Andrzej T Slominski

Summary

Publications

  1. pmc High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives
    Z Janjetovic
    Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, Memphis, TN 38163, USA
    Br J Cancer 105:1874-84. 2011
  2. doi request reprint In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland
    Andrzej T Slominski
    Department of Pathology and Medicine, University of Tennessee HSC, Memphis, TN, USA Division of Rheumatology and Connective Tissue Diseases of the Department of Medicine, University of Tennessee HSC, Memphis, TN, USA Electronic address
    Mol Cell Endocrinol 383:181-92. 2014
  3. pmc Cytochromes p450 and skin cancer: role of local endocrine pathways
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, Memphis, TN 38163, USA
    Anticancer Agents Med Chem 14:77-96. 2014
  4. pmc Key role of CRF in the skin stress response system
    Andrzej T Slominski
    MD, PhD, Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center 930 Madison Avenue, Suite 500, Memphis, Tennessee 38163
    Endocr Rev 34:827-84. 2013
  5. pmc Steroidogenesis in the skin: implications for local immune functions
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA Electronic address
    J Steroid Biochem Mol Biol 137:107-23. 2013
  6. pmc Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes
    Andrzej T Slominski
    Department of Pathology and Medicine, University of Tennessee HSC, Memphis, TN 38163, USA
    Int J Biochem Cell Biol 44:2003-18. 2012
  7. pmc Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    Anticancer Res 32:3733-42. 2012
  8. pmc In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    FASEB J 26:3901-15. 2012
  9. pmc Regulated proenkephalin expression in human skin and cultured skin cells
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    J Invest Dermatol 131:613-22. 2011
  10. pmc Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 5:e9907. 2010

Research Grants

  1. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2002
  2. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2003
  3. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
  4. Novel biosynthetic pathway for secosteroids and the skin
    Andrzej Slominski; Fiscal Year: 2006
  5. Novel biosynthetic pathway for secosteroids and the skin
    Andrzej Slominski; Fiscal Year: 2007
  6. Novel biosynthetic pathway for secosteroids and the skin
    Andrzej Slominski; Fiscal Year: 2009
  7. Novel biosynthetic pathway for secosteroids and the skin
    Andrzej T Slominski; Fiscal Year: 2010

