G Sersa

Summary

Affiliation: Institute of Oncology
Country: Slovenia

Publications

  1. pmc Magnetofection: a reproducible method for gene delivery to melanoma cells
    Lara Prosen
    Kolektor Group, Nanotesla Institute Ljubljana, Stegne 29, 1521 Ljubljana, Slovenia
    Biomed Res Int 2013:209452. 2013
  2. pmc Potentiation of electrochemotherapy by intramuscular IL-12 gene electrotransfer in murine sarcoma and carcinoma with different immunogenicity
    Ales Sedlar
    Institute of Oncology Ljubljana, Department of Experimental Oncology, Ljubljana, Slovenia
    Radiol Oncol 46:302-11. 2012
  3. pmc IL-12 based gene therapy in veterinary medicine
    Darja Pavlin
    University of Ljubljana, Veterinary Faculty, Small Animal Clinic, Cesta v Mestni log 47, Ljubljana, 1000, Slovenia
    J Transl Med 10:234. 2012
  4. pmc Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcoma
    Ales Sedlar
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
    BMC Cancer 13:38. 2013
  5. doi request reprint Electrochemotherapy of chest wall breast cancer recurrence
    Gregor Sersa
    Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Cancer Treat Rev 38:379-86. 2012
  6. pmc The effect of electroporation pulses on functioning of the heart
    Barbara Mali
    Laboratory of Biocybernetics, Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, 1000, Ljubljana, Slovenia
    Med Biol Eng Comput 46:745-57. 2008
  7. pmc Increased cellular uptake of biocompatible superparamagnetic iron oxide nanoparticles into malignant cells by an external magnetic field
    Sara Prijic
    Kolektor Group, Nanotesla Institute, Stegne 29, 1521, Ljubljana, Slovenia
    J Membr Biol 236:167-79. 2010
  8. pmc Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy
    Damijan Miklavcic
    Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Biomed Eng Online 9:10. 2010
  9. pmc Electric pulses used in electrochemotherapy and electrogene therapy do not significantly change the expression profile of genes involved in the development of cancer in malignant melanoma cells
    Vid Mlakar
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, Ljubljana, Slovenia
    BMC Cancer 9:299. 2009
  10. pmc Radiosensitising effect of electrochemotherapy with bleomycin in LPB sarcoma cells and tumors in mice
    Simona Kranjc
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    BMC Cancer 5:115. 2005

