Vivek R Sinha

Summary

Publications

  1. ncbi request reprint Formulation, characterization, and evaluation of ketorolac tromethamine-loaded biodegradable microspheres
    Vivek Ranjan Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Drug Deliv 12:133-9. 2005
  2. pmc A Stability-Indicating RP-HPLC Assay Method for 5-Fluorouracil
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Indian J Pharm Sci 71:630-7. 2009
  3. ncbi request reprint Critical aspects in rationale design of fluorouracil-based adjuvant therapies for the management of colon cancer
    V R Sinha
    Pharmaceutics Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh 160014, India
    Crit Rev Ther Drug Carrier Syst 29:89-148. 2012
  4. ncbi request reprint Influence of formulation and excipient variables on the pellet properties prepared by extrusion spheronization
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Curr Drug Deliv 2:1-8. 2005
  5. ncbi request reprint Development of pulsatile systems for targeted drug delivery of celecoxib for prophylaxis of colorectal cancer
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Drug Deliv 13:221-5. 2006
  6. ncbi request reprint Biodegradable microspheres for parenteral delivery
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Crit Rev Ther Drug Carrier Syst 22:535-602. 2005
  7. ncbi request reprint Compression coated systems for colonic delivery of 5-fluorouracil
    V R Sinha
    Pharmaceutics Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    J Pharm Pharmacol 59:359-65. 2007
  8. pmc Influence of operational variables on properties of piroxicam pellets prepared by extrusion-spheronization: a technical note
    Vivek R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    AAPS PharmSciTech 8:20. 2007
  9. ncbi request reprint Oral colon-specific drug delivery of protein and peptide drugs
    V Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Crit Rev Ther Drug Carrier Syst 24:63-92. 2007
  10. ncbi request reprint Stress studies on acyclovir
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    J Chromatogr Sci 45:319-24. 2007

