M Cemazar

Summary

Affiliation: Institute of Oncology
Country: Slovenia

Publications

  1. pmc Electric pulses used in electrochemotherapy and electrogene therapy do not significantly change the expression profile of genes involved in the development of cancer in malignant melanoma cells
    Vid Mlakar
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, Ljubljana, Slovenia
    BMC Cancer 9:299. 2009
  2. ncbi request reprint Schedule-dependent interaction between vinblastine and irradiation in experimental sarcoma
    Maja Cemazar
    Institute of Oncology Ljubljana, Zaloska 2, 1000, Ljubljana, Slovenia
    Strahlenther Onkol 190:661-6. 2014
  3. pmc Multiple delivery of siRNA against endoglin into murine mammary adenocarcinoma prevents angiogenesis and delays tumor growth
    Tanja Dolinsek
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
    PLoS ONE 8:e58723. 2013
  4. pmc Differential mechanisms associated with vascular disrupting action of electrochemotherapy: intravital microscopy on the level of single normal and tumor blood vessels
    Bostjan Markelc
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
    PLoS ONE 8:e59557. 2013
  5. pmc Evaluation of p21 promoter for interleukin 12 radiation induced transcriptional targeting in a mouse tumor model
    Urska Kamensek
    Institute of Oncology Ljubljana, Ljubljana, Slovenia
    Mol Cancer 12:136. 2013
  6. pmc IL-12 based gene therapy in veterinary medicine
    Darja Pavlin
    University of Ljubljana, Veterinary Faculty, Small Animal Clinic, Cesta v Mestni log 47, Ljubljana, 1000, Slovenia
    J Transl Med 10:234. 2012
  7. pmc In vivo molecular imaging and histological analysis of changes induced by electric pulses used for plasmid DNA electrotransfer to the skin: a study in a dorsal window chamber in mice
    Bostjan Markelc
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, 1000 Ljubljana, Slovenia
    J Membr Biol 245:545-54. 2012
  8. pmc Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcoma
    Ales Sedlar
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
    BMC Cancer 13:38. 2013
  9. pmc Hyaluronidase and collagenase increase the transfection efficiency of gene electrotransfer in various murine tumors
    Maja Cemazar
    Department of Experimental Oncology, Institute of Oncology Ljubljana, SI 1000 Ljubljana, Slovenia
    Hum Gene Ther 23:128-37. 2012
  10. pmc Irradiation, cisplatin, and 5-azacytidine upregulate cytomegalovirus promoter in tumors and muscles: implementation of non-invasive fluorescence imaging
    Urska Kamensek
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Mol Imaging Biol 13:43-52. 2011

Collaborators

Detail Information

Publications74

  1. pmc Electric pulses used in electrochemotherapy and electrogene therapy do not significantly change the expression profile of genes involved in the development of cancer in malignant melanoma cells
    Vid Mlakar
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, Ljubljana, Slovenia
    BMC Cancer 9:299. 2009
    ..We studied the effect of ECT and EGT pulses on human malignant melanoma cells in vitro in order to understand and predict the possible effect of electric pulses on gene expression and their possible effect on cell behaviour...
  2. ncbi request reprint Schedule-dependent interaction between vinblastine and irradiation in experimental sarcoma
    Maja Cemazar
    Institute of Oncology Ljubljana, Zaloska 2, 1000, Ljubljana, Slovenia
    Strahlenther Onkol 190:661-6. 2014
    ..The aim of our study was to evaluate the dose- and time-dependent interactions between split-dose VLB treatment (mimicking prolonged infusion) and IR of sarcoma SA-1 tumours in A/J mice...
  3. pmc Multiple delivery of siRNA against endoglin into murine mammary adenocarcinoma prevents angiogenesis and delays tumor growth
    Tanja Dolinsek
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
    PLoS ONE 8:e58723. 2013
    ..The obtained results demonstrate that silencing of endoglin is a promising antiangiogenic therapy of tumors that could not be used as single treatment, but as an adjunct to the established cytotoxic treatment approaches...
  4. pmc Differential mechanisms associated with vascular disrupting action of electrochemotherapy: intravital microscopy on the level of single normal and tumor blood vessels
    Bostjan Markelc
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
    PLoS ONE 8:e59557. 2013
    ..The study confirms the current model of tumor blood flow modifying effects of EP and provides conclusive evidence that ECT is a vascular disrupting therapy with a specific effect on the tumor blood vessels...
