A population-based study of survival among elderly persons diagnosed with colorectal cancer: does race matter if all are insured? (United States)Selwyn O Rogers
Department of Surgery Meharry Medical College, Nashville, TN 37232, USA
Cancer Causes Control 15:193-9. 2004
..We examined the effect of race on CRC outcomes in a population-based study of elderly Tennesseeans who had identical healthcare coverage - simultaneous enrollment in both Medicaid and Medicare...
Lifestyle factors and their combined impact on the risk of colorectal polypsZhenming Fu
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Am J Epidemiol 176:766-76. 2012
..This study provides strong evidence that lifestyle modification is important for the prevention of colorectal polyps, especially advanced and multiple adenomas, which are established precursors of colorectal cancer...
- Fruit and vegetable intakes are associated with lower risk of colorectal adenomas
Huiyun Wu
Department of Biostatistics and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA
J Nutr 139:340-4. 2009
..74 (95% CI = 0.58-0.96) for green vegetables. This study provides additional evidence that high total fruit intake and certain fruit and vegetable intakes may be associated with a reduced risk of colorectal adenomas...
- Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk
Aesun Shin
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 8th Floor, 2525 West End Avenue, Nashville, TN 37203, USA
Cancer Epidemiol Biomarkers Prev 17:320-9. 2008
..These results provide strong evidence for a modifying effect of metabolizing genes on the association of meat intake and HCA exposure with colorectal polyp risk...
- Using gene-environment interaction analyses to clarify the role of well-done meat and heterocyclic amine exposure in the etiology of colorectal polyps
Zhenming Fu
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
Am J Clin Nutr 96:1119-28. 2012
..The role of well-done meat intake and meat-derived mutagen heterocyclic amine (HCA) exposure in the risk of colorectal neoplasm has been suggested but not yet established...
- Nonsteroidal anti-inflammatory drug use and risk of adenomatous and hyperplastic polyps
Harvey J Murff
Division of General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA
Cancer Prev Res (Phila) 4:1799-807. 2011
..The use of any NSAID regardless of type was associated with a reduced risk of adenomatous polyps; however, regular aspirin and COX-2 inhibitors use was not associated with hyperplastic polyp risk...
- Association of meat intake and meat-derived mutagen exposure with the risk of colorectal polyps by histologic type
Zhenming Fu
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Nashville, TN, USA
Cancer Prev Res (Phila) 4:1686-97. 2011
..This study supports a role for red meat and meat-derived mutagen exposure in the development of colorectal tumor...
- Dietary intake of PUFAs and colorectal polyp risk
Harvey J Murff
Division of General Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
Am J Clin Nutr 95:703-12. 2012
..Marine-derived n-3 (omega-3) PUFAs may reduce risk of developing colorectal cancer; however, few studies have investigated the association of n-3 PUFA intakes on colorectal polyp risk...
Alcohol drinking, cigarette smoking, and risk of colorectal adenomatous and hyperplastic polypsMartha J Shrubsole
Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37203 1738, USA
Am J Epidemiol 167:1050-8. 2008
..2 (95% CI: 0.2, 0.4) for both polyp types. These findings support the adverse role of cigarette smoking in colorectal tumorigenesis and suggest that quitting smoking may substantially reduce the risk of colorectal polyps...
- The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk
Qi Dai
Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
Am J Clin Nutr 86:743-51. 2007
..Transient receptor potential melastatin 7 (TRPM7) is a newly found gene essential to magnesium absorption and homeostasis...
- Association of genetic variants for colorectal cancer differs by subtypes of polyps in the colorectum
Ben Zhang
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Carcinogenesis 33:2417-23. 2012
..11, 95% CI: 1.04-1.18, P (trend) = 0.002). These findings suggest that genetic factors play a significant role in the development of polyps with different malignant potential...
- An automated database case definition for serious bleeding related to oral anticoagulant use
Andrew Cunningham
Division of Clinical Pharmacology, Department of Medicine, Nashville, TN, USA
Pharmacoepidemiol Drug Saf 20:560-6. 2011
..To facilitate epidemiologic investigations of bleeding complications, we developed and validated an automated database case definition for bleeding-related hospitalizations...
- Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study
Wayne A Ray
Vanderbilt University School of Medicine and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA
Ann Intern Med 152:337-45. 2010
..Proton-pump inhibitors (PPIs) and clopidogrel are frequently coprescribed, although the benefits and harms of their concurrent use are unclear...
- Interaction of cigarette smoking and carcinogen-metabolizing polymorphisms in the risk of colorectal polyps
Zhenming Fu
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA
Carcinogenesis 34:779-86. 2013
....
- Urinary prostaglandin E2 metabolite and risk for colorectal adenoma
Martha J Shrubsole
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
Cancer Prev Res (Phila) 5:336-42. 2012
..Our study suggests that PGE-M may be a useful risk marker for assessing the risk of harboring clinically more important versus less important colorectal neoplasia...
- The interaction of age and hormone replacement therapy on colon adenoma risk
Harvey J Murff
Division of General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA
Cancer Detect Prev 31:161-5. 2007
..We re-evaluated this interaction and determined if this interaction may be explained by the longer duration of estrogen use in older, rather than younger, women...
- Risk of peptic ulcer hospitalizations in users of NSAIDs with gastroprotective cotherapy versus coxibs
Wayne A Ray
Division of Pharmacoepidemiology, Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
Gastroenterology 133:790-8. 2007
..However, the relative clinical effectiveness of these therapeutic alternatives is understudied...
- Endoscopic ultrasound: impact on survival in patients with esophageal cancer
Jason J Schrager
Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
Am J Surg 190:682-6. 2005
..Endoscopic ultrasound (EUS) is an additional staging modality to assess locoregional extent of this disease. We hypothesized that EUS may improve survival through more effective staging and better optimization of treatment...
- Health care utilization after medical and surgical therapy for gastroesophageal reflux disease: a population-based study, 1996 to 2000
Leena Khaitan
Department of Surgery, Vanderbilt University School of Medicine, Vanderbilt University Center for Education and Research on Therapeutics, Nashville, TN 37232, USA
Arch Surg 138:1356-61. 2003
..85 in year 3, and 0.74 vs 0.90 in year 4). CONCLUSION: The utilization of health care resources in patients treated surgically for GERD is associated with a modest decrease in the use of GERD-related medications and GERD-related visits...
- Meat and meat-mutagen intake, doneness preference and the risk of colorectal polyps: the Tennessee Colorectal Polyp Study
Aesun Shin
Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37232 2587, USA
Int J Cancer 121:136-42. 2007
..This study provides additional support for a positive association of high intake of red meat with colorectal adenomas, and suggests that high intake of meats and meat carcinogens may also be associated with hyperplastic polyps...
