Genomes and Genes


Ima Dovinova


Affiliation: Slovak Academy of Sciences
Country: Slovakia


  1. Dovinova I, Hrabarova E, Jansen E, Kvandová M, Majzúnová M, Berenyiova A, et al. ADMA, homocysteine and redox status improvement affected by 7-nitroindazole in spontaneously hypertensive rats. Biomed Pharmacother. 2018;106:1478-1483 pubmed publisher
    ..We observed that 7-NI, an exogenous NOinhibitor, can decrease and improve the levels of ADMA, Hcy, and ROM, and increase TTL/ROM ratio in the plasma of spontaneously hypertensive rats. ..
  2. Majzúnová M, Dovinova I, Barancik M, Chan J. Redox signaling in pathophysiology of hypertension. J Biomed Sci. 2013;20:69 pubmed publisher
    ..Finally, we discuss the transcriptional factors involved in redox-sensitive gene transcription and antioxidant response, as well as their roles in hypertension. ..
  3. Barteková M, Å imončíková P, Fogarassyová M, Ivanová M, Okruhlicová Ä, Tribulová N, et al. Quercetin improves postischemic recovery of heart function in doxorubicin-treated rats and prevents doxorubicin-induced matrix metalloproteinase-2 activation and apoptosis induction. Int J Mol Sci. 2015;16:8168-85 pubmed publisher
    ..Moreover, QCT influenced myocardial responses to acute ischemic stress. These facts bring new insights into mechanisms of QCT action on rat hearts exposed to the chronic effects of DOX. ..
  4. Kvandová M, Barancik M, Bališ P, Puzserova A, Majzúnová M, Dovinova I. The peroxisome proliferator-activated receptor gamma agonist pioglitazone improves nitric oxide availability, renin-angiotensin system and aberrant redox regulation in the kidney of pre-hypertensive rats. J Physiol Pharmacol. 2018;69: pubmed publisher
    ..We also observed that the most sensitive tissue responses to PPARγ-dependent activation of Nrf2 have been primarily found in the kidney of young hypertensive animals. ..
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    Kvandová M, Majzúnová M, Dovinova I. The role of PPARgamma in cardiovascular diseases. Physiol Res. 2016;65:S343-S363 pubmed
    ..In this context, activation and functioning of PPARgamma is very important in the regulation of several disorders such as diabetes mellitus, hypertension and/or metabolic syndrome. ..
  6. Majzúnová M, Pakanova Z, Kvasnička P, Balis P, Cacanyiova S, Dovinova I. Age-dependent redox status in the brain stem of NO-deficient hypertensive rats. J Biomed Sci. 2017;24:72 pubmed publisher
    ..Triggering of the radical pathway was followed by activation of protective compensation mechanism at the gene expression level. ..
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    Dovinova I, Cacanyiova S, Fáberová V, Kristek F. The effect of an NO donor, pentaerythrityl tetranitrate, on biochemical, functional, and morphological attributes of cardiovascular system of spontaneously hypertensive rats. Gen Physiol Biophys. 2009;28:86-93 pubmed
    ..The small effect of PETN on cardiovascular system suggests that NO deficiency is probably not the main cause of pathological alterations in SHR...