Tea Lanisnik Rizner

Summary

Affiliation: University of Ljubljana
Country: Slovenia

Publications

  1. doi Data on expression of genes involved in estrogen and progesterone action, inflammation and differentiation according to demographic, histopathological and clinical characteristics of endometrial cancer patients
    Maša Sinreih
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Data Brief 12:632-643. 2017
  2. pmc Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases
    Tea Lanisnik Rizner
    Faculty of Medicine, Institute of Biochemistry, University of Ljubljana Ljubljana, Slovenia
    Front Pharmacol 3:34. 2012
  3. doi Noninvasive biomarkers of endometriosis: myth or reality?
    Tea Lanisnik Rizner
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia 386 1 5437 657 386 1 5437 641
    Expert Rev Mol Diagn 14:365-85. 2014
  4. pmc Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism
    Tea Lanisnik Rizner
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia Electronic address
    Steroids 79:49-63. 2014
  5. doi Estrogen biosynthesis, phase I and phase II metabolism, and action in endometrial cancer
    Tea Lanisnik Rizner
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia Electronic address
    Mol Cell Endocrinol 381:124-39. 2013
  6. doi Estrogen metabolism and action in endometriosis
    Tea Lanisnik Rizner
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Mol Cell Endocrinol 307:8-18. 2009
  7. ncbi AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer
    Tea Lanisnik Rizner
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 248:126-35. 2006
  8. ncbi Melanin biosynthesis in the fungus Curvularia lunata (teleomorph: Cochliobolus lunatus)
    Tea Lanisnik Rizner
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Can J Microbiol 49:110-9. 2003
  9. doi Aberrant pre-receptor regulation of estrogen and progesterone action in endometrial cancer
    Tina Smuc
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 301:74-82. 2009
  10. ncbi Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1
    Petra Brozic
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 259:30-42. 2006

Collaborators

Detail Information

Publications58

  1. doi Data on expression of genes involved in estrogen and progesterone action, inflammation and differentiation according to demographic, histopathological and clinical characteristics of endometrial cancer patients
    Maša Sinreih
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Data Brief 12:632-643. 2017
    ..This article includes data referenced in the manuscript entitled »STAR and AKR1B10 are down-regulated in high-grade endometrial cancer by Sinreih et al. (in press) [1]...
  2. pmc Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases
    Tea Lanisnik Rizner
    Faculty of Medicine, Institute of Biochemistry, University of Ljubljana Ljubljana, Slovenia
    Front Pharmacol 3:34. 2012
    ..The potential implications of the AKR1B and AKR1C enzymes in the pathophysiologies are then discussed, followed by conclusions and future perspectives...
  3. doi Noninvasive biomarkers of endometriosis: myth or reality?
    Tea Lanisnik Rizner
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia 386 1 5437 657 386 1 5437 641
    Expert Rev Mol Diagn 14:365-85. 2014
    ..The current status of noninvasive diagnostic biomarkers of endometriosis is discussed, with the limitations of these studies identified and recommendations for future biomarker discovery provided. ..
  4. pmc Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism
    Tea Lanisnik Rizner
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia Electronic address
    Steroids 79:49-63. 2014
    ..Mutations in AKR1C1 and AKR1C4 are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency. ..
  5. doi Estrogen biosynthesis, phase I and phase II metabolism, and action in endometrial cancer
    Tea Lanisnik Rizner
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia Electronic address
    Mol Cell Endocrinol 381:124-39. 2013
    ....
  6. doi Estrogen metabolism and action in endometriosis
    Tea Lanisnik Rizner
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Mol Cell Endocrinol 307:8-18. 2009
    ..The disturbed expression of estrogen receptors in endometriosis is detailed, and the estrogen biosynthetic enzymes and receptors are discussed as novel therapeutic targets for the treatment of endometriosis...
  7. ncbi AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer
    Tea Lanisnik Rizner
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 248:126-35. 2006
    ..It is suggested that the expression of AKR1C1 and AKR1C3 in endometrial cancer will govern the ratio of P:E2...