Collaborators

Detail Information

Publications44

  1. pmc Magnetofection: a reproducible method for gene delivery to melanoma cells
    Lara Prosen
    Kolektor Group, Nanotesla Institute Ljubljana, Stegne 29, 1521 Ljubljana, Slovenia
    Biomed Res Int 2013:209452. 2013
    ..To achieve high gene expression is important, however, the pH of PEI water solution for SPIONs-PAA functionalization, which should be in the alkaline range. ..
  2. pmc Potentiation of electrochemotherapy by intramuscular IL-12 gene electrotransfer in murine sarcoma and carcinoma with different immunogenicity
    Ales Sedlar
    Institute of Oncology Ljubljana, Department of Experimental Oncology, Ljubljana, Slovenia
    Radiol Oncol 46:302-11. 2012
    ....
  3. pmc IL-12 based gene therapy in veterinary medicine
    Darja Pavlin
    University of Ljubljana, Veterinary Faculty, Small Animal Clinic, Cesta v Mestni log 47, Ljubljana, 1000, Slovenia
    J Transl Med 10:234. 2012
    ..Hopefully, such results will lead to further investigation of this therapy in veterinary medicine and successful translation into human clinical trials...
  4. pmc Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcoma
    Ales Sedlar
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
    BMC Cancer 13:38. 2013
    ....
  5. doi request reprint Electrochemotherapy of chest wall breast cancer recurrence
    Gregor Sersa
    Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Cancer Treat Rev 38:379-86. 2012
    ..With development of the technology electrochemotherapy could even be suggested as a primary local therapy in patients not suitable for surgical removal of the primary tumor...
  6. pmc The effect of electroporation pulses on functioning of the heart
    Barbara Mali
    Laboratory of Biocybernetics, Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, 1000, Ljubljana, Slovenia
    Med Biol Eng Comput 46:745-57. 2008
    ....
  7. pmc Increased cellular uptake of biocompatible superparamagnetic iron oxide nanoparticles into malignant cells by an external magnetic field
    Sara Prijic
    Kolektor Group, Nanotesla Institute, Stegne 29, 1521, Ljubljana, Slovenia
    J Membr Biol 236:167-79. 2010
    ..Their cellular uptake was dependent on the cell type, and their accumulation within the cells was dependent on the duration of exposure to an external magnetic field...
  8. pmc Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy
    Damijan Miklavcic
    Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Biomed Eng Online 9:10. 2010
    ..Electrochemotherapy has been successfully used for treatment of easily accessible superficial tumor nodules. In this paper, we present the first case of deep-seated tumor electrochemotherapy based on numerical treatment planning...
  9. pmc Electric pulses used in electrochemotherapy and electrogene therapy do not significantly change the expression profile of genes involved in the development of cancer in malignant melanoma cells
    Vid Mlakar
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, Ljubljana, Slovenia
    BMC Cancer 9:299. 2009
    ..We studied the effect of ECT and EGT pulses on human malignant melanoma cells in vitro in order to understand and predict the possible effect of electric pulses on gene expression and their possible effect on cell behaviour...
  10. pmc Radiosensitising effect of electrochemotherapy with bleomycin in LPB sarcoma cells and tumors in mice
    Simona Kranjc
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    BMC Cancer 5:115. 2005
    ..The aim of the study was to evaluate whether a physical drug delivery system - electroporation can increase radiosensitising effect of bleomycin in vitro and in vivo...
  11. pmc Direct visualization of electroporation-assisted in vivo gene delivery to tumors using intravital microscopy - spatial and time dependent distribution
    Maja Cemazar
    Department of Experimental Oncology, Institute of Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
    BMC Cancer 4:81. 2004
    ..Intravital microscopy of tumors growing in dorsal skin fold window chambers is a useful method for monitoring gene transfection, since it allows non-invasive dynamic monitoring of gene expression in tumors in a live animal...
  12. pmc Vascular disrupting action of electroporation and electrochemotherapy with bleomycin in murine sarcoma
    G Sersa
    Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Br J Cancer 98:388-98. 2008
    ....
  13. doi request reprint Electrochemotherapy of mouse sarcoma tumors using electric pulse trains with repetition frequencies of 1 Hz and 5 kHz
    G Sersa
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska c 2, 1000, Ljubljana, Slovenia
    J Membr Biol 236:155-62. 2010
    ..These differences are observed at suboptimal drug doses, whereas at optimal drug doses of bleomycin or cisplatin the antitumor effectiveness is the same, as demonstrated in clinical trials...
  14. ncbi request reprint Electrochemotherapy with cisplatin: clinical experience in malignant melanoma patients
    G Sersa
    Institute of Oncology and Faculty of Electrical Engineering, University of Ljubljana, Slovenia
    Clin Cancer Res 6:863-7. 2000
