Vito Turk

Summary

Affiliation: Jozef Stefan Institute
Country: Slovenia

Publications

  1. ncbi request reprint Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer
    Vito Turk
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Adv Enzyme Regul 42:285-303. 2002
  2. pmc Lysosomal cysteine proteases: facts and opportunities
    V Turk
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Ljubljana, Slovenia
    EMBO J 20:4629-33. 2001
  3. ncbi request reprint Cystatins: biochemical and structural properties, and medical relevance
    Vito Turk
    J Stefan Institute, Dept of Biochemistry, Molecular and Structural Biology, SI 1000 Ljubljana, Slovenia
    Front Biosci 13:5406-20. 2008
  4. ncbi request reprint Cysteine cathepsins (proteases)--on the main stage of cancer?
    Vito Turk
    Jozef Stefan Institute, Department of Biochemistry and Molecular Biology, Jamova 39, SI 1000, Ljubljana, Slovenia
    Cancer Cell 5:409-10. 2004
  5. ncbi request reprint Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues
    Janko Kos
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI 1000 Ljubljana, Slovenia
    Exp Cell Res 306:103-13. 2005
  6. doi request reprint Size and morphology of toxic oligomers of amyloidogenic proteins: a case study of human stefin B
    Slavko Ceru
    Department of Biochemistry, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Amyloid 15:147-59. 2008
  7. doi request reprint Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues
    Gabriela Droga-Mazovec
    Department of Biochemistry, Molecular and Structural Biology, J Stefan Institute, Sl 1000 Ljubljana, Slovenia
    J Biol Chem 283:19140-50. 2008
  8. ncbi request reprint Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions
    Dejan Caglic
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    J Biol Chem 282:33076-85. 2007
  9. pmc Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis
    Uros Gregorc
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Ljubljana, Slovenia
    Apoptosis 12:343-54. 2007
  10. ncbi request reprint Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors
    Marko Novinec
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    J Biol Chem 282:7893-902. 2007

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer
    Vito Turk
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Adv Enzyme Regul 42:285-303. 2002
  2. pmc Lysosomal cysteine proteases: facts and opportunities
    V Turk
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Ljubljana, Slovenia
    EMBO J 20:4629-33. 2001
    ..Some of the features and roles of their structures, specificity, regulation and physiology are discussed...
  3. ncbi request reprint Cystatins: biochemical and structural properties, and medical relevance
    Vito Turk
    J Stefan Institute, Dept of Biochemistry, Molecular and Structural Biology, SI 1000 Ljubljana, Slovenia
    Front Biosci 13:5406-20. 2008
    ..The levels of some stefins and cystatins in tissue and body fluids can serve as relatively reliable markers for a variety of diseases. In this review we summarize present knowledge about cystatins and their role in some diseases...
  4. ncbi request reprint Cysteine cathepsins (proteases)--on the main stage of cancer?
    Vito Turk
    Jozef Stefan Institute, Department of Biochemistry and Molecular Biology, Jamova 39, SI 1000, Ljubljana, Slovenia
    Cancer Cell 5:409-10. 2004
    ..Moreover, this study shows that a broad-spectrum cysteine cathepsin inhibitor effectively blocks several stages of tumorigenesis in the RIP1-Tag2 transgenic mouse model, offering new therapeutic opportunities in cancer treatment...
  5. ncbi request reprint Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues
    Janko Kos
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI 1000 Ljubljana, Slovenia
    Exp Cell Res 306:103-13. 2005
    ..Its expression, restricted to immune cells suggests a role in phagocytosis and the regulation of immune response...
  6. doi request reprint Size and morphology of toxic oligomers of amyloidogenic proteins: a case study of human stefin B
    Slavko Ceru
    Department of Biochemistry, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Amyloid 15:147-59. 2008
    ..They also bound, similarly to prefibrillar aggregates, to the plasma membrane and became internalized. Taken together, our results confirm the importance of membrane interaction and perforation in the phenomenon of cytotoxicity...
  7. doi request reprint Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues
    Gabriela Droga-Mazovec
    Department of Biochemistry, Molecular and Structural Biology, J Stefan Institute, Sl 1000 Ljubljana, Slovenia
    J Biol Chem 283:19140-50. 2008
    ..Moreover, XIAP (X-chromosome-linked inhibitor of apoptosis) was also found to be a target of cysteine cathepsins, suggesting that cathepsins can mediate caspase-dependent apoptosis also downstream of mitochondria...
