Janko Kos

Summary

Affiliation: University of Ljubljana
Country: Slovenia

Publications

  1. pmc Cathepsin H indirectly regulates morphogenetic protein-4 (BMP-4) in various human cell lines
    Matija Rojnik
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    Radiol Oncol 45:259-66. 2011
  2. pmc Profilin 1 as a target for cathepsin X activity in tumor cells
    Ursa Pecar Fonović
    Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    PLoS ONE 8:e53918. 2013
  3. pmc Cathepsin X in serum from patients with colorectal cancer: relation to prognosis
    Tjasa Vizin
    Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    Radiol Oncol 46:207-12. 2012
  4. pmc Prognostic and predictive value of cathepsin X in serum from colorectal cancer patients
    Tjasa Vizin
    Chair of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    BMC Cancer 14:259. 2014
  5. pmc Maturation of dendritic cells depends on proteolytic cleavage by cathepsin X
    Natasa Obermajer
    University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    J Leukoc Biol 84:1306-15. 2008
  6. pmc The role of cathepsin X in cell signaling
    Janko Kos
    University of Ljubljana, Slovenia
    Cell Adh Migr 3:164-6. 2009
  7. doi request reprint Inactivation of harmful tumour-associated proteolysis by nanoparticulate system
    Janko Kos
    University of Ljubljana, Faculty of Pharmacy, Askerceva 7, SI 1000 Ljubljana, Slovenia
    Int J Pharm 381:106-12. 2009
  8. ncbi request reprint Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues
    Janko Kos
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI 1000 Ljubljana, Slovenia
    Exp Cell Res 306:103-13. 2005
  9. ncbi request reprint Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells
    Natasa Obermajer
    Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI 1000 Ljubljana, Slovenia
    Exp Cell Res 312:2515-27. 2006
  10. ncbi request reprint Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody
    Petra Kocbek
    University of Ljubljana, Faculty of Pharmacy, Askerceva 7, Ljubljana, Slovenia
    J Control Release 120:18-26. 2007

Collaborators

Detail Information

Publications72

  1. pmc Cathepsin H indirectly regulates morphogenetic protein-4 (BMP-4) in various human cell lines
    Matija Rojnik
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    Radiol Oncol 45:259-66. 2011
    ..In order to clarify whether cathepsin H also regulates BMP-4 in humans, its impact on BMP-4 expression, processing and degradation was investigated in prostate cancer (PC-3), osteosarcoma (HOS) and pro-monocytic (U937) human cell lines...
  2. pmc Profilin 1 as a target for cathepsin X activity in tumor cells
    Ursa Pecar Fonović
    Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    PLoS ONE 8:e53918. 2013
    ..The latter is thus designated as a target for development of new antitumor strategies...
  3. pmc Cathepsin X in serum from patients with colorectal cancer: relation to prognosis
    Tjasa Vizin
    Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    Radiol Oncol 46:207-12. 2012
    ..Enhanced secretion of pro-Cat X was observed in malignant processes, and therefore, the level of total serum Cat X rather than the active enzyme may better reflect the tumour status...
  4. pmc Prognostic and predictive value of cathepsin X in serum from colorectal cancer patients
    Tjasa Vizin
    Chair of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    BMC Cancer 14:259. 2014
    ..In a previous, pilot, study on 77 colorectal patients we demonstrated the correlation of higher serum levels with shorter overall survival...
  5. pmc Maturation of dendritic cells depends on proteolytic cleavage by cathepsin X
    Natasa Obermajer
    University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    J Leukoc Biol 84:1306-15. 2008
    ..These results stress the importance of cathepsin X in regulating DC adhesion, a crucial event for their maturation and T cell activation...
  6. pmc The role of cathepsin X in cell signaling
    Janko Kos
    University of Ljubljana, Slovenia
    Cell Adh Migr 3:164-6. 2009
    ..The cleavage of C-terminal amino acids of alpha and gamma enolase by cathepsin X abolishes their neurotrophic activity affecting neuronal cell survival and neuritogenesis...