Collaborators

Detail Information

Publications38

  1. pmc High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives
    Z Janjetovic
    Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee Health Science Center, 930 Madison Avenue, Memphis, TN 38163, USA
    Br J Cancer 105:1874-84. 2011
    ..Nuclear factor-κB (NF-κB) is constitutively activated in melanoma and can serve as a molecular target for cancer therapy and steroid/secosteroid action...
  2. doi request reprint In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland
    Andrzej T Slominski
    Department of Pathology and Medicine, University of Tennessee HSC, Memphis, TN, USA Division of Rheumatology and Connective Tissue Diseases of the Department of Medicine, University of Tennessee HSC, Memphis, TN, USA Electronic address
    Mol Cell Endocrinol 383:181-92. 2014
    ..This is the first in vivo evidence for a novel pathway of vitamin D2 metabolism initiated by CYP11A1 and modified by CYP27B1, with the product profile showing tissue- and cell-type specificity...
  3. pmc Cytochromes p450 and skin cancer: role of local endocrine pathways
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, Memphis, TN 38163, USA
    Anticancer Agents Med Chem 14:77-96. 2014
    ..In addition, melatonin is metabolized by local CYPs. In conclusion cutaneously expressed CYPs have significant effects on skin physiology and pathology trough regulation of its chemical milieu. ..
  4. pmc Key role of CRF in the skin stress response system
    Andrzej T Slominski
    MD, PhD, Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center 930 Madison Avenue, Suite 500, Memphis, Tennessee 38163
    Endocr Rev 34:827-84. 2013
    ..CRF and CRFR-1 may constitute novel targets through the use of specific agonists or antagonists, especially for therapy of skin diseases that worsen with stress, such as atopic dermatitis and psoriasis. ..
  5. pmc Steroidogenesis in the skin: implications for local immune functions
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA Electronic address
    J Steroid Biochem Mol Biol 137:107-23. 2013
    ..This article is part of a Special Issue entitled 'CSR 2013'. ..
  6. pmc Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes
    Andrzej T Slominski
    Department of Pathology and Medicine, University of Tennessee HSC, Memphis, TN 38163, USA
    Int J Biochem Cell Biol 44:2003-18. 2012
    ..In conclusion, tissues expressing P450scc can metabolize 7DHC to biologically active 7DHP with 22(OH)7DHC and 20,22(OH)(2)7DHC serving as intermediates, and with further metabolism to 7-dehydroprogesterone and (OH)7DHP...
  7. pmc Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    Anticancer Res 32:3733-42. 2012
    ..To test the activity of novel hydroxyvitamin D(3) analogs (20(OH)D(3), 20,23(OH)(2)D and 1,20(OH)(2)D(3)) on normal and malignant melanocytes in comparison to 1,25(OH)(2)D(3)...
  8. pmc In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    FASEB J 26:3901-15. 2012
    ..These findings define the pathway intermediates as natural products/endogenous bioregulators and break the current dogma that vitamin D is solely activated through the sequence D3 → 25(OH)D3 → 1,25(OH)(2)D3...
  9. pmc Regulated proenkephalin expression in human skin and cultured skin cells
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    J Invest Dermatol 131:613-22. 2011
    ..Not only does human skin express proenkephalin, but this expression is upregulated by stressful stimuli and can be altered by pathological conditions...
  10. pmc Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 5:e9907. 2010
    ..UVB induces transformation of the steroidal 5,7-dienes to pregnacalciferol (pD) and a lumisterol-like compounds (pL)...
  11. pmc L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee, Memphis, TN, USA
    Pigment Cell Melanoma Res 25:14-27. 2012
    ....
  12. pmc Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength
    Tae Kang Kim
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Cell Endocrinol 361:143-52. 2012
    ..In contrast, docking scores for the non-genomic binding site of the VDR were poor. In conclusion, both the length of the side chain and the number and position of hydroxyl groups affect the activation of VDR by novel secosteroids...
  13. pmc 20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation
    Blazej Zbytek
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Invest Dermatol 128:2271-80. 2008
    ..These data imply that the previously unreported pathway of vitamin D3 metabolism by P450scc may have wider biological implications depending, for example, on the extent of adrenal gland or cutaneous metabolism...
  14. pmc Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells
    Tae Kang Kim
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    FASEB J 27:2742-55. 2013
    ..Furthermore, melatonin and its metabolite AFMK stimulate differentiation in human epidermis, indicating their key role in building the skin barrier...
  15. pmc Design, synthesis, and biological action of 20R-hydroxyvitamin D3
    Yan Lu
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Med Chem 55:3573-7. 2012
    ..A comparison of 20R isomer to its 20S counterpart in biological evaluation demonstrates that they have different behaviors in antiproliferative and metabolic studies...
  16. pmc Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin
    Andrzej T Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 4:e4309. 2009
    ..The 5-7 dienal intermediates of the pathway can be a source of biologically active vitamin D3 derivatives after delivery to or production in the skin, an organ intermittently exposed to solar radiation...
  17. pmc 20,23-dihydroxyvitamin D3, novel P450scc product, stimulates differentiation and inhibits proliferation and NF-kappaB activity in human keratinocytes
    Zorica Janjetovic
    Department for Pathology and Laboratory Medicine, Cancer Research Center, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Cell Physiol 223:36-48. 2010
    ..In summary, we have characterized 20,23(OH)2D3 as a novel secosteroidal regulator of keratinocytes proliferation and differentiation and a modifier of their immune activity...
  18. pmc 20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes
    Zorica Janjetovic
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 4:e5988. 2009
    ....
  19. pmc Photo-conversion of two epimers (20R and 20S) of pregna-5,7-diene-3beta, 17alpha, 20-triol and their bioactivity in melanoma cells
    Michal A Zmijewski
    Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Steroids 74:218-28. 2009
    ....
  20. pmc 20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells
    Andrzej T Slominski
    Dept of Pathology and Laboratory Medicine, Center for Cancer Research, Univ of Tennessee Health Science Center, 930 Madison Ave, RM525, Memphis, TN 38163, USA
    Am J Physiol Cell Physiol 300:C526-41. 2011
    ..Thus 20(OH)D(2) shows cell-type dependent antiproliferative and prodifferentiation activities through activation of VDR, while having no detectable toxic calcemic activity, and is a poor substrate for CYP27B1...
  21. pmc Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives
    Michal A Zmijewski
    Department of Pathology and Laboratory Medicine and the Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Photochem Photobiol Sci 7:1570-6. 2008
    ..Further biological evaluation of newly synthesized compounds should help to select the best candidate(s) for potential treatment of hyperproliferative diseases including cancer...
  22. ncbi request reprint Novel vitamin D analogs as potential therapeutics: metabolism, toxicity profiling, and antiproliferative activity
    Jianjun Chen
    Department of Pharmaceutical Science, University of Tennessee Health Science Center, 847 Monroe Avenue, Memphis, TN 38163, U S A
    Anticancer Res 34:2153-63. 2014
    ..To discover novel [20(OH)D3] analogs as antiproliferative therapeutics...
  23. ncbi request reprint Corticotropin-releasing hormone induces keratinocyte differentiation in the adult human epidermis
    Blazej Zbytek
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Cell Physiol 203:118-26. 2005
    ....
  24. pmc Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system
    Andrzej T Slominski
    University of Tennessee Health Science Center, Department of Pathology and Laboratory Medicine, Memphhis, TN, USA
    Adv Anat Embryol Cell Biol 212:v, vii, 1-115. 2012
    ..In conclusion, skin cells and skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis...
  25. pmc CRF1 receptor splicing in epidermal keratinocytes: potential biological role and environmental regulations
    Michal A Zmijewski
    Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Cell Physiol 218:593-602. 2009
    ..We suggest that alternative splicing of CRF1 may play an important role in the regulation of skin cell phenotype with potential implications in pathology...
  26. ncbi request reprint Structure-activity relationship studies of arylthiazolidine amides as selective cytotoxic agents for melanoma
    Wei Li
    Department of Pharmaceutical Sciences, College of Pharmacy, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Anticancer Res 27:883-8. 2007
    ..New drugs are urgently needed for improved therapy for melanoma...
  27. pmc CRH inhibits NF-kappa B signaling in human melanocytes
    Blazej Zbytek
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Avenue 525, Memphis, TN 38163, USA
    Peptides 27:3276-83. 2006
    ..g. through activation of POMC. We suggest that induction of POMC by CRH serves as a feedback mechanism to self-restrict inflammatory response in the skin...
  28. pmc Expression of molecular equivalent of hypothalamic-pituitary-adrenal axis in adult retinal pigment epithelium
    Michal A Zmijewski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, Memphis, Tennessee 38163, USA
    J Endocrinol 193:157-69. 2007
    ..Therefore, we suggest that ocular tissue expresses CRF-driven signalling system that follows organisational structure of the HPA axis...
  29. pmc High-resolution magic angle spinning nuclear magnetic resonance analysis of metabolic changes in melanoma cells after induction of melanogenesis
    Wei Li
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Anal Biochem 386:282-4. 2009
    ....
  30. doi request reprint Synergistic activation of steroidogenic acute regulatory protein expression and steroid biosynthesis by retinoids: involvement of cAMP/PKA signaling
    Pulak R Manna
    Department of Cell Biology and Biochemistry P R M, S R K, D M S, Department of Dermatology and Pathology C L S, Texas Tech University Health Sciences Center, Lubbock, Texas 79430 and Department of Pathology and Laboratory Medicine A T S, University of Tennessee Health Science Center, Memphis, Tennessee 38163
    Endocrinology 155:576-91. 2014
    ..These findings delineate the molecular events by which retinoids influence cAMP/PKA signaling and provide additional and novel insight into the regulation of StAR expression and steroidogenesis in mouse Leydig cells. ..
  31. pmc Molecular cloning and initial characterization of African green monkey (Cercopithecus aethiops) corticotropin releasing factor receptor type 1 (CRF1) from COS-7 cells
    Andrzej T Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Gene 389:154-62. 2007
    ....
  32. ncbi request reprint Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee, Health Science Center, Memphis, TN, USA Department of Medicine, Division of Rheumatology and Connective Tissue Diseases, University of Tennessee, Health Science Center, Memphis, TN, USA
    Exp Dermatol 23:369-74. 2014
    ..We propose that local glucocorticosteroidogenic systems and their regulators, in concert with cognate receptors operate to stabilize skin homeostasis and prevent or attenuate skin pathology...
  33. pmc Commentary on the practical guide for the study of sebaceous glands
    Reza Nejati
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    Exp Dermatol 22:629-30. 2013
    ..In this issue of Experimental Dermatology, Hinde et al. present a practical guide to SG research - outlining methods, defining immunohistochemical markers and providing guidance to both novice and more experienced SG researchers...
  34. pmc Genetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses
    Cezary Skobowiat
    Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA Electronic address
    Gene 530:1-7. 2013
    ....
  35. pmc Melatonin membrane receptors in peripheral tissues: distribution and functions
    Radomir M Slominski
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Cell Endocrinol 351:152-66. 2012
    ..Melatonin receptor agonists and antagonists have an exciting future since they could define multiple mechanisms by which melatonin modulates the complexity of such a wide variety of physiological and pathological processes...
  36. pmc Corticotropin-releasing hormone stimulates NF-kappaB in human epidermal keratinocytes
    Blazej Zbytek
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    J Endocrinol 181:R1-7. 2004
    ..CRH-dependent stimulation of NF-kappaB activity is consistent with accumulated data about role of this neuropeptide in the regulation of local epidermal homeostasis...