  8. ncbi Melanin biosynthesis in the fungus Curvularia lunata (teleomorph: Cochliobolus lunatus)
    Tea Lanisnik Rizner
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Can J Microbiol 49:110-9. 2003
    ..No 3HNR reductase gene expression nor melanization was observed when Curvularia lunata was grown in yeast nitrogen base medium...
  9. doi Aberrant pre-receptor regulation of estrogen and progesterone action in endometrial cancer
    Tina Smuc
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 301:74-82. 2009
    ..Up-regulation of AKR1C1 and AKR1C3 can result in lower levels of the protective progesterone, which acts mainly via PR-B...
  10. ncbi Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1
    Petra Brozic
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 259:30-42. 2006
    ..Docking of the flavones in the active site of AKR1C1 revealed their possible binding modes, in which they are sandwiched between the Leu308 and Trp227 of AKR1C1...
  11. doi Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line
    Nataša Beranič
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Chem Biol Interact 202:218-25. 2013
    ....
  12. doi Disturbed estrogen and progesterone action in ovarian endometriosis
    Tina Smuc
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 301:59-64. 2009
    ..Changes in estrogen receptor expression suggest that estradiol may also act via non-estrogen receptor-mediated pathways, while expression of progesterone receptors still needs further investigation...
  13. doi Two homologous fungal carbonyl reductases with different substrate specificities
    Katja Kristan
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Chem Biol Interact 178:295-302. 2009
    ..Our data show that in spite of high homology and similar backbone structure, differences between 3HNR and 17beta-HSDcl were not only in substrate specificities, but also in temperature and pH optima...
  14. doi Mutations that affect coenzyme binding and dimer formation of fungal 17beta-hydroxysteroid dehydrogenase
    Mojca Brunskole
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Mol Cell Endocrinol 301:47-50. 2009
    ....
  15. doi Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1
    Stefan Starcević
    Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    J Med Chem 54:248-61. 2011
    ..The best inhibitor in the series proved to be 6a, with an IC(50) of 270 nM, and with exceptional selectivity for 17β-HSD1 over 17β-HSD2 and against the α and β estrogen receptors...
  16. ncbi Expression analysis of estrogen-metabolizing enzymes in human endometrial cancer
    Tina Smuc
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 248:114-7. 2006
    ..When we compared the expression in endometrial cancer samples and in the adjacent normal endometrium, ERalpha and ERbeta, sulfatase and sulfotransferase were seen to be downregulated in the majority of the cancerous tissue specimens...
  17. doi Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis
    Katja Vouk
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg, 2, 1000 Ljubljana, Slovenia
    J Steroid Biochem Mol Biol 125:231-42. 2011
    ..Our study thus reveals differential expression of several genes that have not previously been associated with endometriosis and that encode potential novel biomarkers and drug targets...
  18. doi Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening
    Mojca Brunskole
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Bioorg Med Chem 16:5881-9. 2008
    ..Homology modelling of 3HNR from C. lunata can explain their binding modes and will enable further structure-based design of new and improved inhibitors...
  19. doi New enzymatic assay for the AKR1C enzymes
    Nataša Beranič
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Chem Biol Interact 202:204-9. 2013
    ..Our data thus confirm that the new enzymatic assays with two cyclopentane substrates CBP-ol and CBP-one, and especially reduction of CBCP-one with NADPH, are appropriate for the evaluation of AKR1C inhibitors...
  20. doi Altered expression of genes involved in progesterone biosynthesis, metabolism and action in endometrial cancer
    Maša Sinreih
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Chem Biol Interact 202:210-7. 2013
    ..This down-regulation of STAR, CYP11A1 and PGR in endometrial cancer may lead to decreased progesterone biosynthesis and actions although the effects on progesterone levels should be further studied...
  21. doi Effects of progestins on local estradiol biosynthesis and action in the Z-12 endometriotic epithelial cell line
    Nataša Beranič
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    J Steroid Biochem Mol Biol 132:303-10. 2012
    ..Although progestins significantly decrease CYP19A1 mRNA levels, the protein itself was not detectable by Western blotting. As progestins down-regulate expression of ESR1, ESR2 and GPER, they might also prevent E2-mediated proliferation...
