Donald F Smith

Summary

Publications

  1. pmc Molecular Neurobiology of Depression: PET Findings on the Elusive Correlation with Symptom Severity
    Donald F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University Risskov, Denmark
    Front Psychiatry 4:8. 2013
  2. pmc Quest for biomarkers of treatment-resistant depression: shifting the paradigm toward risk
    Donald F Smith
    Translational Neuropsychiatry Unit, Psychiatric Hospital of Aarhus University, Risskov, Denmark
    Front Psychiatry 4:57. 2013
  3. pmc PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain
    Ole L Munk
    Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Nørrebrogade 44, Aarhus C 8000, Denmark
    EJNMMI Res 1:36. 2011
  4. doi request reprint Meta-analysis on anxiety and depression in adult celiac disease
    D F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University, Risskov, Denmark
    Acta Psychiatr Scand 125:189-93. 2012
  5. doi request reprint [11C]Mirtazapine binding in depressed antidepressant nonresponders studied by PET neuroimaging
    Donald F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University, Risskov, 8240, Denmark
    Psychopharmacology (Berl) 206:133-40. 2009
  6. doi request reprint Molecular tools for assessing human depression by positron emission tomography
    Donald F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University, 8240 Risskov, Denmark
    Eur Neuropsychopharmacol 19:611-28. 2009
  7. doi request reprint Neuroimaging of mirtazapine enantiomers in humans
    Donald F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University, 8240, Risskov, Denmark
    Psychopharmacology (Berl) 200:273-9. 2008
  8. ncbi request reprint Receptor occupancy of mirtazapine determined by PET in healthy volunteers
    Donald F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University, 8240, Risskov, Denmark
    Psychopharmacology (Berl) 195:131-8. 2007
  9. ncbi request reprint Inhibition of [11C]mirtazapine binding by alpha2-adrenoceptor antagonists studied by positron emission tomography in living porcine brain
    Donald F Smith
    Center for Basic Psychiatric Research, Psychiatric Hospital of Aarhus University, DK 8240 Risskov, Denmark
    Synapse 59:463-71. 2006
  10. ncbi request reprint Stereoselective neuroimaging in vivo
    Donald F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University, 8240 Risskov, Denmark
    Eur Neuropsychopharmacol 17:507-22. 2007

Detail Information

Publications11

  1. pmc Molecular Neurobiology of Depression: PET Findings on the Elusive Correlation with Symptom Severity
    Donald F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University Risskov, Denmark
    Front Psychiatry 4:8. 2013
    ..This situation may contribute to the currently limited use of PET for exploring the neuropathways that are currently viewed as being responsible for beneficial effects of antidepressant treatment regimes...
  2. pmc Quest for biomarkers of treatment-resistant depression: shifting the paradigm toward risk
    Donald F Smith
    Translational Neuropsychiatry Unit, Psychiatric Hospital of Aarhus University, Risskov, Denmark
    Front Psychiatry 4:57. 2013
    ..Particular attention in future studies should be on shifting the experimental paradigm toward procedures that can determine the risk for developing treatment resistance in untreated depressed individuals...
  3. pmc PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain
    Ole L Munk
    Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Nørrebrogade 44, Aarhus C 8000, Denmark
    EJNMMI Res 1:36. 2011
    ..abstract:..
  4. doi request reprint Meta-analysis on anxiety and depression in adult celiac disease
    D F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University, Risskov, Denmark
    Acta Psychiatr Scand 125:189-93. 2012
    ..We used meta-analysis to test hypotheses concerning whether adult celiac disease is reliably linked with anxiety and/or depression...
  5. doi request reprint [11C]Mirtazapine binding in depressed antidepressant nonresponders studied by PET neuroimaging
    Donald F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University, Risskov, 8240, Denmark
    Psychopharmacology (Berl) 206:133-40. 2009
    ..We want to know whether nonresponse to antidepressants can be linked to aberrant neuroreceptor binding...
  6. doi request reprint Molecular tools for assessing human depression by positron emission tomography
    Donald F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University, 8240 Risskov, Denmark
    Eur Neuropsychopharmacol 19:611-28. 2009
    ....
  7. doi request reprint Neuroimaging of mirtazapine enantiomers in humans
    Donald F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University, 8240, Risskov, Denmark
    Psychopharmacology (Berl) 200:273-9. 2008
    ..Mirtazapine is a racemic antidepressant with a multireceptor profile. Previous studies have shown that the enantiomers of mirtazapine have different pharmacologic effects in the brain of laboratory animals...
  8. ncbi request reprint Receptor occupancy of mirtazapine determined by PET in healthy volunteers
    Donald F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University, 8240, Risskov, Denmark
    Psychopharmacology (Berl) 195:131-8. 2007
    ..Molecular tools are needed for assessing anti-depressant actions by positron emission tomography (PET) in the living human brain...
  9. ncbi request reprint Inhibition of [11C]mirtazapine binding by alpha2-adrenoceptor antagonists studied by positron emission tomography in living porcine brain
    Donald F Smith
    Center for Basic Psychiatric Research, Psychiatric Hospital of Aarhus University, DK 8240 Risskov, Denmark
    Synapse 59:463-71. 2006
    ..Thus, PET studies confirm that [(11)C]mirtazapine affects alpha(2)-adrenoceptor binding sites in living brain...
  10. ncbi request reprint Stereoselective neuroimaging in vivo
    Donald F Smith
    Center for Psychiatric Research, Psychiatric Hospital of Aarhus University, 8240 Risskov, Denmark
    Eur Neuropsychopharmacol 17:507-22. 2007
    ..This review presents the findings obtained in those studies of cholinergic, noradrenergic, dopaminergic, serotonergic, glutamatergic, opioid, cannabinoid, and second messenger neurotransmission...
  11. ncbi request reprint PET neuroimaging of [11C]mirtazapine enantiomers in pigs
    Donald F Smith
    Center for Basic Psychiatric Research, Psychiatric Hospital of Aarhus University, 8240 Risskov, Denmark
    Eur Neuropsychopharmacol 16:350-7. 2006
    ..No reliable difference occurred in the rate of metabolism of S- and R-[11C]mirtazapine in the bloodstream of the pigs. The present findings indicate that enantioselective processes affect the cerebral pharmacokinetics of rac-mirtazapine...