Nikolaos Sofikitis



  1. Tsili A, Sylakos A, Ntorkou A, Stavrou S, Astrakas L, Sofikitis N, et al. Apparent diffusion coefficient values and dynamic contrast enhancement patterns in differentiating seminomas from nonseminomatous testicular neoplasms. Eur J Radiol. 2015;84:1219-26 pubmed publisher
    ..No differences between the two groups were observed for peak enhancement (P=0.18), time to peak (P=0.63) wash-in rate (P=0.32) and wash-out rate (P=0.18). ADC values may be used to preoperatively differentiate seminomas from NSGCTs. ..
  2. Tsili A, Ntorkou A, Baltogiannis D, Goussia A, Astrakas L, Malamou Mitsi V, et al. The role of apparent diffusion coefficient values in detecting testicular intraepithelial neoplasia: preliminary results. Eur J Radiol. 2015;84:828-33 pubmed publisher
    ..001), groups 2 and 1 (P<0.001), but not between groups 3 and 1 (P=0.87). Based on our preliminary results, ADC values do not provide a reliable differentiation between TIN and testicular carcinoma or normal testicular parenchyma. ..
  3. Tsili A, Ntorkou A, Baltogiannis D, Sylakos A, Stavrou S, Astrakas L, et al. Magnetization transfer imaging of normal and abnormal testis: preliminary results. Eur Radiol. 2016;26:613-21 pubmed publisher
    ..MTR might be helpful in the diagnostic work-up of testicular lesions. MTR of normal testes shows age-related changes. Testicular carcinomas have high MTR values. MTR may be useful in the diagnostic work-up of testicular lesions. ..
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    Sofikitis N, Baltogiannis D, Takenaka M, Tsoukanelis K, Tsambalas S, Yamamoto Y, et al. Pre-decondensed sperm head injections into female pronuclei result in chromosomal mingling, zygotic cleavage, and adequate embryonic and fetal development up to delivery of healthy offspring: a novel method of assisted syngamy. Andrologia. 2004;36:291-304 pubmed
    ..Successful performance of human IPSHI techniques might serve as a novel method to manage cases of intracytoplasmic sperm injection failure due to lack of development of male pronucleus or due to failure in pronuclei fusion. ..
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    Sofikitis N, Pappas E, Kawatani A, Baltogiannis D, Loutradis D, Kanakas N, et al. Efforts to create an artificial testis: culture systems of male germ cells under biochemical conditions resembling the seminiferous tubular biochemical environment. Hum Reprod Update. 2005;11:229-59 pubmed
    ..Finally, the role of in vitro cultures of immature diploid germ cells in the therapeutic management of men negative for haploid cells in their testes and the subsequent potential genetic and epigenetic risks are discussed. ..
  6. Sofikitis N, Giotitsas N, Tsounapi P, Baltogiannis D, Giannakis D, Pardalidis N. Hormonal regulation of spermatogenesis and spermiogenesis. J Steroid Biochem Mol Biol. 2008;109:323-30 pubmed publisher
    ..This review article provides an overview of the literature concerning the hormonal pathways regulating spermatogenesis. ..
  7. Tsili A, Ntorkou A, Astrakas L, Xydis V, Tsampalas S, Sofikitis N, et al. Diffusion-weighted magnetic resonance imaging in the characterization of testicular germ cell neoplasms: Effect of ROI methods on apparent diffusion coefficient values and interobserver variability. Eur J Radiol. 2017;89:1-6 pubmed publisher
    ..Multiple, small round ROIs and round ROI proved the more accurate methods for ADC measurement in the characterization of TGCNs and in the differentiation between seminomas and NSGCNs, respectively. ..
  8. Tsili A, Ntorkou A, Astrakas L, Boukali E, Giannakis D, Maliakas V, et al. Magnetic resonance diffusion tensor imaging of the testis: Preliminary observations. Eur J Radiol. 2017;95:265-270 pubmed publisher
    ..Both ADC and FA significantly differ between testicular lesions and normal testis, although FA did not show an incremental diagnostic value compared to ADC in lesion differentiation. ..