Tea Lanisnik Rizner


Affiliation: University of Ljubljana
Country: Slovenia


  1. Traven K, Sinreih M, Stojan J, Seršen S, Kljun J, Bezenšek J, et al. Ruthenium complexes as inhibitors of the aldo-keto reductases AKR1C1-1C3. Chem Biol Interact. 2015;234:349-59 pubmed publisher
    ..To the best of our knowledge, this is the first study that has examined interactions between these AKR1C enzymes and ruthenium(II) complexes. ..
  2. Kreft M, Jerman U, Lasič E, Hevir Kene N, Rižner T, Peternel L, et al. The characterization of the human cell line Calu-3 under different culture conditions and its use as an optimized in vitro model to investigate bronchial epithelial function. Eur J Pharm Sci. 2015;69:1-9 pubmed publisher
  3. Hevir Kene N, Rižner T. The endometrial cancer cell lines Ishikawa and HEC-1A, and the control cell line HIEEC, differ in expression of estrogen biosynthetic and metabolic genes, and in androstenedione and estrone-sulfate metabolism. Chem Biol Interact. 2015;234:309-19 pubmed publisher
  4. Lanisnik Rizner T, Wheeler M. Melanin biosynthesis in the fungus Curvularia lunata (teleomorph: Cochliobolus lunatus). Can J Microbiol. 2003;49:110-9 pubmed
    ..No 3HNR reductase gene expression nor melanization was observed when Curvularia lunata was grown in yeast nitrogen base medium. ..
  5. Kocbek V, Vouk K, Bersinger N, Mueller M, Lanišnik Rižner T. Panels of cytokines and other secretory proteins as potential biomarkers of ovarian endometriosis. J Mol Diagn. 2015;17:325-34 pubmed publisher
    ..5% to 84.2%), specificity (78.4% to 91.2%), and area under the curve (0.85 to 0.90). ..
  6. Rizner T. Estrogen biosynthesis, phase I and phase II metabolism, and action in endometrial cancer. Mol Cell Endocrinol. 2013;381:124-39 pubmed publisher
  7. Sinreih M, Anko M, Kene N, Kocbek V, Rižner T. Expression of AKR1B1, AKR1C3 and other genes of prostaglandin F2α biosynthesis and action in ovarian endometriosis tissue and in model cell lines. Chem Biol Interact. 2015;234:320-31 pubmed publisher
    ..These cell models characterized in this study will enable further investigations into the role of PGF2α in the pathophysiology of endometriosis and the involvement of AKR1B1 and AKR1C3. ..
  8. Knific T, Vouk K, Smrkolj S, Prehn C, Adamski J, Rizner T. Models including plasma levels of sphingomyelins and phosphatidylcholines as diagnostic and prognostic biomarkers of endometrial cancer. J Steroid Biochem Mol Biol. 2018;178:312-321 pubmed publisher
    ..89%, specificity of 84.31%, and AUC of 0.935. ..
  9. Vouk K, Ribič Pucelj M, Adamski J, Rižner T. Altered levels of acylcarnitines, phosphatidylcholines, and sphingomyelins in peritoneal fluid from ovarian endometriosis patients. J Steroid Biochem Mol Biol. 2016;159:60-9 pubmed publisher

More Information


  1. Knific T, Frkovic Grazio S, Rizner T. Detection of Aristaless-related homeobox protein in ovarian sex cord-stromal tumors. Exp Mol Pathol. 2018;104:38-44 pubmed publisher
    ..ARX is present in ovarian stroma and cells derived from ovarian stroma as well as in all types of sex cord-stromal tumors of the ovary and could thus be used as a marker for sex cord-stromal differentiation in ovarian tumors. ..
  2. Rizner T. Estrogen metabolism and action in endometriosis. Mol Cell Endocrinol. 2009;307:8-18 pubmed publisher
    ..The disturbed expression of estrogen receptors in endometriosis is detailed, and the estrogen biosynthetic enzymes and receptors are discussed as novel therapeutic targets for the treatment of endometriosis. ..
  3. Sinreih M, Knific T, Thomas P, Frkovic Grazio S, Rizner T. Membrane progesterone receptors β and γ have potential as prognostic biomarkers of endometrial cancer. J Steroid Biochem Mol Biol. 2018;178:303-311 pubmed publisher
    ..The potential role of mPRβ and mPRγ as prognostic biomarkers needs to be further assessed on a larger number of samples. ..
  4. Sinreih M, Anko M, Zukunft S, Adamski J, Rižner T. Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines. Chem Biol Interact. 2015;234:297-308 pubmed publisher
    ..Our data confirm that in model cell lines of endometrial cancer, AKR1C2 and SRD5A1 have crucial roles in progesterone metabolism, and may represent novel targets for treatment. ..
  5. Knific T, Osredkar J, Smrkolj S, Tonin I, Vouk K, Blejec A, et al. Novel algorithm including CA-125, HE4 and body mass index in the diagnosis of endometrial cancer. Gynecol Oncol. 2017;147:126-132 pubmed publisher
    ..In patients with endometrial cancer, serum HE4 levels allow prediction of deep myometrial and lymphovascular invasion. ..
  6. Sinreih M, Štupar S, Čemažar L, Verdenik I, Frkovic Grazio S, Smrkolj S, et al. STAR and AKR1B10 are down-regulated in high-grade endometrial cancer. J Steroid Biochem Mol Biol. 2017;171:43-53 pubmed publisher
    ..These data thus reveal the potential of STAR and AKR1B10 as prognostic biomarkers, which calls for further validation at the protein level. ..
  7. Rizner T, Penning T. Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism. Steroids. 2014;79:49-63 pubmed publisher
    ..Mutations in AKR1C1 and AKR1C4 are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency. ..
  8. Rizner T, Smuc T, Rupreht R, Sinkovec J, Penning T. AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer. Mol Cell Endocrinol. 2006;248:126-35 pubmed
    ..It is suggested that the expression of AKR1C1 and AKR1C3 in endometrial cancer will govern the ratio of P:E2. ..