Daniel Sliva

Summary

Publications

  1. pmc BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202, USA
    Oncol Rep 28:1139-45. 2012
  2. pmc NAHA, a novel hydroxamic acid-derivative, inhibits growth and angiogenesis of breast cancer in vitro and in vivo
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e34283. 2012
  3. pmc Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7
    Shujie Cheng
    Department of Bioengineering, College of Food Science, South China Agricultural University, Guangzhou, P R China
    Int J Oncol 42:1869-74. 2013
  4. pmc Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e47873. 2012
  5. ncbi request reprint Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, IN 46202, USA
    J Altern Complement Med 9:491-7. 2003
  6. ncbi request reprint Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion
    Anita Thyagarajan
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Mol Med 18:657-64. 2006
  7. ncbi request reprint Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Mol Med 21:577-84. 2008
  8. doi request reprint Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK)
    Anita Thyagarajan
    Methodist Research Institute, Indianapolis, Indiana, USA
    Nutr Cancer 62:630-40. 2010
  9. ncbi request reprint Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Nutr Cancer 49:209-16. 2004
  10. ncbi request reprint Green tea polyphenols modulate secretion of urokinase plasminogen activator (uPA) and inhibit invasive behavior of breast cancer cells
    Veronika Slivova
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Nutr Cancer 52:66-73. 2005

Collaborators

  • Jiahua Jiang
  • Andrej Jedinak
  • Isaac Eliaz
  • Rafat A Siddiqui
  • Jiri Adamec
  • Joe G N Garcia
  • Viktor Krchnak
  • Anita Thyagarajan-Sahu
  • Anita Thyagarajan
  • Veronika Slivova
  • Tatiana Valachovicova
  • Kevin Harvey
  • Jagadish Loganathan
  • Shujie Cheng
  • Erin M Kennedy
  • Kevin A Harvey
  • Shailesh Dudhgaonkar
  • Zachary Welch
  • Gwenaelle Stanley
  • Frank P Lloyd
  • Denis English
  • George Boguslawski
  • Harikrishna Nakshatri
  • Amanda Smith
  • George E Sandusky
  • Junfang Lin
  • Steven J P'pool
  • Robert E Minto
  • Hai Nguyen
  • Lee Ann Baldridge
  • Colin Terry
  • Jiashi Zhu
  • Amber Hopf
  • Pradip Mukerji
  • Gary Zaloga
  • Stephen J Demichele
  • Yung Sheng Huang
  • Heidi Bergman
  • Jennifer Shuherk
  • Patrick McGlynn
  • Sandra Ciechanowicz
  • Rodney A Rhoades
  • David N Brindley
  • A Thomas Kovala
  • Jeremy R Grogg

