence of chronic diseases in a primary prevention setting...
The atherosclerotic risk profile is affected differently by fish flesh with a similar EPA and DHA content but different n-6/n-3 ratioFrancesco Sofi
Department of Clinica and Experimental Medicine, Thrombosis Centre, Florence, Italy
Asia Pac J Clin Nutr 22:32-40. 2013
..In conclusion, similar EPA+DHA content with different n- 6/n-3 ratio fish flesh intake was shown to have varied affects on lipid, inflammatory and haemorheological parameters in a group of healthy subjects...
- Identification of change-points in the relationship between food groups in the Mediterranean diet and overall mortality: an 'a posteriori' approach
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, Florence, Italy
Eur J Nutr 51:167-72. 2012
..The aim of the present study was to identify change-points in the relationship between food groups composing Mediterranean diet and overall mortality...
Lifestyle modifications after acute coronary syndromes in a subset of the AMI-Florence 2 RegistryFrancesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
Acta Cardiol 66:791-6. 2011
..The aim of this study was to evaluate the adherence to recommendations for secondary prevention of cardiovascular diseases in patients with acute coronary syndromes (ACS)...
- Physical activity during leisure time and primary prevention of coronary heart disease: an updated meta-analysis of cohort studies
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy
Eur J Cardiovasc Prev Rehabil 15:247-57. 2008
..The real magnitude of the association between physical activity during leisure time (LTPA) and primary prevention of coronary heart disease (CHD) has, however, not been completely defined...
- Effectiveness of the Mediterranean diet: can it help delay or prevent Alzheimer's disease?
Francesco Sofi
Regional Centre of Nutrition, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
J Alzheimers Dis 20:795-801. 2010
..Moreover, the Mediterranean diet has been extensively reported to be associated with a favorable health outcome and a better quality of life...
- Residual platelet reactivity on aspirin therapy and recurrent cardiovascular events--a meta-analysis
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Int J Cardiol 128:166-71. 2008
..The aim of this study was to systematically assess the relationship between RPR on acetylic salicylic acid (ASA) therapy and the occurrence of recurrent events in a meta-analysis of prospective studies...
- Protein Z plasma levels in different phases of activity of coronary atherosclerosis
F Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
J Thromb Haemost 3:2254-8. 2005
..1-8.9, P = 0.02). In conclusion, these results strengthen our previous data on low protein Z plasma levels in ACS and indicate a possible dose-response effect of decreasing protein Z plasma levels on the coronary atherosclerotic disease...
- Role of haemorheological factors in patients with retinal vein occlusion
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
Thromb Haemost 98:1215-9. 2007
..In conclusion, our data indicate that an alteration of haemorheological parameters may modulate the susceptibility to the RVO, by possibly helping to identify patients who may benefit from haemodilution...
- Low protein Z levels in patients with peripheral arterial disease
Francesco Sofi
Thrombosis Centre, Department of Medical and Surgical Critical Care, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Thromb Haemost 98:1114-7. 2007
..03). In conclusion, our data shows an association between low protein Z levels and the occurrence of PAD. These findings provide evidence for the role of protein Z in the pathogenesis of the atherosclerotic disease...
- Cytochrome P450 2C19*2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a meta-analysis
F Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy
Pharmacogenomics J 11:199-206. 2011
....
- Clopidogrel non-responsiveness and risk of cardiovascular morbidity. An updated meta-analysis
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Thromb Haemost 103:841-8. 2010
....
- Cardiovascular evaluation, including resting and exercise electrocardiography, before participation in competitive sports: cross sectional study
Francesco Sofi
Department of Medical and Surgical Critical Area, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
BMJ 337:a346. 2008
..To evaluate the clinical usefulness of complete preparticipation cardiovascular screening in a large cohort of sports participants...
- A meta-analysis of potential risks of low levels of protein Z for diseases related to vascular thrombosis
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy
Thromb Haemost 103:749-56. 2010
..18, 95%CI 1.19-4.00; p=0.01). The results of this meta-analysis are consistent with a role for protein Z deficiency in thrombotic diseases, including arterial thrombosis, pregnancy complications and venous thromboembolism...
