Ajit Sodhi

Summary

Publications

  1. ncbi request reprint Involvement of mitogen-activated protein kinases in the signal transduction pathway of bone marrow-derived macrophage activation in response to in vitro treatment with thymosin alpha 1
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi, India
    Int Immunopharmacol 2:47-58. 2002
  2. ncbi request reprint Asp 187 and Phe 190 residues in lethal factor are required for the expression of anthrax lethal toxin activity
    Aparna Singh
    Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India
    FEMS Microbiol Lett 212:183-6. 2002
  3. ncbi request reprint Involvement of MAP kinase signal transduction pathway in UVB-induced activation of macrophages in vitro
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    Immunol Lett 90:123-30. 2003
  4. ncbi request reprint Role of p38 mitogen-activated protein kinase and caspases in UV-B-induced apoptosis of murine peritoneal macrophages
    Gautam Sethi
    School of Biotechnology, Banaras Hindu University, Varanasi, India
    Photochem Photobiol 79:48-54. 2004
  5. ncbi request reprint In vitro activation of murine peritoneal macrophages by ultraviolet B radiation: upregulation of CD18, production of NO, proinflammatory cytokines and a signal transduction pathway
    Gautam Sethi
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    Mol Immunol 40:1315-23. 2004
  6. ncbi request reprint Recombinant fraction 1 protein of Yersinia pestis activates murine peritoneal macrophages in vitro
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi 221 005, UP, India
    Cell Immunol 229:52-61. 2004
  7. ncbi request reprint Role of protein kinase Cdelta in UV-B-induced apoptosis of macrophages in vitro
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Faculty of Science, Varanasi 221005, India
    Cell Signal 17:377-83. 2005
  8. ncbi request reprint Yersinia rLcrV and rYopB inhibits the activation of murine peritoneal macrophages in vitro
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi, UP, India
    Immunol Lett 99:146-52. 2005
  9. ncbi request reprint Interaction between cisplatin treated murine peritoneal macrophages and L929 cells: involvement of adhesion molecules, cytoskeletons, upregulation of Ca2+ and nitric oxide dependent cytotoxicity
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    Mol Immunol 44:2265-76. 2007
  10. ncbi request reprint Concanavalin A induced expression of Toll-like receptors in murine peritoneal macrophages in vitro
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi, India
    Int Immunopharmacol 7:454-63. 2007

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Involvement of mitogen-activated protein kinases in the signal transduction pathway of bone marrow-derived macrophage activation in response to in vitro treatment with thymosin alpha 1
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi, India
    Int Immunopharmacol 2:47-58. 2002
    ..These observations suggest that p42/44 MAPK activation is one of the essential signaling events triggered by Talpha1 and may be responsible for the in vitro activation of BMDMs...
  2. ncbi request reprint Asp 187 and Phe 190 residues in lethal factor are required for the expression of anthrax lethal toxin activity
    Aparna Singh
    Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India
    FEMS Microbiol Lett 212:183-6. 2002
    ..Their protective antigen-binding ability was drastically reduced. We propose that Asp187 and Phe190 are crucial for the expression of anthrax lethal toxin activity...
  3. ncbi request reprint Involvement of MAP kinase signal transduction pathway in UVB-induced activation of macrophages in vitro
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    Immunol Lett 90:123-30. 2003
    ..The data suggests the involvement of p42/44, p38 and JNK MAPK pathway and subsequent induction of c-fos and c-jun in the signal transduction process leading to the activation of macrophages exposed to UVB...
  4. ncbi request reprint Role of p38 mitogen-activated protein kinase and caspases in UV-B-induced apoptosis of murine peritoneal macrophages
    Gautam Sethi
    School of Biotechnology, Banaras Hindu University, Varanasi, India
    Photochem Photobiol 79:48-54. 2004
    ..These results suggest that activation of p38 MAPK upstream of caspases might play an important role in the apoptotic process of macrophages exposed to UV-B irradiation...
  5. ncbi request reprint In vitro activation of murine peritoneal macrophages by ultraviolet B radiation: upregulation of CD18, production of NO, proinflammatory cytokines and a signal transduction pathway
    Gautam Sethi
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    Mol Immunol 40:1315-23. 2004
    ....
