Marko Marhl

Summary

Affiliation: University of Maribor
Country: Slovenia

Publications

  1. doi request reprint Prevalence of stochasticity in experimentally observed responses of pancreatic acinar cells to acetylcholine
    Matjaz Perc
    Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Maribor, Slovenia
    Chaos 19:037113. 2009
  2. ncbi request reprint Complex calcium oscillations and the role of mitochondria and cytosolic proteins
    M Marhl
    Department of Physics, Faculty of Education, University of Maribor, Koroska cesta 160, SI 2000, Maribor, Slovenia
    Biosystems 57:75-86. 2000
  3. ncbi request reprint Role of cascades in converting oscillatory signals into stationary step-like responses
    Marko Marhl
    Department of Physics, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Biosystems 87:58-67. 2007
  4. ncbi request reprint Selective regulation of cellular processes via protein cascades acting as band-pass filters for time-limited oscillations
    Marko Marhl
    Department of Physics, Faculty of Education, University of Maribor, Slovenia
    FEBS Lett 579:5461-5. 2005
  5. ncbi request reprint Under what conditions signal transduction pathways are highly flexible in response to external forcing? A case study on calcium oscillations
    Marko Marhl
    Department of Physics, Faculty of Education, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    J Theor Biol 224:491-500. 2003
  6. ncbi request reprint Spatio-temporal modelling explains the effect of reduced plasma membrane Ca2+ efflux on intracellular Ca2+ oscillations in hepatocytes
    Marko Marhl
    Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Koroska cesta 160, Maribor SI 2000, Slovenia
    J Theor Biol 252:419-26. 2008
  7. doi request reprint Importance of cell variability for calcium signaling in rat airway myocytes
    Marko Marhl
    Department of Physics, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Biophys Chem 148:42-50. 2010
  8. ncbi request reprint Establishing the stochastic nature of intracellular calcium oscillations from experimental data
    Matjaz Perc
    Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Biophys Chem 132:33-8. 2008
  9. ncbi request reprint Modeling of molecular and cellular mechanisms involved in Ca2+ signal encoding in airway myocytes
    Marko Marhl
    University of Maribor, Department of Physics, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Cell Biochem Biophys 46:285-302. 2006
  10. pmc Functional connectivity in islets of Langerhans from mouse pancreas tissue slices
    Andraž Stožer
    Institute of Physiology, Faculty of Medicine, University of Maribor, Maribor, Slovenia
    PLoS Comput Biol 9:e1002923. 2013

