Joost Smolders

Summary

Affiliation: Netherlands Institute for Neuroscience
Location: Amsterdam, the Netherlands

Publications

  1. ncbi request reprint [Balance disorder and subacute hydrocephalus due to haemorrhage in a cerebral cavernous malformation]
    A H C M L Schreuder
    Atrium Medisch Centrum, Postbus 4446, 640I CX Heerlen
    Ned Tijdschr Geneeskd 149:2577-81. 2005
  2. pmc Vitamin d and multiple sclerosis: correlation, causality, and controversy
    Joost Smolders
    Division of Clinical and Experimental Immunology, Department of Internal Medicine and School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, P O Box 616, 6200 MD Maastricht, The Netherlands
    Autoimmune Dis 2011:629538. 2011
  3. doi request reprint Vitamin D as a T-cell modulator in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Vitam Horm 86:401-28. 2011
  4. doi request reprint Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands
    J Neuroimmunol 235:91-7. 2011
  5. doi request reprint Efficacy of vitamin D3 as add-on therapy in patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon β-1a: a Phase II, multicenter, double-blind, randomized, placebo-controlled trial
    Joost Smolders
    Maastricht University Medical Centre, Maastricht, The Netherlands
    J Neurol Sci 311:44-9. 2011
  6. doi request reprint Effects of vitamin D on the peripheral adaptive immune system: a review
    Evelyn Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Autoimmun Rev 10:733-43. 2011
  7. doi request reprint Effect of vitamin D(3) supplementation on peripheral B cell differentiation and isotype switching in patients with multiple sclerosis
    Stephanie Knippenberg
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Mult Scler 17:1418-23. 2011
  8. doi request reprint Vitamin D in the healthy and inflamed central nervous system: access and function
    Joost Smolders
    Department of Internal Medicine, Division of Clinical and Experimental Immunology, and School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Neurol Sci 311:37-43. 2011
  9. doi request reprint Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission
    Stephanie Knippenberg
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, Maastricht, The Netherlands
    J Neuroimmunol 239:80-6. 2011
  10. doi request reprint Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse
    Evelyn Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Neuroimmunol 240:97-103. 2011

