Yue Wang

Summary

Country: Singapore

Publications

  1. pmc Use of multiple methods for genotyping Fusarium during an outbreak of contact lens associated fungal keratitis in Singapore
    Roland Jureen
    Department of Laboratory Medicine, Alexandra Hospital, Singapore
    BMC Infect Dis 8:92. 2008
  2. doi request reprint CDKs and the yeast-hyphal decision
    Yue Wang
    Genes and Development Division, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Curr Opin Microbiol 12:644-9. 2009
  3. doi request reprint Linking cellular actin status with cAMP signaling in Candida albicans
    Yue Wang
    Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore
    Virulence 1:202-5. 2010
  4. doi request reprint Ras1 and Ras2 play antagonistic roles in regulating cellular cAMP level, stationary-phase entry and stress response in Candida albicans
    Yong Zhu
    Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, 61 Biopolis Drive, Singapore 138673, Singapore
    Mol Microbiol 74:862-75. 2009
  5. ncbi request reprint The formin family protein CaBni1p has a role in cell polarity control during both yeast and hyphal growth in Candida albicans
    Chang Run Li
    Molecular and Cell Biology Laboratory, Institute of Molecular and Cell Biology, Singapore
    J Cell Sci 118:2637-48. 2005
  6. pmc MNN5 encodes an iron-regulated alpha-1,2-mannosyltransferase important for protein glycosylation, cell wall integrity, morphogenesis, and virulence in Candida albicans
    Chen Bai
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Eukaryot Cell 5:238-47. 2006
  7. ncbi request reprint Candida albicans hyphal morphogenesis occurs in Sec3p-independent and Sec3p-dependent phases separated by septin ring formation
    Chang Run Li
    Candida albicans Molecular and Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore
    J Cell Sci 120:1898-907. 2007
  8. doi request reprint Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p
    Xiao Li Xu
    Institute of Molecular and Cell Biology, Agency for Science, Technology and Research A STAR, 61 Biopolis Drive, Proteos, Singapore 138673
    Cell Host Microbe 4:28-39. 2008
  9. pmc Phosphorylation of Rga2, a Cdc42 GAP, by CDK/Hgc1 is crucial for Candida albicans hyphal growth
    Xin De Zheng
    Laboratory of Candida albicans, Institute of Molecular and Cell Biology, Singapore, Singapore
    EMBO J 26:3760-9. 2007
  10. pmc Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis
    Xinde Zheng
    Institute of Molecular and Cell Biology, Singapore, Singapore
    EMBO J 23:1845-56. 2004

Collaborators

  • Yong Zhu
  • Guisheng Zeng
  • Wanjin Hong
  • Rong Li
  • Chih Fong Chou
  • Yee Joo Tan
  • Natalia Gustavsson
  • Chang Run Li
  • Chen Bai
  • Raymond Teck Ho Lee
  • Xin De Zheng
  • Xiao Li Xu
  • Hao Ming Fang
  • Hao Zou
  • Fong Yee Chan
  • Roland Jureen
  • Indrajit Sinha
  • Qing Mei Shi
  • Xinde Zheng
  • Jie Ying Au Yong
  • Hai Shan Wang
  • Yong W Wong
  • Grace Wang
  • Ai L Tan
  • Louis Y A Chai
  • Tracy Chai
  • Tse H Koh
  • Donald Tan
  • Paul A Tambyah
  • Roger Beuerman
  • Qi shan Lin
  • Wai Ho Yap
  • Robin Philp
  • Hui Yan Liang
  • Jason Chih Wei Tang
  • Narendrakumar Ramanan

