Vita Dolzan

Summary

Affiliation: University of Ljubljana
Country: Slovenia

Publications

  1. pmc Inducible nitric oxide synthase genetic polymorphism and risk of asbestosis
    Alenka Franko
    Clinical Institute of Occupational Medicine, University Medical Center, Poljanski nasip 58, 1000 Ljubljana, Slovenia
    J Biomed Biotechnol 2011:685870. 2011
  2. doi request reprint Acute antipyschotic efficacy and side effects in schizophrenia: association with serotonin transporter promoter genotypes
    Vita Dolzan
    University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Vrazov trg 2, SI 1000 Ljubljana, Slovenia
    Prog Neuropsychopharmacol Biol Psychiatry 32:1562-6. 2008
  3. ncbi request reprint Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment
    Vita Dolzan
    Institute of Biochemistry, Faculty of Medicine, Ljubljana, Slovenia
    Am J Med Genet B Neuropsychiatr Genet 144:809-15. 2007
  4. ncbi request reprint Genetic susceptibility to environmental carcinogenesis in Slovenian melanoma patients
    V Dolzan
    Institute of Biochemistry, Faculty of Medicine, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Acta Dermatovenerol Alp Pannonica Adriat 15:69-78. 2006
  5. doi request reprint MDR1 gene polymorphisms and response to acute risperidone treatment
    Matej Kastelic
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Prog Neuropsychopharmacol Biol Psychiatry 34:387-92. 2010
  6. doi request reprint DNA repair polymorphisms influence the risk of second neoplasm after treatment of childhood acute lymphoblastic leukemia
    Nina Erculj
    Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    J Cancer Res Clin Oncol 138:1919-30. 2012
  7. doi request reprint Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis
    Petra Bohanec Grabar
    Faculty of Medicine, Institute of Biochemistry, University of Ljubljana, 1000 Ljubljana, Slovenia
    Drug Metab Dispos 37:2061-8. 2009
  8. doi request reprint Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia
    Nina Erculj
    Institute of Biochemistry, University of Ljubljana, Ljubljana, Slovenia
    Leuk Lymphoma 53:1096-104. 2012
  9. pmc Manganese and extracellular superoxide dismutase polymorphisms and risk for asbestosis
    Alenka Franko
    Clinical Institute of Occupational Medicine, University Medical Centre, Ljubljana, Slovenia
    J Biomed Biotechnol 2009:493083. 2009
  10. pmc Genetic polymorphisms in genes encoding antioxidant enzymes are associated with diabetic retinopathy in type 1 diabetes
    Tinka Hovnik
    Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases, University Children s Hospital, University Medical Centre, Ljubljana, Slovenia
    Diabetes Care 32:2258-62. 2009