  22. ncbi Cinnamates and cinnamamides inhibit fungal 17beta-hydroxysteroid dehydrogenase
    Katja Kristan
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 248:239-41. 2006
    ..The compounds presented in this paper are potential leads for the development of inhibitors of human 17beta-HSD isoforms, which may prove to have different therapeutic applications...
  23. ncbi Flavonoids and cinnamic acid esters as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase: a synthesis, QSAR and modelling study
    Matej Sova
    Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    Bioorg Med Chem 14:7404-18. 2006
    ..The results stress the importance of a hydrogen bond with Asn154 and hydrophobic interactions with the aromatic side chain of Tyr212 for optimal molecular recognition...
  24. doi Simultaneous binding of coenzyme and two ligand molecules into the active site of fungal trihydroxynaphthalene reductase
    Jure Stojan
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Chem Biol Interact 178:268-73. 2009
    ..Substrate inhibition can be discriminated from true cooperativity through the effects of apigenin, a flavonoid inhibitor that is structurally similar, but larger, than the substrate used in the study...
  25. doi New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3
    Bogdan Stefane
    Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, 1000 Ljubljana, Slovenia
    Eur J Med Chem 44:2563-71. 2009
    ..These compounds represent promising starting points in the development of new anticancer agents for the treatment of hormone-dependent forms of cancer and other diseases where AKR1C1 and AKR1C3 are involved...
  26. doi Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT
    Neli Hevir
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 331:158-67. 2011
    ..The importance of the changed ratio between soluble and membrane-bound COMT still needs to be evaluated in further studies...
  27. ncbi Coenzyme specificity in fungal 17beta-hydroxysteroid dehydrogenase
    Katja Kristan
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 241:80-7. 2005
    ....
  28. doi 2,3-Diarylpropenoic acids as selective non-steroidal inhibitors of type-5 17β-hydroxysteroid dehydrogenase (AKR1C3)
    Martin Gazvoda
    Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, SI 1000 Ljubljana, Slovenia
    Eur J Med Chem 62:89-97. 2013
    ..e., acids 28, 29, 37, and 39, respectively). These compounds represent an important step toward the development of drug candidates for a treatment of the hormone-dependent and hormone-independent forms of prostate and breast cancers...
  29. pmc N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3
    Maša Sinreih
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
    Bioorg Med Chem Lett 22:5948-51. 2012
    ..In addition, five selective inhibitors of AKR1C3 were identified. The most promising inhibitors were compounds 10 and 13, with IC(50) values of 0.31 μM and 0.35 μM for AKR1C3, respectively...
  30. doi The role of Ala231 and Trp227 in the substrate specificities of fungal 17β-hydroxysteroid dehydrogenase and trihydroxynaphthalene reductase: Steroids versus smaller substrates
    Mojca Brunskole Svegelj
    Institute of Biochemistry, Ljubljana, Slovenia
    J Steroid Biochem Mol Biol 129:92-8. 2012
    ..Our study thus confirms the important roles of Ala231 in 17β-HSDcl and Trp227 in 3HNR, for the selection between larger and smaller substrates. Article from a special issue on steroids and microorganisms...
  31. pmc Dimerization and enzymatic activity of fungal 17beta-hydroxysteroid dehydrogenase from the short-chain dehydrogenase/reductase superfamily
    Katja Kristan
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    BMC Biochem 6:28. 2005
    ..SDR proteins usually function as dimers or tetramers and 17beta-HSDcl is also a homodimer under native conditions...
  32. ncbi Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase
    Katja Kristan
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Steroids 70:694-703. 2005
    ..The structural features of phytoestrogens, inhibitors of both oxidation and reduction catalyzed by the fungal 17beta-HSD, are similar to the reported structural features of phytoestrogen inhibitors of human 17beta-HSD types 1 and 2...
  33. ncbi Cinnamic acids as new inhibitors of 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3)
    Petra Brozic
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 248:233-5. 2006
    ..The most active compounds in this series represent promising starting points for further structural modifications in the search for more potent inhibitors of AKR1C3...
