Research Topics
| C AltanerSummaryAffiliation: Slovak Academy of Sciences Country: Slovakia Publications
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Detail Information
Publications
Stem cell based glioblastoma gene therapyC Altaner
Cancer Research Institute SAS, Bratislava, Slovakia
Neoplasma 59:756-60. 2012..Encouraging results of preclinical studies of stem cell based gene therapy for glioblastoma support the argument to begin clinical studies...
Tumor cell behaviour modulation by mesenchymal stromal cellsLucia Kucerova
Laboratory of Molecular Oncology, Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia
Mol Cancer 9:129. 2010..We aimed to show whether multipotent MSC derived from human adipose tissue (AT-MSC) could create tumor cell-protective milieu and affect tumor cell behaviour in vitro and in vivo...
Genotoxic damage of human adipose-tissue derived mesenchymal stem cells triggers their terminal differentiationV Altanerova
Laboratory of Molecular Oncology, Cancer Research Institute, Bratislava, Slovakia
Neoplasma 56:542-7. 2009..Surviving cells after genotoxic stress were not transformed but underwent replicative senescence. Irreparable DNA damage caused triggered adipogenic terminal differentiation, rather than apoptosis induction in all kinds of cells tested...
Glioblastoma and stem cellsC Altaner
Cancer Research Institute SAS Bratislava, Slovakia
Neoplasma 55:369-74. 2008..BMP4 may act as a key inhibitory regulator of cancer initiation and therefore may be used in combined stem cell-based therapy as a non-cytotoxic therapeutic agent...
Human glioma cells expressing herpes simplex virus thymidine kinase gene treated with acyclovir, ganciclovir and bromovinyldeoxyuridine. Evaluation of their activity in vitro and in nude miceK Hlubinova
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovak Republic
Neoplasma 48:398-406. 2001..Therefore the effect of GCV treatment on 8-MG-BA xenografts inoculated with PA-317JH5cl13 virus producer cells was further studied on nude mice...
Tumor targeted gene therapy with plasmid expressing human tumor necrosis factor alpha in vitro and in vivoA Pastorakova
Cancer Research Institute, Slovak Academy of Sciences, 833 91 Bratislava, Slovak Republic
Neoplasma 52:344-51. 2005..This strategy may be a simple and promising gene therapy approach to the treatment of some human tumors...
Combine cancer gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and Herpes simplex thymidine kinase suicide geneA Pastorakova
Cancer Research Institute, Slovak Academy of Sciences, 83391 Bratislava, Slovak Republic
Neoplasma 53:353-62. 2006..Whether the bicistronic plasmid containing both genes would improve the therapeutic effect need to be assessed in the future...
Treatment of human tumor cells by combine gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and bacterial cytosine deaminase suicide geneA Pastorakova
Cancer Research Institute, Slovak Academy of Sciences, 833 91 Bratislava, Slovak Republic
Neoplasma 53:478-84. 2006..Whether the bicistronic vector containing both therapeutic genes improve the therapy need to be assessed in the future...
Influence of diet containing lyophilized Enterococcus faecium M-74 with organic selenium on tumor incidence in Apc1638N miceK Hlubinova
Cancer Research Institute, Slovak Academy of Sciences, 833 91 Bratislava, Slovak Republic
Neoplasma 51:341-4. 2004..Feeding of Apc1638N transgenic mice with enriched diet with probiotic components during 8 months have shown a minor therapeutic effect on the clinical manifestations in small intestine in comparison with control group...
The human homologue of the bovine leukemia virus receptor BLVRcp1 is the delta-subunit of adaptor-related AP-3 protein that does not bind the BVLgp51J Ban
Cancer Research Institute of the Slovak Academy of Sciences, Bratislava, Slovakia
Arch Virol 144:2013-22. 1999..This finding implies that this BLVgp51 binding site is present only on the bovine BLVRcp and therefore its human homologue cannot be recognized by BLVgp51. This might also explain the resistance of human cells to BLV infection...
Site-specific in vivo targeting of magnetoliposomes using externally applied magnetic fieldM Babincova
Department of Biophysics, Comenius University, Bratislava, Slovakia
Z Naturforsch C 55:278-81. 2000..Difference between the relative radioactivity in the magnetically targeted right kidney (25.92+/-5.84%) and non-targeted left kidney (0.93+/-0.05%) is sufficiently high for relevant clinical applications...
In vitro analysis of cisplatin functionalized magnetic nanoparticles in combined cancer chemotherapy and electromagnetic hyperthermiaM Babincov
Department of Nuclear Physics and Biophysics, Comenius University, Bratislava, Slovakia
IEEE Trans Nanobioscience 7:15-9. 2008....
Cancer stem cellsA Soltysova
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovak Republic
Neoplasma 52:435-40. 2005..Further characterization of cancer stem cells is needed in order to find ways to destroy them, which might contribute significantly to the therapeutic management of malignant tumors...
Suppression of tumorigenicity in clones of hamster cells transformed with avian sarcoma virusV Altanerova
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Czechoslovakia
Neoplasma 35:207-13. 1988..The isolated nontumorigenic cells represent cell mutants in which the viral src gene is controlled by a suppressor gene. The cells might be useful for further characterization of a putative antioncogene...
Germline mutation of the RET proto-oncogene in members of Slovak families with multiple endocrine neoplasia 2M Poturnajova
Cancer Research Institute, Slovak Academy of Sciences Bratislava
Neoplasma 48:445-50. 2001..The data indicate that the mechanism of MEN2 syndrome is not only due to the RET gene mutation, and strongly support the conclusion that additional genetic events are involved in the disease formation...