Detail Information

Publications36

  1. pmc Inducible nitric oxide synthase genetic polymorphism and risk of asbestosis
    Alenka Franko
    Clinical Institute of Occupational Medicine, University Medical Center, Poljanski nasip 58, 1000 Ljubljana, Slovenia
    J Biomed Biotechnol 2011:685870. 2011
    ..86-1.85) for the LL genotype compared to the SL genotype. The results of this study are borderline significant and suggest a possible role of iNOS (CCTTT)(n) polymorphism in the risk of asbestosis; however, further studies are needed...
  2. doi request reprint Acute antipyschotic efficacy and side effects in schizophrenia: association with serotonin transporter promoter genotypes
    Vita Dolzan
    University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Vrazov trg 2, SI 1000 Ljubljana, Slovenia
    Prog Neuropsychopharmacol Biol Psychiatry 32:1562-6. 2008
    ..In the present study, we investigated the effects of the 44 bp insertion/deletion polymorphism in the promoter region of 5-HTT gene (5-HTTLPR) on symptomatology of psychosis and clinical response to antipsychotic drugs...
  3. ncbi request reprint Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment
    Vita Dolzan
    Institute of Biochemistry, Faculty of Medicine, Ljubljana, Slovenia
    Am J Med Genet B Neuropsychiatr Genet 144:809-15. 2007
    ..Our study suggests that DRD1 and DRD2 variants are not liability factors for tardive dyskinesia...
  4. ncbi request reprint Genetic susceptibility to environmental carcinogenesis in Slovenian melanoma patients
    V Dolzan
    Institute of Biochemistry, Faculty of Medicine, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Acta Dermatovenerol Alp Pannonica Adriat 15:69-78. 2006
    ..42; 95% CI: 0.36-29.6). Our results indicate that factors other than the polymorphic genes coding xenobiotic metabolising enzymes play a major role in protection against environmental carcinogenesis in human skin...
  5. doi request reprint MDR1 gene polymorphisms and response to acute risperidone treatment
    Matej Kastelic
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Prog Neuropsychopharmacol Biol Psychiatry 34:387-92. 2010
    ..The present study does not suggest a major influence of MDR1 G2677T/A and C3435T polymorphisms on treatment response during short-term risperidone therapy in patients with schizophrenia or schizoaffective disorder...
  6. doi request reprint DNA repair polymorphisms influence the risk of second neoplasm after treatment of childhood acute lymphoblastic leukemia
    Nina Erculj
    Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    J Cancer Res Clin Oncol 138:1919-30. 2012
    ..The aim of our study was to identify DNA repair polymorphisms contributing to the risk of second neoplasm in clinically well-characterized Slovenian patients treated for childhood ALL...
  7. doi request reprint Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis
    Petra Bohanec Grabar
    Faculty of Medicine, Institute of Biochemistry, University of Ljubljana, 1000 Ljubljana, Slovenia
    Drug Metab Dispos 37:2061-8. 2009
    ..Our results suggest that genetic variability in leflunomide-metabolizing enzymes influences leflunomide metabolite concentrations that are associated with the treatment response but not with leflunomide-induced toxicity...
  8. doi request reprint Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia
    Nina Erculj
    Institute of Biochemistry, University of Ljubljana, Ljubljana, Slovenia
    Leuk Lymphoma 53:1096-104. 2012
    ..None of the investigated polymorphisms influenced survival. Our study suggests an important role of polymorphisms and gene-gene interactions within the folate pathway in HD-MTX-related toxicity in childhood ALL...
  9. pmc Manganese and extracellular superoxide dismutase polymorphisms and risk for asbestosis
    Alenka Franko
    Clinical Institute of Occupational Medicine, University Medical Centre, Ljubljana, Slovenia
    J Biomed Biotechnol 2009:493083. 2009
    ..62-4.27). The finding that the SOD2 - 9Ala/Ala genotype increases the risk for asbestosis indicates that, in addition to asbestos exposure, genetic factors may also have a significant influence on the development of asbestosis...
  10. pmc Genetic polymorphisms in genes encoding antioxidant enzymes are associated with diabetic retinopathy in type 1 diabetes
    Tinka Hovnik
    Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases, University Children s Hospital, University Medical Centre, Ljubljana, Slovenia
    Diabetes Care 32:2258-62. 2009
    ..We investigated polymorphic markers in genes encoding enzymes regulating production of reactive oxygen species in association with diabetic retinopathy or diabetic nephropathy...
  11. doi request reprint DNA repair polymorphisms and treatment outcomes of patients with malignant mesothelioma treated with gemcitabine-platinum combination chemotherapy
    Nina Erculj
    Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    J Thorac Oncol 7:1609-17. 2012
