Affiliation: Institute of Molecular Physiology and Genetics
- Inhibitors of proteases as anticancer drugsA Jedinak
Istitute of Molecular Physiology and Genetics, Slovak Academy of Science, Bratislava 83334, Slovak Republic
Neoplasma 52:185-92. 2005..Thus inhibition of protease activity by low molecular weight inhibitors represents a promising strategy for anticancer and antimetastatic therapy. The review surveys low molecular inhibitors of MMPs, uPA and lysosomal proteases...
- Inhibition activities of natural products on serine proteasesAndrej Jedinak
Institute of Molecular Physiology and Genetics, Vlarska 5, Bratislava 835 34, Slovakia
Phytother Res 20:214-7. 2006..A very high inhibitory activity on trypsin was observed for the flavonoid silybin (IC50 = 3.7 microm), indicating a prospective structure on which to base possible polyphenolic trypsin inhibitors...
- Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalisAndrej Jedinak
Institute of Molecular Physiology and Genetics, Vlarska 5, Bratislava 83334, Slovakia
Z Naturforsch C 61:777-82. 2006..p. to inhibit lung colonization of beta16 mouse melanoma cells in vivo. We found, that beta-ursolic acid significantly decreased the number of B16 colonies in the lungs of mice at the dose 50 mg/kg (p < 0.05)...