Influence of Terminalia chebula on dermal wound healing in ratsLonchin Suguna
Department of Biochemistry, Central Leather Research Institute, Adyar, Chennai, India
Phytother Res 16:227-31. 2002
..chebula possessed antimicrobial activity and was active largely against Staphylococcus aureus and Klebsiella. These results strongly document the beneficial effects of T. chebula in the acceleration of the healing process...
The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in ratsS Singh
Department of Pharmacology, Indian Institute of Integrative Medicine CSIR, Canal Road Jammu Tawi, J and K 180001, India
Phytomedicine 15:408-15. 2008
..Nevertheless it is possible that BA might be acting by increasing the gastric mucosal resistance and local synthesis of cytoprotective prostaglandins and inhibiting the leukotriene synthesis...
- Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats
Surjeet Singh
Department of Pharmacology, Indian Institute of Integrative Medicine, Canal Road Jammu Tawi, Jammu and Kashmir 180001, India
Bioorg Med Chem Lett 17:3706-11. 2007
..In conclusion, a synergistic effect was observed in chronic inflammatory conditions when two chemical entities were administered in combination in preclinical study...
- Boswellic acids: A leukotriene inhibitor also effective through topical application in inflammatory disorders
S Singh
Department of Pharmacology, Indian Institute of Integrative Medicine CSIR, Canal Road, Jammu Tawi 180001, J and K, India
Phytomedicine 15:400-7. 2008
....
- Immunomodulatory studies of a bioactive fraction from the fruit of Prunus cerasus in BALB/c mice
Sheikh Abid
Dept of Biotechnology, Indian Institute of Integrative Medicine CSIR, Srinagar 190005, India
Int Immunopharmacol 12:626-34. 2012
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- Immunomodulatory activity of biopolymeric fraction BOS 2000 from Boswellia serrata
Anamika Khajuria
Division of Pharmacology, Indian Institute of Integrative Medicine, CSIR, Jammu 180001, India
Phytother Res 22:340-8. 2008
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- A novel sarsasapogenin glycoside from Asparagus racemosus elicits protective immune responses against HBsAg
Tabasum Sidiq
Division of Pharmacology, Indian Institute of Integrative Medicine CSIR, Jammu 180001, India
Immunol Lett 135:129-35. 2011
..Effect of immunoside on red blood cell haemolysis was determined. The results have suggested that immunoside potentially enhanced anti-HBsAg immune response via augmenting Th1/Th2 response in a dose dependent manner...
- Possible role of macrophages induced by an irridoid glycoside (RLJ-NE-299A) in host defense mechanism
Tabasum Sidiq
Division of Pharmacology, Indian Institute of Integrative Medicine CSIR, Jammu 180001, India
Int Immunopharmacol 11:128-35. 2011
..The effects of this agent on these cells at concentrations relevant to in vivo therapy support its immunopharmacologic application to modify cellular immunity...
- RLJ-NE-299A: a new plant based vaccine adjuvant
Anamika Khajuria
Division of Pharmacology, Regional Research Laboratory CSIR, Jammu 180001, India
Vaccine 25:2706-15. 2007
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- Metals in herbal drugs from Himalayan region
Yogesh B Pakade
Hill Area Tea Science Division, Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research CSIR, Palampur 176061, India
Bull Environ Contam Toxicol 86:133-6. 2011
..The studied toxic elements were present in the herbal drugs (0.2-8.34 mg/kg As, 0.11-0.48 mg/kg Cd, 2.5-6.0 mg/kg Pb). Zinc was found in the range 7-32 mg/kg and all the samples were free from mercury contamination...
- Immune modulation and apoptosis induction: Two sides of antitumoural activity of a standardised herbal formulation of Withania somnifera
Fayaz Malik
Division of Pharmacology, Indian Institute of Integrative Medicine Council of Scientific and Industrial Research, Canal Road, Jammu 180001, India
Eur J Cancer 45:1494-509. 2009
..WSF being safe when given orally up to 1500mg/kg to rats for 6 months may be found useful in the management of malignancy by targeting at multiple pathways...
- A new vaccine adjuvant (BOS 2000) a potent enhancer mixed Th1/Th2 immune responses in mice immunized with HBsAg
Anamika Khajuria
Division of Pharmacology, Indian Institute of Integrative Medicine CSIR, Jammu, Jammu Tawi 180001, India
Vaccine 25:4586-94. 2007
..We conclude that BOS 2000 is a potent enhancer of antigen-specific Th1 and Th2 immune responses in comparison to alum with Th2 limitation and is a promising adjuvant for vaccine applications...
- Acute, sub-acute and general pharmacological evaluation of 5-(3,4-methylenedioxyphenyl)-4-ethyl-2E,4E-pentadienoic acid piperidide (SK-20): a novel drug bioavailability enhancer
Sheikh Rayees
PK PD Toxicology Division, Indian Institute of Integrative Medicine, CSIR, Jammu 180001, India
Environ Toxicol Pharmacol 35:347-59. 2013
..Pharmacokinetics of SK-20 revealed it to have retention time at 10.2 min and half life 2.47 h...
- A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up regulation of Th1-dominant polarization in BALB/c mice
Fayaz Malik
Division of Pharmacology, Regional Research Laboratory, Council of Scientific and Industrial Research, Canal Road Jammu Tawi, 180001 India
Life Sci 80:1525-38. 2007
..The standardized root extract of no toxicological consequences might therefore, find useful applications against the intracellular pathogens and in the management of immune suppressed diseases...
- Delivery of siRNA mediated by histidine-containing reducible polycations
Mark Stevenson
Department of Clinical Pharmacology, University of Oxford, Old Road Campus, Oxford OX3 7DQ, UK
J Control Release 130:46-56. 2008
..siRNA targeted to the hepatitis B virus surface antigen delivered by CS-His6 RPC, mediated falls in both mRNA and protein expression, suggesting that this delivery system could be developed for potential therapies for viral hepatitis...
- Formulation development and manufacturing of a gastrin/CCK-2 receptor targeting peptide as an intermediate drug product for a clinical imaging study
Jane K Sosabowski
Department of Nuclear Medicine, St Bartholomew s Hospital, London, EC1A 7BE, UK
Eur J Pharm Sci 31:102-11. 2007
..9% w/v saline solution. Specific uptake of the radiopharmaceutical in CCK-2R-expressing AR42J tumours in nude mice has been demonstrated...