- High lipoprotein (a) levels are associated with an increased risk of retinal vein occlusion
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Atherosclerosis 210:278-81. 2010
..The aim of this study was to investigate, in a large group of RVO patients, the role of such an emerging thrombophilic parameter on the pathogenesis of RVO...
- Protein Z-dependent protease inhibitor and protein Z in peripheral arterial disease patients
F Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy
J Thromb Haemost 7:731-5. 2009
..The aim of this study was to more fully assess the protein Z-ZPI system in individuals with atherosclerosis selected by the presence of symptomatic PAD...
- Dietary intake of trans fatty acids as a cardiovascular risk factor in a population of Italian teenagers
Francesco Sofi
Regional Agency of Nutrition, Azienda Ospedaliero Universitaria Careggi, University of Florence, Viale Morgagni 85, Florence, Italy
Cardiol Young 19:589-93. 2009
....
- Lipid, inflammatory and haemorheological profiles are significantly affected by farmed fish eating: an intervention study
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, Florence, Italy
Int J Food Sci Nutr 60:50-9. 2009
..The objective of the present study was to evaluate the influence of short-term dietary intake of farmed fish on biomarkers related to the atherosclerotic process...
- Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inflammatory and haemorheological variables: a dietary intervention study
F Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy
Nutr Metab Cardiovasc Dis 20:117-24. 2010
....
- Low vitamin B6 and folic acid levels are associated with retinal vein occlusion independently of homocysteine levels
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Atherosclerosis 198:223-7. 2008
..In conclusion, the present study documents, on a large sample of patients, that low vitamin B6 levels, low folic acid levels and elevated Hcy levels are each independently associated with RVO...
- Lipoprotein (a) and venous thromboembolism in adults: a meta-analysis
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
Am J Med 120:728-33. 2007
..The aim of this article is to systematically examine the published data on the association between high Lp(a) levels and venous thromboembolism...
- Protein Z: "light and shade" of a new thrombotic factor
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
Clin Lab 50:647-52. 2004
..Most of these studies were performed on ischemic vascular diseases. Recently, the possible role of protein Z deficiency in the occurrence of cardiovascular diseases has been evaluated...
- Dietary habits, lifestyle and cardiovascular risk factors in a clinically healthy Italian population: the 'Florence' diet is not Mediterranean
F Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, Florence, Italy
Eur J Clin Nutr 59:584-91. 2005
....
- Thrombophilic risk factors for symptomatic peripheral arterial disease
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
J Vasc Surg 41:255-60. 2005
..The aim of this study was to determine an extended thrombophilic risk profile of patients with symptomatic PAD...
- Adaptive physical activity and back pain: a non-randomised community-based intervention trial
F Sofi
Department of Medical and Surgical Critical Care, University of Florence, Italy
Eur J Phys Rehabil Med 47:543-9. 2011
..Back pain is a significant problem due to the high healthcare utilization, rising costs of care and low effectiveness of many current treatments...
- Effects of a 1-year dietary intervention with n-3 polyunsaturated fatty acid-enriched olive oil on non-alcoholic fatty liver disease patients: a preliminary study
Francesco Sofi
Regional Agency of Nutrition, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy
Int J Food Sci Nutr 61:792-802. 2010
..The aim of our preliminary study was to evaluate the effectiveness of long-term consumption of food enriched with n-3 polyunsaturated fatty acids (PUFA) in patients with NAFLD...
- Physical activity and risk of cognitive decline: a meta-analysis of prospective studies
F Sofi
Don Carlo Gnocchi Foundation, Centro S Maria agli Ulivi, Onlus IRCCS, Italy
J Intern Med 269:107-17. 2011
..We performed a systematic meta-analysis of all the available prospective studies that investigated the association between physical activity and risk of cognitive decline in nondemented subjects...
- High levels of homocysteine, lipoprotein (a) and plasminogen activator inhibitor-1 are present in patients with abdominal aortic aneurysm
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Thromb Haemost 94:1094-8. 2005
..13; p = 0.005). In conclusion, a significant association between abnormal levels of some metabolic parameters related to thrombosis such as Hcy, Lp(a) and PAI-1 and AAA has been observed...
- Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy
Am J Clin Nutr 92:1189-96. 2010
..The Mediterranean diet has long been reported to be protective against the occurrence of several different health outcomes...
- Low adherence of a clinically healthy Italian population to nutritional recommendations for primary prevention of chronic diseases
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Nutr Metab Cardiovasc Dis 16:436-44. 2006
..The aims of this study were to evaluate dietary habits, and to assess the adherence of the general population to the recommendations for correct nutritional behaviour...
- Protein Z levels and prognosis in patients with acute coronary syndromes
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Center, University of Florence, Florence, Italy
Clin Chem Lab Med 44:1098-102. 2006
..The aims of this study were to test changes in protein Z and their association with outcome at 1-year follow-up in 193 (150 male, 43 female) patients with ACS...
- Coffee consumption and risk of coronary heart disease: a meta-analysis
Francesco Sofi
Department of Medical and Surgical Critical Care and Center for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
Nutr Metab Cardiovasc Dis 17:209-23. 2007
..The aim of this study was to systematically examine the data published on the association between habitual coffee consumption and risk of CHD...
- Adherence to a healthful life attenuates lipid parameters among a healthy Italian population
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
Nutr Metab Cardiovasc Dis 17:642-8. 2007
....
- Effects of short-term consumption of bread obtained by an old Italian grain variety on lipid, inflammatory, and hemorheological variables: an intervention study
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
J Med Food 13:615-20. 2010
..Short-term dietary intake of whole grain bread obtained from an old grain variety seems to impose a favorable status with regard to lower circulating levels of markers of atherosclerosis...
- Fish intake and LPA 93C>T polymorphism: gene-environment interaction in modulating lipoprotein (a) concentrations
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
Atherosclerosis 195:e147-54. 2007
..In conclusion, this study reported a significant interaction of daily fish intake and LPA 93C>T polymorphism in decreasing Lp(a) concentrations...
- The Mediterranean diet revisited: evidence of its effectiveness grows
Francesco Sofi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Italy
Curr Opin Cardiol 24:442-6. 2009
..The purpose of this review is to examine the evidence in support of the effectiveness of the Mediterranean diet in reducing the prevalence of cardiovascular and chronic disease and their associated risk factors...
- eNOS and ACE genes influence peripheral arterial disease predisposition in smokers
Elena Sticchi
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
J Vasc Surg 52:97-102.e1. 2010
..In this study, we evaluated the role of eNOS-786T>C, -894G>T and 4a/4b polymorphisms as markers of PAD per se and in the presence of the ACE D allele in patients previously investigated...
- Endothelial nitric oxide synthase -786T>C, but not 894G>T and 4a4b, polymorphism influences plasma homocysteine concentrations in persons with normal vitamin status
Cinzia Fatini
Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
Clin Chem 51:1159-64. 2005
..The aim of this study was to investigate the role of endothelial nitric oxide synthase (eNOS) -786T>C, 894G>T, and 4a4b polymorphisms in influencing Hcy concentrations...
- Multilocus analysis in candidate genes ACE, AGT, and AGTR1 and predisposition to peripheral arterial disease: role of ACE D/-240T haplotype
Cinzia Fatini
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
J Vasc Surg 50:1399-404. 2009
..This study investigated four polymorphisms in angiotensinogen (AGT), angiotensin converting enzyme (ACE), and angiotensin II receptor type 1 (AGTR1), genes of RAS, in both predicting PAD and modulating the severity of the disease...
- Association between polymorphisms of the renin angiotensin system and carotid stenosis
Elena Sticchi
Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
J Vasc Surg 54:467-73. 2011
..In this study, we investigated the role of angiotensin-converting enzyme (ACE) I/D and -240A>T, angiotensinogen (AGT) M235T, and angiotensin type 1 receptor (AGTR1) 1166A > C polymorphisms in modulating the susceptibility to the disease...
- Atherosclerotic and thrombophilic risk factors in patients with ischemic central retinal vein occlusion
Andrea Sodi
Eye Clinic, University of Florence, Florence, Italy
Retina 31:724-9. 2011
..To investigate atherosclerotic and thrombophilic risk factors in patients affected by acute ischemic and nonischemic central retinal vein occlusions (CRVOs)...
