Manfred V Singer

Summary

Publications

  1. ncbi Alcohol and smoking
    Manfred V Singer
    Department of Medicine II, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Dig Dis 29:177-83. 2011
  2. ncbi Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma
    Andreas Gerloff
    Department of Medicine II, Universitatsmedizin Mannheim, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    Int J Environ Res Public Health 7:1093-104. 2010
  3. ncbi TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I
    Loredana Ciuclan
    Molecular Hepatology Alcohol Dependent Diseases, II Medical Clinic, Faculty of Medicine at Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    J Hepatol 52:407-16. 2010
  4. ncbi Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis
    Alexander Schneider
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Theodor Kutzer Ufer 1 3, Mannheim D 68135, Germany
    World J Gastroenterol 12:6507-14. 2006
  5. ncbi Beer-induced pancreatic enzyme secretion: characterization of some signaling pathways and of the responsible nonalcoholic compounds
    Andreas Gerloff
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Alcohol Clin Exp Res 33:1638-45. 2009
  6. ncbi Comparison of magnetic resonance imaging and video capsule enteroscopy in diagnosing small-bowel pathology: localization-dependent diagnostic yield
    Ulrich Bocker
    University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Scand J Gastroenterol 45:490-500. 2010
  7. ncbi Beer but not wine, hard liquors, or pure ethanol stimulates amylase secretion of rat pancreatic acinar cells in vitro
    Andreas Gerloff
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Alcohol Clin Exp Res 33:1545-54. 2009
  8. ncbi Pancreas - non-alcoholic constituents and their effects
    Andreas Gerloff
    Department of Medicine II, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Dig Dis 28:812-9. 2010
  9. ncbi Interleukin-18 serum levels in inflammatory bowel diseases: correlation with disease activity and inflammatory markers
    Stephan L Haas
    Department of Medicine II, Medical Faculty at Mannheim, University of Heidelberg, Mannheim, Germany
    Swiss Med Wkly 139:140-5. 2009
  10. ncbi Esomeprazole reduces gastroesophageal reflux after beer consumption in healthy volunteers
    Andreas Franke
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Scand J Gastroenterol 43:1425-31. 2008

