Tobias Sjoblom

Summary

Publications

  1. pmc Structural alterations from multiple displacement amplification of a human genome revealed by mate-pair sequencing
    Xiang Jiao
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e22250. 2011
  2. pmc Scalable in situ hybridization on tissue arrays for validation of novel cancer and tissue-specific biomarkers
    Sara Kiflemariam
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e32927. 2012
  3. pmc Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing
    Xiang Jiao
    Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, SE 751 85, Sweden
    BMC Genomics 14:165. 2013
  4. pmc Automated serial extraction of DNA and RNA from biobanked tissue specimens
    Lucy Mathot
    Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, SE 751 85, Uppsala, Sweden
    BMC Biotechnol 13:66. 2013
  5. pmc Automated genotyping of biobank samples by multiplex amplification of insertion/deletion polymorphisms
    Lucy Mathot
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e52750. 2012
  6. pmc Sequence based analysis of U-2973, a cell line established from a double-hit B-cell lymphoma with concurrent MYC and BCL2 rearrangements
    Sean D Hooper
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden
    BMC Res Notes 5:648. 2012
  7. pmc In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics
    Ida Grundberg
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory
    Oncotarget 4:2407-18. 2013
  8. pmc Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers
    Xiang Jiao
    Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Genes Chromosomes Cancer 51:480-9. 2012
  9. doi request reprint Efficient and scalable serial extraction of DNA and RNA from frozen tissue samples
    Lucy Mathot
    Department of Genetics and Pathology, Uppsala University, SE 751 85 Uppsala, Sweden
    Chem Commun (Camb) 47:547-9. 2011
  10. doi request reprint Molecular pathways in tumor progression: from discovery to functional understanding
    Muhammad Akhtar Ali
    Department of Genetics and Pathology, Uppsala University, SE 751 85 Uppsala, Sweden
    Mol Biosyst 5:902-8. 2009

Collaborators

Detail Information

Publications11

  1. pmc Structural alterations from multiple displacement amplification of a human genome revealed by mate-pair sequencing
    Xiang Jiao
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e22250. 2011
    ..While multiple strand displacement amplification may find uses in translocation analyses, it is likely that alternative amplification strategies need to be developed to meet the demands of cancer genomics...
  2. pmc Scalable in situ hybridization on tissue arrays for validation of novel cancer and tissue-specific biomarkers
    Sara Kiflemariam
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e32927. 2012
    ..The present study provides a foundation for comprehensive in situ gene set or transcriptome analyses of human normal and tumor tissues...
  3. pmc Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing
    Xiang Jiao
    Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, SE 751 85, Sweden
    BMC Genomics 14:165. 2013
    ..To identify novel somatic chromosomal rearrangements, we determined the genome structures of 15 hormone-receptor negative breast tumors by long-insert mate pair massively parallel sequencing...
  4. pmc Automated serial extraction of DNA and RNA from biobanked tissue specimens
    Lucy Mathot
    Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, SE 751 85, Uppsala, Sweden
    BMC Biotechnol 13:66. 2013
    ..A purpose developed magnetic bead based technology to serially extract both DNA and RNA from tissues was automated on a Tecan Freedom Evo robotic workstation...
  5. pmc Automated genotyping of biobank samples by multiplex amplification of insertion/deletion polymorphisms
    Lucy Mathot
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 7:e52750. 2012
    ..24 tumor-normal patient samples were successfully matched using this method. The potential use of the developed assay for forensic applications is discussed...
  6. pmc Sequence based analysis of U-2973, a cell line established from a double-hit B-cell lymphoma with concurrent MYC and BCL2 rearrangements
    Sean D Hooper
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden
    BMC Res Notes 5:648. 2012
    ..Recently, a cell line was established from a patient with this complex lymphoma and analyzed using conventional tools revealing it contains both MYC and BCL2 translocation events...
  7. pmc In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics
    Ida Grundberg
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory
    Oncotarget 4:2407-18. 2013
    ..This in situ method holds great promise as a tool to investigate the role of somatic mutations during tumor progression and for prediction of response to targeted therapy. ..
  8. pmc Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers
    Xiang Jiao
    Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Genes Chromosomes Cancer 51:480-9. 2012
    ..These findings strengthen the evidence for involvement of the Notch, Hedgehog, NF-KB, and PIK3CA pathways in breast cancer development, and point to novel processes that likely are involved...
  9. doi request reprint Efficient and scalable serial extraction of DNA and RNA from frozen tissue samples
    Lucy Mathot
    Department of Genetics and Pathology, Uppsala University, SE 751 85 Uppsala, Sweden
    Chem Commun (Camb) 47:547-9. 2011
    ..We here present a process for serial extraction of nucleic acids from the same frozen tissue sample based on magnetic silica particles. The process is automation friendly with high recoveries of pure DNA and RNA suitable for analysis...
  10. doi request reprint Molecular pathways in tumor progression: from discovery to functional understanding
    Muhammad Akhtar Ali
    Department of Genetics and Pathology, Uppsala University, SE 751 85 Uppsala, Sweden
    Mol Biosyst 5:902-8. 2009
    ....
  11. ncbi request reprint Systematic analyses of the cancer genome: lessons learned from sequencing most of the annotated human protein-coding genes
    Tobias Sjoblom
    Department of Genetics and Pathology, Uppsala University, Sweden
    Curr Opin Oncol 20:66-71. 2008
    ..This review discusses recent insights from such analyses of protein-coding genes in breast and colorectal cancers...