Detail Information

Publications44

  1. pmc BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202, USA
    Oncol Rep 28:1139-45. 2012
    ..In conclusion, BD may be considered as a biological therapeutic agent against invasive breast cancers...
  2. pmc NAHA, a novel hydroxamic acid-derivative, inhibits growth and angiogenesis of breast cancer in vitro and in vivo
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e34283. 2012
    ..Here, we evaluate the anticancer activity of NAHA against highly invasive human breast cancer cells MDA-MB-231 in vitro and in vivo...
  3. pmc Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7
    Shujie Cheng
    Department of Bioengineering, College of Food Science, South China Agricultural University, Guangzhou, P R China
    Int J Oncol 42:1869-74. 2013
    ..In conclusion, triterpenes from P. cocos demonstrate anticancer and anti-invasive effects on human pancreatic cancer cells and can be considered as new therapeutic agents in the treatment of pancreatic cancer...
  4. pmc Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e47873. 2012
    ..The aim of the present study was to evaluate whether GLT prevents colitis-associated carcinogenesis in mice...
  5. ncbi request reprint Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, IN 46202, USA
    J Altern Complement Med 9:491-7. 2003
    ..Because the dried powder of ganoderma is commercially available as a dietary supplement itself, the purpose of this study was to evaluate the biologic activity of samples of Ganoderma lucidum from different sources...
  6. ncbi request reprint Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion
    Anita Thyagarajan
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Mol Med 18:657-64. 2006
    ..In summary, our results suggest that G. lucidum inhibits the oxidative stress-induced invasive behavior of breast cancer cells by modulating Erk1/2 signaling and can be potentially considered as an antioxidant in adjuvant cancer therapy...
  7. ncbi request reprint Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Mol Med 21:577-84. 2008
    ..In conclusion, hydroxylated triterpenes from G. lucidum could be promising natural agents for the therapy of invasive breast cancers...
  8. doi request reprint Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK)
    Anita Thyagarajan
    Methodist Research Institute, Indianapolis, Indiana, USA
    Nutr Cancer 62:630-40. 2010
    ..Taken together, our data demonstrate a novel mechanism responsible for the inhibition of colon cancer cells by G. lucidum and suggest GLT as natural product for the treatment of colon cancer...
  9. ncbi request reprint Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Nutr Cancer 49:209-16. 2004
    ..Our results suggest that Ganoderma lucidum inhibits the growth of MDA-MB-231 breast cancer cells by modulating Akt/NF-kappaB signaling and could have potential therapeutic use for the treatment of breast cancer...
  10. ncbi request reprint Green tea polyphenols modulate secretion of urokinase plasminogen activator (uPA) and inhibit invasive behavior of breast cancer cells
    Veronika Slivova
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Nutr Cancer 52:66-73. 2005
    ..Our results indicate that GTP may contribute to the anticancer effects of green tea by inhibiting the invasive behavior of cancer cells...
  11. doi request reprint Suppression of proliferation and invasive behavior of human metastatic breast cancer cells by dietary supplement BreastDefend
    Jiahua Jiang
    Methodist Research Institute, Indianapolis, IN 46202, USA
    Integr Cancer Ther 10:192-200. 2011
    ..The study was to evaluate the effect of the dietary supplement BreastDefend (BD) on the proliferation and invasive behavior of highly metastatic human breast cancer cells in vitro...
  12. ncbi request reprint Protein kinase C induces motility of breast cancers by upregulating secretion of urokinase-type plasminogen activator through activation of AP-1 and NF-kappaB
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Incorporated, 1633 North Capitol Avenue, MT 350, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 290:552-7. 2002
    ..The disruption of PKC, AP- 1, and NF-kappaB signaling in breast cancer may be used to develop therapies for breast cancer prevention and intervention by reducing the secretion of uPA...
  13. doi request reprint Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling
    Andrej Jedinak
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Oncol 38:761-7. 2011
    ..In conclusion, our data suggest that ganodermanontriol might be a potential chemotherapeutic agent for the treatment of cancer...
  14. ncbi request reprint Aspirin inhibits highly invasive prostate cancer cells
    Frank P Lloyd
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, IN 46202, USA
    Int J Oncol 23:1277-83. 2003
    ..These results indicate that aspirin may contribute directly to reducing invasion and metastasis of prostate cancers by inhibiting cell migration and invasion...
  15. ncbi request reprint Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1-dependent and -independent pathways