Detail Information

Publications26

  1. pmc Use of multiple methods for genotyping Fusarium during an outbreak of contact lens associated fungal keratitis in Singapore
    Roland Jureen
    Department of Laboratory Medicine, Alexandra Hospital, Singapore
    BMC Infect Dis 8:92. 2008
    ..Epidemiological investigations have indicated that improper contact lens wear and the use of specific contact lens solutions were risk factors...
  2. doi request reprint CDKs and the yeast-hyphal decision
    Yue Wang
    Genes and Development Division, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Curr Opin Microbiol 12:644-9. 2009
    ..This review will discuss both conserved mechanisms and ones specific for hyphal development in C. albicans...
  3. doi request reprint Linking cellular actin status with cAMP signaling in Candida albicans
    Yue Wang
    Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore
    Virulence 1:202-5. 2010
    ..We discovered that G-actin plays a regulatory role, rendering cAMP synthesis responsive to actin dynamics. These findings shed new lights on the mechanisms that regulate cAMP-mediated responses in fungi...
  4. doi request reprint Ras1 and Ras2 play antagonistic roles in regulating cellular cAMP level, stationary-phase entry and stress response in Candida albicans
    Yong Zhu
    Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, 61 Biopolis Drive, Singapore 138673, Singapore
    Mol Microbiol 74:862-75. 2009
    ..Together, our data reveal a novel regulatory mechanism by which two antagonizing Ras GTPases balance each other in regulating multiple cellular processes in C. albicans...
  5. ncbi request reprint The formin family protein CaBni1p has a role in cell polarity control during both yeast and hyphal growth in Candida albicans
    Chang Run Li
    Molecular and Cell Biology Laboratory, Institute of Molecular and Cell Biology, Singapore
    J Cell Sci 118:2637-48. 2005
    ..Cabni1Delta exhibited reduced virulence in mice. These results indicate that the formins play an important role in Candida albicans polarized growth and CaBni1p's function is required for virulence...
  6. pmc MNN5 encodes an iron-regulated alpha-1,2-mannosyltransferase important for protein glycosylation, cell wall integrity, morphogenesis, and virulence in Candida albicans
    Chen Bai
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Eukaryot Cell 5:238-47. 2006
    ..Of particular interest was the observed role of iron in regulating the enzymatic activity, suggesting an underlying relationship between Mnn5 activity and cellular iron homeostasis...
  7. ncbi request reprint Candida albicans hyphal morphogenesis occurs in Sec3p-independent and Sec3p-dependent phases separated by septin ring formation
    Chang Run Li
    Candida albicans Molecular and Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore
    J Cell Sci 120:1898-907. 2007
    ..Our results reveal that C. albicans hyphal development occurs through Sec3p-independent and dependent phases, and provide strong genetic and biochemical evidence for a role of septins in polarized exocytosis...
  8. doi request reprint Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p
    Xiao Li Xu
    Institute of Molecular and Cell Biology, Agency for Science, Technology and Research A STAR, 61 Biopolis Drive, Proteos, Singapore 138673
    Cell Host Microbe 4:28-39. 2008
    ..Given the abundance of PGN in the intestine, a natural habitat and invasion site for C. albicans, our findings have important implications for the mechanisms of infection by this pathogen...
  9. pmc Phosphorylation of Rga2, a Cdc42 GAP, by CDK/Hgc1 is crucial for Candida albicans hyphal growth
    Xin De Zheng
    Laboratory of Candida albicans, Institute of Molecular and Cell Biology, Singapore, Singapore
    EMBO J 26:3760-9. 2007
    ..This study reveals a direct molecular link between CDKs and the polarity machinery...
  10. pmc Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis
    Xinde Zheng
    Institute of Molecular and Cell Biology, Singapore, Singapore
    EMBO J 23:1845-56. 2004
    ..C. albicans seems to have adapted a conserved strategy to control specifically hyphal morphogenesis...
  11. doi request reprint Candida albicans Cyr1, Cap1 and G-actin form a sensor/effector apparatus for activating cAMP synthesis in hyphal growth
    Hao Zou
    Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, 61 Biopolis Drive, Singapore 138673, Singapore
    Mol Microbiol 75:579-91. 2010
    ..Furthermore, G-actin's regulatory role in this apparatus may prove to be the missing link whereby cellular actin status knowingly influences cAMP-mediated cellular processes...
  12. ncbi request reprint Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development
    Indrajit Sinha
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673 Singapore
    Dev Cell 13:421-32. 2007
    ..cerevisiae. Our study uncovers a direct link between the cell-cycle engine and the septin cytoskeleton that may be part of a conserved mechanism underlying polarized morphogenesis...