  34. ncbi His164 regulates accessibility to the active site in fungal 17beta-hydroxysteroid dehydrogenase
    Katja Kristan
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Biochimie 89:63-71. 2007
    ....
  35. ncbi Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis
    Tina Smuc
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrasov trg 2, 1000 Ljubljana, Slovenia
    Gynecol Endocrinol 23:105-11. 2007
    ..This could thus be responsible for the estrogen-dependent growth of endometriotic tissue. Surprisingly ERalpha was downregulated...
  36. doi Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
    Petra Brozic
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 301:229-34. 2009
    ..None of flavonoids affected the proliferation of T-47D breast cancer cells...
  37. pmc Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library
    Petra Brozic
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    J Med Chem 55:7417-24. 2012
    ..Two of the best selective AKR1C3 inhibitors had K(i) values of 0.1 and 2.7 μM, exceeding expected activity for fragments. The compounds identified represent an excellent starting point for further hit-to-lead development...
  38. doi Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins
    Nataša Beranič
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    J Steroid Biochem Mol Biol 130:16-25. 2012
    ..Their potential in vivo effects should be further studied...
  39. ncbi Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents
    Stanislav Gobec
    Faculty of Pharmacy, University of Ljubljana, Slovenia
    Bioorg Med Chem Lett 15:5170-5. 2005
    ..68microM). These compounds represent promising starting points for the development of new anticancer agents...
  40. ncbi New inhibitors of fungal 17beta-hydroxysteroid dehydrogenase based on the [1,5]-benzodiazepine scaffold
    Matej Zivec
    Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    J Enzyme Inhib Med Chem 22:29-36. 2007
    ....
  41. doi Discovery of highly potent, nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors by virtual high-throughput screening
    Stefan Starcević
    Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    J Steroid Biochem Mol Biol 127:255-61. 2011
    ..The most potent in the series, compound 1, showed an IC(50) of 45nM in our 17β-HSD1 inhibition assay, and also showed good selectivity for 17β-HSD1 over 17β-HSD2...
  42. doi Novel inhibitors of trihydroxynaphthalene reductase with antifungal activity identified by ligand-based and structure-based virtual screening
    Mojca Brunskole Svegelj
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    J Chem Inf Model 51:1716-24. 2011
    ..Discovery of competitive inhibitors with K(i) values in low micromolar and even nanomolar concentration range proves the aplicability of homology-built model of 3HNR for hit finding by virtual screening methods...
  43. doi Steroid-transforming enzymes in fungi
    Katja Kristan
    Institute of Biochemistry, University of Ljubljana, Ljubljana, Slovenia
    J Steroid Biochem Mol Biol 129:79-91. 2012
    ..The substrate specificities of these enzymes, their cellular localisation, their association with protein super-families, and their potential applications are discussed. Article from a special issue on steroids and microorganisms...
  44. pmc Combined liquid chromatography-tandem mass spectrometry analysis of progesterone metabolites
    Maša Sinreih
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    PLoS ONE 10:e0117984. 2015
    ..The investigation of possible biological effects of these metabolites on the endometrium is currently undergoing. ..
  45. ncbi Rational design of novel mutants of fungal 17beta-hydroxysteroid dehydrogenase
    Katja Kristan
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    J Biotechnol 129:123-30. 2007
    ..The replacement of His164, located in the non-flexible part of the 'lid' covering the active center resulted in a conformation of the enzyme that possessed a higher catalytic activity...
  46. ncbi Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase
    Katja Kristan
    Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Steroids 70:626-35. 2005
    ..The structural features of phytoestrogens, inhibitors of both oxidation and reduction catalyzed by the fungal 17beta-HSD, are similar to the reported structural features of phytoestrogen inhibitors of human 17beta-HSD types 1 and 2...
  47. doi Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: a source of excessive hydroxy-estrogens and ROS?
    Neli Hevir
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Mol Cell Endocrinol 367:74-84. 2013
    ..This is the first report on disturbed expression of estrogen oxidative metabolism genes in ovarian endometriosis...
