Andrej Jedinak

Summary

Affiliation: Institute of Molecular Physiology and Genetics
Country: Slovakia

Publications

  1. ncbi Inhibitors of proteases as anticancer drugs
    A Jedinak
    Istitute of Molecular Physiology and Genetics, Slovak Academy of Science, Bratislava 83334, Slovak Republic
    Neoplasma 52:185-92. 2005
  2. ncbi Inhibition activities of natural products on serine proteases
    Andrej Jedinak
    Institute of Molecular Physiology and Genetics, Vlarska 5, Bratislava 835 34, Slovakia
    Phytother Res 20:214-7. 2006
  3. ncbi Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis
    Andrej Jedinak
    Institute of Molecular Physiology and Genetics, Vlarska 5, Bratislava 83334, Slovakia
    Z Naturforsch C 61:777-82. 2006

Detail Information

Publications3

  1. ncbi Inhibitors of proteases as anticancer drugs
    A Jedinak
    Istitute of Molecular Physiology and Genetics, Slovak Academy of Science, Bratislava 83334, Slovak Republic
    Neoplasma 52:185-92. 2005
    ..Thus inhibition of protease activity by low molecular weight inhibitors represents a promising strategy for anticancer and antimetastatic therapy. The review surveys low molecular inhibitors of MMPs, uPA and lysosomal proteases...
  2. ncbi Inhibition activities of natural products on serine proteases
    Andrej Jedinak
    Institute of Molecular Physiology and Genetics, Vlarska 5, Bratislava 835 34, Slovakia
    Phytother Res 20:214-7. 2006
    ..A very high inhibitory activity on trypsin was observed for the flavonoid silybin (IC50 = 3.7 microm), indicating a prospective structure on which to base possible polyphenolic trypsin inhibitors...
  3. ncbi Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis
    Andrej Jedinak
    Institute of Molecular Physiology and Genetics, Vlarska 5, Bratislava 83334, Slovakia
    Z Naturforsch C 61:777-82. 2006
    ..p. to inhibit lung colonization of beta16 mouse melanoma cells in vivo. We found, that beta-ursolic acid significantly decreased the number of B16 colonies in the lungs of mice at the dose 50 mg/kg (p < 0.05)...