  6. ncbi request reprint Recombinant fraction 1 protein of Yersinia pestis activates murine peritoneal macrophages in vitro
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi 221 005, UP, India
    Cell Immunol 229:52-61. 2004
    ..Significantly increased transcription of TLR5 was observed in macrophages treated with rF1, while the expression of TLR2 and TLR4 remained unaffected...
  7. ncbi request reprint Role of protein kinase Cdelta in UV-B-induced apoptosis of macrophages in vitro
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Faculty of Science, Varanasi 221005, India
    Cell Signal 17:377-83. 2005
    ..It is, therefore, suggested that activation of PKCdelta might play an important role in the UV-B-induced apoptosis and that specific activated isoforms of PKC may have distinct functions in cell death...
  8. ncbi request reprint Yersinia rLcrV and rYopB inhibits the activation of murine peritoneal macrophages in vitro
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi, UP, India
    Immunol Lett 99:146-52. 2005
    ..The data, therefore, suggests a possible role of IL-10 in rLcrV and rYopB mediated inhibition of LPS-induced production of IL-1beta in macrophages...
  9. ncbi request reprint Interaction between cisplatin treated murine peritoneal macrophages and L929 cells: involvement of adhesion molecules, cytoskeletons, upregulation of Ca2+ and nitric oxide dependent cytotoxicity
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    Mol Immunol 44:2265-76. 2007
    ..The addition of excess L-arginine (2mM) reversed the L-NMMA induced inhibition of NO production and L929 cell cytotoxicity...
  10. ncbi request reprint Concanavalin A induced expression of Toll-like receptors in murine peritoneal macrophages in vitro
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi, India
    Int Immunopharmacol 7:454-63. 2007
    ..The results suggest that treatment of macrophages with Con A renders them more susceptible to subsequent activation and induction of proinflammatory cytokines and nitric oxide production by different TLR ligands...
  11. doi request reprint In vitro activation of murine peritoneal macrophages by recombinant YopJ: production of nitric oxide, proinflammatory cytokines and chemokines
    Ajit Sodhi
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Immunobiology 216:358-66. 2011
    ....
  12. ncbi request reprint Production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma in murine peritoneal macrophages on treatment with wheat germ agglutinin in vitro: involvement of tyrosine kinase pathways
    Ajit Sodhi
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Glycoconj J 24:573-82. 2007
    ....
  13. ncbi request reprint Signaling molecules involved in production and regulation of IL-1beta by murine peritoneal macrophages in vitro on treatment with concanavalin A
    Ajit Sodhi
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Int Immunopharmacol 7:1403-13. 2007
    ....
  14. doi request reprint Prolactin and growth hormone induce differential cytokine and chemokine profile in murine peritoneal macrophages in vitro: involvement of p-38 MAP kinase, STAT3 and NF-kappaB
    Ajit Sodhi
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, UP 221005, India
    Cytokine 41:162-73. 2008
    ..It is further shown that p38 MAP kinase, STAT3 and NF-kappaB could play a differential regulatory role in PRL or GH induced production of cytokines by macrophages...
  15. doi request reprint Prolactin induced production of cytokines in macrophages involves Ca++ and p42/44 MAP kinase signaling pathway
    Ajit Sodhi
    Faculty of Science, School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    Growth Factors 26:212-9. 2008
    ..These observations clearly suggest the involvement of PKC-delta/Ca++/p42-44 MAP kinase cascade in PRL induced activation of murine peritoneal macrophages...
  16. ncbi request reprint Mechanism of rLcrV and rYopB mediated Immunosuppression in murine peritoneal macrophages
    Ajit Sodhi
    School of Biotechnology, BHU, Varanasi, UP 221005, India
    Mol Immunol 41:767-74. 2004
    ..The inhibition in the expression of these signaling molecules has been correlated to the inhibition of TNF-alpha and NO production in macrophages...
