Reijo Sironen

Summary

Publications

  1. Siiskonen H, Poukka M, Tyynelä Korhonen K, Sironen R, Pasonen Seppänen S. Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma. BMC Cancer. 2013;13:181 pubmed publisher
    ..These results provide new information about hyaluronan metabolism in benign, premalignant and malignant melanocytic tumors of the skin. ..
  2. Jouppila Mättö A, Närkiö Mäkelä M, Soini Y, Pukkila M, Sironen R, Tuhkanen H, et al. Twist and snai1 expression in pharyngeal squamous cell carcinoma stroma is related to cancer progression. BMC Cancer. 2011;11:350 pubmed publisher
    ..TWIST and SNAI1 expression in stromal cells is associated with clinical and histopathological characteristics that indicate progressive disease. Negative expression of these EMT-promoting transcription factors predicts a better outcome. ..
  3. Soini Y, Tuhkanen H, Sironen R, Virtanen I, Kataja V, Auvinen P, et al. Transcription factors zeb1, twist and snai1 in breast carcinoma. BMC Cancer. 2011;11:73 pubmed publisher
    ..However, epithelial expression of twist was associated with a poor prognosis, hinting at its importance in the spread of breast carcinoma. ..
  4. Nykopp T, Rilla K, Tammi M, Tammi R, Sironen R, Hamalainen K, et al. Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma. BMC Cancer. 2010;10:512 pubmed publisher
    ..While immunoreactivity for HASs increased in the cancer cells, tumor mRNA levels for HASs were not changed, suggesting that reduced turnover of HAS protein may also have contributed to the accumulation of hyaluronan. ..