Natasa Kopitar-Jerala

Summary

Affiliation: Jozef Stefan Institute
Country: Slovenia

Publications

  1. pmc The role of cysteine proteinases and their inhibitors in the host-pathogen cross talk
    Natasa Kopitar-Jerala
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Curr Protein Pept Sci 13:767-75. 2012
  2. ncbi request reprint Cleavage of the myristoylated alanine-rich C kinase substrate (MARCKS) by cysteine cathepsins in cells and tissues of stefin B-deficient mice
    Natasa Kopitar-Jerala
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biol Chem 388:847-52. 2007
  3. ncbi request reprint Sensitization of stefin B-deficient thymocytes towards staurosporin-induced apoptosis is independent of cysteine cathepsins
    Natasa Kopitar-Jerala
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    FEBS Lett 579:2149-55. 2005
  4. ncbi request reprint The role of cystatins in cells of the immune system
    Natasa Kopitar-Jerala
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    FEBS Lett 580:6295-301. 2006
  5. doi request reprint Size and morphology of toxic oligomers of amyloidogenic proteins: a case study of human stefin B
    Slavko Ceru
    Department of Biochemistry, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Amyloid 15:147-59. 2008
  6. doi request reprint Intracellular aggregation of human stefin B: confocal and electron microscopy study
    Slavko Ceru
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Biol Cell 102:319-34. 2010
  7. pmc Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L
    Spela Konjar
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    Immunology 131:257-67. 2010
  8. doi request reprint Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages
    Spela Konjar
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    FEBS Lett 584:2201-6. 2010
  9. pmc Interaction between oligomers of stefin B and amyloid-beta in vitro and in cells
    Katja Skerget
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, Slovenia
    J Biol Chem 285:3201-10. 2010
  10. pmc Stefin B interacts with histones and cathepsin L in the nucleus
    Slavko Ceru
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana SI 1000, Slovenia
    J Biol Chem 285:10078-86. 2010