    ..Therefore, the aim of our study was to evaluate the influence of genetic variability in DNA repair genes on treatment outcome in patients with malignant mesothelioma (MM) treated with gemcitabine-platinum combination chemotherapy...
  12. doi request reprint A population pharmacokinetic evaluation of the influence of CYP2D6 genotype on risperidone metabolism in patients with acute episode of schizophrenia
    Igor Locatelli
    Department of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, Ljubljana, Slovenia
    Eur J Pharm Sci 41:289-98. 2010
    ..0066) and parkinsonism (p=0.046). The results of this study imply the potential role of CYP2D6 genotyping in personalizing risperidone therapy in patients with schizophrenia to reduce the incidence of adverse extrapyramidal symptoms...
  13. ncbi request reprint Glutathione S-transferases GSTM1 and GSTT1 polymorphisms and asbestosis
    Alenka Franko
    Clinical Institute of Occupational Medicine, University Medical Centre, Ljubljana, Slovenia
    J Occup Environ Med 49:667-71. 2007
    ..In a nested case-control study, the authors investigated whether the deletion polymorphism of glutathione S-transferases GSTM1 and GSTT1 represents a risk factor for the development of asbestosis...
  14. doi request reprint Association of SOD2, GPX1, CAT, and TNF genetic polymorphisms with oxidative stress, neurochemistry, psychopathology, and extrapyramidal symptoms in schizophrenia
    Marija Boskovic
    Faculty of Pharmacy, University of Ljubljana, Askerceva cesta 7, 1000 Ljubljana, Slovenia
    Neurochem Res 38:433-42. 2013
    ..PANSS positive and general scores, were associated with the increased risk of tardive dyskinesia. PANSS positive, negative, and general scores, and GAF score were all associated with the increased risk of akathisia...
  15. ncbi request reprint Asbestosis and catalase genetic polymorphism
    Alenka Franko
    Clinical Institute of Occupational, Traffic and Sports Medicine, University Medical Centre, Ljubljana, Slovenia
    Arh Hig Rada Toksikol 59:233-40. 2008
    ..These results are an important contribution to understanding the interactions between genetic and environmental factors that may modify the risk of asbestosis...
  16. ncbi request reprint The influence of sequence variations in factor VII, gamma-glutamyl carboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirement
    Darja Herman
    Institute of Biochemistry, Faculty of Medicine, Vrazov trg 2, SI 1000 Ljubljana, Slovenia
    Thromb Haemost 95:782-7. 2006
    ..When aiming for individualised warfarin therapy, at least VKORC1 polymorphisms should be included in predictive genotyping besides CYP2C9...
  17. doi request reprint The influence of genetic polymorphisms of GSTP1 on the development of asbestosis
    Alenka Franko
    Clinical Institute of Occupational Medicine, University Medical Center Ljubljana, Poljanski nasip 58, Ljubljana, Slovenia
    J Occup Environ Med 50:7-12. 2008
    ..Genetic factors play an important role in the development of asbestosis. The aim of this study was to investigate whether genetic polymorphisms of glutathione S-transferase (GST) P1 represent a risk factor for this disease...
  18. pmc Genetic polymorphisms modifying oxidative stress are associated with disease activity in rheumatoid arthritis patients
    Petra Bohanec Grabar
    University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Ljubljana, Slovenia
    Dis Markers 26:41-8. 2009
    ..003, OR = 3.585, 95% CI = 1.538-8.357). Our results suggest that CAT and TNFA polymorphisms alone and in combination influence the activity of RA...
  19. doi request reprint Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients
    Petra Bohanec Grabar
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Eur J Clin Pharmacol 64:871-6. 2008
    ..The aim of our study was to investigate whether genetic polymorphisms of CYP1A2, CYP2C19, and CYP2C9 influence leflunomide toxicity...
  20. doi request reprint Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma
    Barbara Faganel Kotnik
    Department of Oncology and Haematology, University Children s Hospital, University Medical Centre Ljubljana, Bohoriceva 20, Ljubljana, Slovenia
    Eur J Clin Pharmacol 67:993-1006. 2011
    ....
  21. ncbi request reprint The influence of co-treatment with carbamazepine, amiodarone and statins on warfarin metabolism and maintenance dose
    Darja Herman
    Institute of Biochemistry, Faculty of Medicine, Ljubljana, Slovenia
    Eur J Clin Pharmacol 62:291-6. 2006
    ..As, in many patients, drug co-treatment cannot be avoided, we investigated the effect of co-treatment with carbamazepine, amiodarone and statins on warfarin metabolism and maintenance dose...
  22. doi request reprint Genetic variation in the SLC19A1 gene and methotrexate toxicity in rheumatoid arthritis patients
    Petra Bohanec Grabar
    Pharmacogenetics Laboratory, Institute of Biochemistry, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Pharmacogenomics 13:1583-94. 2012