  7. doi request reprint Inactivation of harmful tumour-associated proteolysis by nanoparticulate system
    Janko Kos
    University of Ljubljana, Faculty of Pharmacy, Askerceva 7, SI 1000 Ljubljana, Slovenia
    Int J Pharm 381:106-12. 2009
    ....
  8. ncbi request reprint Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues
    Janko Kos
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI 1000 Ljubljana, Slovenia
    Exp Cell Res 306:103-13. 2005
    ..Its expression, restricted to immune cells suggests a role in phagocytosis and the regulation of immune response...
  9. ncbi request reprint Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells
    Natasa Obermajer
    Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI 1000 Ljubljana, Slovenia
    Exp Cell Res 312:2515-27. 2006
    ....
  10. ncbi request reprint Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody
    Petra Kocbek
    University of Ljubljana, Faculty of Pharmacy, Askerceva 7, Ljubljana, Slovenia
    J Control Release 120:18-26. 2007
    ..Furthermore, the results show the effectiveness of the new carrier system for targeted delivery of small or large active substances into cells or tissues of interest...
  11. doi request reprint Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells
    Natasa Obermajer
    University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
    Int J Biochem Cell Biol 41:1685-96. 2009
    ..On the other hand, the proliferation of cells is decreased, indicating induction of differentiation. Our study reveals enolase isozymes as crucial neurotrophic factors that are regulated by the proteolytic activity of cathepsin X...
  12. doi request reprint Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells
    Spela Magister
    Jozef Stefan Institute, Department of Biotechnology, Ljubljana, Slovenia
    Eur J Cell Biol 91:391-401. 2012
    ....
  13. pmc Bivalent carbohydrate binding is required for biological activity of Clitocybe nebularis lectin (CNL), the N,N'-diacetyllactosediamine (GalNAcβ1-4GlcNAc, LacdiNAc)-specific lectin from basidiomycete C. nebularis
    Jure Pohleven
    Department of Biotechnology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    J Biol Chem 287:10602-12. 2012
    ..Thus, the bivalent carbohydrate-binding property of homodimeric CNL is essential for its activity, providing one of the rare pieces of evidence that certain activities of lectins are associated with their multivalency...
  14. doi request reprint The role of cathepsin X in the migration and invasiveness of T lymphocytes
    Zala Jevnikar
    Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    J Cell Sci 121:2652-61. 2008
    ..We propose that cathepsin X causes cytoskeletal rearrangements and stimulates migration of T lymphocytes by modulating the activity of the beta2 integrin receptor LFA-1...
  15. ncbi request reprint Poly(lactide-co-glycolide) nanoparticles as a carrier system for delivering cysteine protease inhibitor cystatin into tumor cells
    Mateja Cegnar
    Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    Exp Cell Res 301:223-31. 2004
    ..The approach can be applied to other protein drugs active against intracellular targets...
  16. ncbi request reprint Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis
    Natasa Levicar
    Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia
    Cancer Gene Ther 10:141-51. 2003
    ..These data show that cathepsin L is an important protein mediating the malignancy of gliomas and its inhibition may diminish their invasion and lead to increased tumor cell apoptosis by reducing apoptotic threshold...
  17. pmc Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells
    Zala Jevnikar
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, SI 1000 Ljubljana, Slovenia
    J Biol Chem 288:2201-9. 2013
    ..We propose that CtsH-mediated processing of talin might promote cancer cell progression by affecting integrin activation and adhesion strength...
  18. doi request reprint Three-dimensional invasion of macrophages is mediated by cysteine cathepsins in protrusive podosomes
    Zala Jevnikar
    Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI 1000 Ljubljana, Slovenia
    Eur J Immunol 42:3429-41. 2012
    ..The targeting of cysteine cathepsins, as the major mediators of human Mf 3D invasion, could be an approach to the treatment of inflammatory and cancerous diseases...