    Tatiana Valachovicova
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, 1800 N Capitol Avenue, Indianapolis, IN 46202, USA
    Int J Oncol 25:1389-95. 2004
    ..Taken together, our results suggest that dietary soy isoflavones inhibit adhesion and motility of highly invasive breast cancer cells by distinct signaling pathways...
  16. ncbi request reprint Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Avenue E504, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 298:603-12. 2002
    ..Our data suggest that spores and unpurified fruiting body of G. lucidum inhibit invasion of breast and prostate cancer cells by a common mechanism and could have potential therapeutic use for cancer treatment...
  17. doi request reprint Activated macrophages induce metastatic behavior of colon cancer cells
    Andrej Jedinak
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Immunobiology 215:242-9. 2010
    ..In conclusion, the interruption of signaling between activated macrophages and colon cancer cells could be considered as a new therapeutic strategy...
  18. ncbi request reprint Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells
    Anita Thyagarajan
    Cancer Research Laboratory, Methodist Research Institute, E504, Indianapolis, IN 46202, USA
    Int J Oncol 30:963-9. 2007
    ..Our study suggests the potential use of combined green tea and G. lucidum extracts for the suppression of growth and invasiveness of metastatic breast cancers...
  19. doi request reprint ProstaCaid inhibits tumor growth in a xenograft model of human prostate cancer
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN, USA
    Int J Oncol 40:1339-44. 2012
    ....
  20. doi request reprint Role of Rho kinase in sphingosine 1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation
    Kevin A Harvey
    Cellular Biochemistry Laboratory, Methodist Research Institute, Clarian Health Partners, Room E504, Indianapolis, IN, USA
    Mol Cell Biochem 342:7-19. 2010
    ..In conclusion, S1P-induced PAEC angiogenic responses are regulated by S1P(1) and/or S1P(3) receptors independent of Rho kinase activation, whereas S1P(2) receptor-mediated curtailment of PASMC function by S1P...
  21. doi request reprint Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaid™: mechanism of activity
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Int J Oncol 38:1675-82. 2011
    ..In conclusion, the dietary supplement PC is a promising natural complex with the potency to inhibit invasive human prostate cancer...
  22. pmc Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling
    Andrej Jedinak
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, 46202, USA
    Nutr J 10:52. 2011
    ..In the present study, we evaluated anti-inflammatory properties of an edible oyster mushroom (Pleurotus ostreatus) in vitro and in vivo...
  23. ncbi request reprint Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Oncol 29:695-703. 2006
    ..lucidum as a suitable herb for chemoprevention and chemotherapy of breast cancer...
  24. doi request reprint Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN, USA
    Biochem Biophys Res Commun 415:325-9. 2011
    ..In conclusion, mushroom GDNT is a natural agent that has potential as a therapy for invasive breast cancers...
  25. pmc Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway
    Andrej Jedinak
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Oncol 33:1307-13. 2008
    ..In conclusion, our results indicated that the edible oyster mushroom has potential therapeutic/preventive effects on breast and colon cancer...
  26. ncbi request reprint Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Oncol 37:1529-36. 2010
    ..In conclusion, the MC dietary supplement could have potential therapeutic value in the treatment of invasive human breast cancer...
  27. ncbi request reprint Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, E504, Indianapolis, IN 46202, USA
    Int J Oncol 24:1093-9. 2004
    ..Thus, Ganoderma lucidum exerts its effect on cancer cells by multiple mechanisms and may have potential therapeutic use for the prevention and treatment of cancer...
  28. doi request reprint Synergistic and additive effects of modified citrus pectin with two polybotanical compounds, in the suppression of invasive behavior of human breast and prostate cancer cells
    Jiahua Jiang
    Indiana University Health, Indianapolis, IN, USA
    Integr Cancer Ther 12:145-52. 2013
    ....
  29. doi request reprint Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum
    Shailesh Dudhgaonkar
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Int Immunopharmacol 9:1272-80. 2009
    ..In conclusion, the anti-inflammatory and anti-proliferative effects of GLT on macrophages are mediated through the inhibition of NF-kappaB and AP-1 signaling pathways...
  30. ncbi request reprint Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice
    Andrej Jedinak
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Mol Med 26:643-50. 2010
    ....
  31. ncbi request reprint Suppression of cancer invasiveness by dietary compounds