- Relationship between blood viscosity and infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
Emanuele Cecchi
Dipartimento di Area Critica Medico Chirurgica, Centro Trombosi, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy
Int J Cardiol 134:189-94. 2009
....
- Polymorphisms of genes involved in extracellular matrix remodeling and abdominal aortic aneurysm
Claudia Saracini
Department of Medical and Surgical Critical Care, University of Florence, Atherothrombotic Diseases Center, Florence, Italy
J Vasc Surg 55:171-179.e2. 2012
..Abdominal aortic aneurysm (AAA) has a multifactorial etiology and the relevance of genetic factors is getting increasing interest, in particular those related to the destructive remodeling of extracellular matrix...
- Postacute rehabilitation after coronary surgery: the effect of preoperative physical activity on the incidence of paroxysmal atrial fibrillation
Marzia Giaccardi
Cardiac Rehabilitation Unit, Don Gnocchi Foundation, Florence, Italy
Am J Phys Med Rehabil 90:308-15. 2011
..In this study, we hypothesized that moderate-intensity physical activity in the year before surgery might favorably affect the incidence of AF during postacute rehabilitation...
- Predictors of vitamin B6 and folate concentrations in older persons: the InCHIANTI study
Anna Maria Gori
Department of Medical and Surgical Critical Care, Multidisciplinary Centre of Research on Food Sciences G R A, University of Florence, Florence, Italy
Clin Chem 52:1318-24. 2006
....
- Evaluation of traditional and emerging cardiovascular risk factors in patients with non-arteritic anterior ischemic optic neuropathy: a case-control study
Barbara Giambene
Eye Clinic, University of Florence, Viale Morgagni, 85 50134, Florence, Italy
Graefes Arch Clin Exp Ophthalmol 247:693-7. 2009
..This study aims at evaluating the role of traditional and emerging cardiovascular risk factors on the development of NAION...
- ACE and TGFBR1 genes interact in influencing the susceptibility to abdominal aortic aneurysm
Laura Lucarini
Department of Medical and Surgical Critical Care, University of Florence, Thrombosis Centre, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Atherosclerosis 202:205-10. 2009
..01]. This study, which demonstrates an interaction between ACE and TGFBR1 genes in predisposing to AAA, may provide further information on the mechanisms contributing to AAA susceptibility, and offer a topic for future larger studies...
- eNOS G894T polymorphism as a mild predisposing factor for abdominal aortic aneurysm
Cinzia Fatini
Department of Medical and Surgical Critical Care, University of Florence, Thrombosis Centre, Italy
J Vasc Surg 42:415-9. 2005
..No information is available about the influence of the eNOS gene T-786C, G894T, and 4a/4b polymorphisms in the susceptibility to the disease...
- Physical activity and circulating endothelial progenitor cells: an intervention study
Francesca Cesari
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy
Eur J Clin Invest 42:927-32. 2012
..To assess the effect of a personalized physical activity programme on weight and circulating (CPC) and endothelial progenitor cells (EPC) in overweight and obese subjects...
- Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation
Cinzia Fatini
Department of Medical and Surgical Critical Care Thrombosis Centre, Azienda Ospedaliero Universitaria, University of Florence, Viale Morgagni 85, 50134, Italy
Eur Heart J 27:1712-8. 2006
..We evaluated the role of eNOS -786T>C, 894G>T, 4a/4b and of minK S38G polymorphisms as predisposing factors to non-valvular atrial fibrillation (NVAF)...
- Comparison of hemorheological variables in ST-elevation myocardial infarction versus those in non-ST-elevation myocardial infarction or unstable angina pectoris
Emanuele Cecchi
Dipartimento di Area Critica Medico Chirurgica, Centro Trombosi, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Am J Cardiol 102:125-8. 2008
....
