F Donelson Smith

Summary

Publications

  1. doi request reprint Scaffolding proteins: not such innocent bystanders
    F Donelson Smith
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Curr Biol 23:R515-7. 2013
  2. pmc Discovery of cellular substrates for protein kinase A using a peptide array screening protocol
    F Donelson Smith
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Avenue NE, Seattle, WA 98195, USA
    Biochem J 438:103-10. 2011
  3. pmc AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway
    Graeme K Carnegie
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Mol Cell 32:169-79. 2008
  4. pmc AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade
    F Donelson Smith
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Avenue NE, Seattle, WA 98195, USA
    Nat Cell Biol 12:1242-9. 2010
  5. ncbi request reprint AKAP-Lbc nucleates a protein kinase D activation scaffold
    Graeme K Carnegie
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA
    Mol Cell 15:889-99. 2004
  6. ncbi request reprint The where's and when's of kinase anchoring
    F Donelson Smith
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Sciences University, MRB322, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Trends Biochem Sci 31:316-23. 2006
  7. doi request reprint E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis
    Jonathan N Pruneda
    Department of Biochemistry, University of Washington, Seattle, WA, USA
    EMBO J 33:437-49. 2014

Collaborators

Detail Information

Publications7

  1. doi request reprint Scaffolding proteins: not such innocent bystanders
    F Donelson Smith
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Curr Biol 23:R515-7. 2013
    ..Though frequently considered to be inert organizational elements, two recent reports implicate kinase-scaffolding proteins as active participants in signal relay. ..
  2. pmc Discovery of cellular substrates for protein kinase A using a peptide array screening protocol
    F Donelson Smith
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Avenue NE, Seattle, WA 98195, USA
    Biochem J 438:103-10. 2011
    ....
  3. pmc AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway
    Graeme K Carnegie
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Mol Cell 32:169-79. 2008
    ..These studies uncover a role for AKAP-Lbc in which increased expression of the anchoring protein selectively amplifies a signaling pathway that drives cardiac myocytes toward a pathophysiological outcome...
  4. pmc AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade
    F Donelson Smith
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Avenue NE, Seattle, WA 98195, USA
    Nat Cell Biol 12:1242-9. 2010
    ..This offers mechanistic insight into cAMP-responsive control of ERK signalling events...
  5. ncbi request reprint AKAP-Lbc nucleates a protein kinase D activation scaffold
    Graeme K Carnegie
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA
    Mol Cell 15:889-99. 2004
    ..This configuration illustrates the utility of kinase anchoring as a mechanism to constrain the action of broad-spectrum enzymes...
  6. ncbi request reprint The where's and when's of kinase anchoring
    F Donelson Smith
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Sciences University, MRB322, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Trends Biochem Sci 31:316-23. 2006
    ....
  7. doi request reprint E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis
    Jonathan N Pruneda
    Department of Biochemistry, University of Washington, Seattle, WA, USA
    EMBO J 33:437-49. 2014
    ..Recognizing conserved E2 features, OspG can interact with at least ten distinct human E2s~Ub. Mouse oral infection studies indicate that E2~Ub conjugates act as novel regulators of OspG effector kinase function in eukaryotic host cells. ..