Research Topics
| G SersaSummaryAffiliation: Institute of Oncology Country: Slovenia Publications
| Collaborators
|
Detail Information
Publications
Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcomaAles Sedlar
Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
BMC Cancer 13:38. 2013....
Electrochemotherapy of chest wall breast cancer recurrenceGregor Sersa
Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
Cancer Treat Rev 38:379-86. 2012..With development of the technology electrochemotherapy could even be suggested as a primary local therapy in patients not suitable for surgical removal of the primary tumor...- The effect of electroporation pulses on functioning of the heartBarbara Mali
Laboratory of Biocybernetics, Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, 1000, Ljubljana, Slovenia
Med Biol Eng Comput 46:745-57. 2008.... - Increased cellular uptake of biocompatible superparamagnetic iron oxide nanoparticles into malignant cells by an external magnetic fieldSara Prijic
Kolektor Group, Nanotesla Institute, Stegne 29, 1521, Ljubljana, Slovenia
J Membr Biol 236:167-79. 2010..Their cellular uptake was dependent on the cell type, and their accumulation within the cells was dependent on the duration of exposure to an external magnetic field... - Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapyDamijan Miklavcic
Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
Biomed Eng Online 9:10. 2010..Electrochemotherapy has been successfully used for treatment of easily accessible superficial tumor nodules. In this paper, we present the first case of deep-seated tumor electrochemotherapy based on numerical treatment planning... - Electric pulses used in electrochemotherapy and electrogene therapy do not significantly change the expression profile of genes involved in the development of cancer in malignant melanoma cellsVid Mlakar
Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, Ljubljana, Slovenia
BMC Cancer 9:299. 2009..We studied the effect of ECT and EGT pulses on human malignant melanoma cells in vitro in order to understand and predict the possible effect of electric pulses on gene expression and their possible effect on cell behaviour... - Radiosensitising effect of electrochemotherapy with bleomycin in LPB sarcoma cells and tumors in miceSimona Kranjc
Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
BMC Cancer 5:115. 2005..The aim of the study was to evaluate whether a physical drug delivery system - electroporation can increase radiosensitising effect of bleomycin in vitro and in vivo... - Direct visualization of electroporation-assisted in vivo gene delivery to tumors using intravital microscopy - spatial and time dependent distributionMaja Cemazar
Department of Experimental Oncology, Institute of Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
BMC Cancer 4:81. 2004..Intravital microscopy of tumors growing in dorsal skin fold window chambers is a useful method for monitoring gene transfection, since it allows non-invasive dynamic monitoring of gene expression in tumors in a live animal... 
Electrochemotherapy with cisplatin: clinical experience in malignant melanoma patientsG Sersa
Institute of Oncology and Faculty of Electrical Engineering, University of Ljubljana, Slovenia
Clin Cancer Res 6:863-7. 2000..The advantages of this therapy include its simplicity, the short duration of treatment sessions, low cisplatin doses, and insignificant side effects, as well as the fact that it can be done on an outpatient basis...- Vascular disrupting action of electroporation and electrochemotherapy with bleomycin in murine sarcomaG Sersa
Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
Br J Cancer 98:388-98. 2008.... - Electrochemotherapy with bleomycin in the treatment of hypernephroma metastasis: case report and literature reviewG Sersa
Institute of Oncology, Ljubljana, Slovenia
Tumori 86:163-5. 2000..This treatment resulted in stabilization of the tumor volume for 12 months, whereas the subcutaneous metastasis next to the electrochemotherapy-treated one that did not receive electric pulses progressed immediately... - Reduced blood flow and oxygenation in SA-1 tumours after electrochemotherapy with cisplatinG Sersa
Laboratory of Radiation Biology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
Br J Cancer 87:1047-54. 2002.... - Tumor blood flow modifying effect of electrochemotherapy with bleomycinG Sersa
Institute of Oncology Ljubljana, Department of Tumor Biology, Slovenia