  19. pmc Cytokeratin 8 ectoplasmic domain binds urokinase-type plasminogen activator to breast tumor cells and modulates their adhesion, growth and invasiveness
    Natasa Obermajer
    Jozef Stefan Institute, Department of Biotechnology, Jamova 39, 1000 Ljubljana, Slovenia
    Mol Cancer 8:88. 2009
    ..The process is accelerated if plasminogen and plasminogen activator are bound to their cell surface receptors...
  20. ncbi request reprint Intracellular delivery of cysteine protease inhibitor cystatin by polymeric nanoparticles
    Mateja Cegnar
    University of Ljubljana, Faculty of Pharmacy, Askerceva 7, 1000 Ljubljana, Slovenia
    J Nanosci Nanotechnol 6:3087-94. 2006
    ..Our results suggest new strategy to inactivate intracellular tumour-associated proteases, and consequently the invasion behaviour of tumour cells, which could contribute to cancer therapy...
  21. doi request reprint Regulation of cathepsin B activity by 2A2 monoclonal antibody
    Bojana Mirković
    Faculty of Pharmacy, University of Ljubljana, Slovenia
    FEBS J 276:4739-51. 2009
    ....
  22. doi request reprint DC-SIGN ligation greatly affects dendritic cell differentiation from monocytes compromising their normal function
    Urban Svajger
    Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia
    J Leukoc Biol 89:893-905. 2011
    ..Collectively, evidence is presented confirming a crucial role for DC-SIGN signaling in DC generation from monocytes...
  23. ncbi request reprint Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro
    Ales Premzl
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    J Cell Biochem 97:1230-40. 2006
    ..These results show that, besides multiple regulatory molecules, intracellular cathepsin B also contributes to the neovascularization process and should be considered as a potential therapeutic target...
  24. doi request reprint Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells
    Zala Jevnikar
    University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    J Leukoc Biol 90:99-109. 2011
    ..CatX post-translational modifications may thus represent a mechanism of LFA-1 fine-tuning that enables the trafficking of T cells...
  25. doi request reprint Monoclonal antibody to cytokeratin VKIALEVEIATY sequence motif reduces plasminogen activation in breast tumour cells
    Bojan Doljak
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    Cancer Lett 267:75-84. 2008
    ..Our results show that, besides their use in diagnosis, anti-cytokeratin antibodies could be used in therapy of invasive breast cancer...
  26. doi request reprint The influence of differential processing of procathepsin H on its aminopeptidase activity, secretion and subcellular localization in human cell lines
    Matija Rojnik
    Department of Pharmaceutical Biology, University of Ljubljana, Ljubljana, Slovenia
    Eur J Cell Biol 91:757-64. 2012
    ..These results provide an insight into the dependence of human cathepsin H processing and regulation on cell type...
  27. ncbi request reprint Immunonanoparticles--an effective tool to impair harmful proteolysis in invasive breast tumor cells
    Natasa Obermajer
    Faculty of Pharmacy, University of Ljubljana, Slovenia
    FEBS J 274:4416-27. 2007
    ..This approach may be applied for treatment of breast and other tumors in which intracellular proteolytic activity is a part of the process of malignant progression...
  28. doi request reprint Cathepsin X cleaves the beta2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and alpha-actinin-1 binding
    Zala Jevnikar
    Faculty of Pharmacy, University of Ljubljana, Askerceva, Ljubljana, Slovenia
    Eur J Immunol 39:3217-27. 2009
    ..Gradual cleavage of LFA-1 by cathepsin X enables the transition between intermediate and high affinity LFA-1, an event that is crucial for effective T-cell migration...
  29. pmc Inhibitory p41 isoform of invariant chain and its potential target enzymes cathepsins L and H in distinct populations of macrophages in human lymph nodes
    Valentina Zavasnik-Bergant
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    Immunology 112:378-85. 2004
    ....
  30. ncbi request reprint Differentiation- and maturation-dependent content, localization, and secretion of cystatin C in human dendritic cells
    Tina Zavasnik-Bergant
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia, EU
    J Leukoc Biol 78:122-34. 2005
    ..However, these interactions may occur extracellularly in lymph, as suggested by the large excess of CyC over secreted CatS, -L, and -H, and they may facilitate DC migration to lymph nodes...