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Mini Rev Med Chem 8:677-88. 2008
    ....
  32. ncbi request reprint Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells
    Gwenaelle Stanley
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 330:46-52. 2005
    ..In summary, our results suggest that G. lucidum inhibits prostate cancer-dependent angiogenesis by modulating MAPK and Akt signaling and could have potential therapeutic use for the treatment of prostate cancer...
  33. doi request reprint Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202, USA
    Clin Exp Metastasis 29:165-78. 2012
    ..In summary, our data suggest that gossypol could have potential therapeutic effect for the treatment of invasive prostate cancer...
  34. ncbi request reprint Serum factors involved in human microvascular endothelial cell morphogenesis
    Kevin Harvey
    Methodist Research Institute, the Department of Biology of Indiana University Purdue University, Indianapolis, 46202, USA
    J Lab Clin Med 140:188-98. 2002
    ..Lipid and protein growth factors apparently exert complementary roles in the angiogenic response, as demonstrated by their ability to promote chemotaxis, angiogenic differentiation, and angiogenesis in vivo...
  35. ncbi request reprint Signaling pathways responsible for cancer cell invasion as targets for cancer therapy
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, and Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Curr Cancer Drug Targets 4:327-36. 2004
    ..This review will summarize different approaches to targeting distinct signaling molecules involved in cancer invasion and metastasis...
  36. doi request reprint Semisynthesis and biological evaluation of ganodermanontriol and its stereoisomeric triols
    Erin M Kennedy
    Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, 402 N Blackford Street, Indianapolis, Indiana 46202, USA
    J Nat Prod 74:2332-7. 2011
    ..The effect of ganodermanontriol and its isomers on cell proliferation was assayed; IC50 values of 5.8 and 9.7 μM on breast cancer cell lines MCF-7 and MDA-MB-231, respectively, were found for ganodermanontriol...
  37. ncbi request reprint Ganoderma lucidum (Reishi) in cancer treatment
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Integr Cancer Ther 2:358-64. 2003
    ..However, because of the availability of Ganoderma lucidum from different sources, it is advisable to test its biologic activity...
  38. ncbi request reprint The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes
    Jagadish Loganathan
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202, USA
    Int J Oncol 44:2009-15. 2014
    ..The anti-metastatic benefits of GLE warrant further clinical studies. ..
  39. ncbi request reprint Cellular and physiological effects of soy flavonoids
    Tatiana Valachovicova
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, IN 46202, USA
    Mini Rev Med Chem 4:881-7. 2004
    ..Recent studies suggest beneficial health effects of soy and recommend increasing the intake of isoflavone-rich soy protein to the level of intake commonly used in Asian countries...
  40. pmc Apurinic/Apyrimidinic endonuclease 1 regulates inflammatory response in macrophages
    Andrej Jedinak
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Anticancer Res 31:379-85. 2011
    ..In conclusion, pharmacological inhibition of APE1 by E3330 suppresses inflammatory response in activated macrophages and can be considered as a novel therapeutic strategy for the inhibition of tumor-associated macrophages...
  41. pmc ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK
    Anita Thyagarajan-Sahu
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    BMC Complement Altern Med 11:74. 2011
    ....
  42. ncbi request reprint Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response
    George Boguslawski
    Experimental Cell Research Laboratory, Methodist Research Institute, Indianapolis, Indiana 46202, USA
    Exp Cell Res 274:264-74. 2002
    ..SPP and related lipids may play a key role in angiogenesis by coordinating the migration of both endothelial cells and vascular smooth muscle cells in response to the changing gradients of these bioactive lipid messengers...
  43. ncbi request reprint Phosphatidylinositol 3-kinase and NF-kappaB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen activator
    Daniel Sliva
    Cancer Research Laboratory, the Signal Transduction Laboratory, and the Experimental Cell Research Program, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, Indiana 46202, USA
    J Biol Chem 277:3150-7. 2002
    ..Thus, constitutively active PI 3-kinase controls cell motility by the regulation of expression of uPA through the activation of NF-kappaB...
  44. ncbi request reprint Cellular and physiological effects of Ganoderma lucidum (Reishi)
    Daniel Sliva
    Methodist Research Institute, Clarian Health Partners, Inc, Indianapolis, IN 46202, USA
    Mini Rev Med Chem 4:873-9. 2004
    ..This review summarizes the biological effects of Ganoderma lucidum upon specific signaling molecules and pathways, which are responsible for its therapeutic effects...