A Drgova

Summary

Affiliation: Comenius University
Country: Slovakia

Publications

  1. ncbi request reprint Changes of phospholipid composition and superoxide dismutase activity during global brain ischemia and reperfusion in rats
    A Drgova
    Department of Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    Gen Physiol Biophys 23:337-46. 2004
  2. ncbi request reprint Combination of budesonide and aminophylline diminished acute lung injury in animal model of meconium aspiration syndrome
    D Mokra
    Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    J Physiol Pharmacol 59:461-71. 2008
  3. doi request reprint Anti-inflammatory treatment in dysfunction of pulmonary surfactant in meconium-induced acute lung injury
    D Mokra
    Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    Adv Exp Med Biol 756:189-96. 2013
  4. ncbi request reprint Impact of Ginkgo Biloba Extract EGb 761 on ischemia/reperfusion - induced oxidative stress products formation in rat forebrain
    A Uríková
    Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, MalaHora 4, SK 03601, Martin, Slovakia
    Cell Mol Neurobiol 26:1343-53. 2006
  5. pmc Effects of long-term oxygen treatment on alpha-ketoglutarate dehydrogenase activity and oxidative modifications in mitochondria of the guinea pig heart
    Peter Kaplan
    Department of Medical Biochemistry, Center of Excellence for Cardiovacular Research of the Slovak Academy of Sciences, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    Eur J Med Res 14:116-20. 2009
  6. ncbi request reprint Dimethyl sulfoxide in a 10% concentration has no effect on oxidation stress induced by ovalbumin-sensitization in a guinea-pig model of allergic asthma
    P Mikolka
    Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    J Physiol Pharmacol 63:179-86. 2012
  7. ncbi request reprint Comparison of the effects of low-dose vs. high-dose aminophylline on lung function in experimental meconium aspiration syndrome
    D Mokra
    Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    J Physiol Pharmacol 59:449-59. 2008
  8. ncbi request reprint Ischemia-reperfusion induces inhibition of mitochondrial protein synthesis and cytochrome c oxidase activity in rat hippocampus
    P Racay
    Institute of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic
    Physiol Res 58:127-38. 2009
  9. ncbi request reprint [The effect of ischemia and ischemia-reperfusion on ion transport systems]
    P Racay
    Ustav lekárskej biochémie Jeseniovej lekárskej fakulty Univerzity Komenského v Martine
    Bratisl Lek Listy 99:386-94. 1998
  10. ncbi request reprint Intratracheally administered corticosteroids improve lung function in meconium-instilled rabbits
    D Mokra
    Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    J Physiol Pharmacol 58:389-98. 2007