Collaborators

Detail Information

Publications27

  1. doi request reprint Prevalence of stochasticity in experimentally observed responses of pancreatic acinar cells to acetylcholine
    Matjaz Perc
    Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Maribor, Slovenia
    Chaos 19:037113. 2009
    ....
  2. ncbi request reprint Complex calcium oscillations and the role of mitochondria and cytosolic proteins
    M Marhl
    Department of Physics, Faculty of Education, University of Maribor, Koroska cesta 160, SI 2000, Maribor, Slovenia
    Biosystems 57:75-86. 2000
    ..With our model, we are able to explain simple calcium oscillations, bursting and chaos. Chaos is also observed for calcium oscillations in the bursting mode...
  3. ncbi request reprint Role of cascades in converting oscillatory signals into stationary step-like responses
    Marko Marhl
    Department of Physics, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Biosystems 87:58-67. 2007
    ....
  4. ncbi request reprint Selective regulation of cellular processes via protein cascades acting as band-pass filters for time-limited oscillations
    Marko Marhl
    Department of Physics, Faculty of Education, University of Maribor, Slovenia
    FEBS Lett 579:5461-5. 2005
    ..The physiological relevance for the selective regulation of cellular processes is demonstrated for the case of regulation by time-limited calcium oscillations...
  5. ncbi request reprint Under what conditions signal transduction pathways are highly flexible in response to external forcing? A case study on calcium oscillations
    Marko Marhl
    Department of Physics, Faculty of Education, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    J Theor Biol 224:491-500. 2003
    ..For biological systems this appears to be of special importance since for thermodynamic reasons, notably in view of low free energy consumption, dissipation should be minimized...
  6. ncbi request reprint Spatio-temporal modelling explains the effect of reduced plasma membrane Ca2+ efflux on intracellular Ca2+ oscillations in hepatocytes
    Marko Marhl
    Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Koroska cesta 160, Maribor SI 2000, Slovenia
    J Theor Biol 252:419-26. 2008
    ..By converting an existing temporal model into a spatio-temporal one, we obtain theoretical predictions that are in much better agreement with the experimental observations...
  7. doi request reprint Importance of cell variability for calcium signaling in rat airway myocytes
    Marko Marhl
    Department of Physics, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Biophys Chem 148:42-50. 2010
    ..Foremost, we reveal that only cell variability in theoretical modeling can appropriately describe the observed diversity in single-cell responses...
  8. ncbi request reprint Establishing the stochastic nature of intracellular calcium oscillations from experimental data
    Matjaz Perc
    Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Biophys Chem 132:33-8. 2008
    ....
  9. ncbi request reprint Modeling of molecular and cellular mechanisms involved in Ca2+ signal encoding in airway myocytes
    Marko Marhl
    University of Maribor, Department of Physics, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Cell Biochem Biophys 46:285-302. 2006
    ..Modeling the mechanisms responsible for the decoding of calcium signals is developed in a lesser extent; however, the most recent theoretical studies are briefly presented in relation with the known experimental results...
  10. pmc Functional connectivity in islets of Langerhans from mouse pancreas tissue slices
    Andraž Stožer
    Institute of Physiology, Faculty of Medicine, University of Maribor, Maribor, Slovenia
    PLoS Comput Biol 9:e1002923. 2013
    ....
  11. ncbi request reprint Local dissipation and coupling properties of cellular oscillators: a case study on calcium oscillations
    Matjaz Perc
    Faculty of Education, Department of Physics, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Bioelectrochemistry 62:1-10. 2004
    ..The results are discussed in the sense of their biological importance for systems where the synchronous responses of cells were recognised to be indispensable for appropriate physiological functioning of the tissue...
  12. ncbi request reprint Spatial coherence resonance in excitable biochemical media induced by internal noise
    Marko Gosak
    Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Biophys Chem 128:210-4. 2007
    ..Remarkably, the spatial periodicity is best pronounced at an intermediate level of internal stochasticity. Thus, the reported phenomenon is an observation of internal noise spatial coherence resonance in excitable biochemical media...
  13. ncbi request reprint A minimal model for decoding of time-limited Ca2+ oscillations
    Marko Marhl
    Department of Physics, Faculty of Education, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Biophys Chem 120:161-7. 2006
    ..We found that proteins are activated more specifically by shorter oscillatory signals with narrower spikes...
  14. ncbi request reprint Amplification of information transfer in excitable systems that reside in a steady state near a bifurcation point to complex oscillatory behavior
    Matjaz Perc
    Department of Physics, Faculty of Education, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Phys Rev E Stat Nonlin Soft Matter Phys 71:026229. 2005
    ..Additionally, the biological importance of presented results in the field of neuroscience is outlined...