  17. ncbi request reprint fMLP-induced in vitro nitric oxide production and its regulation in murine peritoneal macrophages
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi, India
    J Leukoc Biol 71:262-70. 2002
    ..The role of protein phosphatases in the above pathway has been suggested using the specific inhibitors of these phosphatases, i.e., okadaic acid and sodium orthovanadate...
  18. ncbi request reprint Monocyte chemoattractant protein-1-induced activation of p42/44 MAPK and c-Jun in murine peritoneal macrophages: a potential pathway for macrophage activation
    Ajit Sodhi
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    J Interferon Cytokine Res 22:517-26. 2002
    ..Taken together, these data suggest the involvement of the p42/44 MAPK/c-Jun pathway in the signal transduction process, leading to activation of murine peritoneal macrophages...
  19. ncbi request reprint Effect of rLcrV and rYopB from Yersinia pestis on murine peritoneal macrophages in vitro
    Rajesh Kumar Sharma
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Immunol Lett 93:179-87. 2004
    ..Our data suggests a possible role of IL-10 and TLR2 in rLcrV and rYopB mediated inhibition of macrophage function...
  20. ncbi request reprint Phosphorylation of p42/44 MAP kinase is required for rF1-induced activation of murine peritoneal macrophages
    Rajesh Kumar Sharma
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221 005, Uttar Pradesh, India
    Mol Immunol 42:1385-92. 2005
    ....
  21. ncbi request reprint Involvement of c-Jun N-terminal kinase in rF1 mediated activation of murine peritoneal macrophages in vitro
    Rajesh Kumar Sharma
    School of Biotechnology, Banaras Hindu University, Varanasi, 221005, India
    J Clin Immunol 25:215-23. 2005
    ..Taken together, the data suggests the involvement of JNK MAPK/NF-kB pathway in rF1-induced activation of macrophages...
  22. doi request reprint Cisplatin primes murine peritoneal macrophages for enhanced expression of nitric oxide, proinflammatory cytokines, TLRs, transcription factors and activation of MAP kinases upon co-incubation with L929 cells
    Puja Chauhan
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    Immunobiology 214:197-209. 2009
    ..The data thus suggests that pretreatment of macrophages with cisplatin makes them biologically more responsive to interaction with L929 cells and become activated...
  23. ncbi request reprint In vitro activation of murine peritoneal macrophages by monocyte chemoattractant protein-1: upregulation of CD11b, production of proinflammatory cytokines, and the signal transduction pathway
    Subhra K Biswas
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    J Interferon Cytokine Res 22:527-38. 2002
    ....
  24. ncbi request reprint Involvement of tyrosine kinases and MAP kinases in the production of TNF-alpha and IL-1beta by macrophages in vitro on treatment with phytohemagglutinin
    Varun Kesherwani
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    J Interferon Cytokine Res 27:497-505. 2007
    ..It was also observed that p38 is activated after 12 h of PHA treatment. Pharmacologic inhibitor of tyrosine kinase, genistein down-regulated the PHA-induced activation of p42/44 and JNK...
  25. doi request reprint Growth hormone-induced production of cytokines in murine peritoneal macrophages in vitro: role of JAK/STAT, PI3K, PKC and MAP kinases
    Anurag Tripathi
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Immunobiology 214:430-40. 2009
    ..These results suggest that JAK2 plays a central role in mediating proinflammatory responses of macrophages on GH treatment...
  26. doi request reprint Prolactin-induced production of cytokines in macrophages in vitro involves JAK/STAT and JNK MAPK pathways
    Anurag Tripathi
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Int Immunol 20:327-36. 2008
    ..AG490, inhibitor of JAK2, down-regulated transcription factors c-jun and STAT1 and inhibited the PRL-induced IFN-gamma, TNF-alpha, IL-1 beta and IL-12p40 production in macrophages...
  27. doi request reprint Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro
    Kunal H Bhatt
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Mol Immunol 47:861-70. 2010
    ..These observations suggest that PGN induces enhanced expression of iNOS and NO production through activation of protein tyrosine kinases and PKCdelta, which in turn initiates NF-kappaB activation and translocation to nucleus...