  8. ncbi request reprint Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions
    Dejan Caglic
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    J Biol Chem 282:33076-85. 2007
    ..Because procathepsin B and GAGs often co-localize in vivo, we propose that GAGs may play a physiological role in the activation of procathepsin B...
  9. pmc Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis
    Uros Gregorc
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Ljubljana, Slovenia
    Apoptosis 12:343-54. 2007
    ..Thus, MAGI-1 cleavage appears to be an important step in the disassembly of cell-cell contacts during apoptosis...
  10. ncbi request reprint Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors
    Marko Novinec
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    J Biol Chem 282:7893-902. 2007
    ..In contrast, thyropins were relatively inefficient in preventing elastinolysis by cysteine cathepsins...
  11. ncbi request reprint Presence of the propeptide on recombinant lysosomal dipeptidase controls both activation and dimerization
    Iztok Dolenc
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biol Chem 388:47-51. 2007
    ..The propeptide thus controls dimerization, as well as activation, of lysosomal dipeptidase...
  12. ncbi request reprint Dual concentration-dependent activity of thyroglobulin type-1 domain of testican: specific inhibitor and substrate of cathepsin L
    Primoz Meh
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biol Chem 386:75-83. 2005
    ..Secondly, the prolonged first loop of the domain occupies a position near the catalytic cysteine residue in a more substrate-like manner, enabling cleavage of the Gly22-Ala23 bond...
  13. ncbi request reprint Amyloid fibril formation by human stefin B in vitro: immunogold labelling and comparison to stefin A
    Eva Zerovnik
    Department of Biochemistry and Molecular Biology, Institute Jozef Stefan, Ljubljana, Slovenia
    Biol Chem 383:859-63. 2002
    ..Samples were examined by transmission electron microscopy. Fibrils of stefin B were strongly labelled using polyclonal antibody and Protein A gold, whereas no positive reaction was observed with monoclonal antibody A6/2...
  14. doi request reprint Intracellular aggregation of human stefin B: confocal and electron microscopy study
    Slavko Ceru
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Biol Cell 102:319-34. 2010
    ..Human StB proved to be a good model system to study amyloid fibril formation in vitro and, as we show here, to study protein aggregation in cells...
  15. doi request reprint N-terminally truncated forms of human cathepsin F accumulate in aggresome-like inclusions
    Barbara Jerič
    Department of Biochemistry and Molecular and Structural Biology, J Stefan Institute, Ljubljana, Slovenia
    Biochim Biophys Acta 1833:2254-66. 2013
    ..These results suggested the clearance of the N-terminally truncated forms of human cathepsin F via the autophagy pathway, underlying its protective and prosurvival mechanisms. ..
  16. ncbi request reprint Biochemical characterization and structural modeling of human cathepsin E variant 2 in comparison to the wild-type protein
    Vida Puizdar
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biol Chem 393:177-86. 2012
    ....
  17. doi request reprint The mechanism of amyloid-fibril formation by stefin B: temperature and protein concentration dependence of the rates
    Katja Skerget
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, 1000 Ljubljana, Slovenia
    Proteins 74:425-36. 2009
    ....
  18. ncbi request reprint Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro
    Ales Premzl
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    J Cell Biochem 97:1230-40. 2006
    ..These results show that, besides multiple regulatory molecules, intracellular cathepsin B also contributes to the neovascularization process and should be considered as a potential therapeutic target...
  19. doi request reprint Autocatalytic processing of procathepsin B is triggered by proenzyme activity
    Jerica Rozman Pungercar
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    FEBS J 276:660-8. 2009
    ....
  20. ncbi request reprint Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins
    Tina Cirman
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    J Biol Chem 279:3578-87. 2004
    ..Incubation of full-length Bid treated with cathepsins B, H, L, and S resulted in rapid cytochrome c release from isolated mitochondria. Thus, Bid may be an important mediator of apoptosis induced by lysosomal disruption...
  21. doi request reprint Cysteine cathepsins are not critical for TNF-alpha-induced cell death in T98G and U937 cells
    Martina Klarić
    Department of Biochemistry and Molecular and Structural Biology, J Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biochim Biophys Acta 1794:1372-7. 2009
    ....
  22. pmc Interaction between oligomers of stefin B and amyloid-beta in vitro and in cells
    Katja Skerget
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, Slovenia
    J Biol Chem 285:3201-10. 2010
    ..It also co-immunoprecipitates with the APP fragment containing the Abeta epitope. Thus, stefin B is another APP/Abeta-binding protein in vitro and likely in cells...
