Meharvan Singh

Summary

Publications

  1. pmc Progesterone-induced neuroprotection: factors that may predict therapeutic efficacy
    Meharvan Singh
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Brain Res 1514:98-106. 2013
  2. pmc Progesterone, brain-derived neurotrophic factor and neuroprotection
    M Singh
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Neuroscience 239:84-91. 2013
  3. pmc Progesterone and neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Horm Behav 63:284-90. 2013
  4. pmc Progesterone potentiates calcium release through IP3 receptors by an Akt-mediated mechanism in hippocampal neurons
    Ji Yeon Hwang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Cell Calcium 45:233-42. 2009
  5. pmc The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression
    Parmeet K Jodhka
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107 2699, USA
    Endocrinology 150:3162-8. 2009
  6. ncbi request reprint The Impact of APOE Status on Relationship of Biomarkers of Vascular Risk and Systemic Inflammation to Neuropsychiatric Symptoms in Alzheimer's Disease
    James R Hall
    Institute of Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Department of Psychiatry and Behavioral Health, University of North Texas Health Science Center, Fort Worth, TX, USA
    J Alzheimers Dis 40:887-96. 2014
  7. pmc Oxidative stress defines the neuroprotective or neurotoxic properties of androgens in immortalized female rat dopaminergic neuronal cells
    Shaletha Holmes
    PhD, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107 2699
    Endocrinology 154:4281-92. 2013
  8. pmc Estrogens and progesterone as neuroprotectants: what animal models teach us
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Front Biosci 13:1083-9. 2008
  9. pmc Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signaling
    Chang Su
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center at Fort Worth, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107, USA
    Endocrinology 153:4389-400. 2012
  10. ncbi request reprint Oxidative stress, testosterone, and cognition among Caucasian and Mexican-American men with and without Alzheimer's disease
    Rebecca L Cunningham
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Center FOR HER, University of North Texas Health Science Center, Fort Worth, TX, USA
    J Alzheimers Dis 40:563-73. 2014