  31. pmc CNL, a ricin B-like lectin from mushroom Clitocybe nebularis, induces maturation and activation of dendritic cells via the toll-like receptor 4 pathway
    Urban Svajger
    Blood Transfusion Centre of Slovenia, Slajmerjeva 6, Ljubljana, Slovenia
    Immunology 134:409-18. 2011
    ..Our results encourage the use of mushroom-derived lectins for use in therapeutic strategies with aims such as to strengthen anti-tumour immune responses...
  32. pmc Versatile loops in mycocypins inhibit three protease families
    Miha Renko
    Department of Biochemistry and Molecular, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    J Biol Chem 285:308-16. 2010
    ..These loops present a versatile surface with the potential to bind to additional classes of proteases. When appropriately engineered, they could provide the basis for possible exploitation in crop protection...
  33. doi request reprint LFA-1 fine-tuning by cathepsin X
    Zala Jevnikar
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    IUBMB Life 63:686-93. 2011
    ..Cathepsin X regulation that would allow precise modulation of LFA-1 affinity has a great potential for anti-LFA-1 therapy...
  34. doi request reprint Trypsin-specific inhibitors from the basidiomycete Clitocybe nebularis with regulatory and defensive functions
    Petra Avanzo
    Department of Biotechnology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Microbiology 155:3971-81. 2009
    ..These findings, together with the biochemical and genetic characterization of cnispin, suggest a dual physiological role for this serine protease inhibitor of the I66 MEROPS family...
  35. pmc Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety
    Bojana Mirković
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    PLoS ONE 6:e27197. 2011
    ..Such follow-up studies are both time and resource consuming...
  36. ncbi request reprint Inhibition of the growth of colorado potato beetle larvae by macrocypins, protease inhibitors from the parasol mushroom
    Ida Smid
    Department of Biotechnology and Systems Biology, National Institute of Biology, Vecna pot 111, 1000 Ljubljana, Slovenia
    J Agric Food Chem 61:12499-509. 2013
    ..Macrocypins are the first fungal protease inhibitors to be reported as having a negative effect on growth and development of CPB larvae and could also be evaluated as control agents for other pests. ..
  37. doi request reprint Cathepsin X prevents an effective immune response against Helicobacter pylori infection
    Natasa Obermajer
    University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Biology, Askerceva 7, 1000 Ljubljana, Slovenia
    Eur J Cell Biol 88:461-71. 2009
    ..pylori antigens leading to either successful eradication of the infection or maintenance of chronic inflammation, revealing cathepsin X location and activity as a regulator of the effectiveness of H. pylori eradication...
  38. ncbi request reprint Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro
    Ales Premzl
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Exp Cell Res 283:206-14. 2003
    ..Our results show that intracellular and extracellular cathepsin B activity contribute to in vitro invasion of MCF-10A neoT cells and suggest that inhibitors capable of impairing both fractions have a potential as new anticancer drugs...
  39. pmc Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins
    Natasa Obermajer
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    Immunology 124:76-88. 2008
    ..We demonstrate that cathepsin X is involved in the regulation of two beta2 integrin receptors, LFA-1 and Mac-1, which exhibit opposing roles in lymphocyte activation...
  40. doi request reprint Basidiomycete Clitocybe nebularis is rich in lectins with insecticidal activities
    Jure Pohleven
    Department of Biotechnology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Appl Microbiol Biotechnol 91:1141-8. 2011
    ..Mushroom C. nebularis is shown to be rich in a variety of lectins with versatile biological activities, including insecticidal and anti-nutritional effects. C. nebularis lectins could thus have potential for use as natural insecticides...
  41. ncbi request reprint Cysteine protease-mediated cytoskeleton interactions with LFA-1 promote T-cell morphological changes
    Zala Jevnikar
    Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    Cell Motil Cytoskeleton 66:1030-40. 2009
    ..This interaction is restricted to the uropod and results in the stabilization of this region, promoting LFA-1-mediated cell uropod elongation...
