S S Skandalis

Summary

Publications

  1. ncbi request reprint The greatly increased amounts of accumulated versican and decorin with specific post-translational modifications may be closely associated with the malignant phenotype of pancreatic cancer
    Spyros S Skandalis
    Laboratory of Cell Proliferation and Ageing, Institute of Biology, NCSR Demokritos, 15310 Athens, Greece
    Biochim Biophys Acta 1760:1217-25. 2006
  2. pmc Versican but not decorin accumulation is related to malignancy in mammographically detected high density and malignant-appearing microcalcifications in non-palpable breast carcinomas
    Spyros S Skandalis
    Laboratory of Biochemistry, Department of Chemistry, University of Patras, Rio 26504, Greece
    BMC Cancer 11:314. 2011
  3. ncbi request reprint The increased accumulation of structurally modified versican and decorin is related with the progression of laryngeal cancer
    S S Skandalis
    Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 26500 Patras, Greece
    Biochimie 88:1135-43. 2006
  4. ncbi request reprint Stage-related decorin and versican expression in human laryngeal cancer
    M Stylianou
    Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece
    Anticancer Res 28:245-51. 2008
  5. doi request reprint Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma
    S Filou
    Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece
    Biochimie 95:725-34. 2013
  6. ncbi request reprint Keratan sulphate in cerebrum, cerebellum and brainstem of sheep brain
    N Papageorgakopoulou
    Department of Chemistry, Organic Chemistry, Biochemistry and Natural Products Division, University of Patras, Patras 26500, Greece
    Biochimie 83:973-8. 2001
  7. ncbi request reprint Targeting the tumor proteasome as a mechanism to control the synthesis and bioactivity of matrix macromolecules
    S S Skandalis
    Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece
    Curr Mol Med 12:1068-82. 2012
  8. ncbi request reprint Pathophysiology and pharmacological targeting of tumor-induced bone disease: current status and emerging therapeutic interventions
    V T Labropoulou
    Division of Oncology, School of Medicine, University of Patras, 26500 Patras, Greece
    Curr Med Chem 18:1584-98. 2011
  9. ncbi request reprint Cartilage aggrecan undergoes significant compositional and structural alterations during laryngeal cancer
    Spyros S Skandalis
    Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 26500 Patras, Greece
    Biochim Biophys Acta 1760:1046-53. 2006
  10. ncbi request reprint The extractability of extracellular matrix components as a marker of cartilage remodeling in laryngeal squamous cell carcinoma
    Spyros S Skandalis
    Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 265 00 Patras, Greece
    Biochim Biophys Acta 1721:81-8. 2005

