Marek Dudas

Summary

Affiliation: Faculty of Medicine
Country: Slovakia

Publications

  1. pmc Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion
    Marek Dudas
    Developmental Biology Program, The Saban Research Institute of Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Dev Biol 296:298-314. 2006
  2. ncbi request reprint Palatal fusion - where do the midline cells go? A review on cleft palate, a major human birth defect
    Marek Dudas
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Mail Stop 35, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Acta Histochem 109:1-14. 2007
  3. pmc Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects
    Jikui Wang
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    BMC Dev Biol 6:51. 2006
  4. pmc Signaling through Tgf-beta type I receptor Alk5 is required for upper lip fusion
    Wai Yee Li
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA
    Mech Dev 125:874-82. 2008
  5. ncbi request reprint Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells
    Vesa Kaartinen
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Departments of Pathology and Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Development 131:3481-90. 2004
  6. pmc Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart
    Jikui Wang
    Developmental Biology, The Saban Research Institute of Children s Hospital Los Angeles, CA 90027, USA
    Dev Biol 286:299-310. 2005
  7. ncbi request reprint Tgf-beta superfamily and mouse craniofacial development: interplay of morphogenetic proteins and receptor signaling controls normal formation of the face
    Marek Dudas
    Developmental Biology Program at the Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, California 90027, USA
    Curr Top Dev Biol 66:65-133. 2005
  8. ncbi request reprint Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells
    Marek Dudas
    Developmental Biology Program, Departments of Pathology and Surgery, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Mech Dev 121:173-82. 2004
  9. doi request reprint Memory encoded throughout our bodies: molecular and cellular basis of tissue regeneration
    Marek Dudas
    Developmental Biology Program, The Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Pediatr Res 63:502-12. 2008
  10. ncbi request reprint Transforming growth factor-beta3 affects plasminogen activator inhibitor-1 expression in fetal mice and modulates fibroblast-mediated collagen gel contraction
    Wai Yee Li
    Department of Surgery, The Saban Research Institute of Childrens Hospital, Los Angeles, California 90027, USA
    Wound Repair Regen 14:516-25. 2006

Collaborators

Detail Information

Publications11

  1. pmc Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion
    Marek Dudas
    Developmental Biology Program, The Saban Research Institute of Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Dev Biol 296:298-314. 2006
    ....
  2. ncbi request reprint Palatal fusion - where do the midline cells go? A review on cleft palate, a major human birth defect
    Marek Dudas
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Mail Stop 35, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Acta Histochem 109:1-14. 2007
    ..Mechanisms of normal disintegration of the midline epithelial seam are reviewed together with pathologic processes that prevent this disintegration, thus causing cleft palate...
  3. pmc Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects
    Jikui Wang
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    BMC Dev Biol 6:51. 2006
    ..While TGF-beta-superfamily signaling has been strongly implicated in neural crest cell development, the detailed molecular signaling mechanisms in vivo are still poorly understood...
  4. pmc Signaling through Tgf-beta type I receptor Alk5 is required for upper lip fusion
    Wai Yee Li
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA
    Mech Dev 125:874-82. 2008
    ..These mice also display retarded development of palatal shelves and die at E15. Our findings support a role for Alk5 in normal upper lip formation not previously reported...
  5. ncbi request reprint Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells
    Vesa Kaartinen
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Departments of Pathology and Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Development 131:3481-90. 2004
    ..Thus, the type I BMP receptor ALK2 plays an essential cell-autonomous role in the development of the cardiac outflow tract and aortic arch derivatives...
  6. pmc Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart
    Jikui Wang
    Developmental Biology, The Saban Research Institute of Children s Hospital Los Angeles, CA 90027, USA
    Dev Biol 286:299-310. 2005
    ..Collectively, these results indicate that the BMP type I receptor ALK2 in endothelial cells plays a critical non-redundant role in early phases of endocardial cushion formation during cardiac morphogenesis...
  7. ncbi request reprint Tgf-beta superfamily and mouse craniofacial development: interplay of morphogenetic proteins and receptor signaling controls normal formation of the face
    Marek Dudas
    Developmental Biology Program at the Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, California 90027, USA
    Curr Top Dev Biol 66:65-133. 2005
  8. ncbi request reprint Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells
    Marek Dudas
    Developmental Biology Program, Departments of Pathology and Surgery, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Mech Dev 121:173-82. 2004
    ..Based on the present results we conclude that signaling via Alk2 receptors is non-redundant and regulates normal development of a restricted set of structures derived from the cranial neural crest...
  9. doi request reprint Memory encoded throughout our bodies: molecular and cellular basis of tissue regeneration
    Marek Dudas
    Developmental Biology Program, The Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Pediatr Res 63:502-12. 2008
    ..Selected developmental, surgical, and tissue engineering aspects are presented and discussed in the light of recent findings in the field...
  10. ncbi request reprint Transforming growth factor-beta3 affects plasminogen activator inhibitor-1 expression in fetal mice and modulates fibroblast-mediated collagen gel contraction
    Wai Yee Li
    Department of Surgery, The Saban Research Institute of Childrens Hospital, Los Angeles, California 90027, USA
    Wound Repair Regen 14:516-25. 2006
    ..These findings provide a further avenue for the interactive role of TGF-beta3 and PAI-1 during fetal scarless repair...
  11. ncbi request reprint Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway
    Marek Dudas
    Developmental Biology Program, Department of Pathology of University of Southern California, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 266:96-108. 2004
    ..Based on these observations, we conclude that the Smad2-dependent Alk-5 signaling pathway is dominant in palatal fusion driven by Tgf-beta3...