Collaborators

Detail Information

Publications22

  1. ncbi request reprint [Balance disorder and subacute hydrocephalus due to haemorrhage in a cerebral cavernous malformation]
    A H C M L Schreuder
    Atrium Medisch Centrum, Postbus 4446, 640I CX Heerlen
    Ned Tijdschr Geneeskd 149:2577-81. 2005
    ..Treatment consists of surgery if the lesion is easily accessible and can be completely removed. Other options are gamma-knife surgery, stereotactic radiotherapy and conservative treatment...
  2. pmc Vitamin d and multiple sclerosis: correlation, causality, and controversy
    Joost Smolders
    Division of Clinical and Experimental Immunology, Department of Internal Medicine and School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, P O Box 616, 6200 MD Maastricht, The Netherlands
    Autoimmune Dis 2011:629538. 2011
    ..This review discusses studies on vitamin D status, Expanded Disability Status Scale (EDSS) score, and relapse activity of MS. Furthermore, several considerations for intervention studies on vitamin D supplementation in MS are provided...
  3. doi request reprint Vitamin D as a T-cell modulator in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Vitam Horm 86:401-28. 2011
    ....
  4. doi request reprint Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands
    J Neuroimmunol 235:91-7. 2011
    ..Our results suggest that vit-D processing by immune cells is not impaired in RRMS, and is potentially relevant for the composition of the peripheral CD4+ T-cell compartment...
  5. doi request reprint Efficacy of vitamin D3 as add-on therapy in patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon β-1a: a Phase II, multicenter, double-blind, randomized, placebo-controlled trial
    Joost Smolders
    Maastricht University Medical Centre, Maastricht, The Netherlands
    J Neurol Sci 311:44-9. 2011
    ..Recruitment began in February 2011 and is aimed to take place over 1 calendar year due to the potential influence of seasonal differences in 25(OH)D levels...
  6. doi request reprint Effects of vitamin D on the peripheral adaptive immune system: a review
    Evelyn Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Autoimmun Rev 10:733-43. 2011
    ..Upcoming vitamin D supplementation trials will further elucidate the in vivo effects of vitamin D on the immune system and its potency to serve as an immune regulating agent in autoimmune diseases...
  7. doi request reprint Effect of vitamin D(3) supplementation on peripheral B cell differentiation and isotype switching in patients with multiple sclerosis
    Stephanie Knippenberg
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Mult Scler 17:1418-23. 2011
    ..Since there is an increasing interest in the role of B cells in the pathophysiology of MS, we studied the role of vitamin D on B cells in vivo in patients with MS...
  8. doi request reprint Vitamin D in the healthy and inflamed central nervous system: access and function
    Joost Smolders
    Department of Internal Medicine, Division of Clinical and Experimental Immunology, and School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Neurol Sci 311:37-43. 2011
    ..We conclude that a local role of vitamin D in the inflamed CNS is likely and potentially relevant to MS. Future studies should further characterize the impact of vitamin D on the local disease process of MS in the CNS...
  9. doi request reprint Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission
    Stephanie Knippenberg
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, Maastricht, The Netherlands
    J Neuroimmunol 239:80-6. 2011
    ..We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers...
  10. doi request reprint Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse
    Evelyn Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Neuroimmunol 240:97-103. 2011
    ..A clear role for vitamin D in this regulation could not be established...
  11. pmc Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    PLoS ONE 5:e15235. 2010
    ..In the present study, we studied the effects of high dose vitamin D3 supplementation on safety and T cell related outcome measures...
  12. ncbi request reprint Control of T cell activation by vitamin D
    Joost Smolders
    Nat Immunol 12:3; author reply 3-4. 2011
  13. doi request reprint Vitamin D as an immune modulator in multiple sclerosis, a review
    Joost Smolders
    Department of Neurology, University Hospital Maastricht, Maastricht, The Netherlands
    J Neuroimmunol 194:7-17. 2008
    ....
  14. doi request reprint Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis
    J Smolders
    School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Mult Scler 14:1220-4. 2008
    ..We investigated the association between serum levels of 25(OH)D and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active metabolite, and clinical MS severity as expressed by EDSS-score and relapse rate...
  15. doi request reprint Fok-I vitamin D receptor gene polymorphism (rs10735810) and vitamin D metabolism in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Neuroimmunol 207:117-21. 2009
    ..In conclusion, we demonstrated the importance of the Fok-I VDRG polymorphism for vitamin D metabolism. This should be taken into account in association and ultimately intervention studies on vitamin D and MS...
  16. doi request reprint The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Autoimmun Rev 8:621-6. 2009
    ..We conclude that polymorphisms of the VDR have major effects on vitamin D function and metabolism, and should therefore be assessed in studies on vitamin D and MS...
  17. pmc Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    PLoS ONE 4:e6635. 2009
    ..A poor vitamin D status has been linked with MS incidence and MS disease activity. In the present study, we assess a potential in vivo correlation between vitamin D status and Treg function in relapsing remitting MS (RRMS) patients...
  18. doi request reprint Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolites in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Ann N Y Acad Sci 1173:515-20. 2009
    ..Another SNP of the VDR gene, Fokl (rs10735810), has been associated with serum levels of 25-hydroxyvitamin D [25(OH)D]...
  19. doi request reprint Complementary and alternative medicine in alopecia areata
    Frank J H M van den Biggelaar
    Alopecia Areata Patient Organization, Utrecht, The Netherlands
    Am J Clin Dermatol 11:11-20. 2010
    ..The review concludes with some recommendations for improving the quality of trials incorporating CAM in the treatment of alopecia areata...
  20. doi request reprint Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, PO Box 616, 6200MD Maastricht, The Netherlands
    J Steroid Biochem Mol Biol 121:243-6. 2010
    ..These results suggest that the serum levels of 1,25(OH)2D, PTH, and total calcium are not critically involved in the correlation between vitamin D status and T cell regulation...
  21. doi request reprint Vitamin D status in patients with MS is negatively correlated with depression, but not with fatigue
    S Knippenberg
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Acta Neurol Scand 124:171-5. 2011
    ..Depressive symptoms and fatigue are frequent and disabling symptoms of multiple sclerosis (MS). Depression and fatigue have been associated with a poor vitamin D status, and a poor vitamin D status is often found in MS...
  22. doi request reprint Expression of vitamin D receptor and metabolizing enzymes in multiple sclerosis-affected brain tissue
    Joost Smolders
    Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 72:91-105. 2013
    ....