  5. pmc Evaluation of p21 promoter for interleukin 12 radiation induced transcriptional targeting in a mouse tumor model
    Urska Kamensek
    Institute of Oncology Ljubljana, Ljubljana, Slovenia
    Mol Cancer 12:136. 2013
    ....
  6. pmc IL-12 based gene therapy in veterinary medicine
    Darja Pavlin
    University of Ljubljana, Veterinary Faculty, Small Animal Clinic, Cesta v Mestni log 47, Ljubljana, 1000, Slovenia
    J Transl Med 10:234. 2012
    ..Hopefully, such results will lead to further investigation of this therapy in veterinary medicine and successful translation into human clinical trials...
  7. pmc In vivo molecular imaging and histological analysis of changes induced by electric pulses used for plasmid DNA electrotransfer to the skin: a study in a dorsal window chamber in mice
    Bostjan Markelc
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, 1000 Ljubljana, Slovenia
    J Membr Biol 245:545-54. 2012
    ..When combined with plasmid DNA for vaccination, this could enable the initial and prolonged contact of immune cells with encoded therapeutic proteins...
  8. pmc Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcoma
    Ales Sedlar
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
    BMC Cancer 13:38. 2013
    ....
  9. pmc Hyaluronidase and collagenase increase the transfection efficiency of gene electrotransfer in various murine tumors
    Maja Cemazar
    Department of Experimental Oncology, Institute of Oncology Ljubljana, SI 1000 Ljubljana, Slovenia
    Hum Gene Ther 23:128-37. 2012
    ....
  10. pmc Irradiation, cisplatin, and 5-azacytidine upregulate cytomegalovirus promoter in tumors and muscles: implementation of non-invasive fluorescence imaging
    Urska Kamensek
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Mol Imaging Biol 13:43-52. 2011
    ..The aim of our study was to evaluate the role of methylation and upregulation of the CMV promoter by irradiation and the chemotherapeutic agent cisplatin in vivo using non-invasive fluorescence in vivo imaging...
  11. pmc The effect of electroporation pulses on functioning of the heart
    Barbara Mali
    Laboratory of Biocybernetics, Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, 1000, Ljubljana, Slovenia
    Med Biol Eng Comput 46:745-57. 2008
    ....
  12. pmc Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy
    Damijan Miklavcic
    Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Biomed Eng Online 9:10. 2010
    ..Electrochemotherapy has been successfully used for treatment of easily accessible superficial tumor nodules. In this paper, we present the first case of deep-seated tumor electrochemotherapy based on numerical treatment planning...
  13. pmc Radiosensitising effect of electrochemotherapy with bleomycin in LPB sarcoma cells and tumors in mice
    Simona Kranjc
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    BMC Cancer 5:115. 2005
    ..The aim of the study was to evaluate whether a physical drug delivery system - electroporation can increase radiosensitising effect of bleomycin in vitro and in vivo...
  14. ncbi request reprint Cancer electrogene therapy with interleukin-12
    Maja Cemazar
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Curr Gene Ther 10:300-11. 2010
    ....
  15. ncbi request reprint Effects of electrogenetherapy with p53wt combined with cisplatin on curvival of human tumor cell lines with different p53 status
    Maja Cemazar
    Institute of Oncology, SI 1000 Ljubljana, Slovenia
    DNA Cell Biol 22:765-75. 2003
    ..This therapy was effective and dependent on the p53 status of the tumor cell lines. Combination of electrogenetherapy and cisplatin resulted in additional cell kill by cisplatin, and was not dependent on the p53 status...
  16. ncbi request reprint Cytotoxicity of different platinum (II) analogues to human tumour cell lines in vitro and murine tumour in vivo alone or combined with electroporation
    Maja Cemazar
    Department of Experimental Oncology, Institute of Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Anticancer Res 26:1997-2002. 2006
    ..The in vivo efficiencies of CDDP and 3P-SK in MCA mammary carcinoma tumours induced in CBA mice were compared...
  17. pmc Direct visualization of electroporation-assisted in vivo gene delivery to tumors using intravital microscopy - spatial and time dependent distribution
    Maja Cemazar
    Department of Experimental Oncology, Institute of Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
    BMC Cancer 4:81. 2004
    ..Intravital microscopy of tumors growing in dorsal skin fold window chambers is a useful method for monitoring gene transfection, since it allows non-invasive dynamic monitoring of gene expression in tumors in a live animal...