    ..We investigated the clinical relevance of SLC19A1 genetic variability for methotrexate (MTX) toxicity in rheumatoid arthritis patients using a haplotype-based approach...
  23. pmc Soluble mesothelin-related peptides levels in patients with malignant mesothelioma
    Alenka Franko
    Clinical Institute of Occupational Medicine, University Medical Center Ljubljana, Ljubljana, Slovenia
    Dis Markers 32:123-31. 2012
    ..001). Our findings suggest that SMRP may be a useful tumor marker for detecting the progression of malignant mesothelioma and evaluating tumor response to treatment...
  24. ncbi request reprint Characterization of the novel defective CYP2C9*24 allele
    Darja Herman
    Institute of Biochemistry, Faculty of Medicine, Vrazov trg 2, SI 1000 Ljubljana, Slovenia
    Drug Metab Dispos 35:831-4. 2007
    ..The data obtained in the expression systems are consistent with our findings in vivo. In conclusion, we have identified a novel defective CYP2C9 variant allele of potential importance for drug metabolism in vivo...
  25. doi request reprint Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism
    Petra Bohanec Grabar
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Eur J Clin Pharmacol 64:1057-68. 2008
    ....
  26. doi request reprint The influence of gemcitabine pathway polymorphisms on treatment outcome in patients with malignant mesothelioma
    Nina Erculj
    Pharmacogenetics Laboratory, Faculty of Medicine, Institute of Biochemistry, University of Ljubljana, Slovenia
    Pharmacogenet Genomics 22:58-68. 2012
    ..The aim of our study was to evaluate the influence of gemcitabine pathway polymorphisms on treatment outcome in patients with malignant mesothelioma (MM)...
  27. ncbi request reprint No evidence of association of methylenetetrahydrofolate reductase polymorphism with occurrence of second neoplasms after treatment of childhood leukemia
    Janez Jazbec
    Department of Pediatrics, Unit of Oncology and Haematology, Medical Centre Ljubljana, Ljubljana, Slovenia
    Leuk Lymphoma 46:893-7. 2005
    ..43-5.31] or one polymorphic A1298C allele (OR 1; 95% CI 0.29?-?3.46). Our study suggests that MTHFR polymorphisms are not associated with increased risk of second cancer in children treated with high-dose methotrexate...
  28. ncbi request reprint Polymorphisms in translesion polymerase genes influence treatment outcome in malignant mesothelioma
    Katja Goričar
    Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Pharmacogenomics 15:941-50. 2014
    ..Conclusion: Our results suggest for the first time that REV1 and REV3L SNPs might serve as potential predictive markers of outcome of cisplatin-based chemotherapy. Original submitted 7 October 2013; Revision submitted 15 January 2014. ..
  29. ncbi request reprint A novel sequence variant in exon 7 of CYP2C9 gene (CYP2C9*24) in a patient on warfarin therapy
    Darja Herman
    Institute of Biochemistry, Faculty of Medicine, Vrazov trg 2, St 1000 Ljubljana, Slovenia
    Thromb Haemost 95:192-4. 2006
  30. ncbi request reprint CYP 2D6 polymorphism and antipsychotic therapy
    Blanka Kores Plesnicar
    University Clinical Centre Maribor, Department of Psychiatry, and Medical faculty Maribor, Slovenia
    Psychiatr Danub 20:369-71. 2008
    ....
  31. ncbi request reprint The influence of the CYP2D6 polymorphism on psychopathological and extrapyramidal symptoms in the patients on long-term antipsychotic treatment
    Blanka Kores Plesnicar
    Department of Psychiatry, Teaching Hospital Maribor, Maribor, Slovenia
    J Psychopharmacol 20:829-33. 2006
    ..However, CYP2D6 genotype might be a factor contributing to the persistent negative symptoms of schizophrenia...
  32. ncbi request reprint CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene-gene interactions
    Paolo Vineis
    Imperial College London, London, UK
    Biomarkers 9:298-305. 2004
    ..7 (95% CI = 0.5-15.3). An association between lung cancer and the homozygous CYP1A1*2A genotype is confirmed. An apparent and biologically plausible interaction is suggested between this genotype and GSTM1...
  33. ncbi request reprint Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
    Kim M Smits
    University Maastricht, Maastricht, The Netherlands
    Int J Cancer 110:266-70. 2004
    ..No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected...
  34. ncbi request reprint CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls
    Paolo Vineis
    Universita degli Studi di Torino, Torino, Italy
    Int J Cancer 104:650-7. 2003
    ..The analyses were more inconsistent and failed to reach statistical significance in Asians. This observation might be due to design specificities or unknown effect modifiers in the Asian studies...
  35. ncbi request reprint Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk
    Simone Benhamou
    INSERM U521, EMI 00 06, Evry, France
    Carcinogenesis 23:1343-50. 2002
    ..08, 95% CI 0.98-1.18) and no evidence of interaction between GSTM1 genotype and either smoking status or cumulative tobacco consumption...