  28. ncbi request reprint Differential expression of Toll-like receptors in murine peritoneal macrophages in vitro on treatment with cisplatin
    Shikha Tarang
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    Int Immunol 19:635-43. 2007
    ..It is proposed that the pharmacological reagents like cisplatin can be used to manipulate the innate immune responses, which may be effectively used for the development of novel therapeutic approaches...
  29. ncbi request reprint Quantitative role of p42/44 and p38 in the production and regulation of cytokines TNF-alpha, IL-1beta and IL-12 by murine peritoneal macrophages in vitro by concanavalin A
    Varun Kesherwani
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Cytokine 37:62-70. 2007
    ..Using different combinations of MAPK inhibitors, it was found that 45% signal is conveyed via p42/44 and 25% via p38 in the production of these cytokines, by ConA treated macrophages while 30% signal passes through unidentified pathways...
  30. doi request reprint Peptidoglycan induced expression of peroxisome proliferator-activated receptor γ in mouse peritoneal macrophages: role of ERK and JNK MAP kinases
    Kunal H Bhatt
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India
    Cytokine 60:778-86. 2012
    ..These results provide insight into how these pathways could be modulated in inflammatory diseases...
  31. pmc Mycobacterium indicus pranii supernatant induces apoptotic cell death in mouse peritoneal macrophages in vitro
    Rajeev Kumar Pandey
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, India
    PLoS ONE 6:e17093. 2011
    ..Experiments with pharmacological inhibitors suggest a possible role of PKC in mitochondria-mediated apoptosis of macrophages...
  32. ncbi request reprint Involvement of TLR6/1 in rLcrV-mediated immunomodulation of murine peritoneal macrophages in vitro
    Rajesh Kumar Sharma
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    Mol Immunol 42:695-701. 2005
    ..Adaptor molecule MyD88, CD11b, and MHC-I expression did not modulate upon treatment with rLcrV...
  33. ncbi request reprint Cisplatin-treated murine peritoneal macrophages induce apoptosis in L929 cells: role of Fas-Fas ligand and tumor necrosis factor-tumor necrosis factor receptor 1
    Puja Chauhan
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    Anticancer Drugs 18:187-96. 2007
    ..The induction of apoptosis in L929 cells was investigated by DNA fragmentation, Annexin V staining and Western blot analysis of Bax, Bcl-2, Bid, cytochrome c, poly(ADP ribose) polymerase, CAD, caspase-8 and caspase-3...
  34. ncbi request reprint Differential activation of macrophages in vitro by lectin Concanavalin A, Phytohemagglutinin and Wheat germ agglutinin: production and regulation of nitric oxide
    Varun Kesherwani
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Nitric Oxide 16:294-305. 2007
    ..The data also provides the relative measure and importance of different key signaling molecules in the regulation of NO production by macrophages on activation...
  35. ncbi request reprint Production of nitric oxide by murine peritoneal macrophages in vitro on treatment with prolactin and growth hormone: involvement of protein tyrosine kinases, Ca(++), and MAP kinase signal transduction pathways
    Anurag Tripathi
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Mol Immunol 44:3185-94. 2007
    ..Similarly, there is no autocrine or paracrine effect of TNF-alpha on GH or PRL induced NO production and iNOS expression...
  36. doi request reprint Role of prostaglandin E2 in peptidoglycan mediated iNOS expression in mouse peritoneal macrophages in vitro
    Yogesh Dahiya
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, India
    FEBS Lett 584:4227-32. 2010
    ....
  37. doi request reprint Ultraviolet B induces high mobility group box 1 release from mouse peritoneal macrophages in vitro via caspase-1 mediated secretion pathway
    Rituparna Chakraborty
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Immunobiology 218:135-44. 2013
    ..Thus our data suggests that optimal dose of UVB (50 mJ/cm(2)) induces HMGB1 upregulation and active release from mouse peritoneal MΦs which is mediated by caspase-1 in a Ca(2+) dependent manner...
  38. doi request reprint Recombinant YopJ induces apoptosis in murine peritoneal macrophages in vitro: involvement of mitochondrial death pathway
    Ashok Kumar Pandey
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, India
    Int Immunol 21:1239-49. 2009
    ....
