Affiliation: Temasek Life Sciences Laboratory
Zhang F, Huang Z, Bao H, Cong F, Wang H, Chai P, et al
. Phosphotyrosyl phosphatase activator facilitates localization of Miranda through dephosphorylation in dividing neuroblasts. Development. 2016;143:35-44 pubmed publisher
..On the basis of these results, a two-step process for the basal localization of Mira during NB division is revealed: cortical association of Mira mediated by the PTPA-PP4 complex is followed by apical aPKC-mediated basal restriction. ..
Li Z, Liu S, Cai Y. Differential Notch activity is required for homeostasis of malpighian tubules in adult Drosophila. J Genet Genomics. 2014;41:649-52 pubmed publisher
Liu Z, Zhong G, Chai P, Luo L, Liu S, Yang Y, et al
. Coordinated niche-associated signals promote germline homeostasis in the Drosophila ovary. J Cell Biol. 2015;211:469-84 pubmed publisher
..Collectively, our data suggest a complex interplay of niche-associated signals that controls the development of a stem cell lineage. ..
Li Z, Liu S, Cai Y. EGFR/MAPK signaling regulates the proliferation of Drosophila renal and nephric stem cells. J Genet Genomics. 2015;42:9-20 pubmed publisher
..Together, our data suggest a principal role of EGFR/MAPK signaling in regulating RNSC proliferation, which may provide important clues for understanding mammalian kidney repair and regeneration following injury. ..
Luo L, Wang H, Fan C, Liu S, Cai Y. Wnt ligands regulate Tkv expression to constrain Dpp activity in the Drosophila ovarian stem cell niche. J Cell Biol. 2015;209:595-608 pubmed publisher
..Our data demonstrate a self-restraining mechanism by which the Drosophila ovarian GSC niche acts to define its own boundary. ..
Luo L, Siah C, Cai Y. Engrailed acts with Nejire to control decapentaplegic expression in the Drosophila ovarian stem cell niche. Development. 2017;144:3224-3231 pubmed publisher
..Therefore, our study defines the molecular pathway controlling dpp expression in the Drosophila ovarian stem cell niche. ..
Shan Z, Tu Y, Yang Y, Liu Z, Zeng M, Xu H, et al
. Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nat Commun. 2018;9:737 pubmed publisher
..Such phase-transition-mediated protein condensations on distinct membrane cortices may be a general mechanism for various cell polarity regulatory complexes. ..