  18. ncbi request reprint Sequence and time dependence of transfection efficiency of electrically-assisted gene delivery to tumors in mice
    Maja Cemazar
    Institute of Oncology Ljubljana, and University of Ljubljana, Veterinary Faculty, Slovenia
    Curr Drug Deliv 3:77-81. 2006
    ....
  19. ncbi request reprint Schedule-dependent interaction between vinblastine and cisplatin in Ehrlich ascites tumors in mice
    Maja Cemazar
    Institute of Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
    J Pharmacol Exp Ther 302:337-43. 2002
    ....
  20. ncbi request reprint Electrotransfer of therapeutic molecules into tissues
    Maja Cemazar
    Department of Experimental Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Curr Opin Mol Ther 9:554-62. 2007
    ..Therefore, it can be presumed that electrotransfer of therapeutic genes into tissues will soon form a validated alternative to viral delivery systems in a clinical setting...
  21. ncbi request reprint Electrochemotherapy of tumours resistant to cisplatin: a study in a murine tumour model
    M Cemazar
    Department of Tumor Biology, Institute of Oncology, Zaloska 2, SI 1000, Ljubljana, Slovenia
    Eur J Cancer 37:1166-72. 2001
    ..In conclusion, electrochemotherapy is an effective treatment of cisplatin-resistant solid tumours and may prove useful in clinical chemotherapy for the treatment of tumours with intrinsic or acquired resistance to cisplatin...
  22. ncbi request reprint Cytotoxicity of bioreductive drug tirapazamine is increased by application of electric pulses in SA-1 tumours in mice
    M Cemazar
    Department of Tumor Biology, Institute of Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Anticancer Res 21:1151-6. 2001
    ..The effect is more likely to be attributed to increased tumour hypoxia as a consequence of reduced tumour blood flow induced by application of electric pulses...
  23. ncbi request reprint Effective gene transfer to solid tumors using different nonviral gene delivery techniques: electroporation, liposomes, and integrin-targeted vector
    Maja Cemazar
    Tumor Microcirculation Group, Gray Cancer Institute, Mount Vernon Hospital, Northwood HA6 2JR, UK
    Cancer Gene Ther 9:399-406. 2002
    ..In conclusion, our results demonstrate that some nonviral methods of gene delivery are feasible and efficient in transfecting solid tumors. Therefore, this makes nonviral methods attractive for further development...
  24. ncbi request reprint The effect of the histological properties of tumors on transfection efficiency of electrically assisted gene delivery to solid tumors in mice
    S Mesojednik
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, Ljubljana, Slovenia
    Gene Ther 14:1261-9. 2007
    ..Therefore, knowledge about the histology of tumors is important in planning electrogene therapy with respect to the time interval between DNA injection and electroporation...
  25. doi request reprint Control by pulse parameters of DNA electrotransfer into solid tumors in mice
    M Cemazar
    Department of Experimental Oncology, Institute of Oncology, Ljubljana, Slovenia
    Gene Ther 16:635-44. 2009
    ....
  26. ncbi request reprint MicroRNAs targeting mutant K-ras by electrotransfer inhibit human colorectal adenocarcinoma cell growth in vitro and in vivo
    S Vidic
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
    Cancer Gene Ther 17:409-19. 2010
    ..The obtained results demonstrate that electrogene therapy with miRNA-K-ras molecules can be potential therapeutic strategy for treatment of colorectal cancers harboring K-ras mutations...
  27. pmc Electroporation of human microvascular endothelial cells: evidence for an anti-vascular mechanism of electrochemotherapy
    M Cemazar
    Department of Tumor Biology, Institute of Oncology, Zaloska 2, SI 1000, Ljubljana, Slovenia
    Br J Cancer 84:565-70. 2001
    ..Further studies are necessary to identify the determinants of endothelial response and its relationship to the anti-vascular action of electrochemotherapy in vivo...
  28. ncbi request reprint Improvement of combined modality therapy with cisplatin and radiation using electroporation of tumors
    G Sersa
    Department of Tumor Biology, Institute of Oncology, Ljubljana, Slovenia
    Int J Radiat Oncol Biol Phys 46:1037-41. 2000
    ..To evaluate whether a local drug delivery method, i.e., electroporation of tumors, increases the radiosensitizing effect of cisplatin...