  42. ncbi request reprint Inhibitory properties of cystatin F and its localization in U937 promonocyte cells
    Tomaz Langerholc
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    FEBS J 272:1535-45. 2005
    ..The finding that cystatin F was not colocalized with cystatin C suggests distinct functions for these two cysteine protease inhibitors in U937 cells...
  43. pmc Structural basis of trypsin inhibition and entomotoxicity of cospin, serine protease inhibitor involved in defense of Coprinopsis cinerea fruiting bodies
    Jerica Sabotic
    Department of Biotechnology, Jozef Stefan Institute, Jamova 39, Ljubljana, Slovenia
    J Biol Chem 287:3898-907. 2012
    ..cinerea genome, these results suggest that cospin and its homologs are effectors of a fungal defense mechanism against fungivorous insects that function by specific inhibition of serine proteases in the insect gut...
  44. doi request reprint Role of cysteine cathepsins in matrix degradation and cell signalling
    Natasa Obermajer
    Department of Pharmaceutical Biology, University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
    Connect Tissue Res 49:193-6. 2008
    ..In this review we emphasize recent studies on cathepsins in regard to ECM degradation and cell signalling...
  45. ncbi request reprint Improved acylation method enables efficient delivery of functional palmitoylated cystatin into epithelial cells
    Nina Kocevar
    The Chair of Pharmaceutical Biology, University of Ljubljana, Faculty of Pharmacy, Askerceva 7, 1000 Ljubljana, Slovenia
    Chem Biol Drug Des 69:124-31. 2007
    ..In contrast, the unmodified control cystatin was unable to inhibit the intracellular enzymes. These results strongly suggest protein palmitoylation to be a very effective strategy for improving cell internalization...
  46. ncbi request reprint Nanoscale polymer carriers to deliver chemotherapeutic agents to tumours
    Mateja Cegnar
    University of Ljubljana, Faculty of Pharmacy, Askercceva 7, 1000 Ljubljana, Slovenia
    Expert Opin Biol Ther 5:1557-69. 2005
    ..This review is focused on the different types of nanoscale polymer carriers used for the delivery of chemotherapeutic agents and on the factors that affect their cellular uptake and trafficking...
  47. ncbi request reprint Cystatin incorporated in poly(lactide-co-glycolide) nanoparticles: development and fundamental studies on preservation of its activity
    Mateja Cegnar
    University of Ljubljana, Faculty of Pharmacy, Askereeva 7, SI 1000 Ljubljana, Slovenia
    Eur J Pharm Sci 22:357-64. 2004
    ..Cystatin incorporated into nanoparticles in this way maintains its structural integrity, making it suitable for effective drug delivery...
  48. doi request reprint γ-Enolase C-terminal peptide promotes cell survival and neurite outgrowth by activation of the PI3K/Akt and MAPK/ERK signalling pathways
    Anja Hafner
    Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    Biochem J 443:439-50. 2012
    ....
  49. doi request reprint Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B
    Izidor Sosič
    Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    Eur J Med Chem 46:4648-56. 2011
    ..The inhibitory activities of selected compounds were also assessed against two related cysteine proteases, cathepsin H and cathepsin L, to estimate their selectivity; these compounds have a selective profile for catB and catL over catH...
  50. ncbi request reprint Helicobacter pylori susceptible/resistant to antibiotic eradication therapy differ in the maturation and activation of dendritic cells
    Andreja N Kopitar
    Medical Faculty Ljubljana, Institute of Microbiology and Immunology, University of Ljubljana, Ljubljana, Slovenia
    Helicobacter 18:444-53. 2013
    ....
  51. doi request reprint In vitro and in vivo characterization of temoporfin-loaded PEGylated PLGA nanoparticles for use in photodynamic therapy
    Matija Rojnik
    Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    Nanomedicine (Lond) 7:663-77. 2012
    ..In this study we evaluated temoporfin-loaded polyethylene glycol (PEG) Poly-(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) as a new formulation for potential use in cancer treatment...