  39. ncbi request reprint Activation of c-Jun N-terminal kinase is required for ultraviolet B-induced apoptosis of murine peritoneal macrophages in vitro
    Gautam Sethi
    School of Biotechnology, Banaras Hindu University, Varanasi 221 005, India
    J Photochem Photobiol B 73:133-40. 2004
    ..However, it had no effect on procaspase-8 activation. These results indicate that activation of JNK MAPK upstream of caspases might play an important role in the apoptotic process of macrophages exposed to UVB irradiation...
  40. doi request reprint High mobility group box 1 protein synergizes with lipopolysaccharide and peptidoglycan for nitric oxide production in mouse peritoneal macrophages in vitro
    Rituparna Chakraborty
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Mol Immunol 54:48-57. 2013
    ....
  41. doi request reprint Mycobacterium indicus pranii downregulates MMP-9 and iNOS through COX-2 dependent and TNF-α independent pathway in mouse peritoneal macrophages in vitro
    Rajeev Kumar Pandey
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    Microbes Infect 14:348-56. 2012
    ..MIP has been shown to provide clinical improvement in all phases of leprosy and used for treatment of leprosy and tuberculosis...
  42. pmc Nod2 downregulates TLR2/1 mediated IL1β gene expression in mouse peritoneal macrophages
    Yogesh Dahiya
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India
    PLoS ONE 6:e27828. 2011
    ..These results demonstrate that Nod2 and TLR2/1 signaling pathways are independent and do not interact at the level of MAPK or NF-κB activation...
  43. doi request reprint Recombinant YopJ induces apoptotic cell death in macrophages through TLR2
    Ashok Kumar Pandey
    Faculty of Science, School of Biotechnology, Banaras Hindu University, Varanasi 221005, India
    Mol Immunol 48:392-8. 2011
    ....
  44. ncbi request reprint Modulatory role of thymosin-alpha-1 in normal bone-marrow haematopoiesis and its effect on myelosuppression in T-cell lymphoma bearing mice
    Saki Paul
    School of Biotechnology, Banaras Hindu University, Varanasi 221 005, India
    Immunol Lett 82:171-82. 2002
    ..The present observations suggest that Talpha1 can positively modulate the haematopoietic functions of normal murine BMCs, in addition to its myelorestorative role in tumour-bearing mice showing suppressed myelopoiesis...
  45. doi request reprint Mycobacterium indicus pranii mediates macrophage activation through TLR2 and NOD2 in a MyD88 dependent manner
    Rajeev Kumar Pandey
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Vaccine 30:5748-54. 2012
    ..However, further studies should clarify whether additional TLR-dependent or -independent pathways also exist in regulating the full spectrum of MIP action on macrophage activation...
  46. pmc Role of mitogen-activated protein kinases in peptidoglycan-induced expression of inducible nitric oxide synthase and nitric oxide in mouse peritoneal macrophages: extracellular signal-related kinase, a negative regulator
    Kunal H Bhatt
    School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India
    Clin Vaccine Immunol 18:994-1001. 2011
    ..These results indicate that the JNK MAPK positively regulate PGN-induced iNOS and NO expression by activating NF-κB and AP-1 transcription factors, whereas the ERK pathway plays a negative regulatory role via affecting NF-κB activity...
  47. ncbi request reprint Tyrosine phosphorylation-mediated signal transduction in MCP-1-induced macrophage activation: role for receptor dimerization, focal adhesion protein complex and JAK/STAT pathway
    Subhra Kumar Biswas
    School of Biotechnology, Banaras Hindu University, Varanasi, India
    Int Immunopharmacol 2:1095-107. 2002
    ....
  48. ncbi request reprint Baculovirus P35 inhibits NO-induced apoptosis in activated macrophages by inhibiting cytochrome c release
    Priya Ranjan
    Department of Pathology and Vermont Cancer Center, University of Vermont, Burlington, VT 05405, USA
    J Cell Sci 117:3031-9. 2004
    ..These findings indicate that P35 inhibits NO-induced apoptotic cell death of activated macrophages by inhibiting mitochondrial cytochrome c release, which suggests that P35 has targets upstream of the caspase cascade in apoptosis...