    ..The advantages of this therapy include its simplicity, the short duration of treatment sessions, low cisplatin doses, and insignificant side effects, as well as the fact that it can be done on an outpatient basis...
  15. pmc Reduced blood flow and oxygenation in SA-1 tumours after electrochemotherapy with cisplatin
    G Sersa
    Laboratory of Radiation Biology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Br J Cancer 87:1047-54. 2002
    ....
  16. ncbi request reprint Tumour blood flow changes induced by application of electric pulses
    G Sersa
    Department of Tumour Biology, Institute of Oncology, Ljubljana, Slovenia
    Eur J Cancer 35:672-7. 1999
    ..Tumour blood flow reduction by electric pulses could have potential in exploiting modalities mediated by tumour hypoxia, e.g. activation of bioreductive agents...
  17. ncbi request reprint Tumor blood flow modifying effect of electrochemotherapy with bleomycin
    G Sersa
    Institute of Oncology Ljubljana, Department of Tumor Biology, Slovenia
    Anticancer Res 19:4017-22. 1999
    ..The aim of this study was to determine the tumor blood flow modifying effect of electrochemotherapy with bleomycin and correlate it with its antitumor effectiveness and extent of tumor necrosis...
  18. ncbi request reprint Improvement of combined modality therapy with cisplatin and radiation using electroporation of tumors
    G Sersa
    Department of Tumor Biology, Institute of Oncology, Ljubljana, Slovenia
    Int J Radiat Oncol Biol Phys 46:1037-41. 2000
    ..To evaluate whether a local drug delivery method, i.e., electroporation of tumors, increases the radiosensitizing effect of cisplatin...
  19. ncbi request reprint Electrochemotherapy with bleomycin in the treatment of hypernephroma metastasis: case report and literature review
    G Sersa
    Institute of Oncology, Ljubljana, Slovenia
    Tumori 86:163-5. 2000
    ..This treatment resulted in stabilization of the tumor volume for 12 months, whereas the subcutaneous metastasis next to the electrochemotherapy-treated one that did not receive electric pulses progressed immediately...
  20. ncbi request reprint Reduced tumor oxygenation by treatment with vinblastine
    G Sersa
    Department of Tumor Biology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Cancer Res 61:4266-71. 2001
    ....
  21. ncbi request reprint Electrochemotherapy with cisplatin: the systemic antitumour effectiveness of cisplatin can be potentiated locally by the application of electric pulses in the treatment of malignant melanoma skin metastases
    G Sersa
    Institute of Oncology, Ljubljana, Slovenia
    Melanoma Res 10:381-5. 2000
    ..Therefore, electrochemotherapy may be used as an adjunct to systemic ongoing cisplatin treatment, predominantly in patients in whom antitumour effectiveness needs to be potentiated locally...
  22. doi request reprint Control by pulse parameters of DNA electrotransfer into solid tumors in mice
    M Cemazar
    Department of Experimental Oncology, Institute of Oncology, Ljubljana, Slovenia
    Gene Ther 16:635-44. 2009
    ....
  23. doi request reprint Antitumor effectiveness of electrochemotherapy: a systematic review and meta-analysis
    B Mali
    Department of Biomedical Engineering, Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, SI 1000 Ljubljana, Slovenia
    Eur J Surg Oncol 39:4-16. 2013
    ....
  24. pmc Electroporation of human microvascular endothelial cells: evidence for an anti-vascular mechanism of electrochemotherapy
    M Cemazar
    Department of Tumor Biology, Institute of Oncology, Zaloska 2, SI 1000, Ljubljana, Slovenia
    Br J Cancer 84:565-70. 2001
    ..Further studies are necessary to identify the determinants of endothelial response and its relationship to the anti-vascular action of electrochemotherapy in vivo...
  25. pmc Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with cisplatin
    M Cemazar
    Institute of Oncology, Ljubljana, Slovenia
    Br J Cancer 79:1386-91. 1999
    ..In addition, besides electroporation, immune system and tumour blood flow changes could be involved in the observed anti-tumour effectiveness of electrochemotherapy...
  26. ncbi request reprint The effect of the histological properties of tumors on transfection efficiency of electrically assisted gene delivery to solid tumors in mice
    S Mesojednik
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, Ljubljana, Slovenia
    Gene Ther 14:1261-9. 2007
    ..Therefore, knowledge about the histology of tumors is important in planning electrogene therapy with respect to the time interval between DNA injection and electroporation...
  27. ncbi request reprint Cytotoxicity of bioreductive drug tirapazamine is increased by application of electric pulses in SA-1 tumours in mice
    M Cemazar
    Department of Tumor Biology, Institute of Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Anticancer Res 21:1151-6. 2001
    ..The effect is more likely to be attributed to increased tumour hypoxia as a consequence of reduced tumour blood flow induced by application of electric pulses...
  28. pmc Muscle gene electrotransfer is increased by the antioxidant tempol in mice
    B Markelc
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