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Changes of phospholipid composition and superoxide dismutase activity during global brain ischemia and reperfusion in rats
    A Drgova
    Department of Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    Gen Physiol Biophys 23:337-46. 2004
    ..These results suggest that ischemia/reperfusion is accompanied by a significant and selective degradation of brain phospholipids that may be attributable to oxidative stress and activation of phospholipases...
  2. ncbi request reprint Combination of budesonide and aminophylline diminished acute lung injury in animal model of meconium aspiration syndrome
    D Mokra
    Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    J Physiol Pharmacol 59:461-71. 2008
    ..However, no additive effect of budesonide was observed on lung peroxidation and in vitro airway reactivity...
  3. doi request reprint Anti-inflammatory treatment in dysfunction of pulmonary surfactant in meconium-induced acute lung injury
    D Mokra
    Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    Adv Exp Med Biol 756:189-96. 2013
    ....
  4. ncbi request reprint Impact of Ginkgo Biloba Extract EGb 761 on ischemia/reperfusion - induced oxidative stress products formation in rat forebrain
    A Uríková
    Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, MalaHora 4, SK 03601, Martin, Slovakia
    Cell Mol Neurobiol 26:1343-53. 2006
    ..Our results indicate that extract of EGb 761 has potent antioxidant activity and could play a role to attenuate the IRI-induced oxidative protein modification and lipoperoxidation in the neuroprotective process...
  5. pmc Effects of long-term oxygen treatment on alpha-ketoglutarate dehydrogenase activity and oxidative modifications in mitochondria of the guinea pig heart
    Peter Kaplan
    Department of Medical Biochemistry, Center of Excellence for Cardiovacular Research of the Slovak Academy of Sciences, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    Eur J Med Res 14:116-20. 2009
    ..Oxygen therapy is used for the treatment of various diseases, but prolonged exposure to high concentrations of O(2) is also associated with formation of free radicals and oxidative damage...
  6. ncbi request reprint Dimethyl sulfoxide in a 10% concentration has no effect on oxidation stress induced by ovalbumin-sensitization in a guinea-pig model of allergic asthma
    P Mikolka
    Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    J Physiol Pharmacol 63:179-86. 2012
    ..10% DMSO had no effect on lipid and protein oxidation in a guinea-pig model of allergic asthma...
  7. ncbi request reprint Comparison of the effects of low-dose vs. high-dose aminophylline on lung function in experimental meconium aspiration syndrome
    D Mokra
    Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    J Physiol Pharmacol 59:449-59. 2008
    ..Although LD-aminophylline showed some anti-inflammatory potential, HD-aminophylline improved most of the parameters more effectively...
  8. ncbi request reprint Ischemia-reperfusion induces inhibition of mitochondrial protein synthesis and cytochrome c oxidase activity in rat hippocampus
    P Racay
    Institute of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic
    Physiol Res 58:127-38. 2009
    ..3, 80.3, 81.9 and 83.5 % of control, respectively. Based on our data, we suggest that inhibition of COX activity is rather caused by ischemia-induced modification of COX polypeptides than by inhibition of mitochondrial translation...
  9. ncbi request reprint [The effect of ischemia and ischemia-reperfusion on ion transport systems]
    P Racay
    Ustav lekárskej biochémie Jeseniovej lekárskej fakulty Univerzity Komenského v Martine
    Bratisl Lek Listy 99:386-94. 1998
    ..In addition to the inhibitory effect of ischaemia-reperfusion injury, intracellular water accumulation, as the possible consequence of altered ion homeostasis, is documented by nuclear magnetic resonance (imaging)...
  10. ncbi request reprint Intratracheally administered corticosteroids improve lung function in meconium-instilled rabbits
    D Mokra
    Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    J Physiol Pharmacol 58:389-98. 2007
    ..The intratracheally administered corticosteroid budesonide effectively improved pulmonary functions and alleviated changes associated with inflammation in meconium-instilled rabbits...
  11. ncbi request reprint Single-dose versus two-dose dexamethasone effects on lung inflammation and airway reactivity in meconium-instilled rabbits
    D Mokra
    Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    J Physiol Pharmacol 58:379-87. 2007
    ..We conclude that two-dose dexamethasone is superior to single-dose dexamethasone in prevention lung injury in meconium-instilled rabbits...
  12. ncbi request reprint Surfactant lung lavage using asymmetric high-frequency jet ventilation followed by conventional ventilation in rabbits with meconium aspiration
    D Mokra
    Department of Physiology, Comenius University, Jessenius Faculty of Medicine, Martin, Slovakia
    Bratisl Lek Listy 106:412-5. 2005
    ....
  13. ncbi request reprint Lung lavage using high-frequency jet ventilation in rabbits with meconium aspiration
    D Sevecova
    Department of Physiology, Comenius University, Jessenius Faculty of Medicine, Martin, Slovakia
    Acta Paediatr 92:314-9. 2003
    ..To determine the efficacy of the expulsion effect of high-frequency jet ventilation (HFJV) on meconium clearance from the airways in comparison with conventional suctioning in adult rabbits with meconium aspiration...
  14. ncbi request reprint Short-term cardiovascular effects of selective phosphodiesterase 3 inhibitor olprinone versus non-selective phosphodiesterase inhibitor aminophylline in a meconium-induced acute lung injury
    D Mokra
    Department of Physiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovakia
    J Physiol Pharmacol 64:751-9. 2013
    ..Considering that systemic administration of olprinone and aminophylline was accompanied by acute cardiovascular changes in the meconium-instilled animals, use of PDE inhibitors in the newborns with MAS should be carefully monitored. ..
  15. ncbi request reprint Differences in oxidative status, lung function, and pulmonary surfactant during long-term inhalation of medical oxygen and partially ionized oxygen in guinea pigs
    A Calkovska
    Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    J Physiol Pharmacol 59:173-81. 2008
    ..In conclusion, long-term inhalation of partially positively ionized oxygen is associated with less oxidative stress, milder lung inflammatory response, and better surfactant activity than molecular or negatively ionized oxygen...
  16. ncbi request reprint Ischemia/Reperfusion-induced oxidative stress causes structural changes of brain membrane proteins and lipids
    R Murin
    Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    Gen Physiol Biophys 20:431-8. 2001
    ..Ischemia/reperfusion induces formation of lipid peroxidation products as well as protein modifications...
  17. ncbi request reprint Effect of aging on the expression of intracellular Ca(2+) transport proteins in a rat heart
    P Kaplan
    Department of Biochemistry, Jessenius Faculty of Medicine, Comenius University, Mala Hora 4, Martin, Slovak Republic
    Mol Cell Biochem 301:219-26. 2007
    ..5 +/- 18.1 and 304.6 +/- 14.8 nmol P(i) min(-1) mg(-1). These results suggest that altered transporting activity and/or gene expression of Ca(2+)-handling proteins of intracellular Ca(2+) stores might affect cardiac function during aging...