  23. doi request reprint Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery
    Dejan Caglic
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biol Chem 390:175-9. 2009
    ..Thus, both enzymes were expressed and biochemically characterized. The enzymes exhibited similar biochemical properties, indicating that cathepsin B transgenic mouse models could be useful for studying its role in human pathologies...
  24. pmc Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L
    Spela Konjar
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    Immunology 131:257-67. 2010
    ..We conclude that granule-bound cathepsins are essential for processing perforin to its active form, and that CatL is an important, but not exclusive, participant in this process...
  25. doi request reprint Interaction with model membranes and pore formation by human stefin B: studying the native and prefibrillar states
    Sabina Rabzelj
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    FEBS J 275:2455-66. 2008
    ..Similarities to other amyloidogenic proteins and the possible physiological implications of our findings are discussed...
  26. doi request reprint Lysosomes in apoptosis
    Saska Ivanova
    Department of Biochemistry, Molecular and Structural Biology, J Stefan Institute, Ljubljana, Slovenia
    Methods Enzymol 442:183-99. 2008
    ..This chapter reviews the methods used to study lysosomes and lysosomal proteases...
  27. ncbi request reprint Mouse stefins A1 and A2 (Stfa1 and Stfa2) differentiate between papain-like endo- and exopeptidases
    Marko Mihelic
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    FEBS Lett 580:4195-9. 2006
    ..In contrast, the inhibitory activities of Stfa2-a and Stfa2-b were found to be roughly equivalent for all targets peptidases...
  28. ncbi request reprint Sensitization of stefin B-deficient thymocytes towards staurosporin-induced apoptosis is independent of cysteine cathepsins
    Natasa Kopitar-Jerala
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    FEBS Lett 579:2149-55. 2005
    ..We conclude that sensitization to apoptosis induced by STS in thymocytes of stefin B-deficient and wild-type mice is not dependent on cathepsin inhibition by stefin B...
  29. ncbi request reprint Differentiation- and maturation-dependent content, localization, and secretion of cystatin C in human dendritic cells
    Tina Zavasnik-Bergant
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia, EU
    J Leukoc Biol 78:122-34. 2005
    ..However, these interactions may occur extracellularly in lymph, as suggested by the large excess of CyC over secreted CatS, -L, and -H, and they may facilitate DC migration to lymph nodes...
  30. pmc In vitro study of stability and amyloid-fibril formation of two mutants of human stefin B (cystatin B) occurring in patients with EPM1
    Sabina Rabzelj
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Protein Sci 14:2713-22. 2005
    ..The G4R mutant exhibited a much longer lag phase than the wild type, with the accumulation of prefibrillar aggregates. Implications for pathology in view of the higher toxicity of prefibrillar aggregates to cells are discussed...
  31. ncbi request reprint Recombinant human cathepsin H lacking the mini chain is an endopeptidase
    Olga Vasiljeva
    Department of Biochemistry and Molecular Biology, Josef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Biochemistry 42:13522-8. 2003
    ..These results thus indicate that the cathepsin H mini chain is essential for the aminopeptidase activity of the enzyme but has only a minor effect on the inhibition by cystatins...
  32. pmc Inhibitory p41 isoform of invariant chain and its potential target enzymes cathepsins L and H in distinct populations of macrophages in human lymph nodes
    Valentina Zavasnik-Bergant
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    Immunology 112:378-85. 2004
    ....
  33. doi request reprint Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis
    Urska Pozgan
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    Biol Chem 391:571-9. 2010
    ..In addition to proteases, interleukin-6 was detected at significant levels in most samples, suggesting that proinflammatory cytokines might be in-volved in the stimulation of expression of these proteases during inflammation...
  34. ncbi request reprint Recombinant human procathepsin S is capable of autocatalytic processing at neutral pH in the presence of glycosaminoglycans
    Olga Vasiljeva
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    FEBS Lett 579:1285-90. 2005
    ..5. This novel property of procathepsin S may have implications in pathological conditions associated with the appearance of active cathepsins outside lysosomes...
  35. ncbi request reprint Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines
    Aleš Spes
    J Stefan Institute, Department of Biochemistry and Molecular and Structural Biology, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biol Chem 393:1417-31. 2012
    ....
  36. doi request reprint Recombinant human SMOCs produced by in vitro refolding: calcium-binding properties and interactions with serum proteins
    Marko Novinec
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    Protein Expr Purif 62:75-82. 2008
    ..Their identification is among the first pieces of information about the action of the SMOCs on molecular level and opens new possibilities for future research aimed towards elucidating the physiological roles of these versatile proteins...
