S Sinha

Summary

Publications

  1. ncbi request reprint Nickel induced toxic effects and bioaccumulation in the submerged plant, Hydrilla verticillata (L.F.) Royle under repeated metal exposure
    S Sinha
    Ecotoxicology and Bioremediation, Environmental Sciences Division, National Botanical Research Institute, Lucknow 226 001 U P, India
    Bull Environ Contam Toxicol 71:1175-83. 2003
  2. ncbi request reprint Accumulation of chromium and scanning electron microscopic studies in Scirpus lacustris L. Treated with metal and tannery effluent
    M R Suseela
    National Botanical Research Institute, Lucknow, India
    Bull Environ Contam Toxicol 68:540-8. 2002
  3. ncbi request reprint Purification and cloning of amyloid precursor protein beta-secretase from human brain
    S Sinha
    Elan Pharmaceuticals, South San Francisco, California 94080, USA
    Nature 402:537-40. 1999
  4. ncbi request reprint Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes
    J Zhao
    Athena Neurosciences, Inc, South San Francisco, California 94080, USA
    J Biol Chem 271:31407-11. 1996
  5. pmc Cellular mechanisms of beta-amyloid production and secretion
    S Sinha
    Elan Pharmaceuticals, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 96:11049-53. 1999
  6. ncbi request reprint The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II
    T Oltersdorf
    Athena Neurosciences, Inc, South San Francisco, California 94080
    Nature 341:144-7. 1989
  7. ncbi request reprint BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics
    S L Roberds
    Department of Genomics, Pharmacia Corp, 301 Henrietta Street, Kalamazoo, MI 49007, USA
    Hum Mol Genet 10:1317-24. 2001
  8. ncbi request reprint Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2
    S Sinha
    Department of Cancer Biology, NB40, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Gene 258:15-29. 2000
  9. ncbi request reprint Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus
    B Perelman
    Department of Biochemistry, Tel Aviv University, Ramat Aviv, Israel
    Genomics 41:397-405. 1997
  10. ncbi request reprint Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor
    S Sinha
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genomics 37:260-3. 1996

Collaborators

  • L Mucke
  • J Zhao
  • S Wang
  • D Schenk
  • Puttur D Prasad
  • D Walker
  • Chiranjib Chakraborty
  • B R Wamhoff
  • G K Owens
  • O G McDonald
  • M R Suseela
  • A Misra
  • L McConlogue
  • W A Maltese
  • M Kala
  • S L Roberds
  • A Burns
  • M H Hoofnagle
  • A P Somlyo
  • D K Bowles
  • A V Somlyo
  • B Perelman
  • S Singh
  • R Saxena
  • R Kekuda
  • G Basi
  • K Chosdol
  • R Kuehn
  • D G Branstetter
  • N L Frigon
  • M E Shuck
  • K Hu
  • H Tintrup
  • K S Chen
  • A K Mahapatra
  • J Anderson
  • W Liu
  • Y Tan
  • J Wijsman
  • K Johnson-Wood
  • S Suomensaari
  • T T Kawabe
  • K Bajaj
  • D W Robertson
  • M J Bienkowski
  • M Lee
  • R Barbour
  • R Motter
  • I Kola
  • C Sarkar
  • S Wright
  • N F Nichols
  • M Power
  • G M Shopp
  • K A Svensson
  • M Schoor
  • D Games
  • K E Kappenman
  • S B Freedman
  • S Wilson
  • G Tatsuno
  • G Weber
  • A Sancar
  • S Khodaei
  • D Canaani
  • M Yaakov
  • D Eli
  • I Dotan
  • T L Feng
  • T Naiman
  • N Dafni
  • V Ganapathy
  • T L Yang-Feng
  • V Torres-zamorano
  • Y J Fei
  • F H Leibach
  • T Oltersdorf
  • H Narimatsu
  • K L Johnson-Wood
  • H Okayama
  • E C Beattie
  • H F Dovey
  • K Brew
  • R W Blacher
  • L C Fritz
  • P K Qasba
  • I Lieberburg
  • P J Ward