  29. ncbi request reprint Reduced tumor oxygenation by treatment with vinblastine
    G Sersa
    Department of Tumor Biology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Cancer Res 61:4266-71. 2001
    ....
  30. ncbi request reprint Electrochemotherapy: potentiation of local antitumour effectiveness of cisplatin in dogs and cats
    N Tozon
    University of Ljubljana, Veterinary Faculty, Small Animal Clinic, Slovenia
    Anticancer Res 21:2483-8. 2001
    ..046). This study showed that electrochemotherapy with cisplatin is an effective, safe and simple local treatment of different histological types of cutaneous and subcutaneous tumours in cats and dogs...
  31. ncbi request reprint Electrochemotherapy with cisplatin: the systemic antitumour effectiveness of cisplatin can be potentiated locally by the application of electric pulses in the treatment of malignant melanoma skin metastases
    G Sersa
    Institute of Oncology, Ljubljana, Slovenia
    Melanoma Res 10:381-5. 2000
    ..Therefore, electrochemotherapy may be used as an adjunct to systemic ongoing cisplatin treatment, predominantly in patients in whom antitumour effectiveness needs to be potentiated locally...
  32. pmc Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with cisplatin
    M Cemazar
    Institute of Oncology, Ljubljana, Slovenia
    Br J Cancer 79:1386-91. 1999
    ..In addition, besides electroporation, immune system and tumour blood flow changes could be involved in the observed anti-tumour effectiveness of electrochemotherapy...
  33. ncbi request reprint Tumor blood flow modifying effect of electrochemotherapy with bleomycin
    G Sersa
    Institute of Oncology Ljubljana, Department of Tumor Biology, Slovenia
    Anticancer Res 19:4017-22. 1999
    ..The aim of this study was to determine the tumor blood flow modifying effect of electrochemotherapy with bleomycin and correlate it with its antitumor effectiveness and extent of tumor necrosis...
  34. pmc Vascular disrupting action of electroporation and electrochemotherapy with bleomycin in murine sarcoma
    G Sersa
    Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Br J Cancer 98:388-98. 2008
    ....
  35. ncbi request reprint Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability
    G M Tozer
    Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex, HA6 2JR, United Kingdom
    Cancer Res 61:6413-22. 2001
    ..These results suggest a mechanism of action of CA-4-P in vivo. Combination of CA-4-P with a NOS inhibitor has an additive effect, which it may be possible to exploit therapeutically...
  36. ncbi request reprint Electrochemotherapy with cisplatin: clinical experience in malignant melanoma patients
    G Sersa
    Institute of Oncology and Faculty of Electrical Engineering, University of Ljubljana, Slovenia
    Clin Cancer Res 6:863-7. 2000
    ..The advantages of this therapy include its simplicity, the short duration of treatment sessions, low cisplatin doses, and insignificant side effects, as well as the fact that it can be done on an outpatient basis...
  37. pmc Muscle gene electrotransfer is increased by the antioxidant tempol in mice
    B Markelc
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
    Gene Ther 19:312-20. 2012
    ..4-fold by tempol. The study indicates that ROS are generated on cells during EP and can be scavenged by antioxidants. Specifically, tempol can be used to improve gene electrotransfer into the muscle and possibly also to other tissues...
  38. ncbi request reprint Tumour blood flow changes induced by application of electric pulses
    G Sersa
    Department of Tumour Biology, Institute of Oncology, Ljubljana, Slovenia
    Eur J Cancer 35:672-7. 1999
    ..Tumour blood flow reduction by electric pulses could have potential in exploiting modalities mediated by tumour hypoxia, e.g. activation of bioreductive agents...
  39. ncbi request reprint EPR oximetry of tumors in vivo in cancer therapy
    Marjeta Sentjurc
    Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    Spectrochim Acta A Mol Biomol Spectrosc 60:1379-85. 2004
    ....
  40. doi request reprint Electrochemotherapy of mouse sarcoma tumors using electric pulse trains with repetition frequencies of 1 Hz and 5 kHz
    G Sersa
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska c 2, 1000, Ljubljana, Slovenia
    J Membr Biol 236:155-62. 2010
    ..These differences are observed at suboptimal drug doses, whereas at optimal drug doses of bleomycin or cisplatin the antitumor effectiveness is the same, as demonstrated in clinical trials...
  41. doi request reprint Gene electrotransfer of siRNAs against CD146 inhibits migration and invasion of human malignant melanoma cells SK-MEL28
    V Todorovic
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, Ljubljana, Slovenia
    Cancer Gene Ther 20:208-10. 2013
    ..CD146 is therefore a potential target for the development of adjuvant therapies for metastatic melanoma...