  48. doi Decreased levels of AKR1B1 and AKR1B10 in cancerous endometrium compared to adjacent non-cancerous tissue
    Neli Hevir
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Chem Biol Interact 202:226-33. 2013
    ..To the best of our knowledge, this is the first report on the expression of AKR1B1 and AKR1B10 in endometrial cancer. Further studies are needed to define the precise roles of these enzymes in the pathogenesis of endometrial cancer...
  49. doi Selectivity and potency of the retroprogesterone dydrogesterone in vitro
    Tea Lanisnik Rizner
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Steroids 76:607-15. 2011
    ..Overall, our data show that the anti-androgenic potential of dydrogesterone and 20α-dihydrodydrogesterone is less pronounced compared to progesterone...
  50. ncbi Conformational stability of 17 beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus
    Natasa Poklar Ulrih
    Department of Food Science and Technology, University of Ljubljana, Slovenia
    FEBS J 273:3927-37. 2006
    ..2 and 0.4 M, respectively. Binding of the coenzyme NADPH to 17beta-HSDcl causes local structural changes that do not significantly affect the thermal stability of this protein...
  51. doi Elevated glycodelin-A concentrations in serum and peritoneal fluid of women with ovarian endometriosis
    Vida Kocbek
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg, 2, 1000 Ljubljana, Slovenia
    Gynecol Endocrinol 29:455-9. 2013
    ..1% and 78.4% in serum, and 79.7% and 77.5% in PF, respectively. These results indicate that Glycodelin-A has a potential role as a biomarker to be used in combination with other, independent marker molecules...
  52. doi Pyrithione-based ruthenium complexes as inhibitors of aldo-keto reductase 1C enzymes and anticancer agents
    Jakob Kljun
    Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI 1000 Ljubljana, Slovenia
    Dalton Trans 45:11791-800. 2016
    ..The organoruthenium complex of ligand pyrithione as well as pyrithione itself also displayed toxicity on the hormone-dependent MCF-7 breast cancer cell line with EC50 values in the low micromolar range. ..
  53. doi Discovery of new inhibitors of aldo-keto reductase 1C1 by structure-based virtual screening
    Petra Brozic
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 301:245-50. 2009
    ..Three structurally diverse hits were obtained that inhibit aldo-keto reductase 1C1 in the low micromolar range of IC(50) values. These hits represent promising starting points for structural optimization in hit-to-lead development...
  54. ncbi Evidence for 1,8-dihydroxynaphthalene melanin in three halophilic black yeasts grown under saline and non-saline conditions
    Tina Kogej
    University of Ljubljana, Biotech Faculty, Department of Biology, Vecna pot 111, SI 1000 Ljubljana, Slovenia
    FEMS Microbiol Lett 232:203-9. 2004
    ..This investigation showed that the three fungi synthesized DHN-melanin under saline and non-saline growth conditions...
  55. ncbi Cinnamic acid esters as potent inhibitors of fungal 17beta-hydroxysteroid dehydrogenase--a model enzyme of the short-chain dehydrogenase/reductase superfamily
    Stanislav Gobec
    Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    Bioorg Med Chem Lett 14:3933-6. 2004
    ..In a series of cinnamates and related coumarin-3-carboxylates, a number of compounds proved to be potent inhibitors of both the oxidative and reductive reactions catalyzed by 17beta-HSDcl, with IC(50) values in the low micromolar range...
  56. doi The characterization of the human nasal epithelial cell line RPMI 2650 under different culture conditions and their optimization for an appropriate in vitro nasal model
    Mateja Erdani Kreft
    Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Pharm Res 32:665-79. 2015
    ..The further characterization of the cell line RPMI 2650 and the evaluation of different culture conditions for an in vitro model for nasal mucosa...
  57. doi Correlation between erythropoietin receptor(s) and estrogen and progesterone receptor expression in different breast cancer cell lines
    Nina Trošt
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Int J Mol Med 31:717-25. 2013
    ..The expression of EPOR, GPER and EPHB4 may be considered as additional classification factors...
  58. ncbi Significance of individual amino acid residues for coenzyme and substrate specificity of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus
    Katja Kristan
    Medical Faculty, Institute of Biochemistry, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia
    Chem Biol Interact 143:493-501. 2003
    ....