Detail Information

Publications32

  1. ncbi request reprint Formulation, characterization, and evaluation of ketorolac tromethamine-loaded biodegradable microspheres
    Vivek Ranjan Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Drug Deliv 12:133-9. 2005
    ..From our study it as concluded that with careful selection of different polymers and their combinations, we can tailor the release of ketorolac tromethamine for long periods...
  2. pmc A Stability-Indicating RP-HPLC Assay Method for 5-Fluorouracil
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Indian J Pharm Sci 71:630-7. 2009
    ..69%. Thus, the developed RP-HPLC method was found to be suitable for the determination of 5-fluorouracil in bulk as well as stability samples of the pharmaceutical dosage forms containing various excipients...
  3. ncbi request reprint Critical aspects in rationale design of fluorouracil-based adjuvant therapies for the management of colon cancer
    V R Sinha
    Pharmaceutics Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh 160014, India
    Crit Rev Ther Drug Carrier Syst 29:89-148. 2012
    ....
  4. ncbi request reprint Influence of formulation and excipient variables on the pellet properties prepared by extrusion spheronization
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Curr Drug Deliv 2:1-8. 2005
    ..Less water was required for formulations containing higher amounts of lactose and DCPD. Plain DCPD failed to spheronize, although pellets of plain lactose could be formed at the investigated level of water...
  5. ncbi request reprint Development of pulsatile systems for targeted drug delivery of celecoxib for prophylaxis of colorectal cancer
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Drug Deliv 13:221-5. 2006
    ..The coat weight required in these tablets for protection in the upper gastrointestinal conditions varied from 9.69% in OM-KC tablets to 4.65% in OM-SC tablets...
  6. ncbi request reprint Biodegradable microspheres for parenteral delivery
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Crit Rev Ther Drug Carrier Syst 22:535-602. 2005
    ..This review covers various molecules encapsulated in biodegradable microspheres for parenteral delivery...
  7. ncbi request reprint Compression coated systems for colonic delivery of 5-fluorouracil
    V R Sinha
    Pharmaceutics Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    J Pharm Pharmacol 59:359-65. 2007
    ..Therefore, this study lays a basis for use of compression coating of 5-FU as a tool for delaying the release of the drug, which ensures better clinical management of the disease...
  8. pmc Influence of operational variables on properties of piroxicam pellets prepared by extrusion-spheronization: a technical note
    Vivek R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    AAPS PharmSciTech 8:20. 2007
  9. ncbi request reprint Oral colon-specific drug delivery of protein and peptide drugs
    V Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Crit Rev Ther Drug Carrier Syst 24:63-92. 2007
    ..This review also includes studies conducted on colonic targeting of such drugs. Further studies may lead to improvements in therapy using protein/peptide drugs and refinements in the technology of colon-specific drug delivery...
  10. ncbi request reprint Stress studies on acyclovir
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    J Chromatogr Sci 45:319-24. 2007
    ..34% to 102.35%. From the previous study it is concluded that the stability-indicating method developed for acyclovir can be used for analysis of the drug in various stability samples...
  11. ncbi request reprint Development, characterization, and evaluation of ketorolac tromethamine-loaded biodegradable microspheres as a depot system for parenteral delivery
    Vivek Ranjan Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Drug Deliv 15:365-72. 2008
    ..We concluded that with careful selection of different polymers and their combinations, we can tailor the release of ketorolac tromethamine for long periods...
  12. ncbi request reprint Stress degradation studies on duloxetine hydrochloride and development of an RP-HPLC method for its determination in capsule formulation
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    J Chromatogr Sci 47:589-93. 2009
    ..83% and 42.75%, respectively) on refluxing the drug for 1 h. The drug was stable under photolytic and thermal stress on exposure in solid form but showed considerable degradation in solution form...
  13. ncbi request reprint Physicochemical characterization and in vitro dissolution behaviour of celecoxib-beta-cyclodextrin inclusion complexes
    Vivek Ranjan Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Acta Pharm 57:47-60. 2007
    ..Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug, indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib...
  14. ncbi request reprint Complexation of celecoxib with beta-cyclodextrin: characterization of the interaction in solution and in solid state
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    J Pharm Sci 94:676-87. 2005
    ..A shorter t50% of dissolution is found for the formulation prepared by spray drying when compared on a weight basis in a USP II apparatus...
  15. ncbi request reprint Chitosan microspheres as a potential carrier for drugs
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Int J Pharm 274:1-33. 2004
    ..This review also includes the factors that affect the entrapment efficiency and release kinetics of drugs from chitosan microspheres...
  16. ncbi request reprint In vivo evaluation of time and site of disintegration of polysaccharide tablet prepared for colon-specific drug delivery
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Int J Pharm 289:79-85. 2005
    ....
  17. ncbi request reprint Radioactive microspheres in therapeutics
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Pharmazie 59:419-26. 2004
    ..This review provides an outlook to various aspects of radioactive microspheres and their role in treatment of various tumors and cancers...
  18. ncbi request reprint Microbially triggered drug delivery to the colon
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Eur J Pharm Sci 18:3-18. 2003
    ....
  19. ncbi request reprint Poly-epsilon-caprolactone microspheres and nanospheres: an overview
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Int J Pharm 278:1-23. 2004
    ..This article reviews the advancements made in PCL-based microspheres and nanospheres with special reference to the method of preparation of these and their suitability in developing effective delivery systems...
  20. ncbi request reprint Polysaccharide matrices for microbially triggered drug delivery to the colon
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Drug Dev Ind Pharm 30:143-50. 2004
    ..Presence of XG in the tablets not only retards the initial drug release from the tablets, but due to high swelling, makes them more vulnerable to digestion by the microbial enzymes in the colon...
  21. ncbi request reprint Binders for colon specific drug delivery: an in vitro evaluation
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Int J Pharm 249:23-31. 2002
    ..Additionally, formulations developed with chitosan and Eudragit E would be highly site specific since drug release would be at a retarded rate till microbial degradation or polymer solubilization takes place in the colon...
  22. ncbi request reprint Diagnostic microspheres: an overview
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Crit Rev Ther Drug Carrier Syst 20:431-60. 2003
    ..This review discusses various aspects of diagnostic microspheres, such as the choice of contrast agents and radioactive molecules, and their applications in blood flow measurements and organ imaging...
  23. ncbi request reprint Coating polymers for colon specific drug delivery: a comparative in vitro evaluation
    Vivek Ranjan Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 1600 14, India
    Acta Pharm 53:41-7. 2003
    ..It retarded drug release by 3-4 h (the usual small intestinal transit time) in simulated small intestinal fluid, whereafter a rapid drug release was observed...
  24. ncbi request reprint Biodegradable microspheres for protein delivery
    V R Sinha
    Department of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, 160014 Chandigarh, India
    J Control Release 90:261-80. 2003
    ..This review presents the outstanding contributions in field of biodegradable microspheres as protein delivery systems, their methods of preparation, drug release, stability, interaction with immune system and regulatory considerations...
  25. ncbi request reprint Polysaccharides in colon-specific drug delivery
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Int J Pharm 224:19-38. 2001
    ..Recent efforts and approaches exploiting these polysaccharides in colon-specific drug delivery are discussed...
  26. ncbi request reprint Colonic drug delivery of 5-fluorouracil: an in vitro evaluation
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Int J Pharm 269:101-8. 2004
    ..2+/-5.23% in presence of 2% cecal content and 80.34+/-3.89% in presence of 4% cecal content after 19 h of incubation...
  27. ncbi request reprint A simple and sensitive stability-indicating RP-HPLC assay method for the determination of aceclofenac
    J R Bhinge
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014
    J Chromatogr Sci 46:440-4. 2008
    ..The method is linear over the concentration range of 17-100 microg/mL (r(2) = 0.9988). The detection wavelength is 275 nm. The method is validated for linearity, range, precision, accuracy, specificity, and selectivity...
  28. ncbi request reprint Colonic drug delivery: prodrug approach
    V R Sinha
    University Institute of Pharamceutical Sciences, Panjab University, Chandigarh, India
    Pharm Res 18:557-64. 2001
    ..g. azoreductase, glucuronidase, glycosidase, dextranase, esterase, nitroreductase, cyclodextranase, etc.). The present review includes varius prodrug approaches investigated for colon drug delivery and their site specificity...
  29. doi request reprint Ketorolac tromethamine formulations: an overview
    V R Sinha
    Panjab University, University Institute of Pharmaceutical Sciences, Chandigarh, India
    Expert Opin Drug Deliv 6:961-75. 2009
    ....
  30. ncbi request reprint Extrusion-spheronization: process variables and characterization
    V R Sinha
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Crit Rev Ther Drug Carrier Syst 26:275-331. 2009
    ..Various methods for the evaluation of the quality of the pellets with regard to the size distribution, shape, friability, granule strength, density, porosity, flow properties, and surface texture are discussed...
  31. pmc Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods
    Sanju Dhawan
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India 160014
    AAPS PharmSciTech 5:e67. 2004
    ..The microspheres prepared by glutaraldehyde and thermal cross-linking showed good stability in HCl as compared with microspheres prepared by tripolyphosphate and emulsification ionotropic gelation...
  32. ncbi request reprint Bioavailability of immediate- and extended-release formulations of glipizide in healthy male volunteers
    Sanju Dhawan
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Clin Pharmacokinet 45:317-24. 2006
    ..This study compared the pharmacokinetic parameters of immediate- and extended-release formulations of glipizide 5mg in healthy male volunteers...