  42. ncbi request reprint Efficient electrotransfection into canine muscle
    D Pavlin
    University of Ljubljana, Veterinary Faculty Ljubljana, Gerbiceva 60, SI 1000 Ljubljana, Slovenia
    Technol Cancer Res Treat 7:45-54. 2008
    ..The results indicate that electrotransfection is a feasible, effective, and safe method for muscle targeted gene therapy in dogs, which could have potential for clinical applications in veterinary medicine of small animals...
  43. ncbi request reprint Local and systemic antitumor effect of intratumoral and peritumoral IL-12 electrogene therapy on murine sarcoma
    Darja Pavlin
    University of Ljubljana, Veterinary Faculty Ljubljana, Ljubljana, Slovenia
    Cancer Biol Ther 8:2114-22. 2009
    ..These data suggest that IL-12 EGT may be useful in the treatment of soft tissue sarcomas, exerting a local and systemic antitumor effect...
  44. ncbi request reprint Electrochemotherapy: a new technological approach in treatment of metastases in the liver
    I Edhemovic
    Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Technol Cancer Res Treat 10:475-85. 2011
    ....
  45. ncbi request reprint Controlled systemic release of interleukin-12 after gene electrotransfer to muscle for cancer gene therapy alone or in combination with ionizing radiation in murine sarcomas
    Gregor Tevz
    Institute of Oncology Ljubljana, Department of Experimental Oncology, Ljubljana, Slovenia
    J Gene Med 11:1125-37. 2009
    ..To avoid toxic side-effects of IL-12 gene therapy, the objective was to achieve the controlled release of IL-12 after intramuscular gene electrotransfer...
  46. ncbi request reprint Electrogene therapy with p53 of murine sarcomas alone or combined with electrochemotherapy using cisplatin
    Alenka Grosel
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
    DNA Cell Biol 25:674-83. 2006
    ..The combination of electrogene therapy and electrochemotherapy after only one application resulted in complete regression of tumors...
  47. pmc Reduced blood flow and oxygenation in SA-1 tumours after electrochemotherapy with cisplatin
    G Sersa
    Laboratory of Radiation Biology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Br J Cancer 87:1047-54. 2002
    ....
  48. doi request reprint Electrochemotherapy in veterinary oncology
    M Cemazar
    Institute of Oncology Ljubljana, University of Ljubljana, Ljubljana, Slovenia the Ecole Vétérinaire de Toulouse, Toulouse, France
    J Vet Intern Med 22:826-31. 2008
    ....
  49. ncbi request reprint Determination of platinum in tumour tissues after cisplatin therapy by electrothermal atomic absorption spectrometry
    R Milacic
    Jozef Stefan Institute, Ljubljana, Slovenia
    J Pharm Biomed Anal 16:343-8. 1997
    ..In 72% of samples analysed the differences between results obtained by the two calibration procedures did not exceed +/- 5%...
  50. ncbi request reprint Electrochemotherapy in treatment of tumours
    G Sersa
    Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Eur J Surg Oncol 34:232-40. 2008
    ....
  51. ncbi request reprint Gene electrotransfer into murine skeletal muscle: a systematic analysis of parameters for long-term gene expression
    Gregor Tevz
    Institute of Oncology Ljubljana, Department of Experimental Oncology, Zaloska 2, Ljubljana, Slovenia
    Technol Cancer Res Treat 7:91-101. 2008
    ..Therefore, transgene expression in muscle can be controlled by appropriate selection of electrotransfection protocol...
  52. doi request reprint Electrochemotherapy of solid tumors--preclinical and clinical experience
    G Sersa
    Institute of Oncology Ljubljana, Ljubljana, Slovenia
    Conf Proc IEEE Eng Med Biol Soc 2011:728-31. 2011
    ..With long needle electrodes and new electric pulse generators, clinical trials are on-going for treatment of liver metastases, bone metastases and soft tissue sarcomas...
  53. ncbi request reprint Electrochemotherapy with bleomycin in the treatment of hypernephroma metastasis: case report and literature review
    G Sersa
    Institute of Oncology, Ljubljana, Slovenia
    Tumori 86:163-5. 2000
    ..This treatment resulted in stabilization of the tumor volume for 12 months, whereas the subcutaneous metastasis next to the electrochemotherapy-treated one that did not receive electric pulses progressed immediately...