  52. ncbi request reprint Cysteine cathepsins (proteases)--on the main stage of cancer?
    Vito Turk
    Jozef Stefan Institute, Department of Biochemistry and Molecular Biology, Jamova 39, SI 1000, Ljubljana, Slovenia
    Cancer Cell 5:409-10. 2004
    ..Moreover, this study shows that a broad-spectrum cysteine cathepsin inhibitor effectively blocks several stages of tumorigenesis in the RIP1-Tag2 transgenic mouse model, offering new therapeutic opportunities in cancer treatment...
  53. ncbi request reprint Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer
    Vito Turk
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Adv Enzyme Regul 42:285-303. 2002
  54. ncbi request reprint Comparison of potential biological markers cathepsin B, cathepsin L, stefin A and stefin B with urokinase and plasminogen activator inhibitor-1 and clinicopathological data of breast carcinoma patients
    Natasa Levicar
    Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia
    Cancer Detect Prev 26:42-9. 2002
    ..In conclusion, this retrospective study showed u-PA to be of better prognostic relevance than the cysteine proteinases, though CatB and CatL were relevant for prognosis in lymph node negative breast cancer patients...
  55. ncbi request reprint Lysosomal enzymes, cathepsins in brain tumour invasion
    Natasa Levicar
    Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia
    J Neurooncol 58:21-32. 2002
    ..Further studies on the expression levels and balance between cysteine endopeptidases (CPs) and CPIs would improve the clinical application of cathepsins in prognosis, which would lead to more-informed therapeutic strategies...
  56. pmc Purification, characterization and cloning of a ricin B-like lectin from mushroom Clitocybe nebularis with antiproliferative activity against human leukemic T cells
    Jure Pohleven
    Department of Biotechnology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biochim Biophys Acta 1790:173-81. 2009
    ..Lectins are a diverse group of carbohydrate-binding proteins exhibiting numerous biological activities and functions...
  57. ncbi request reprint Stefin a and stefin B: markers for prognosis in operable squamous cell carcinoma of the head and neck
    Primoz Strojan
    Department of Radiotherapy, Institute of Oncology, Ljubljana, Slovenia
    Int J Radiat Oncol Biol Phys 68:1335-41. 2007
    ..The aim of this study was to test the hypothesis about the protective role of high stefin A and stefin B concentrations in operable carcinoma of the head and neck...
  58. doi request reprint Neuroprotective role of γ-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X
    Anja Hafner
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, Ljubljana, 1000, Slovenia
    Aging Cell 12:604-14. 2013
    ..These results demonstrate an upregulation of γ-enolase in microglia cells surrounding amyloid plaques in Tg2576 transgenic mice and demonstrate its neuroprotective role in amyloid-β-related neurodegeneration. ..
  59. ncbi request reprint Cysteine cathepsins: regulators of antitumour immune response
    Natasa Obermajer
    University of Ljubljana, Department of Pharmaceutical Biology, Faculty of Pharmacy, Askerceva 7, SI 1000 Ljubljana, Slovenia
    Expert Opin Biol Ther 6:1295-309. 2006
    ..This review is focused on the role of cysteine cathepsins in the antitumour immune response and the evaluation of their pro- and anticancer behaviours during the regulation of these processes...
  60. doi request reprint Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives
    Izidor Sosič
    University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    J Med Chem 56:521-33. 2013
    ....
  61. doi request reprint γ-1-syntrophin mediates trafficking of γ-enolase towards the plasma membrane and enhances its neurotrophic activity
    Anja Hafner
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    Neurosignals 18:246-58. 2010
    ..By disrupting this γ1-syntrophin-guided subcellular distribution, cathepsin X reduces γ-enolase-induced neurotrophic signaling...