    Gene Ther 19:312-20. 2012
    ..4-fold by tempol. The study indicates that ROS are generated on cells during EP and can be scavenged by antioxidants. Specifically, tempol can be used to improve gene electrotransfer into the muscle and possibly also to other tissues...
  29. ncbi request reprint Electrochemotherapy: potentiation of local antitumour effectiveness of cisplatin in dogs and cats
    N Tozon
    University of Ljubljana, Veterinary Faculty, Small Animal Clinic, Slovenia
    Anticancer Res 21:2483-8. 2001
    ..046). This study showed that electrochemotherapy with cisplatin is an effective, safe and simple local treatment of different histological types of cutaneous and subcutaneous tumours in cats and dogs...
  30. ncbi request reprint Electrochemotherapy of tumours resistant to cisplatin: a study in a murine tumour model
    M Cemazar
    Department of Tumor Biology, Institute of Oncology, Zaloska 2, SI 1000, Ljubljana, Slovenia
    Eur J Cancer 37:1166-72. 2001
    ..In conclusion, electrochemotherapy is an effective treatment of cisplatin-resistant solid tumours and may prove useful in clinical chemotherapy for the treatment of tumours with intrinsic or acquired resistance to cisplatin...
  31. doi request reprint MicroRNAs targeting mutant K-ras by electrotransfer inhibit human colorectal adenocarcinoma cell growth in vitro and in vivo
    S Vidic
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
    Cancer Gene Ther 17:409-19. 2010
    ..The obtained results demonstrate that electrogene therapy with miRNA-K-ras molecules can be potential therapeutic strategy for treatment of colorectal cancers harboring K-ras mutations...
  32. ncbi request reprint Efficient electrotransfection into canine muscle
    D Pavlin
    University of Ljubljana, Veterinary Faculty Ljubljana, Gerbiceva 60, SI 1000 Ljubljana, Slovenia
    Technol Cancer Res Treat 7:45-54. 2008
    ..The results indicate that electrotransfection is a feasible, effective, and safe method for muscle targeted gene therapy in dogs, which could have potential for clinical applications in veterinary medicine of small animals...
  33. doi request reprint Gene electrotransfer of siRNAs against CD146 inhibits migration and invasion of human malignant melanoma cells SK-MEL28
    V Todorovic
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, Ljubljana, Slovenia
    Cancer Gene Ther 20:208-10. 2013
    ..CD146 is therefore a potential target for the development of adjuvant therapies for metastatic melanoma...
  34. ncbi request reprint Effect of hydralazine on interstitial fluid pressure in experimental tumours and in normal tissue
    B Podobnik
    University of Ljubljana, Faculty of Electrical Engineering, Trzaska 25, 1000 Ljubljana, Slovenia
    In Vivo 15:417-24. 2001
    ..The initial IFP in tumour is positively-correlated with the tumour size, while the decrease in the tumour IFP is independent of the initial IFP value. In addition, the decrease in tumour IFP is not correlated to tumour volume...
  35. ncbi request reprint Electrochemotherapy: a new technological approach in treatment of metastases in the liver
    I Edhemovic
    Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Technol Cancer Res Treat 10:475-85. 2011
    ....
  36. ncbi request reprint Electrochemotherapy in treatment of tumours
    G Sersa
    Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Eur J Surg Oncol 34:232-40. 2008
    ....
  37. ncbi request reprint Determination of platinum in tumour tissues after cisplatin therapy by electrothermal atomic absorption spectrometry
    R Milacic
    Jozef Stefan Institute, Ljubljana, Slovenia
    J Pharm Biomed Anal 16:343-8. 1997
    ..In 72% of samples analysed the differences between results obtained by the two calibration procedures did not exceed +/- 5%...
  38. pmc Electrochemotherapy: technological advancements for efficient electroporation-based treatment of internal tumors
    D Miklavcic
    Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia
    Med Biol Eng Comput 50:1213-25. 2012
    ..The first clinical experiences in these novel application areas of electrochemotherapy are also described...
  39. doi request reprint Electrochemotherapy of solid tumors--preclinical and clinical experience
    G Sersa
    Institute of Oncology Ljubljana, Ljubljana, Slovenia
    Conf Proc IEEE Eng Med Biol Soc 2011:728-31. 2011
    ..With long needle electrodes and new electric pulse generators, clinical trials are on-going for treatment of liver metastases, bone metastases and soft tissue sarcomas...
  40. doi request reprint Electrochemotherapy in veterinary oncology
    M Cemazar
    Institute of Oncology Ljubljana, University of Ljubljana, Ljubljana, Slovenia the Ecole Vétérinaire de Toulouse, Toulouse, France
    J Vet Intern Med 22:826-31. 2008
    ....
  41. ncbi request reprint Electrically-assisted nucleic acids delivery to tissues in vivo: where do we stand?
    M Cemazar
    IPBS CNRS, UMR 5089, 205, route de Narbonne, 31077 Toulouse Cedex, France
    Curr Pharm Des 12:3817-25. 2006
    ..In the long run, this review should encourage other scientists to consider electrically assisted gene delivery for gene therapy as it matures...