Collaborators

Detail Information

Publications28

  1. ncbi Alcohol and smoking
    Manfred V Singer
    Department of Medicine II, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Dig Dis 29:177-83. 2011
    ..The most recent data about the pathophysiological relevance of non-alcoholic compounds of alcoholic beverages will also be discussed...
  2. ncbi Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma
    Andreas Gerloff
    Department of Medicine II, Universitatsmedizin Mannheim, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    Int J Environ Res Public Health 7:1093-104. 2010
    ..However, beer contains many more non-alcoholic ingredients. Their relevance in beer-induced functional alterations of pancreatic cells leading to pancreatitis and pancreatic cancer in humans needs to be further evaluated...
  3. ncbi TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I
    Loredana Ciuclan
    Molecular Hepatology Alcohol Dependent Diseases, II Medical Clinic, Faculty of Medicine at Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    J Hepatol 52:407-16. 2010
    ..The work presents an assessment of liver damaging cross-talk between ethanol and TGF-beta in hepatocytes...
  4. ncbi Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis
    Alexander Schneider
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Theodor Kutzer Ufer 1 3, Mannheim D 68135, Germany
    World J Gastroenterol 12:6507-14. 2006
    ..To investigate interleukin-18 (IL-18) in patients with chronic panreatitis (CP)...
  5. ncbi Beer-induced pancreatic enzyme secretion: characterization of some signaling pathways and of the responsible nonalcoholic compounds
    Andreas Gerloff
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Alcohol Clin Exp Res 33:1638-45. 2009
    ..The aims of this study were to: (1) investigate the involved signaling pathways in the beer-induced enzyme secretion of rat pancreatic acinar cells and (2) characterize the responsible nonalcoholic compounds from beer...
  6. ncbi Comparison of magnetic resonance imaging and video capsule enteroscopy in diagnosing small-bowel pathology: localization-dependent diagnostic yield
    Ulrich Bocker
    University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Scand J Gastroenterol 45:490-500. 2010
    ....
  7. ncbi Beer but not wine, hard liquors, or pure ethanol stimulates amylase secretion of rat pancreatic acinar cells in vitro
    Andreas Gerloff
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Alcohol Clin Exp Res 33:1545-54. 2009
    ..The aim of the present study was to investigate whether some commonly used alcoholic beverages and pure ethanol influence the main function of rat pancreatic acinar cells, i.e., enzyme output in vitro...
  8. ncbi Pancreas - non-alcoholic constituents and their effects
    Andreas Gerloff
    Department of Medicine II, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Dig Dis 28:812-9. 2010
    ....
  9. ncbi Interleukin-18 serum levels in inflammatory bowel diseases: correlation with disease activity and inflammatory markers
    Stephan L Haas
    Department of Medicine II, Medical Faculty at Mannheim, University of Heidelberg, Mannheim, Germany
    Swiss Med Wkly 139:140-5. 2009
    ..An imbalance of cytokines is believed to contribute to the immunopathogenesis of inflammatory bowel diseases (IBD). Serum cytokine levels may correlate with disease activity and acute phase reactivity...
  10. ncbi Esomeprazole reduces gastroesophageal reflux after beer consumption in healthy volunteers
    Andreas Franke
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Scand J Gastroenterol 43:1425-31. 2008
    ..The aim of the present study was therefore to investigate the effect of esomeprazole, an S-enantiomer of omeprazole, on gastroesophageal reflux after beer consumption...
  11. ncbi Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response
    Stephan L Haas
    Department of Medicine II, Medical Faculty at Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Clin Immunol 29:620-8. 2009
    ..Recently, two functional IL18 promoter variants, -607C>A (rs1946518) and -137G>C (rs187238), were associated with viral clearance in patients with hepatitis C. The present study focused on their relevance for treatment response...
  12. ncbi Transforming growth factor-beta induces nerve growth factor expression in pancreatic stellate cells by activation of the ALK-5 pathway
    Stephan L Haas
    Department of Medicine II, Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Growth Factors 27:289-99. 2009
    ..We conclude that under conditions of upregulated TGF-beta, like fibrosis, NGF levels will also increase in PSC which might contribute to pancreatic wound healing responses...
  13. ncbi Helicobacter pylori infection and dermatologic diseases
    Ana C Hernando-Harder
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital Mannheim, Mannheim, Germany
    Eur J Dermatol 19:431-44. 2009
    ..Systematic studies examining the relationship between dermatologic entities and infection with H. pylori and documentation of the effect of H. pylori eradication are needed to further our understanding on this topic...
  14. ncbi Postprandial walking but not consumption of alcoholic digestifs or espresso accelerates gastric emptying in healthy volunteers
    Andreas Franke