  37. ncbi request reprint Inhibitory properties of cystatin F and its localization in U937 promonocyte cells
    Tomaz Langerholc
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    FEBS J 272:1535-45. 2005
    ..The finding that cystatin F was not colocalized with cystatin C suggests distinct functions for these two cysteine protease inhibitors in U937 cells...
  38. ncbi request reprint Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis
    Saska Ivanova
    Department of Biochemistry, Molecular and Structural Biology, J Stefan Institute, SI 1000, Ljubljana, Slovenia
    Biol Chem 388:1195-8. 2007
    ..When overexpressed in MDCK cells, both N- and C-terminal MAGI-1 caspase cleavage products exhibited minor proapoptotic activity, although their role in apoptosis is probably more passive...
  39. ncbi request reprint Cysteine cathepsins are not involved in Fas/CD95 signalling in primary skin fibroblasts
    Lea Bojic
    Department of Biochemistry, Molecular and Structural Biology, J Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    FEBS Lett 581:5185-90. 2007
    ..Moreover, Bid cleavage was found to be diminished in cathepsin B-deficient cells. These results suggest that cysteine cathepsins have no active role in Fas/CD95 apoptosis...
  40. doi request reprint Lysosomes and lysosomal cathepsins in cell death
    Urska Repnik
    Department of Biochemistry and Molecular and Structural Biology, J Stefan Institute, Jamova, Ljubljana, Slovenia
    Biochim Biophys Acta 1824:22-33. 2012
    ..This further suggests that lysosomes and lysosomal cathepsins have a dual role in cell death. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome...
  41. doi request reprint Cysteine cathepsins: from structure, function and regulation to new frontiers
    Vito Turk
    Department of Biochemistry and Molecular and Structural Biology, J Stefan Institute, Ljubljana, Slovenia
    Biochim Biophys Acta 1824:68-88. 2012
    ..In this review, some of the remarkable advances that have taken place in the past decade are presented. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome...
  42. ncbi request reprint Lysosomal cysteine proteases: structural features and their role in apoptosis
    Veronika Stoka
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Ljubljana, Slovenia
    IUBMB Life 57:347-53. 2005
    ..Special emphasis is given to the newly discovered role of lysosomal cathepsins in apoptotic pathways...
  43. doi request reprint A structural network associated with the kallikrein-kinin and renin-angiotensin systems
    Veronika Stoka
    Department of Biochemistry and Molecular and Structural Biology, J Stefan Institute, Ljubljana, Slovenia
    Biol Chem 391:443-54. 2010
    ..From the latter, all domain interactors up to level 4 were retrieved, thus displaying a more comprehensive representation of the KKS-RAS structural network...
  44. doi request reprint Cathepsin C and plasma glutamate carboxypeptidase secreted from Fischer rat thyroid cells liberate thyroxin from the N-terminus of thyroglobulin
    Dejan Suban
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biochimie 94:719-26. 2012
    ..Additionally, we show that TSH, insulin, and/or somatostatin induce up-regulation of N-acetylglucosaminyltransferase 1, the enzyme responsible for the initiation of biosynthesis of hybrid and complex N-glycosylation of proteins...
  45. ncbi request reprint Individual recombinant thyroglobulin type-1 domains are substrates for lysosomal cysteine proteinases
    Galina Pungercic
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1 000 Ljubljana, Slovenia
    Biol Chem 383:1809-12. 2002
    ..The cleavage points with cathepsins B and L on the second and the fourth domains were determined. The possible reasons for degradation are discussed...
  46. doi request reprint Mechanisms of amyloid fibril formation--focus on domain-swapping
    Eva Zerovnik
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    FEBS J 278:2263-82. 2011
    ..We classify these as: (a) templating and nucleation; (b) linear, colloid-like assembly of spherical oligomers; and (c) domain-swapping. In this review, we stress the role of domain-swapping and discuss the role of proline switches...
  47. ncbi request reprint Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro
    Ales Premzl
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Exp Cell Res 283:206-14. 2003
    ..Our results show that intracellular and extracellular cathepsin B activity contribute to in vitro invasion of MCF-10A neoT cells and suggest that inhibitors capable of impairing both fractions have a potential as new anticancer drugs...