Collaborators

Detail Information

Publications25

  1. pmc Progesterone-induced neuroprotection: factors that may predict therapeutic efficacy
    Meharvan Singh
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Brain Res 1514:98-106. 2013
    ..This article is part of a Special Issue entitled Hormone Therapy...
  2. pmc Progesterone, brain-derived neurotrophic factor and neuroprotection
    M Singh
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Neuroscience 239:84-91. 2013
    ....
  3. pmc Progesterone and neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Horm Behav 63:284-90. 2013
    ....
  4. pmc Progesterone potentiates calcium release through IP3 receptors by an Akt-mediated mechanism in hippocampal neurons
    Ji Yeon Hwang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Cell Calcium 45:233-42. 2009
    ..These results suggest a potential involvement of P4 in particular and of steroid hormone signaling pathways in general in the control of intracellular Ca(2+) signaling and its related functions...
  5. pmc The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression
    Parmeet K Jodhka
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107 2699, USA
    Endocrinology 150:3162-8. 2009
    ....
  6. ncbi request reprint The Impact of APOE Status on Relationship of Biomarkers of Vascular Risk and Systemic Inflammation to Neuropsychiatric Symptoms in Alzheimer's Disease
    James R Hall
    Institute of Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Department of Psychiatry and Behavioral Health, University of North Texas Health Science Center, Fort Worth, TX, USA
    J Alzheimers Dis 40:887-96. 2014
    ..These findings suggest that dysregulation of inflammatory activity is related to NPS, that cholesterol is a significant factor in the occurrence of NPS, and that gender and APOE status need to be considered. ..
  7. pmc Oxidative stress defines the neuroprotective or neurotoxic properties of androgens in immortalized female rat dopaminergic neuronal cells
    Shaletha Holmes
    PhD, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107 2699
    Endocrinology 154:4281-92. 2013
    ..Overall, our results indicate that androgens are neuroprotective when oxidative stress levels are minimal, but when oxidative stress levels are elevated, androgens exacerbate oxidative stress damage. ..
  8. pmc Estrogens and progesterone as neuroprotectants: what animal models teach us
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Front Biosci 13:1083-9. 2008
    ....
  9. pmc Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signaling
    Chang Su
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center at Fort Worth, 3400 Camp Bowie Boulevard, Fort Worth, Texas 76107, USA
    Endocrinology 153:4389-400. 2012
    ....
  10. ncbi request reprint Oxidative stress, testosterone, and cognition among Caucasian and Mexican-American men with and without Alzheimer's disease
    Rebecca L Cunningham
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Center FOR HER, University of North Texas Health Science Center, Fort Worth, TX, USA
    J Alzheimers Dis 40:563-73. 2014
    ..The use of testosterone among aging men has been increasing, but results from studies addressing the effectiveness of testosterone replacement therapy have been equivocal...
  11. doi request reprint More than a decade of estrogen neuroprotection
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Alzheimers Dement 4:S131-6. 2008
    ....
  12. ncbi request reprint Mechanisms of progesterone-induced neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Ann N Y Acad Sci 1052:145-51. 2005
    ....
  13. doi request reprint Neuroprotection and estrogen receptors
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA james simpkins unthsc edu
    Neuroendocrinology 96:119-30. 2012
    ..Finally, further studies that are needed to parse out the relative contribution of receptor versus nonreceptor-mediated signaling are discussed...
  14. doi request reprint ERK1/2 and ERK5 have distinct roles in the regulation of brain-derived neurotrophic factor expression
    Chang Su
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA
    J Neurosci Res 89:1542-50. 2011
    ....
  15. pmc Genistein directly inhibits native and recombinant NMDA receptors
    RenQi Huang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Neuropharmacology 58:1246-51. 2010
    ..Thus, other PTK inhibitors may be more suitable for studying involvement of PTKs in NMDA receptor-mediated events...
  16. ncbi request reprint Progesterone-induced neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Endocrine 29:271-4. 2006
    ....
  17. pmc Biomarkers of vascular risk, systemic inflammation, and microvascular pathology and neuropsychiatric symptoms in Alzheimer's disease
    James R Hall
    Institute of Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Alzheimers Dis 35:363-71. 2013
    ..Gender differences suggest distinct impact of specific risks with total cholesterol, a measure of cardiovascular risk, being the strongest marker for males and IL-15, a marker of inflammation, being the strongest for females...
  18. pmc Risk factors for mild cognitive impairment among Mexican Americans
    Sid E O'Bryant
    Department of Internal Medicine, University of North Texas Health Sciences Center, Fort Worth, TX, USA Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Sciences Center, Fort Worth, TX, USA Electronic address
    Alzheimers Dement 9:622-631.e1. 2013
    ..Although a great deal of literature has focused on risk factors for mild cognitive impairment (MCI), little published work examines risk for MCI among Mexican Americans...
  19. ncbi request reprint Novel mechanisms for estrogen-induced neuroprotection
    Meharvan Singh
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Exp Biol Med (Maywood) 231:514-21. 2006
    ..On the basis of this evidence, we discuss the clinical applicability of estrogens in treating various age-related disorders, including Alzheimer disease and stroke, and identify the caveats that must be considered...
  20. pmc Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants
    Paramjit Kaur
    Department of Pharmacology and Neuroscience and the Institute for Aging and Alzheimer s Disease Research, The Center FOR HER, University of North Texas Health Science Center, Fort Worth, Texas 76107 2699, USA
    J Neurosci Res 85:2441-9. 2007
    ..Collectively, these data suggest that progesterone is protective via multiple and potentially related mechanisms. (c) 2007 Wiley-Liss, Inc...
  21. pmc Is serum brain-derived neurotrophic factor related to craving for or use of alcohol, cocaine, or methamphetamine?
    Craig Hilburn
    University of North Texas Health Science Center at Fort Worth, TX, USA
    Neuropsychiatr Dis Treat 7:357-64. 2011
    ..Here, we examined craving and serum BDNF levels in persons with alcohol versus psychostimulant dependence. Our goals were to explore BDNF as an objective biomarker for 1) craving 2) abstinence, and 3) years of chronic substance use...
  22. doi request reprint Progesterone potentiates IP(3)-mediated calcium signaling through Akt/PKB
    Peter Koulen
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107 2699, USA
    Cell Physiol Biochem 21:161-72. 2008
    ..With a direct control of the gain of the Ca(2+) second messenger system as a signaling gatekeeper for neuronal activity the present study identifies a novel pathway for interaction of the endocrine and central nervous system...
  23. pmc The potential for estrogens in preventing Alzheimer's disease and vascular dementia
    James W Simpkins
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, Center FOR HER Focused On Resources for her Health, Education and Research, University of North Texas Health Science Center, Fort Worth, TX, USA
    Ther Adv Neurol Disord 2:31-49. 2009
    ..Several approaches to enhance brain specificity of estrogen action are now underway in an attempt to reduce the side effects of chronic estrogen therapy in AD...
  24. pmc Androgens exacerbate motor asymmetry in male rats with unilateral 6-hydroxydopamine lesion
    Rebecca L Cunningham
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Horm Behav 60:617-24. 2011
    ..Collectively, the data support the hypothesis that androgens may underlie the gender bias observed in PD...