- Arterial baroreflexes can determine long-term blood pressure. Baroreceptors and hypertension: time for a re-think?
John Radcliffe Hospital, University of Oxford, UK
Exp Physiol 89:337-41. 2004
- Benefits, challenges, and registerability of the polypill
Cardiac Department, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
Eur Heart J 27:1651-6. 2006
..Discussions with regulatory bodies are required in order to obtain some 'balance' between an overcautious registration approach and the potentially large public health benefits that are likely to arise from the use of polypills...
- Cardiovascular effects of music by entraining cardiovascular autonomic rhythms music therapy update: tailored to each person, or does one size fit all?
Cardiovascular Medicine, University of Oxford, Oxford, UK
Neth Heart J 21:99-100. 2013
..These findings need to now be tested in the clinical setting since, if confirmed, this would greatly simplify the practical use of this promising tool...
- The role of angiotensin-converting enzyme inhibitors in the treatment of hypertension
Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, England
Curr Cardiol Rep 3:511-8. 2001
..Nevertheless, there is a strong case for an attack on the renin-angiotensin system. Whether this will be by ACE inhibition, angiotensin-II receptor blockade, or both, is the subject of current clinical trials...
- Prognostic value of blood pressure in patients with high vascular risk in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial study
CV Medicine, John Radcliffe Hospital, Oxford, UK
J Hypertens 27:1360-9. 2009
..We analysed the impact of BP on cardiovascular events in well treated high-risk patients enrolled in a large clinical trial (Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial)...
- Clinical evidence from ONTARGET: the value of an angiotensin II receptor blocker and an angiotensin-converting enzyme inhibitor
Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
J Hypertens Suppl 27:S23-9. 2009
..Thus, telmisartan provides comparable efficacy to ramipril with less adverse events, which may encourage patient compliance...
- Angiotensin II and trials of cardiovascular outcomes
Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, England, Oxford, UK
Am J Cardiol 89:11A-16A; discussion 16A-17A. 2002
- Blood-pressure reduction and cardiovascular risk in HOPE study
Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
Lancet 358:2130-1. 2001
- Where are clinical trials going? Society and clinical trials
University Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
J Intern Med 255:151-8. 2004
..These issues are best resolved by independent financial support (from government or other institutions) rather than relying on the commercial sponsor...
- Systolic and diastolic blood pressure changes in relation with myocardial infarction and stroke in patients with coronary artery disease
From the Department of Medicine, Hospital of Assisi, Assisi, Italy P V Department of Medicine G R and Department of Cardiology and Cardiovascular Pathophysiology F A, University Hospital of Perugia, Perugia, Italy Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Naples, Italy B T Department of Health Sciences, University of Milano Bicocca and IRCCS Istituto Auxologico Italiano, Milano, Italy G M Department of Clinical Epidemiology and Biostatistics and Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada J P, P G, K T, S Y and Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, United Kingdom P S
Hypertension 65:108-14. 2015
..The relationships of BP with risk were much steeper for stroke than for MI. A treatment-induced BP reduction over the explored range seems to be safe in patients with coronary artery disease...
- Systolic blood pressure variation and mean heart rate is associated with cognitive dysfunction in patients with high cardiovascular risk
From the Klinik für Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg, Germany M B, F C, U L Boehringer Ingelheim, Pharma GmbH and Co KG, Ingelheim, Germany H S Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada D L, E L, K T, S Y Centro di Fisiologica Clinica e Ipertensione, Universita Milano Bicocca, Istituto Auxologico, Milan, Italy G M CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands T U Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen, Germany R S Department of Neurology, University Hospital Essen, Essen, Germany H C D Hatter Institute for Cardiovascular Research in Africa and IIDMM, Faculty of Health Sciences, University of Cape Town, South Africa K S Hypertension Unit, KU Leuven University, Leuven, Belgium R F University of Valencia, Spain J R Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, United Kingdom P S The George Institute for Global Health
Hypertension 65:651-61. 2015
..SBP-CV and mean HR showed additive effects. In conclusion, SBP-CV and mean HR are independent predictors of cognitive decline and cognitive dysfunction in patients at high CV risk...
- No HOPE without proof: do ARBs meet the standard for cardiovascular protection?
Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
Medscape J Med 10:S6. 2008
..The results of ONTARGET are anticipated to be available in 2008...
- Impact of telmisartan on cardiovascular outcome in hypertensive patients at high risk: a Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease subanalysis
aCARIM, School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands bKlinik für Innere Medizin III, University Clinic of the Saarland, Homburg Saar cDepartment of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany dCardiovascular Medicine, John Radcliffe Hospital, Oxford, UK ePopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada fBoehringer Ingelheim Pharma GmbH and Co KG, Ingelheim am Rhein, Germany
J Hypertens 32:1334-41. 2014
..We performed a post-hoc analysis to explore the hypothesis that telmisartan has a differential action in hypertensive vs. nonhypertensive patients...
- The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls
Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford OX3 7LF, UK
Eur Heart J 30:2137-46. 2009
..The interdependence of these four risk factors is unclear...