Research Grants8

  1. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2002
    ..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..
  2. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2003
    ..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..
  3. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    ..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..
  4. Novel biosynthetic pathway for secosteroids and the skin
    Andrzej Slominski; Fiscal Year: 2006
    ..6. Defining the effect of 7-DHP, its hydroxy and seco-derivatives and of vitamin D (modified or unmodified) on P450scc mediated pregnenolone production from cholesterol. ..
  5. Novel biosynthetic pathway for secosteroids and the skin
    Andrzej Slominski; Fiscal Year: 2007
    ..6. Defining the effect of 7-DHP, its hydroxy and seco-derivatives and of vitamin D (modified or unmodified) on P450scc mediated pregnenolone production from cholesterol. ..
  6. Novel biosynthetic pathway for secosteroids and the skin
    Andrzej Slominski; Fiscal Year: 2009
    ..6. Defining the effect of 7-DHP, its hydroxy and seco-derivatives and of vitamin D (modified or unmodified) on P450scc mediated pregnenolone production from cholesterol. ..
  7. Novel biosynthetic pathway for secosteroids and the skin
    Andrzej T Slominski; Fiscal Year: 2010
    ..6. Defining the effect of 7-DHP, its hydroxy and seco-derivatives and of vitamin D (modified or unmodified) on P450scc mediated pregnenolone production from cholesterol. ..