Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in miceDaniel Sliva
Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America
PLoS ONE 7:e47873. 2012
..The aim of the present study was to evaluate whether GLT prevents colitis-associated carcinogenesis in mice...
Green tea polyphenols modulate secretion of urokinase plasminogen activator (uPA) and inhibit invasive behavior of breast cancer cellsVeronika Slivova
Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
Nutr Cancer 52:66-73. 2005
..Our results indicate that GTP may contribute to the anticancer effects of green tea by inhibiting the invasive behavior of cancer cells...
Suppression of proliferation and invasive behavior of human metastatic breast cancer cells by dietary supplement BreastDefendJiahua Jiang
Methodist Research Institute, Indianapolis, IN 46202, USA
Integr Cancer Ther 10:192-200. 2011
..The study was to evaluate the effect of the dietary supplement BreastDefend (BD) on the proliferation and invasive behavior of highly metastatic human breast cancer cells in vitro...
- Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK)
Anita Thyagarajan
Methodist Research Institute, Indianapolis, Indiana, USA
Nutr Cancer 62:630-40. 2010
..Taken together, our data demonstrate a novel mechanism responsible for the inhibition of colon cancer cells by G. lucidum and suggest GLT as natural product for the treatment of colon cancer...
- Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling
Jiahua Jiang
Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
Nutr Cancer 49:209-16. 2004
..Our results suggest that Ganoderma lucidum inhibits the growth of MDA-MB-231 breast cancer cells by modulating Akt/NF-kappaB signaling and could have potential therapeutic use for the treatment of breast cancer...
- Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling
Jiahua Jiang
Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
Int J Mol Med 21:577-84. 2008
..In conclusion, hydroxylated triterpenes from G. lucidum could be promising natural agents for the therapy of invasive breast cancers...
- Activated macrophages induce metastatic behavior of colon cancer cells
Andrej Jedinak
Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
Immunobiology 215:242-9. 2010
..In conclusion, the interruption of signaling between activated macrophages and colon cancer cells could be considered as a new therapeutic strategy...
- Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells
Anita Thyagarajan
Cancer Research Laboratory, Methodist Research Institute, E504, Indianapolis, IN 46202, USA
Int J Oncol 30:963-9. 2007
..Our study suggests the potential use of combined green tea and G. lucidum extracts for the suppression of growth and invasiveness of metastatic breast cancers...
- NAHA, a novel hydroxamic acid-derivative, inhibits growth and angiogenesis of breast cancer in vitro and in vivo
Jiahua Jiang
Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America
PLoS ONE 7:e34283. 2012
..Here, we evaluate the anticancer activity of NAHA against highly invasive human breast cancer cells MDA-MB-231 in vitro and in vivo...
- BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer
Jiahua Jiang
Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202, USA
Oncol Rep 28:1139-45. 2012
..In conclusion, BD may be considered as a biological therapeutic agent against invasive breast cancers...
- Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling
Andrej Jedinak
Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
Int J Oncol 38:761-7. 2011
..In conclusion, our data suggest that ganodermanontriol might be a potential chemotherapeutic agent for the treatment of cancer...
- ProstaCaid inhibits tumor growth in a xenograft model of human prostate cancer
Jiahua Jiang
Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN, USA
Int J Oncol 40:1339-44. 2012
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- Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling
Jiahua Jiang
Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
Int J Oncol 29:695-703. 2006
..lucidum as a suitable herb for chemoprevention and chemotherapy of breast cancer...
- Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion
Anita Thyagarajan
Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
Int J Mol Med 18:657-64. 2006
..In summary, our results suggest that G. lucidum inhibits the oxidative stress-induced invasive behavior of breast cancer cells by modulating Erk1/2 signaling and can be potentially considered as an antioxidant in adjuvant cancer therapy...
- Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling
Andrej Jedinak
Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, 46202, USA
Nutr J 10:52. 2011
..In the present study, we evaluated anti-inflammatory properties of an edible oyster mushroom (Pleurotus ostreatus) in vitro and in vivo...
- Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA
Jiahua Jiang
Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN, USA
Biochem Biophys Res Commun 415:325-9. 2011
..In conclusion, mushroom GDNT is a natural agent that has potential as a therapy for invasive breast cancers...
- Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice
Andrej Jedinak
Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
Int J Mol Med 26:643-50. 2010
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- Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum
Shailesh Dudhgaonkar
Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
Int Immunopharmacol 9:1272-80. 2009
..In conclusion, the anti-inflammatory and anti-proliferative effects of GLT on macrophages are mediated through the inhibition of NF-kappaB and AP-1 signaling pathways...
- Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaid™: mechanism of activity
Jiahua Jiang
Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
Int J Oncol 38:1675-82. 2011
..In conclusion, the dietary supplement PC is a promising natural complex with the potency to inhibit invasive human prostate cancer...
- Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells
Jiahua Jiang
Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
Int J Oncol 37:1529-36. 2010
..In conclusion, the MC dietary supplement could have potential therapeutic value in the treatment of invasive human breast cancer...
- Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling
Jiahua Jiang
Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202, USA
Clin Exp Metastasis 29:165-78. 2012
..In summary, our data suggest that gossypol could have potential therapeutic effect for the treatment of invasive prostate cancer...
- Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1-dependent and -independent pathways
Tatiana Valachovicova
Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, 1800 N. Capitol Avenue, Indianapolis, IN 46202, USA
Int J Oncol 25:1389-95. 2004
..Taken together, our results suggest that dietary soy isoflavones inhibit adhesion and motility of highly invasive breast cancer cells by distinct signaling pathways...
- Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells
Gwenaelle Stanley
Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
Biochem Biophys Res Commun 330:46-52. 2005
..In summary, our results suggest that G. lucidum inhibits prostate cancer-dependent angiogenesis by modulating MAPK and Akt signaling and could have potential therapeutic use for the treatment of prostate cancer...
- Suppression of cancer invasiveness by dietary compounds
Daniel Sliva
Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
Mini Rev Med Chem 8:677-88. 2008
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- Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway
Andrej Jedinak
Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
Int J Oncol 33:1307-13. 2008
..In conclusion, our results indicated that the edible oyster mushroom has potential therapeutic/preventive effects on breast and colon cancer...
- Cellular and physiological effects of soy flavonoids
Tatiana Valachovicova
Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, IN 46202, USA
Mini Rev Med Chem 4:881-7. 2004
..Recent studies suggest beneficial health effects of soy and recommend increasing the intake of isoflavone-rich soy protein to the level of intake commonly used in Asian countries...
- Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3
Jiahua Jiang
Cancer Research Laboratory, Methodist Research Institute, E504, Indianapolis, IN 46202, USA
Int J Oncol 24:1093-9. 2004
..Thus, Ganoderma lucidum exerts its effect on cancer cells by multiple mechanisms and may have potential therapeutic use for the prevention and treatment of cancer...
- Apurinic/Apyrimidinic endonuclease 1 regulates inflammatory response in macrophages
Andrej Jedinak
Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
Anticancer Res 31:379-85. 2011
..In conclusion, pharmacological inhibition of APE1 by E3330 suppresses inflammatory response in activated macrophages and can be considered as a novel therapeutic strategy for the inhibition of tumor-associated macrophages...
- Semisynthesis and biological evaluation of ganodermanontriol and its stereoisomeric triols
Erin M Kennedy
Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, 402 N Blackford Street, Indianapolis, Indiana 46202, USA
J Nat Prod 74:2332-7. 2011
..The effect of ganodermanontriol and its isomers on cell proliferation was assayed; IC50 values of 5.8 and 9.7 μM on breast cancer cell lines MCF-7 and MDA-MB-231, respectively, were found for ganodermanontriol...
- ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK
Anita Thyagarajan-Sahu
Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
BMC Complement Altern Med 11:74. 2011
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- Role of Rho kinase in sphingosine 1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation
Kevin A Harvey
Cellular Biochemistry Laboratory, Methodist Research Institute, Clarian Health Partners, Room E504, Indianapolis, IN, USA
Mol Cell Biochem 342:7-19. 2010
..In conclusion, S1P-induced PAEC angiogenic responses are regulated by S1P(1) and/or S1P(3) receptors independent of Rho kinase activation, whereas S1P(2) receptor-mediated curtailment of PASMC function by S1P...
- Synergistic and additive effects of modified citrus pectin with two polybotanical compounds, in the suppression of invasive behavior of human breast and prostate cancer cells
Jiahua Jiang
Indiana University Health, Indianapolis, IN, USA
Integr Cancer Ther 12:145-52. 2013
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- Cellular and physiological effects of Ganoderma lucidum (Reishi)
Daniel Sliva
Methodist Research Institute, Clarian Health Partners, Inc, Indianapolis, IN 46202, USA
Mini Rev Med Chem 4:873-9. 2004
..This review summarizes the biological effects of Ganoderma lucidum upon specific signaling molecules and pathways, which are responsible for its therapeutic effects...
- Signaling pathways responsible for cancer cell invasion as targets for cancer therapy
Daniel Sliva
Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, and Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
Curr Cancer Drug Targets 4:327-36. 2004
..This review will summarize different approaches to targeting distinct signaling molecules involved in cancer invasion and metastasis...
- Ganoderma lucidum (Reishi) in cancer treatment
Daniel Sliva
Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
Integr Cancer Ther 2:358-64. 2003
..However, because of the availability of Ganoderma lucidum from different sources, it is advisable to test its biologic activity...