  48. pmc Phylogenomic analysis of the cystatin superfamily in eukaryotes and prokaryotes
    Dusan Kordis
    Department of Biochemistry and Molecular and Structural Biology, J, Stefan Institute, Ljubljana, Slovenia
    BMC Evol Biol 9:266. 2009
    ..Our aim has been to obtain a comprehensive insight into their origin, distribution, diversity, evolution and classification in Eukaryota, Bacteria and Archaea...
  49. ncbi request reprint Lysosomal cysteine cathepsins: signaling pathways in apoptosis
    Veronika Stoka
    Department of Biochemistry and Molecular Biology, J Stefan Institute, SI 1000 Ljubljana, Slovenia
    Biol Chem 388:555-60. 2007
    ..Once in the cytosol, cathepsins can trigger cell death by different mechanisms. Here we discuss the different signaling pathways used by lysosomal proteases to trigger apoptosis and their potential role in physiological processes...
  50. ncbi request reprint Human cathepsin F: expression in baculovirus system, characterization and inhibition by protein inhibitors
    Marko Fonovic
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biol Chem 385:505-9. 2004
    ..7 nM). Stefin A inhibited cathepsin F slowly (kass=1.6 x 10(5) M(-1) s(-1)) and with a lower affinity (Ki=25 nM). These data suggest that cathepsin F differs from other related endopeptidases by considerably weaker inhibition by stefins...
  51. ncbi request reprint Metacaspases of Trypanosoma cruzi: possible candidates for programmed cell death mediators
    Gregor Kosec
    Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Mol Biochem Parasitol 145:18-28. 2006
    ..Further experiments will be required to complete the characterization of these proteins and elucidate their role in the parasite...
  52. pmc Protease signalling: the cutting edge
    Boris Turk
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    EMBO J 31:1630-43. 2012
    ..Similarly, links with other signalling systems are not well established. Herein, we will highlight current challenges in protease research...
  53. doi request reprint The proinflammatory cytokines interleukin-1α and tumor necrosis factor α promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes
    Dejan Caglic
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biol Chem 394:307-16. 2013
    ....
  54. ncbi request reprint Structural characterization of thyroglobulin type-1 domains of equistatin
    Katja Galesa
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    FEBS Lett 539:120-4. 2003
    ..In addition, we show that the interaction of eq d-2 with cathepsin D results in conformational changes, which is not the case for the eq d-1/papain interaction...
  55. doi request reprint Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment
    Georgy Mikhaylov
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, SI 1000 Ljubljana, Slovenia
    Nat Nanotechnol 6:594-602. 2011
    ....
  56. ncbi request reprint Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme
    Pika Mesko Brguljan
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, Ljubljana 1000, Slovenia
    Peptides 24:1977-84. 2003
    ....
  57. ncbi request reprint Protein aggregation as a possible cause for pathology in a subset of familial Unverricht-Lundborg disease
    Slavko Ceru
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Med Hypotheses 64:955-9. 2005
    ....
  58. ncbi request reprint Do lysosomes induce cell death?
    Veronika Stoka
    J Stefan Institute, Ljubljana, Slovenia
    IUBMB Life 58:493-4. 2006
  59. ncbi request reprint Diversity and evolution of the thyroglobulin type-1 domain superfamily
    Marko Novinec
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, Ljubljana, Slovenia
    Mol Biol Evol 23:744-55. 2006
    ....
  60. ncbi request reprint hDLG/SAP97, a member of the MAGUK protein family, is a novel caspase target during cell-cell detachment in apoptosis
    Uros Gregorc
    Department of Biochemistry and Molecular Biology, J Stefan Institute, SI 1000 Ljubljana, Slovenia
    Biol Chem 386:705-10. 2005
    ....
  61. ncbi request reprint Apoptotic pathways: involvement of lysosomal proteases
    Boris Turk
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    Biol Chem 383:1035-44. 2002
    ..However, there is increasing evidence that lysosomal proteases are also involved in apoptosis. In this review various lysosomal proteases and their potential contribution to propagation of apoptosis are discussed...
  62. ncbi request reprint Human stefin B readily forms amyloid fibrils in vitro
    Eva Zerovnik
    Department of Biochemistry and Molecular Biology, Institute Jozef Stefan, Jamova 39, 1000 Ljubljana, Slovenia
    Biochim Biophys Acta 1594:1-5. 2002
    ..The finding that human stefin B, in contrast to the homologue stefin A, forms amyloid fibrils rather easily should promote further studies of the protein's behaviour in vivo, and/or as a model system for fibrillogenesis...