Research Topics
| Eva MachováSummaryAffiliation: Slovak Academy of Sciences Country: Slovakia Publications
| Collaborators
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Detail Information
Publications
Importance of α- and β/α-linked mannooligosaccharides in antibody response against C. dubliniensisIzabela Medovarska
Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38, Bratislava, Slovak Republic
Glycoconj J 27:697-702. 2010..dubliniensis mannan may represent relevant points of interaction with host immune system during infection and b) anti-mannan antibodies induced by the two antigens (the mannan conjugate and the yeast) are of similar specificities...
Synthesis and immunogenicity of polysaccharide-protein conjugate composed of galactoglucoxylomannan of Cryptococcus laurentiiSlavomir Bystricky
Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 842 38 Bratislava, Slovakia
FEMS Microbiol Lett 235:311-4. 2004..Effectiveness of immune serum to inhibit the growth of C. laurentii was demonstrated. The results indicate that the prepared conjugate could be considered as effective immunogen with potential for incorporation in the vaccine...
Immune responsiveness of a novel peptidoglycan conjugate prepared from surface Candida immunogens: mannan and CR3-related proteinEma Paulovicova
Center for Glycomics, Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia
FEMS Immunol Med Microbiol 53:421-8. 2008..Altogether, it could be assumed that the novel peptide glycoconjugate is a prospective antigenic candidate for further Candida vaccine design...
Cell and antibody mediated immunity induced by vaccination with novel Candida dubliniensis mannan immunogenic conjugateEma Paulovicova
Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, Slovakia
Int Immunopharmacol 7:1325-33. 2007..Immunogenic effectiveness of mannan-HSA conjugate at a dose of 0.25 mg of mannan antigenic moiety overcame that of the mannan alone and of yeast whole cells, thus promising further application in Candida vaccine development...
Immune response to Saccharomyces cerevisiae mannan conjugate in miceEma Paulovicova
Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, Slovakia
Int Immunopharmacol 5:1693-8. 2005..Newly synthesized S. cerevisiae mannan conjugate could be considered as a perspective vaccine candidate for preventive immunomodulation treatment...
Evaluation of different mannan polysaccharide usage in enzyme-linked immunosorbent assay for specific antibodies determinationLucia Libjaková
Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 84538 Bratislava, Slovakia
J Pharm Biomed Anal 45:521-5. 2007..008) efficiency. The use of protein cannot be avoided in normal microplates. All previous statements are supported by experimental data in the paper...
Growth inhibition of Candida albicans in the presence of antiserum elicited in rabbits by mannan-protein conjugateEva Machová
Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, Slovak Republic
Z Naturforsch C 63:909-12. 2008..No growth of treated cells on an agar plate was observed. The results confirmed that the mannan-protein conjugate could be considered as an effective component of perspective vaccine...
Candida albicans mannan-protein conjugate as vaccine candidateSlavomir Bystricky
Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 842 38, Bratislava, Slovakia
Immunol Lett 85:251-5. 2003..Anti-C. albicans effectiveness of immune serum is clearly demonstrated. Based on these results, the mannan conjugate synthesized by this scheme can be considered as actual vaccine candidate for clinical evaluation...
Immunomodulation of T-cell responses with Vibrio cholerae O135 capsular polysaccharide and its protein conjugate, novel cholera vaccine study modelsEma Paulovicova
Slovak Academy of Sciences, Institute of Chemistry, Centre of Excellence GLYCOMED, Bratislava, Slovakia
FEMS Immunol Med Microbiol 65:422-30. 2012..The results revealed different T-cell antigen presentation and activation following administration of CPS and CPS-BSA conjugates, as supported also by evaluation of CD45, MHCII and CD25 expression on CD19(+) B cells...
Preparation of a subcellular conjugate with the lipopolysaccharide from Vibrio cholerae 01 using beta-D-glucan as matrixEva Machová
Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 842 38 Bratislava, Slovakia
Eur J Med Chem 37:681-7. 2002..The obtained construct showed reactivity with the antibodies against V. cholerae and can serve as a prospective candidate for preparation of subcellular anti-cholera vaccine...
Fungal chitin-glucan derivatives exert protective or damaging activity on plasmid DNAGrigorij Kogan
Institute of Chemistry, Slovak Academy of Sciences, 845 38 Bratislava, Slovakia
Carbohydr Res 338:931-5. 2003..However, process of DNA damaging induced by free-radical oxidation initiated with Fe(2+) was inhibited, while the process of DNA breakage induced by H(2)O(2) was increased in the presence of SE-Ch-G...