  54. ncbi request reprint Effective treatment of perianal tumors in dogs with electrochemotherapy
    Natasa Tozon
    University of Ljubljana, Veterinary Faculty, Small Animal Clinic, Cesta v Mestni log 47, SI 1000 Ljubljana, Slovenia
    Anticancer Res 25:839-45. 2005
    ..The aim of the present study was to evaluate the electrochemotherapy treatment of perianal tumors of different sizes in dogs...
  55. ncbi request reprint Electroporation of LPB sarcoma cells in vitro and tumors in vivo increases the radiosensitizing effect of cisplatin
    Simona Kranjc
    Institute of Oncology, Laboratory of Radiation Biology, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Anticancer Res 23:275-81. 2003
    ..Cisplatin is a cytotoxic drug with radiosensitizing effect. In this study a physical drug delivery system, electroporation, was used to facilitate cisplatin delivery into the cells and tumors with the aim of increasing radiation response...
  56. ncbi request reprint Electrochemotherapy compared to surgery for treatment of canine mast cell tumours
    Veronika Kodre
    Janssen Cilag, Division of Johnson Johnson, Ljubljana, Slovenia
    In Vivo 23:55-62. 2009
    ..The aim of this study was to evaluate the effectiveness of local treatment electrochemotherapy (ECT) with cisplatin and to compare it with effectiveness of surgery for treatment of mast cell tumours (MCT) in dogs...
  57. doi request reprint Melanoma metastases to the neck nodes: role of adjuvant irradiation
    Primoz Strojan
    Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia
    Int J Radiat Oncol Biol Phys 77:1039-45. 2010
    ..To review experiences in the treatment of regionally advanced melanoma to the neck and/or parotid with emphasis on the role of adjuvant radiotherapy...
  58. ncbi request reprint Electrochemotherapy with cisplatin of cutaneous tumor lesions in breast cancer
    Martina Rebersek
    Department of Medical Oncology, Institute of Oncology, Ljubljana, Slovenia
    Anticancer Drugs 15:593-7. 2004
    ..We conclude that electrochemotherapy with i.t. cisplatin application is effective in local treatment of cutaneous tumor lesions of breast cancer...
  59. ncbi request reprint Antitumour effectiveness of hyperthermia is potentiated by local application of electric pulses to LPB tumours in mice
    Katarina Barbara Karner
    Institute of Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Anticancer Res 24:2343-8. 2004
    ..The aim of our study was to determine whether local application of electric pulses to tumours, which induce transient reduction of tumour perfusion, could potentiate the antitumour effectiveness of hyperthermia...
  60. ncbi request reprint The effect of high frequency electric pulses on muscle contractions and antitumor efficiency in vivo for a potential use in clinical electrochemotherapy
    Damijan Miklavcic
    University of Ljubljana, Faculty of Electrical Engineering, Trzaska 25, SI 1000 Ljubljana, Slovenia
    Bioelectrochemistry 65:121-8. 2005
    ..These results suggest that there is a considerable potential for clinical use of high frequency pulses in electrochemotherapy...
  61. ncbi request reprint Inoperable oropharyngeal carcinoma treated with concomitant irradiation, mitomycin C and bleomycin - long term results
    M Budihna
    Institute of Oncology, University Department of Otorhinolaryngology and Cervicofacial Surgery, Institute of Oncology, 1105 Ljubljana, Slovenia
    Neoplasma 52:165-74. 2005
    ..86. The outcome of the disease was directly proportional to intensity of irradiation and chemotherapy. It appears that in our concomitant radiochemotherapy MiC increased radioresponsiveness of the tumor by its effect on hypoxic fraction...
  62. ncbi request reprint The influence of electroporation on cytotoxicity of anticancer ruthenium(III) complex KP1339 in vitro and in vivo
    Rosana Hudej
    Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI 1000 Ljubljana, Slovenia
    Anticancer Res 30:2055-63. 2010
    ..The observed antitumour effectiveness is the result of both the direct cytotoxicity of KP1339 and an antivascular effect of electroporation...
  63. ncbi request reprint Successful sphincter-saving treatment of anorectal malignant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy
    Marko Snoj
    Institute of Oncology Ljubljana, Ljubljana, Slovenia
    Anticancer Drugs 16:345-8. 2005
    ..Brachytherapy was postoperatively delivered to the excision site. Fourteen months after the beginning of treatment, the patient is without signs of local recurrence and is continent...