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The greatly increased amounts of accumulated versican and decorin with specific post-translational modifications may be closely associated with the malignant phenotype of pancreatic cancer
    Spyros S Skandalis
    Laboratory of Cell Proliferation and Ageing, Institute of Biology, NCSR Demokritos, 15310 Athens, Greece
    Biochim Biophys Acta 1760:1217-25. 2006
    ....
  2. pmc Versican but not decorin accumulation is related to malignancy in mammographically detected high density and malignant-appearing microcalcifications in non-palpable breast carcinomas
    Spyros S Skandalis
    Laboratory of Biochemistry, Department of Chemistry, University of Patras, Rio 26504, Greece
    BMC Cancer 11:314. 2011
    ..In the present study, we have evaluated the expression of versican and decorin in non-palpable breast carcinomas and their association with high risk mammographic findings and tumor characteristics...
  3. ncbi request reprint The increased accumulation of structurally modified versican and decorin is related with the progression of laryngeal cancer
    S S Skandalis
    Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 26500 Patras, Greece
    Biochimie 88:1135-43. 2006
    ..The modified chemical structure of both PGs could be associated with the degree of aggressiveness of laryngeal squamous cell carcinomas...
  4. ncbi request reprint Stage-related decorin and versican expression in human laryngeal cancer
    M Stylianou
    Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece
    Anticancer Res 28:245-51. 2008
    ..The major proteoglycan of normal human larynx is aggrecan. In laryngeal carcinoma, aggrecan is depleted, with versican and decorin appearing in higher amounts...
  5. doi request reprint Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma
    S Filou
    Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece
    Biochimie 95:725-34. 2013
    ....
  6. ncbi request reprint Keratan sulphate in cerebrum, cerebellum and brainstem of sheep brain
    N Papageorgakopoulou
    Department of Chemistry, Organic Chemistry, Biochemistry and Natural Products Division, University of Patras, Patras 26500, Greece
    Biochimie 83:973-8. 2001
    ..The content of keratan sulphate was found to be about 215, 173 and 144 microg/g dry delipidated tissue for cerebrum, brainstem and cerebellum, respectively...
  7. ncbi request reprint Targeting the tumor proteasome as a mechanism to control the synthesis and bioactivity of matrix macromolecules
    S S Skandalis
    Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece
    Curr Mol Med 12:1068-82. 2012
    ..In this review, the novel approach of targeting the proteasome to selectively regulate the synthesis and the bioactivity of certain matrix PGs and MMPs is presented and discussed...
  8. ncbi request reprint Pathophysiology and pharmacological targeting of tumor-induced bone disease: current status and emerging therapeutic interventions
    V T Labropoulou
    Division of Oncology, School of Medicine, University of Patras, 26500 Patras, Greece
    Curr Med Chem 18:1584-98. 2011
    ..In this review, we analyze the molecular mechanisms, involved in tumor-induced bone disease and discuss the current therapeutic approaches and the most recent clinical developments of emerging targeted therapies...
  9. ncbi request reprint Cartilage aggrecan undergoes significant compositional and structural alterations during laryngeal cancer
    Spyros S Skandalis
    Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 26500 Patras, Greece
    Biochim Biophys Acta 1760:1046-53. 2006
    ..These significant alterations were closely associated with the process of cartilage destruction, indicating the crucial role of aggrecan during LSCC...
  10. ncbi request reprint The extractability of extracellular matrix components as a marker of cartilage remodeling in laryngeal squamous cell carcinoma
    Spyros S Skandalis
    Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 265 00 Patras, Greece
    Biochim Biophys Acta 1721:81-8. 2005
    ..In conclusion, the applied procedure permitted the elucidation of the changes in the cartilage status, regarding the stability and identity of its proteoglycan aggregates/complexes, in both HLC and LCSCC...
  11. ncbi request reprint Matrix proteoglycans are markedly affected in advanced laryngeal squamous cell carcinoma
    Spyros S Skandalis
    Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 26500 Patras, Greece
    Biochim Biophys Acta 1689:152-61. 2004
    ..The altered composition of PGs in cartilage, as well as in tumor-associated stroma, is crucial for the biological behaviour of cancer cells in the diseased tissue...
  12. ncbi request reprint Altered content composition and structure of glycosaminoglycans and proteoglycans in gastric carcinoma
    Achilleas D Theocharis
    Laboratory of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras, 26110 Patras, Greece
    Int J Biochem Cell Biol 35:376-90. 2003
    ..Studies on the modified metabolism of PGs/GAGs are under progress and will help in deeper understanding of the environment in which tumor cells proliferate and invade...
  13. ncbi request reprint Immunological studies of sheep brain keratan sulphate proteoglycans
    Nickoletta Papageorgakopoulou
    Department of Chemistry, University of Patras, Patras, 26500, Greece
    Biochimie 84:1225-8. 2002
    ..These data suggest that the KSs of sheep brain are part of proteoglycans containing protein and KS antigenic sites related to those of corneal and cartilage KSPG, as also of the brain proteoglycan phosphacan-KS...
  14. doi request reprint Biochemical changes of extracellular proteoglycans in squamous cell laryngeal carcinoma
    Demitrios H Vynios
    Department of Chemistry, Laboratory of Biochemistry, University of Patras, Patras, Greece
    Connect Tissue Res 49:239-43. 2008
    ....
  15. doi request reprint Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis
    Paraskevi Heldin
    Ludwig Institute for Cancer Research, Uppsala University, Biomedical Center, Uppsala, Sweden
    Connect Tissue Res 49:215-8. 2008
    ..This review discusses some of the evidence that hyaluronan-CD44 complexes trigger signaling cascades that modulate inflammation and tumor progression...
  16. doi request reprint Hyaluronan and chondroitin sulfate proteoglycans in the supramolecular organization of the mammalian vitreous body
    Dimitrios A Theocharis
    Laboratory of Biological Chemistry, School of Medicine, University of Patras, Patras, Greece
    Connect Tissue Res 49:124-8. 2008
    ..However, versican having the ability to bind hyaluronan via its N-terminal and other binding partners via its C-terminal region can play a crucial role on the structural stability and functionality of the vitreous...
  17. ncbi request reprint The structural and compositional changes of glycosaminoglycans are closely associated with tissue type in human laryngeal cancer
    Spyros S Skandalis
    Laboratory of Biochemistry, Department of Chemistry, School of Natural Sciences, University of Patras, 265 00 Patras, Greece
    Biochimie 89:1573-80. 2007
    ..The kind and the extent of these alterations, which presented an intense stage-related behaviour, depended on the tissue origin and could be associated with the malignant phenotype of human laryngeal cancer...
  18. ncbi request reprint Proteoglycans in human laryngeal cartilage. Identification of proteoglycan types in successive cartilage extracts with particular reference to aggregating proteoglycans
    Spyros S Skandalis
    Organic Chemistry, Biochemistry and Natural Products Division, Department of Chemistry, University of Patras, Patras 26500, Greece
    Biochimie 86:221-9. 2004
    ..The glycosaminoglycans (GAGs) present were chondroitin sulphate with a M(r) of 15 kDa, and keratan sulphate (KS) with a M(r) of 10 kDa, in proportions 84% and 16%, respectively...
  19. ncbi request reprint Chondroitin sulphate proteoglycans in the vitreous gel of sheep and goat
    Spyros S Skandalis
    Department of Chemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Laboratory of Biochemistry, University of Patras, 26500 Patras, Greece
    Biomed Chromatogr 21:451-7. 2007
    ..These findings showed that, firstly, the CS content and the hydrodynamic size of the CS chain and, secondly, the sulphation pattern of CS chains from versican and collagen IX in both sheep and goat vitreous gels are PG type-dependent...