- Low protein Z plasma levels are independently associated with acute coronary syndromes
Sandra Fedi
Department of Medical and Surgical Critical Care, Section of Clinical Medicine and Cardiology, University of Florence, and Thrombosis Center, Azienda Ospedaliera Careggi, viale G Morgagni 85, 50134 Florence, Italy
Thromb Haemost 90:1173-8. 2003
..The contemporary presence of low PZ levels and smoking habit leads to an increased risk of ACS (OR=9.5; 99%CI 2.4-37.2; p < 0.0001). In conclusion, our results suggest a possible role of PZ in the occurrence of arterial thrombosis...
- Relationship between exercise capacity, endothelial progenitor cells and cytochemokines in patients undergoing cardiac rehabilitation
Francesca Cesari
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Viale Morgagni 85, 50134 Florence, Italy
Thromb Haemost 101:521-6. 2009
..Finally, CD34+/KDR+ EPCs showed significant correlation with IL-8 at T1. In conclusion, a short period of CR intervention determines a different pattern of modifications for EPCs in relation to the improvement of exercise capacity...
- Influence of endothelial nitric oxide synthase gene polymorphisms (G894T, 4a4b, T-786C) and hyperhomocysteinemia on the predisposition to acute coronary syndromes
Cinzia Fatini
Department of Medical and Surgical Critical Care, Section of Clinical Medicine and Cardiology, Thrombosis Centre, Azienda Ospedaliera Careggi, Florence, Italy
Am Heart J 147:516-21. 2004
..In this study we investigated the role of endothelial nitric oxide synthase (eNOS) polymorphisms as predisposing factors to acute coronary syndromes (ACS)...
- A proinflammatory state is associated with hyperhomocysteinemia in the elderly
Anna Maria Gori
Department of Medical and Surgical Critical Area, Center for the Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
Am J Clin Nutr 82:335-41. 2005
..A proinflammatory state is related to atherosclerosis, and recent studies suggest that acute phase reactants correlate with circulating concentrations of homocysteine...
- [Which diet for an effective cardiovascular prevention?]
Francesco Sofi
Department of Medical and Surgical Critical Care, University of Florence, Italy
Monaldi Arch Chest Dis 78:60-5. 2012
....
- Association between homocysteine, vitamin B(6) concentrations and inflammation
Anna Maria Gori
Department of Medical and Surgical Critical Care, University of Florence, DeNOTHE Centre for the Study at Molecular and Clinical Level of Chronic, University of Florence, Florence, Italy
Clin Chem Lab Med 45:1728-36. 2007
..This association, independent of the leading factor, may explain, at least in part, why subjects with high concentrations of Hcy and low concentrations of vitamin B(6) have a high risk of developing cardiovascular diseases...
- One-year adherence to exercise in elderly patients receiving postacute inpatient rehabilitation after cardiac surgery
Claudio Macchi
Cardiac Rehabilitation Unit, University of Florence, Florence, Italy
Am J Phys Med Rehabil 88:727-34. 2009
..However, information on the effectiveness of cardiac rehabilitation in promoting lifestyle changes in elderly patients is still scant...
- Relation of inflammatory status to major adverse cardiac events and reverse remodeling in patients undergoing cardiac resynchronization therapy
Antonio Michelucci
Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
J Card Fail 13:207-10. 2007
....
- Retinal vein occlusions: a review for the internist
Rossella Marcucci
Department of Medical and Surgical Critical Area, University of Florence, Florence, Italy
Intern Emerg Med 6:307-14. 2011
..No data are available on the possible role of antithrombotic strategies in the long-term prevention of recurrent RVO or vascular events...
- Role of endothelin-1 in exposure to high altitude: Acute Mountain Sickness and Endothelin-1 (ACME-1) study
Pietro Amedeo Modesti
Clinica Medica Generale e Cardiologia, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
Circulation 114:1410-6. 2006
..The aim of the present study was to investigate the effects of ET-1 antagonism on pulmonary hypertension, renal water, and sodium balance under acute and prolonged exposure to high-altitude-associated hypoxia...
- Effects of de-alcoholised wines with different polyphenol content on DNA oxidative damage, gene expression of peripheral lymphocytes, and haemorheology: an intervention study in post-menopausal women
Lisa Giovannelli
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Eur J Nutr 50:19-29. 2011
..The present intervention study was undertaken to evaluate the in vivo effects of wine polyphenols on gene expression in humans, along with their supposed antioxidant activity...