  64. ncbi request reprint Radiosensitizing effect of electrochemotherapy in a fractionated radiation regimen in radiosensitive murine sarcoma and radioresistant adenocarcinoma tumor model
    Simona Kranjc
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, Ljubljana, Slovenia
    Radiat Res 172:677-85. 2009
    ....
  65. pmc The endothelin B (ETB) receptor agonist IRL 1620 is highly vasoconstrictive in two syngeneic rat tumour lines: potential for selective tumour blood flow modification
    M Cemazar
    Gray Cancer Institute, Mount Vernon Hospital, PO Box 100, Northwood, Middlesex HA6 2JR, UK
    Br J Cancer 93:98-106. 2005
    ..Expression levels of ET(B) receptors on the tumour vasculature could be useful for predicting which tumours are likely to respond to IRL 1620...
  66. pmc Increased cellular uptake of biocompatible superparamagnetic iron oxide nanoparticles into malignant cells by an external magnetic field
    Sara Prijic
    Kolektor Group, Nanotesla Institute, Stegne 29, 1521, Ljubljana, Slovenia
    J Membr Biol 236:167-79. 2010
    ..Their cellular uptake was dependent on the cell type, and their accumulation within the cells was dependent on the duration of exposure to an external magnetic field...
  67. ncbi request reprint Limb sparing treatment of bleeding melanoma recurrence by electrochemotherapy
    Marko Snoj
    Institute of Oncology Ljubljana, Zaloska 2, Ljubljana, Slovenia
    Tumori 95:398-402. 2009
    ..In addition, it was also found to have a vascular-disrupting effect. We report a case of limb-sparing treatment of bleeding melanoma recurrence by electrochemotherapy..
  68. pmc Effective treatment of multiple unresectable skin melanoma metastases by electrochemotherapy
    Marko Snoj
    Institute of Oncology Ljubljana, Ljubljana, Slovenia
    Croat Med J 48:391-5. 2007
    ..Electrochemotherapy with intravenous bleomycin can also be used as a treatment of choice for local control of multiple unresectable cutaneous melanoma skin metastases...
  69. ncbi request reprint Crystal structures and cytotoxicity of isopropylamine Pt(II) complexes: a trinuclear squarato-bridged [Pt3(mu2-C4O4)3(H2NPri)6].3H2O and a mononuclear cis-[Pt(NO3)2(H2NPri)2]
    Sabina Grabner
    Faculty of Chemistry and Chemical Technology, Department of Chemistry, University of Ljubljana, Slovenia
    J Inorg Biochem 99:1465-71. 2005
    ....
  70. ncbi request reprint Pt(II) complexes with N-(3-pyridyl)-2-(4-(trifluoromethyl)phenyl)diazenecarboxamide and their reactions with glutathione
    Sabina Grabner
    Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, 1000 Ljubljana, Slovenia
    J Inorg Biochem 95:105-12. 2003
    ..Complexes [PtCl(dmso)(en)]Cl, 1, 2 and ligand L were tested against T24 bladder carcinoma cells. Ligand L and complexes 1 and 2 showed higher cytotoxicity than [PtCl(dmso)(en)]Cl...
  71. ncbi request reprint In vivo imaging of tumor growth after electrochemotherapy with cisplatin
    Maja Cemazar
    IPBS CNRS UMR 5089, Toulouse, France
    Biochem Biophys Res Commun 348:997-1002. 2006
    ..Ex vivo observations under a fluorescence microscope showed that eGFP was only detected on the outer layer of the tumor. No fluorescence was detected in the central part of the tumors, which were necrotic...
  72. ncbi request reprint The endothelial cytoskeleton as a target of electroporation-based therapies
    Chryso Kanthou
    Cancer Research UK Tumour Microcirculation Group, Academic Unit of Surgical Oncology, Royal Hallamshire Hospital, University of Sheffield, UK
    Mol Cancer Ther 5:3145-52. 2006
    ....
  73. ncbi request reprint Perturbation of blood flow as a mechanism of anti-tumour action of direct current electrotherapy
    Tomaz Jarm
    Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, SI 1000 Ljubljana, Slovenia
    Physiol Meas 24:75-90. 2003
    ..The non-invasive technique of near-infrared spectroscopy proved to be a reliable method for detecting perfusion and oxygenation changes in small solid tumours...