- The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial
Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK
Lancet 377:2181-92. 2011
..The SHARP trial aimed to assess the efficacy and safety of the combination of simvastatin plus ezetimibe in such patients...
- Current options in the management of coronary artery disease
Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
Am J Cardiol 92:4N-8N. 2003
..Current options for the management of CAD have their limitations, thus confirming the appropriateness of continuing the search for improved therapies to reverse the disease process and reduce the global burden...
- Effect of long-term therapy with ramipril in high-risk women
Department of Medicine, Division of Cardiology and Population Health Institute, McMaster University, Hamilton, Ontario, Canada
J Am Coll Cardiol 40:693-702. 2002
..We evaluated the effects of long-term therapy with the angiotensin-converting enzyme (ACE) inhibitor ramipril on major cardiovascular (CV) outcomes in high-risk women...
- Verapamil-sustained release-based treatment strategy is equivalent to atenolol-based treatment strategy at reducing cardiovascular events in patients with prior myocardial infarction: an INternational VErapamil SR-Trandolapril (INVEST) substudy
Division of Cardiovascular Medicine, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
Am Heart J 156:241-7. 2008
..The purpose of the study was to compare a beta-blocker-based strategy with a heart rate-lowering calcium antagonists-based strategy in patients with prior MI...
- Telmisartan, ramipril, or both in patients at high risk for vascular events
Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
N Engl J Med 358:1547-59. 2008
..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
- Progress and problems for randomized clinical trials: from streptomycin to the era of megatrials
Medical Science Department, Boehringer Ingelheim Pharma GmbH and Co KG, 55216 Ingelheim, Germany
Eur Heart J 27:2158-64. 2006
..Megatrials are under threat from over-regulation, increasing costs, and difficulties in execution. These issues merit urgent public and political education and debate...
- Impact of cigarette smoking in high-risk patients participating in a clinical trial. A substudy from the Heart Outcomes Prevention Evaluation (HOPE) trial
Gilles R Dagenais
Laval University Heart and Lung Institute, Ste Foy, Quebec G1V 4G5, Canada
Eur J Cardiovasc Prev Rehabil 12:75-81. 2005
..In recent large cardiovascular trials done in stable patients, 14-31% of the participants were smokers; the consequences of smoking in these trials using medications known to reduce cardiovascular events, have not been assessed...
- Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telmi
McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
Am Heart J 148:52-61. 2004
..Currently, there is uncertainty about the role of ARBs when used alone or in combination with an ACE inhibitor in high-risk populations with controlled hypertension...
- 1999 WHO/ISH Hypertension Guidelines--highlights & ESH update
Sverre E Kjeldsen
Department of Cardiology, Ullevaal University Hospital, Oslo, Norway
J Hypertens 20:153-5. 2002
- Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions
Lancet 363:757-67. 2004
..Despite this observation, previous randomised trials had indicated that cholesterol-lowering statin therapy reduces the risk of stroke, but large-scale prospective confirmation has been needed...
- Use of ramipril in preventing stroke: double blind randomised trial
Canadian Cardiovascular Collaboration, McMaster University, 237 Barton St E, Hamilton, ON, Canada L8L 2X2
BMJ 324:699-702. 2002
..To determine the effect of the angiotensin converting enzyme inhibitor ramipril on the secondary prevention of stroke...
- Preventing stroke with ramipril--authors' reply
BMJ 326:52. 2003
- Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial
Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario
JAMA 293:1338-47. 2005
..Experimental and epidemiological data suggest that vitamin E supplementation may prevent cancer and cardiovascular events. Clinical trials have generally failed to confirm benefits, possibly due to their relatively short duration...
- Who is fooling us?
Lancet 360:873-4. 2002
- Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial
Henry R Black
Rush Medical College of Rush University, Chicago, IL 60612, USA
JAMA 289:2073-82. 2003
..Hypertensive patients are often given a calcium antagonist to reduce cardiovascular disease risk, but the benefit compared with other drug classes is controversial...
- Global differences in blood pressure control and clinical outcomes in the INternational VErapamil SR-Trandolapril STudy (INVEST)
Department of Pharmacy Practice, College of Pharmacy University of Florida, Gainesville, Florida 32610, USA
Clin Cardiol 28:321-8. 2005
- Predictors of adverse outcome among patients with hypertension and coronary artery disease
Carl J Pepine
Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida 32610 0277, USA
J Am Coll Cardiol 47:547-51. 2006
..We sought to determine predictors for adverse outcomes in hypertensive patients with coronary artery disease (CAD)...
- Relationship of electrocardiographic left ventricular hypertrophy to mortality and cardiovascular morbidity in high-risk patients
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Eur J Cardiovasc Prev Rehabil 10:420-8. 2003
..The prognostic significance of left ventricular hypertrophy (LVH) identified by simple electrocardiographic (ECG) criteria in high-risk patients with established cardiovascular (CV) diseases is not clearly understood...