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Theodor Kutzer Ufer 1 3 D 68167 Mannheim, Germany
    J Gastrointestin Liver Dis 17:27-31. 2008
    ..Postprandial satiety, fullness and bloating were determined on a visual analogue scale every 10 minutes. On another occasion subjects received 40 ml of water and walked afterwards slowly (4 km/h) on a treadmill...
  15. ncbi Prospective evaluation of small bowel preparation with bisacodyl and sodium phosphate for capsule endoscopy
    Andreas Franke
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Mannheim D 68167, Germany
    World J Gastroenterol 14:2061-4. 2008
    ..To determine the effect of Prepacol, a combination of sodium phosphate and bisacodyl, on transit and quality of capsule endoscopy (CE)...
  16. ncbi Effect of non-alcoholic compounds of alcoholic drinks on the pancreas
    Peter Feick
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Pancreatology 7:124-30. 2007
    ..Since the effects of these are still unknown, caution is required in attempting to define alcoholic etiology of pancreatitis without considering the effect of non-alcoholic compounds of alcoholic beverages...
  17. ncbi Secretion from acinar cells of the exocrine pancreas: role of enteropancreatic reflexes and cholecystokinin
    Manfred V Singer
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Cell Biol Int 33:1-9. 2009
    ....
  18. ncbi Application of DC beads in hepatocellular carcinoma: clinical and radiological results of a drug delivery device for transcatheter superselective arterial embolization
    Maliha Sadick
    Institute of Clinical Radiology and Nuclear Medicine, University Hospital Mannheim, Mannheim, Germany
    Onkologie 33:31-7. 2010
    ..Application of a drug delivery device for transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). Clinical and radiological treatment assessment...
  19. ncbi HFE genotypes in patients with chronic pancreatitis and pancreatic adenocarcinoma
    Tomas Hucl
    Department of Medicine II, University of Heidelberg, Mannheim, Germany
    Genet Med 9:479-83. 2007
    ..C282Y and p.H63D may increase susceptibility to chronic liver and pancreatic disease. This study determines the frequencies of p.C282Y and p.H63D alterations in patients with chronic pancreatitis and pancreatic adenocarcinoma...
  20. ncbi -137 (G/C) IL-18 promoter polymorphism in patients with inflammatory bowel disease
    Stephan L Haas
    Department of Medicine II, Medical Faculty at Mannheim, University of Heidelberg, Mannheim, Germany
    Scand J Gastroenterol 40:1438-43. 2005
    ..The aim of this study was to determine whether the -137 (G/C) IL-18 promoter polymorphism was associated with IBD susceptibility...
  21. ncbi Poorly differentiated small cell carcinoma of the pancreas. A case report and review of the literature
    Simone Berkel
    Department of Medicine II, Mannheim Medical Faculty, University of Heidelberg, Heidelberg, Germany
    Pancreatology 4:521-6. 2004
    ..Thus, 5-fluorouracil on a weekly basis was started. The patient died 8 months after diagnosis and had not been hospitalised in the meantime...
  22. ncbi Predictors of disease-related concerns and other aspects of health-related quality of life in outpatients with inflammatory bowel disease
    Monika Mussell
    Department of Medicine II (Gastroenterology/Hepatology/Infectious Diseases, University of Heidelberg, Medical Faculty of Mannheim, Mannheim, Germany
    Eur J Gastroenterol Hepatol 16:1273-80. 2004
    ..Further studies are needed to examine the effects that the way of coping with disease have on long-term outcome in IBD...
  23. ncbi Enteropancreatic reflexes mediating the pancreatic enzyme response to nutrients
    Elke Niebergall-Roth
    Department of Medicine II, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Auton Neurosci 125:62-9. 2006
    ....
  24. ncbi Animal models and their results in gastrointestinal alcohol research
    Soren V Siegmund
    Department of Medicine II (Gastroenterology, Hepatology, Infectious Diseases, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Dig Dis 23:181-94. 2005
    ....
  25. ncbi Alcoholic pancreatitis
    Alexander Schneider
    Department of Medicine II (Gastroenterology, Hepatology, Infectious Diseases, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Dig Dis 23:222-31. 2005
    ..Finally, this article summarizes several hypothetical concepts that try to explain the early and late pathophysiological mechanisms of acute and chronic pancreatitis...
  26. ncbi Extrapulmonary sarcoidosis of liver and pancreas: a case report and review of literature
    Hermann Harder
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    World J Gastroenterol 13:2504-9. 2007
    ..An extensive literature review of systemic sarcoidosis, focusing on reported cases with unusual presentation of sarcoidosis in the liver and the pancreas, its diagnosis, treatment, and prognosis was made...
  27. ncbi Small bowel obstruction produced by a phytobezoar
    Jurgen Retter
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Clin Gastroenterol Hepatol 6:A20. 2008
  28. ncbi Control of pancreatic exocrine secretion via muscarinic receptors: which subtype(s) are involved? A review
    Elke Niebergall-Roth
    Department of Medicine II, University Hospital of Heidelberg at Mannheim, Mannheim, Germany
    Pancreatology 3:284-92. 2003
    ....