  13. pmc Cdc28-Cln3 phosphorylation of Sla1 regulates actin patch dynamics in different modes of fungal growth
    Guisheng Zeng
    Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673
    Mol Biol Cell 23:3485-97. 2012
    ..Taken together, our findings establish a molecular link between CDK and a key component of the endocytic machinery, revealing a novel mechanism by which endocytosis contributes to cell morphogenesis...
  14. pmc The IQGAP Iqg1 is a regulatory target of CDK for cytokinesis in Candida albicans
    Chang Run Li
    Genes and Development Division, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research of Singapore, Singapore, Singapore
    EMBO J 27:2998-3010. 2008
    ..Our data therefore strongly support the idea that the Cdc28 CDK regulates cytokinesis partly by directly phosphorylating the actomyosin ring component Iqg1...
  15. doi request reprint Characterization of a hyperactive Cyr1 mutant reveals new regulatory mechanisms for cellular cAMP levels in Candida albicans
    Chen Bai
    Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, Singapore 138673, Singapore
    Mol Microbiol 82:879-93. 2011
    ..Thus, our studies have revealed novel regulatory elements in Cyr1 that normally repress Cyr1 activity to prevent the toxicity of unregulated high cAMP levels...
  16. doi request reprint CDK regulates septin organization through cell-cycle-dependent phosphorylation of the Nim1-related kinase Gin4
    Chang Run Li
    Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Proteos, 61 Biopolis Drive, 138673, Singapore
    J Cell Sci 125:2533-43. 2012
    ..Thus, we have identified a previously unknown signaling pathway linking CDKs and the septins that provides new insights into the mechanisms controlling septin organization and function in coordination with cell-cycle phases...
  17. ncbi request reprint RA domain-mediated interaction of Cdc35 with Ras1 is essential for increasing cellular cAMP level for Candida albicans hyphal development
    Hao Ming Fang
    Institute of Molecular and Cell Biology, ASTAR Biomedical Sciences Institutes, Proteos, 61 Biopolis Drive, Singapore 138673, Singapore
    Mol Microbiol 61:484-96. 2006
    ..These results suggest an essential role for the RA-mediated Ras1-Cdc35 interaction in raising cellular cAMP levels for hyphal morphogenesis...
  18. pmc Identification and functional characterization of a novel Candida albicans gene CaMNN5 that suppresses the iron-dependent growth defect of Saccharomyces cerevisiae aft1Delta mutant
    Chen Bai
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, 138673, Singapore
    Biochem J 389:27-35. 2005
    ..We propose that CaMnn5p promotes iron uptake and usage along the endocytosis pathway under iron-limiting conditions, a novel function that might have evolved in C. albicans...
  19. pmc Critical role of DNA checkpoints in mediating genotoxic-stress-induced filamentous growth in Candida albicans
    Qing Mei Shi
    Institute of Molecular and Cell Biology, Agency for Science, Technology and Research Biological Sciences Institutes, Singapore 138673
    Mol Biol Cell 18:815-26. 2007
    ..albicans...
  20. ncbi request reprint Insulin-stimulated leptin secretion requires calcium and PI3K/Akt activation
    Yue Wang
    Singapore Bioimaging Consortium, Agency for Science, Technology and Research A STAR, Singapore
    Biochem J 458:491-8. 2014
    ..We conclude that insulin stimulates leptin release through the PI3K/Akt pathway and that Ca2+ is required for robust Akt phosphorylation and leptin secretion. ..
  21. pmc Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion
    Natalia Gustavsson
    Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science Technology and Research, Singapore
    PLoS ONE 5:e15414. 2010
    ..Of the other synaptotagmin isoforms that are present in pancreatic islets, the neuronal calcium sensor synaptotagmin-9 is expressed at the highest level after synaptotagmin-7...
  22. doi request reprint One-step targeted gene deletion in Candida albicans haploids
    Guisheng Zeng
    Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Proteos, Singapore
    Nat Protoc 9:464-73. 2014
    ..Desired gene-deletion mutants are identified and their ploidy is assessed simultaneously by colony PCR before final confirmation by flow cytometry. ..
  23. ncbi request reprint Spindle assembly checkpoint component CaMad2p is indispensable for Candida albicans survival and virulence in mice
    Chen Bai
    Microbial Collection and Screening Laboratory, Institute of Molecular and Cell Biology, Singapore
    Mol Microbiol 45:31-44. 2002
    ..This study suggests that SAC is required for survival of C. albicans in the host and could thus be targeted for anti-C. albicans therapies...
  24. ncbi request reprint ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus)
    Chih Fong Chou
    Institute of Molecular and Cell Biology, Proteos, Singapore
    Gene 377:46-55. 2006
    ....