Anticancer Res 19:4017-22. 1999..The aim of this study was to determine the tumor blood flow modifying effect of electrochemotherapy with bleomycin and correlate it with its antitumor effectiveness and extent of tumor necrosis... - Electrochemotherapy with cisplatin: the systemic antitumour effectiveness of cisplatin can be potentiated locally by the application of electric pulses in the treatment of malignant melanoma skin metastasesG Sersa
Institute of Oncology, Ljubljana, Slovenia
Melanoma Res 10:381-5. 2000..Therefore, electrochemotherapy may be used as an adjunct to systemic ongoing cisplatin treatment, predominantly in patients in whom antitumour effectiveness needs to be potentiated locally... - Tumour blood flow changes induced by application of electric pulsesG Sersa
Department of Tumour Biology, Institute of Oncology, Ljubljana, Slovenia
Eur J Cancer 35:672-7. 1999..Tumour blood flow reduction by electric pulses could have potential in exploiting modalities mediated by tumour hypoxia, e.g. activation of bioreductive agents... - Electrochemotherapy of mouse sarcoma tumors using electric pulse trains with repetition frequencies of 1 Hz and 5 kHzG Sersa
Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska c 2, 1000, Ljubljana, Slovenia
J Membr Biol 236:155-62. 2010..These differences are observed at suboptimal drug doses, whereas at optimal drug doses of bleomycin or cisplatin the antitumor effectiveness is the same, as demonstrated in clinical trials... - Reduced tumor oxygenation by treatment with vinblastineG Sersa
Department of Tumor Biology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
Cancer Res 61:4266-71. 2001.... - Improvement of combined modality therapy with cisplatin and radiation using electroporation of tumorsG Sersa
Department of Tumor Biology, Institute of Oncology, Ljubljana, Slovenia
Int J Radiat Oncol Biol Phys 46:1037-41. 2000..To evaluate whether a local drug delivery method, i.e., electroporation of tumors, increases the radiosensitizing effect of cisplatin... - Control by pulse parameters of DNA electrotransfer into solid tumors in miceM Cemazar
Department of Experimental Oncology, Institute of Oncology, Ljubljana, Slovenia
Gene Ther 16:635-44. 2009.... - Antitumor effectiveness of electrochemotherapy: a systematic review and meta-analysisB Mali
Department of Biomedical Engineering, Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, SI 1000 Ljubljana, Slovenia
Eur J Surg Oncol 39:4-16. 2013.... - Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with cisplatinM Cemazar
Institute of Oncology, Ljubljana, Slovenia
Br J Cancer 79:1386-91. 1999..In addition, besides electroporation, immune system and tumour blood flow changes could be involved in the observed anti-tumour effectiveness of electrochemotherapy... - Electroporation of human microvascular endothelial cells: evidence for an anti-vascular mechanism of electrochemotherapyM Cemazar
Department of Tumor Biology, Institute of Oncology, Zaloska 2, SI 1000, Ljubljana, Slovenia
Br J Cancer 84:565-70. 2001..Further studies are necessary to identify the determinants of endothelial response and its relationship to the anti-vascular action of electrochemotherapy in vivo... - Cytotoxicity of bioreductive drug tirapazamine is increased by application of electric pulses in SA-1 tumours in miceM Cemazar
Department of Tumor Biology, Institute of Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
Anticancer Res 21:1151-6. 2001..The effect is more likely to be attributed to increased tumour hypoxia as a consequence of reduced tumour blood flow induced by application of electric pulses... - The effect of the histological properties of tumors on transfection efficiency of electrically assisted gene delivery to solid tumors in miceS Mesojednik
Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, Ljubljana, Slovenia
Gene Ther 14:1261-9. 2007..Therefore, knowledge about the histology of tumors is important in planning electrogene therapy with respect to the time interval between DNA injection and electroporation... - Electrochemotherapy: potentiation of local antitumour effectiveness of cisplatin in dogs and catsN Tozon
University of Ljubljana, Veterinary Faculty, Small Animal Clinic, Slovenia
Anticancer Res 21:2483-8. 2001..046). This study showed that electrochemotherapy with cisplatin is an effective, safe and simple local treatment of different histological types of cutaneous and subcutaneous tumours in cats and dogs... - Muscle gene electrotransfer is increased by the antioxidant tempol in miceB Markelc
Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Gene Ther 19:312-20. 2012..4-fold by tempol. The study indicates that ROS are generated on cells during EP and can be scavenged by antioxidants. Specifically, tempol can be used to improve gene electrotransfer into the muscle and possibly also to other tissues... - Electrochemotherapy of tumours resistant to cisplatin: a study in a murine tumour modelM Cemazar
Department of Tumor Biology, Institute of Oncology, Zaloska 2, SI 1000, Ljubljana, Slovenia
Eur J Cancer 37:1166-72. 2001..In conclusion, electrochemotherapy is an effective treatment of cisplatin-resistant solid tumours and may prove useful in clinical chemotherapy for the treatment of tumours with intrinsic or acquired resistance to cisplatin... - MicroRNAs targeting mutant K-ras by electrotransfer inhibit human colorectal adenocarcinoma cell growth in vitro and in vivoS Vidic
Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Cancer Gene Ther 17:409-19. 2010..The obtained results demonstrate that electrogene therapy with miRNA-K-ras molecules can be potential therapeutic strategy for treatment of colorectal cancers harboring K-ras mutations... - Electrochemotherapy: a new technological approach in treatment of metastases in the liverI Edhemovic
Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
Technol Cancer Res Treat 10:475-85. 2011.... - Effect of hydralazine on interstitial fluid pressure in experimental tumours and in normal tissueB Podobnik
University of Ljubljana, Faculty of Electrical Engineering, Trzaska 25, 1000 Ljubljana, Slovenia
In Vivo 15:417-24. 2001..The initial IFP in tumour is positively-correlated with the tumour size, while the decrease in the tumour IFP is independent of the initial IFP value. In addition, the decrease in tumour IFP is not correlated to tumour volume... - Electrochemotherapy in treatment of tumoursG Sersa
Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
Eur J Surg Oncol 34:232-40. 2008.... - Efficient electrotransfection into canine muscleD Pavlin
University of Ljubljana, Veterinary Faculty Ljubljana, Gerbiceva 60, SI 1000 Ljubljana, Slovenia
Technol Cancer Res Treat 7:45-54. 2008..The results indicate that electrotransfection is a feasible, effective, and safe method for muscle targeted gene therapy in dogs, which could have potential for clinical applications in veterinary medicine of small animals... - Determination of platinum in tumour tissues after cisplatin therapy by electrothermal atomic absorption spectrometryR Milacic
Jozef Stefan Institute, Ljubljana, Slovenia
J Pharm Biomed Anal 16:343-8. 1997..In 72% of samples analysed the differences between results obtained by the two calibration procedures did not exceed +/- 5%... - Electrochemotherapy of solid tumors--preclinical and clinical experienceG Sersa
Institute of Oncology Ljubljana, Ljubljana, Slovenia
Conf Proc IEEE Eng Med Biol Soc 2011:728-31. 2011..With long needle electrodes and new electric pulse generators, clinical trials are on-going for treatment of liver metastases, bone metastases and soft tissue sarcomas... - Electrochemotherapy in veterinary oncologyM Cemazar
Institute of Oncology Ljubljana, University of Ljubljana, Ljubljana, Slovenia the Ecole Vétérinaire de Toulouse, Toulouse, France
J Vet Intern Med 22:826-31. 2008.... - Electrochemotherapy: technological advancements for efficient electroporation-based treatment of internal tumorsD Miklavcic
Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia
Med Biol Eng Comput 50:1213-25. 2012..The first clinical experiences in these novel application areas of electrochemotherapy are also described... - Gene electrotransfer of siRNAs against CD146 inhibits migration and invasion of human malignant melanoma cells SK-MEL28V Todorovic
Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, Ljubljana, Slovenia
Cancer Gene Ther 20:208-10. 2013..CD146 is therefore a potential target for the development of adjuvant therapies for metastatic melanoma... - Electrically-assisted nucleic acids delivery to tissues in vivo: where do we stand?M Cemazar
IPBS CNRS, UMR 5089, 205, route de Narbonne, 31077 Toulouse Cedex, France
Curr Pharm Des 12:3817-25. 2006..In the long run, this review should encourage other scientists to consider electrically assisted gene delivery for gene therapy as it matures...