  15. ncbi request reprint Frequency encoding of intracellular Ca2+ signals
    Vladimir Grubelnik
    Department of Physics, Faculty of Education, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Cell Mol Biol Lett 7:115-7. 2002
    ..This paper focuses on giving a more exhaustive demonstration of this phenomenon of frequency encoding for the model of Dupont et al...
  16. ncbi request reprint Irregularity test for very short electrocardiogram (ECG) signals as a method for predicting a successful defibrillation in patients with ventricular fibrillation
    Timotej Jagric
    Department for Quantitative Economic Analysis, Faculty of Economics and Business, University of Maribor, Maribor, Slovenia
    Transl Res 149:145-51. 2007
    ....
  17. ncbi request reprint Sensitivity and flexibility of regular and chaotic calcium oscillations
    Matjaz Perc
    Department of Physics, Faculty of Education, University of Maribor, Koroska cesta 160, SI 2000, Maribor, Slovenia
    Biophys Chem 104:509-22. 2003
    ..Our results show that regular as well as chaotic Ca(2+) oscillations in the studied model are highly flexible in regimes with weak dissipation. Both results are discussed in the sense of possible biological importance...
  18. doi request reprint Signal amplification in biological and electrical engineering systems: universal role of cascades
    Vladimir Grubelnik
    Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Biophys Chem 143:132-8. 2009
    ....
  19. doi request reprint The influence of gap junction network complexity on pulmonary artery smooth muscle reactivity in normoxic and chronically hypoxic conditions
    Marko Gosak
    M Gosak University of Maribor, Department of Physics, Faculty of Natural Sciences and Mathematics, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Exp Physiol 99:272-85. 2014
    ..Our results thus indicate that chronic hypoxia entails gap junction network rearrangements, leading to disturbances in the intercellular communication pathways. ..
  20. ncbi request reprint Optimal network configuration for maximal coherence resonance in excitable systems
    Marko Gosak
    Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Koroska cesta 160, SI 2000 Maribor, Slovenia
    Phys Rev E Stat Nonlin Soft Matter Phys 81:056104. 2010
    ..Furthermore, we show that long- as well as short-range interactions between neurons should exist in order to achieve the optimal response of the neuronal network...
  21. ncbi request reprint The influence of different InsP(3) receptor isoforms on Ca(2+) signaling in tracheal smooth muscle cells
    Thomas Haberichter
    Theoretical Biophysics, Institute of Biology, Humboldt University Berlin, Invalidenstr 43, 10115 Berlin, Germany
    Bioelectrochemistry 57:129-38. 2002
    ....
  22. doi request reprint Equality of average and steady-state levels in some nonlinear models of biological oscillations
    Beate Knoke
    Department of Bioinformatics, Faculty of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Ernst Abbe Platz 2, 07743 Jena, Germany
    Theory Biosci 127:1-14. 2008
    ..For example, the implications of the findings for the decoding of calcium oscillations are outlined. Moreover, we elucidate interrelations with metabolic control analysis...
  23. pmc Role of sarcoplasmic reticulum and mitochondria in Ca2+ removal in airway myocytes
    Etienne Roux
    Laboratoire de Physiologie Cellulaire Respiratoire, Institut National de la Santé et de Recherche Médicale E 356, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux, France
    Biophys J 86:2583-95. 2004
    ..The experimental and theoretical results indicate that, although Ca2+ pumping back by SERCA is active, it is not primarily involved in [Ca2+]i decrease that is due, in part, to mitochondrial Ca2+ uptake...
  24. ncbi request reprint Differential regulation of proteins by bursting calcium oscillations--a theoretical study
    Stefan Schuster
    Department of Bioinformatics, Faculty of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Ernst Abbe Platz 2, D 07743 Jena, Germany
    Biosystems 81:49-63. 2005
    ..Thus, the two proteins can be regulated virtually independently...
  25. pmc Transition from stochastic to deterministic behavior in calcium oscillations
    Ursula Kummer
    Bioinformatics and Computational Biochemistry Group, EML Research, D 69118 Heidelberg, Germany
    Biophys J 89:1603-11. 2005
    ..We conclude that the attractive properties of a system, expressed, e.g., by the divergence of the system, are a good measure for determining which simulation algorithm is appropriate in terms of speed and realism...
  26. ncbi request reprint Modelling of calcium handling in airway myocytes
    Etienne Roux
    Laboratoire de Physiologie Cellulaire Respiratoire, INSERM E 356, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Prog Biophys Mol Biol 90:64-87. 2006
    ..The development of such models of airway myocytes is important for the understanding of the cellular mechanisms of airway reactivity and their possible modulation by pharmacological agents...
  27. ncbi request reprint Modelling of simple and complex calcium oscillations. From single-cell responses to intercellular signalling
    Stefan Schuster
    Max Delbruck Centre for Molecular Medicine, Department of Bioinformatics, Berlin Buch, Germany
    Eur J Biochem 269:1333-55. 2002
    ..Various suggestions concerning the physiological significance of oscillatory behaviour in intra- and intercellular signalling are discussed. The article is concluded with a discussion of obstacles and prospects...