Slaby O, Redova M, Poprach A, Nekvindova J, Iliev R, Radova L, et al
. Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients. Genes Chromosomes Cancer. 2012;51:707-16 pubmed publisher
..If further validated, we suggest that identified miRNAs might be used for identification of RCC patients at high risk of early relapse after nephrectomy in clinical practice. ..
Vychytilova Faltejskova P, Pesta M, Radova L, Liska V, Daum O, Kala Z, et al
. Genome-wide microRNA Expression Profiling in Primary Tumors and Matched Liver Metastasis of Patients with Colorectal Cancer. Cancer Genomics Proteomics. 2016;13:311-6 pubmed
..These results indicate that miRNAs could serve as new therapeutic targets in patients with metastatic CRC. ..
Slaby O, Laga R, Sedlacek O. Therapeutic targeting of non-coding RNAs in cancer. Biochem J. 2017;474:4219-4251 pubmed publisher
..Finally, we provide the up-to-date summary of clinical trials involving miRNAs and future directions in the development of ncRNA therapeutics. ..
Iliev R, Fedorko M, Machackova T, Mlcochova H, Svoboda M, Pacik D, et al
. Expression Levels of PIWI-interacting RNA, piR-823, Are Deregulated in Tumor Tissue, Blood Serum and Urine of Patients with Renal Cell Carcinoma. Anticancer Res. 2016;36:6419-6423 pubmed
..In blood serum, piR-823 is up-regulated, but with unsatisfactory analytical performance. Preliminary data indicate the promising diagnostic utility of urinary piR-823 in patients with RCC. ..
Vychytilova Faltejskova P, Slaby O. MicroRNA-215: From biology to theranostic applications. Mol Aspects Med. 2019;: pubmed publisher
Ahmad P, Sana J, Slavik M, Gurín D, Radova L, Gablo N, et al
. MicroRNA-15b-5p Predicts Locoregional Relapse in Head and Neck Carcinoma Patients Treated With Intensity-modulated Radiotherapy. Cancer Genomics Proteomics. 2019;16:139-146 pubmed publisher
..25; 95% CI=0.05-0.78; p<0.016). miR-15b-5p represents a potentially helpful biomarker for individualized treatment decisions concerning the management of HNSCC patients. ..
Juracek J, Staník M, Veselá P, Radova L, Dolezel J, Svoboda M, et al
. Tumor expression of miR-34a-3p is an independent predictor of recurrence in non-muscle-invasive bladder cancer and promising additional factor to improve predictive value of EORTC nomogram. Urol Oncol. 2019;37:184.e1-184.e7 pubmed publisher
Vecera M, Sana J, Lipina R, Smrcka M, Slaby O. Long Non-Coding RNAs in Gliomas: From Molecular Pathology to Diagnostic Biomarkers and Therapeutic Targets. Int J Mol Sci. 2018;19: pubmed publisher
..A conclusion follows that these RNAs show great potential to serve as powerful diagnostic, prognostic, and predictive biomarkers as well as therapeutic targets. ..
Obermannová R, Redova Lojova M, Vychytilova Faltejskova P, Grell P, Cho W, Sachlova M, et al
. Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population. Anticancer Res. 2018;38:3719-3724 pubmed publisher
..Our results indicate that selected tissue microRNAs have the potential to serve as relevant diagnostic and prognostic biomarkers of GC in a central European population. ..