Detail Information

Publications21

  1. ncbi request reprint Nickel induced toxic effects and bioaccumulation in the submerged plant, Hydrilla verticillata (L.F.) Royle under repeated metal exposure
    S Sinha
    Ecotoxicology and Bioremediation, Environmental Sciences Division, National Botanical Research Institute, Lucknow 226 001 U P, India
    Bull Environ Contam Toxicol 71:1175-83. 2003
  2. ncbi request reprint Accumulation of chromium and scanning electron microscopic studies in Scirpus lacustris L. Treated with metal and tannery effluent
    M R Suseela
    National Botanical Research Institute, Lucknow, India
    Bull Environ Contam Toxicol 68:540-8. 2002
  3. ncbi request reprint Purification and cloning of amyloid precursor protein beta-secretase from human brain
    S Sinha
    Elan Pharmaceuticals, South San Francisco, California 94080, USA
    Nature 402:537-40. 1999
    ..Cloning and expression of the enzyme reveals that human brain beta-secretase is a new membrane-bound aspartic proteinase...
  4. ncbi request reprint Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes
    J Zhao
    Athena Neurosciences, Inc, South San Francisco, California 94080, USA
    J Biol Chem 271:31407-11. 1996
    ..This provides strong in vivo evidence that the major source of Abeta in brain is from neurons and not from astrocytes...
  5. pmc Cellular mechanisms of beta-amyloid production and secretion
    S Sinha
    Elan Pharmaceuticals, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 96:11049-53. 1999
    ..Peptide aldehyde inhibitors that block Abeta production by inhibiting gamma-secretase cleavage of beta-CTF have been discovered...
  6. ncbi request reprint The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II
    T Oltersdorf
    Athena Neurosciences, Inc, South San Francisco, California 94080
    Nature 341:144-7. 1989
    ..Secreted APP695 did not form complexes with trypsin. We conclude that the secreted form of APP with the Kunitz protease inhibitor domain is PN-II...
  7. ncbi request reprint BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics
    S L Roberds
    Department of Genomics, Pharmacia Corp, 301 Henrietta Street, Kalamazoo, MI 49007, USA
    Hum Mol Genet 10:1317-24. 2001
    ....
  8. ncbi request reprint Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2
    S Sinha
    Department of Cancer Biology, NB40, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Gene 258:15-29. 2000
    ..These results suggest that the various T-box proteins, while highly conserved, likely use different mechanisms to modulate transcription and may have different targets in vivo...
  9. ncbi request reprint Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus
    B Perelman
    Department of Biochemistry, Tel Aviv University, Ramat Aviv, Israel
    Genomics 41:397-405. 1997
    ..Importantly, this region has been shown to be amplified in a variety of human malignancies, including breast cancer...
  10. ncbi request reprint Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor
    S Sinha
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genomics 37:260-3. 1996
    ..We assigned the mouse CBF-C gene (designated Nfyc) to chromosome 4 with tight linkage to Lmyc. Our mouse linkage data suggest that the human NFYC homolog will map to 1p32...
  11. ncbi request reprint A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis
    B R Wamhoff
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908 0736, USA
    Circ Res 95:981-8. 2004
    ....
  12. ncbi request reprint L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism
    B R Wamhoff
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908 0736, USA
    Circ Res 95:406-14. 2004
    ....
  13. ncbi request reprint Interactive metal accumulation and its toxic effects under repeated exposure in submerged plant Najas indica Cham
    S Sinha
    Ecotoxicology and Bioremediation, Environmental Sciences Division, National Botanical Research Institute, Lucknow 226 001, India
    Bull Environ Contam Toxicol 70:696-704. 2003
  14. ncbi request reprint Alteration of a sequence with homology to human endogenous retrovirus (HERV-K) in primary human glioma: implications for viral repeat mediated rearrangement
    A Misra
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India
    Mutat Res 484:53-9. 2001
    ..While not demonstrating a cause effect relationship, this highlights the possible role of such virus-derived sequences in gene inactivation by recombination during tumorigenesis...
  15. pmc Cloning and sequencing of cDNA of bovine N-acetylglucosamine (beta 1-4)galactosyltransferase
    H Narimatsu
    Proc Natl Acad Sci U S A 83:4720-4. 1986
    ..5 kilobases. The results show that pLbGT-1 is a cDNA clone for bovine (beta 1-4)galactosyltransferase, and pLbGT-2 encodes a protein that is structurally and may be functionally related to transferases...
  16. ncbi request reprint Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide
    W A Maltese
    Department of Biochemistry and Molecular Biology, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 276:20267-79. 2001
    ..The results suggest that presenilins may acquire the characteristics of gamma-secretase after leaving the ER, possibly by assembling with other proteins in peripheral membranes...
  17. ncbi request reprint Direct antigen capture by soluble scFv antibodies. A method for detection, characterization, and determination of affinity
    M Kala
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi-110029, India
    Appl Biochem Biotechnol 90:11-22. 2001
    ..Although these techniques have been developed for antibodies to HSAP, they have general utility for phage expression systems without a peptide tag...
  18. pmc Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3
    S Sinha
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston 77030
    Proc Natl Acad Sci U S A 92:1624-8. 1995
    ..Our results indicate that CBF is a unique evolutionarily conserved DNA binding protein...
  19. ncbi request reprint Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line
    R Kekuda
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 271:18657-61. 1996
    ..Chromosomal assignment studies with somatic cell hybrid analysis and fluorescent in situ hybridization have located the ATBo gene to human chromosome 19q13.3...
  20. pmc Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family
    S Sinha
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 96:13074-9. 1999
    ..This conserved site is proposed to be a binding or catalytic site for a ligand or substrate that is common to YabJ and other members of the YER057c/YjgF/UK114 family of proteins...
  21. ncbi request reprint Overexpression and purification of recombinant eel calcitonin and its phylogenetic analysis
    Chiranjib Chakraborty
    Department of Biotechnology, Institute of Applied Medicines and Research, 9th Mile Stone, Ghaziabad UP, India
    Protein Pept Lett 12:263-9. 2005
    ..In this study we describe the over-expression and over-production of C-terminal amidated eCT in recombinant Streptomyces avermitilis. A phylogenetic analysis was performed with all the known CT amino acid sequences...