Collaborators

Detail Information

Publications16

  1. pmc The role of cysteine proteinases and their inhibitors in the host-pathogen cross talk
    Natasa Kopitar-Jerala
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Curr Protein Pept Sci 13:767-75. 2012
    ..In this review, I provide an update on the most recent developments regarding the role of proteinases and their inhibitors in the initiation and regulation of immune responses...
  2. ncbi request reprint Cleavage of the myristoylated alanine-rich C kinase substrate (MARCKS) by cysteine cathepsins in cells and tissues of stefin B-deficient mice
    Natasa Kopitar-Jerala
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Biol Chem 388:847-52. 2007
    ..Processing of cathepsin B was unaltered in the brain of stefin B-deficient mice and we conclude that increased cleavage of MARCKS could be attributed to the lack of inhibitor...
  3. ncbi request reprint Sensitization of stefin B-deficient thymocytes towards staurosporin-induced apoptosis is independent of cysteine cathepsins
    Natasa Kopitar-Jerala
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    FEBS Lett 579:2149-55. 2005
    ..We conclude that sensitization to apoptosis induced by STS in thymocytes of stefin B-deficient and wild-type mice is not dependent on cathepsin inhibition by stefin B...
  4. ncbi request reprint The role of cystatins in cells of the immune system
    Natasa Kopitar-Jerala
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    FEBS Lett 580:6295-301. 2006
    ..The expression of cystatins A, B, C, and F in macrophages, dendritic cells and natural killer cells of the immune system, during differentiation and activation is discussed...
  5. doi request reprint Size and morphology of toxic oligomers of amyloidogenic proteins: a case study of human stefin B
    Slavko Ceru
    Department of Biochemistry, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Amyloid 15:147-59. 2008
    ..They also bound, similarly to prefibrillar aggregates, to the plasma membrane and became internalized. Taken together, our results confirm the importance of membrane interaction and perforation in the phenomenon of cytotoxicity...
  6. doi request reprint Intracellular aggregation of human stefin B: confocal and electron microscopy study
    Slavko Ceru
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Biol Cell 102:319-34. 2010
    ..Human StB proved to be a good model system to study amyloid fibril formation in vitro and, as we show here, to study protein aggregation in cells...
  7. pmc Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L
    Spela Konjar
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    Immunology 131:257-67. 2010
    ..We conclude that granule-bound cathepsins are essential for processing perforin to its active form, and that CatL is an important, but not exclusive, participant in this process...
  8. doi request reprint Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages
    Spela Konjar
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    FEBS Lett 584:2201-6. 2010
    ..Since only pro-inflammatory, but not anti-inflammatory stimuli induce increased nucleolar localization of SpiA3G, we propose that SpiA3g translocation into the nucleolus is important in host defense against pathogens...
  9. pmc Interaction between oligomers of stefin B and amyloid-beta in vitro and in cells
    Katja Skerget
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, Slovenia
    J Biol Chem 285:3201-10. 2010
    ..It also co-immunoprecipitates with the APP fragment containing the Abeta epitope. Thus, stefin B is another APP/Abeta-binding protein in vitro and likely in cells...
  10. pmc Stefin B interacts with histones and cathepsin L in the nucleus
    Slavko Ceru
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana SI 1000, Slovenia
    J Biol Chem 285:10078-86. 2010
    ..Stefin B could thus play an important role in regulating the proteolytic activity of cathepsin L in the nucleus, protecting substrates such as transcription factors from its proteolytic processing...
  11. ncbi request reprint Protein aggregation as a possible cause for pathology in a subset of familial Unverricht-Lundborg disease
    Slavko Ceru
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Med Hypotheses 64:955-9. 2005
    ....
  12. pmc Increased expression of stefin B in the nucleus of T98G astrocytoma cells delays caspase activation
    Tao Sun
    Department of Biochemistry, Molecular and Structural Biology, Jožef Stefan Institute Ljubljana, Slovenia Liaoning Cancer Hospital and Institute Shenyang, Liaoning, PR China
    Front Mol Neurosci 5:93. 2012
    ..We concluded that the delay of caspase activation in T98G cells overexpressing stefin B in the nucleus is independent of cathepsin inhibition...
  13. doi request reprint Influence of partial unfolding and aggregation of human stefin B (cystatin B) EPM1 mutants G50E and Q71P on selective cleavages by cathepsins B and S
    Mira Polajnar
    Jozef Stefan Institute, Department of Biochemistry, Molecular and Structural Biology, Jamova 39, 1000 Ljubljana, Slovenia
    Biol Chem 394:783-90. 2013
    ..We hypothesize that the aggregation of both full-length mutants prevents the cathepsin molecule from accessing the substrate protein's core, whereas the cleaved fragments would be expected to aggregate stronger...
  14. ncbi request reprint Amyloid fibril formation by human stefin B in vitro: immunogold labelling and comparison to stefin A
    Eva Zerovnik
    Department of Biochemistry and Molecular Biology, Institute Jozef Stefan, Ljubljana, Slovenia
    Biol Chem 383:859-63. 2002
    ..Samples were examined by transmission electron microscopy. Fibrils of stefin B were strongly labelled using polyclonal antibody and Protein A gold, whereas no positive reaction was observed with monoclonal antibody A6/2...
  15. ncbi request reprint Interaction of human stefin B in the prefibrillar oligomeric form with membranes. Correlation with cellular toxicity
    Gregor Anderluh
    Department of Biology, Biotechnical Faculty, University of Ljubljana, Slovenia
    FEBS J 272:3042-51. 2005
    ..This study is aimed to contribute to the general model of cellular toxicity induced by prefibrillar oligomers of amyloidogenic proteins, not necessarily involved in pathology...
  16. ncbi request reprint A novel caspase-7 specific monoclonal antibody
    Uros Gregorc
    Immunol Lett 98:167-9. 2005