Affiliation: Slovak Academy of Sciences
Ravingerova T. Intrinsic defensive mechanisms in the heart: a potential novel approach to cardiac protection against ischemic injury. Gen Physiol Biophys. 2007;26:3-13 pubmed
Ravingerová T, Adameova A, Kelly T, Antonopoulou E, Pancza D, Ondrejcakova M, et al
. Changes in PPAR gene expression and myocardial tolerance to ischaemia: relevance to pleiotropic effects of statins. Can J Physiol Pharmacol. 2009;87:1028-36 pubmed publisher
..In conclusion, statin-induced changes in the expression of PPARalpha may contribute to attenuation of myocardial I/R injury and thus suggest the involvement of cardioprotective mechanisms independent of inhibition of HMG-CoA reductase. ..
Ravingerová T, Carnická S, Nemcekova M, Ledvényiová V, Adameova A, Kelly T, et al
. PPAR-alpha activation as a preconditioning-like intervention in rats in vivo confers myocardial protection against acute ischaemia-reperfusion injury: involvement of PI3K-Akt. Can J Physiol Pharmacol. 2012;90:1135-44 pubmed publisher
..Results indicate that PPAR-? up-regulation may confer preconditioning-like protection via metabolic effects. Downstream mechanisms of PPAR-?-mediated cardioprotection may involve PI3K-Akt activation. ..
GriecsovÃ¡ L, FarkaÅ¡ovÃ¡ V, GÃ¡blovskÃ½ I, Khandelwal V, BernÃ¡tovÃ¡ I, TatarkovÃ¡ Z, et al
. Effect of maturation on the resistance of rat hearts against ischemia. Study of potential molecular mechanisms. Physiol Res. 2015;64 Suppl 5:S685-96 pubmed
..Aging-related alterations in myocardial response to ischemia may be caused by dysfunction of proteins involved in protective cell signaling that may occur already during the process of maturation. ..
Ravingerova T, Farkasová V, Griecsová L, CARNICKA S, Muráriková M, Barlaka E, et al
. Remote preconditioning as a novel "conditioning" approach to repair the broken heart: potential mechanisms and clinical applications. Physiol Res. 2016;65 Suppl 1:S55-64 pubmed
..In the present article, the authors provide a short overview of RIPC-induced protection, proposed underlying mechanisms and factors modulating RIPC as a promising cardioprotective strategy. ..
Ravingerová T, Matejíková J, Neckar J, Andelová E, Kolar F. Differential role of PI3K/Akt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart. Mol Cell Biochem. 2007;297:111-20 pubmed
..These results suggest that activation of PI3K/Akt cascade plays a role in the IS-limiting mechanism in the rat heart, however, it is not involved in the mechanisms of antiarrhythmic protection. ..