  62. pmc Differences in the antigens of Helicobacter pylori strains influence on the innate immune response in the in vitro experiments
    Miha Skvarc
    Institute of Microbiology and Immunology, Medical Faculty Ljubljana, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
    Mediators Inflamm 2014:287531. 2014
    ..pylori resistance to eradication due to lack of effective immune response. Differences in lipid A of H. pylori might have an influence on the insufficient immune response, especially on phagocytosis. ..
  63. doi request reprint Protease inhibitors clitocypin and macrocypin are differentially expressed within basidiomycete fruiting bodies
    Jerica Sabotic
    Department of Biotechnology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Biochimie 93:1685-93. 2011
    ..The complex, tissue specific expression patterns for mycocypin genes suggest different biological roles for the products, either in regulation of endogenous proteases or in defense against pathogens or predators...
  64. doi request reprint Proteins of higher fungi--from forest to application
    Jana Erjavec
    Department of Biotechnology and Systems Biology, National Institute of Biology, Vecna pot 111, SI 1000 Ljubljana, Slovenia
    Trends Biotechnol 30:259-73. 2012
    ....
  65. doi request reprint Mycoplasma gallisepticum and Mycoplasma synoviae express a cysteine protease CysP, which can cleave chicken IgG into Fab and Fc
    Ivanka Cizelj
    Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, SI 1230 DomZale, Slovenia
    Microbiology 157:362-72. 2011
    ..gallisepticum and M. synoviae for prolonged survival despite the antibody response of their host...
  66. ncbi request reprint Serum cystatin C in patients with head and neck carcinoma
    Primoz Strojan
    Department of Radiation Oncology, Institute of Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Clin Chim Acta 344:155-61. 2004
    ..The aim of the present study was to determine the changes in the serum cystatin C concentration in patients with squamous cell carcinoma of the head and neck...
  67. doi request reprint Microbial and fungal protease inhibitors--current and potential applications
    Jerica Sabotic
    Department of Biotechnology, Jozef Stefan Institute, Ljubljana, Slovenia
    Appl Microbiol Biotechnol 93:1351-75. 2012
    ..Because there are such a large number and diversity of proteases in prokaryotes, yeasts, filamentous fungi and mushrooms, we can expect them to be a rich source of protease inhibitors as well...
  68. ncbi request reprint Molecular cloning and chimerisation of an inhibitory anti-cathepsin B antibody and its expression in Chinese hamster ovary cells
    Xiaohui Fan
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1 000 Ljubljana, Slovenia
    Biol Chem 383:1817-20. 2002
    ..We could demonstrate an inhibitory effect of the chimeric antibody...
  69. ncbi request reprint Genotoxicity of trivalent chromium in bacterial cells. Possible effects on DNA topology
    Andreja Plaper
    Krka d d, Research Department of New Entities, Novo mesto, Slovenia, University of Ljubljana, Biotechnical Faculty, Ljubljana, Slovenia
    Chem Res Toxicol 15:943-9. 2002
    ..The possible implication for Cr3+ intake by humans is discussed...
  70. ncbi request reprint Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer
    Klaus Kayser
    Institute of Pathology, Charite, Berlin, Germany
    Anticancer Res 23:2767-72. 2003
    ..To immunohistochemically investigate the expression of cathepsin B and cathepsin L in various lung cancer cell types in association with the patients' prognosis...
  71. ncbi request reprint Cystatin C as a potential marker for relapse in patients with non-Hodgkin B-cell lymphoma
    Adaleta Mulaomerović
    Medical Faculty, University of Tuzla, Bosnia and Herzegovina
    Cancer Lett 248:192-7. 2007
    ..Our study reports for the first time that cystatin C is a potential marker for relapse in patients with non-Hodgkin B-cell lymphoma...
  72. ncbi request reprint Cystatins in non-small cell lung cancer: tissue levels, localization and relation to prognosis
    Bernd Werle
    Abteilung für Klinische Chemie und Bakteriologie, Thoraxklinik Heidelberg gGmbH, D 69117 Heidelberg, Germany
    Oncol Rep 16:647-55. 2006
    ..As biological markers they may add independent prognostic information for better assessment of low- and high-risk patients with NSCLC...