P H Tan

Summary

Affiliation: Singapore General Hospital
Country: Singapore

Publications

  1. ncbi request reprint p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study
    Puay Hoon Tan
    Department of Pathology, Singapore General Hospital, Singapore
    Mod Pathol 18:1527-34. 2005
  2. ncbi request reprint Mucinous breast lesions: diagnostic challenges
    P H Tan
    Department of Pathology, Singapore General Hospital, Singapore
    J Clin Pathol 61:11-9. 2008
  3. ncbi request reprint Breast screening in Singapore: implications for pathology
    Puay Hoon Tan
    Department of Pathology, Singapore General Hospital, Singapore
    Ann Acad Med Singapore 36:827-33. 2007
  4. ncbi request reprint Pathology of ductal carcinoma in situ of the breast: a heterogeneous entity in need of greater understanding
    P H Tan
    Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608
    Ann Acad Med Singapore 30:671-6; quiz 677. 2001
  5. pmc Pathological diagnosis of columnar cell lesions of the breast: are there issues of reproducibility?
    P H Tan
    Histopathology Section, Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608
    J Clin Pathol 58:705-9. 2005
  6. pmc Nuclear morphometry in columnar cell lesions of the breast: is it useful?
    C N Lim
    Department of Pathology, Singapore General Hospital, Singapore
    J Clin Pathol 59:1283-6. 2006
  7. ncbi request reprint Parafibromin expression in breast cancer: a novel marker for prognostication?
    S Selvarajan
    Department of Pathology, Singapore General Hospital, Singapore
    J Clin Pathol 61:64-7. 2008
  8. ncbi request reprint Pathologic-radiologic correlations in screen-detected ductal carcinoma in situ of the breast: findings of the Singapore breast screening project
    P H Tan
    Department of Pathology, Singapore General Hospital, Singapore
    Int J Cancer 90:231-6. 2000
  9. ncbi request reprint Preoperative and intraoperative diagnosis of low-grade adenosquamous carcinoma of the breast: potential diagnostic pitfalls
    B C S Ho
    Department of Pathology, Singapore General Hospital, Singapore
    Histopathology 49:603-11. 2006
  10. ncbi request reprint Leiomyomatosis-like lymphangioleiomyomatosis of the colon in a female with tuberous sclerosis
    S G Goh
    Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608
    Mod Pathol 14:1141-6. 2001

Collaborators

  • B H Bay
  • M K Li
  • R H Riddell
  • M Wong
  • E H Ng
  • Y S Tan
  • A Lee
  • G M Tse
  • L Cheng
  • Philip C W Lui
  • Wan-Cheng Chow
  • T Moriya
  • Ivy Chew
  • Benjaporn Chaiwun
  • A H L Loh
  • Rongxian Jin
  • Jingxiang Huang
  • Chow Yin Wong
  • Sathiyamoorthy Selvarajan
  • K L Chuah
  • Chuay Yeng Koo
  • B C S Ho
  • H W Tan
  • Sangeeta Mantoo
  • S G Goh
  • Y M Law
  • W M Yap
  • S Selvarajan
  • Juliana Teng-Swan Ho
  • Esther W L Chuwa
  • Maureen Hong Sing Chen
  • Timothy D Jones
  • Lee Yee Choong
  • Chun Hua Guo
  • G Yip
  • George Wai Cheong Yip
  • S M Fernandopulle
  • C N Lim
  • S K Yip
  • Brian Kp Goh
  • Hwai Liang Loh
  • Siew Kian Tai
  • Chin Ho Wong
  • W S Yong
  • Valerie Chun Ling Lin
  • Khoon Leong Chuah
  • Sim Leng Tien
  • Christina Rudduck Sivaswaren
  • Andrew Choo
  • S C Lian
  • Jacqueline Siok Gek Hwang
  • L G Ng
  • A A Thike
  • Gilbert Shin Chuin Chiang
  • S T Quek
  • S L J Wong
  • Vincent H S Tan
  • Jill Su-Lin Wong
  • M H Tan
  • Wei Sean Yong
  • L H Sii
  • Guy Hui Ho
  • Siew Wan Hee
  • B T Teh
  • Mar Lwin Zin
  • Anuradha Poonepalli
  • Mengfei Pan
  • Suqin Zheng
  • Lee Ann Baldridge
  • Marie Chiew Shia Loh
  • Rodolfo Montironi
  • M Prakash Hande
  • Manuel Salto-Tellez
  • Gregory T MacLennan
  • Yunhao Chen
  • Simin Lim
  • Ming Tse Sung
  • Nilesh Shah
  • Weiyi Toy
  • John N Eble
  • Shaobo Zhang
  • Yoon Pin Lim
  • Brian J Druker
  • Chien Shing Chen
  • George W Yip
  • Xiaohui Man
  • Antonio Lopez-Beltran
  • C H Kuick
  • W Y Siow
  • J Lui

Detail Information

Publications51

  1. ncbi request reprint p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study
    Puay Hoon Tan
    Department of Pathology, Singapore General Hospital, Singapore
    Mod Pathol 18:1527-34. 2005
    ..Although positive p53 stromal immunohistochemical detection may corroborate histologic malignancy, it is CD117 protein expression in phyllodes tumor stromal cells that may be of potential utility in predicting recurrent disease...
  2. ncbi request reprint Mucinous breast lesions: diagnostic challenges
    P H Tan
    Department of Pathology, Singapore General Hospital, Singapore
    J Clin Pathol 61:11-9. 2008
    ..In addition to these lesions with abundant extracellular mucin, there are also conditions that feature stromal mucinous or myxoid material, as well as rare entities that demonstrate both epithelial extracellular and stromal mucin...
  3. ncbi request reprint Breast screening in Singapore: implications for pathology
    Puay Hoon Tan
    Department of Pathology, Singapore General Hospital, Singapore
    Ann Acad Med Singapore 36:827-33. 2007
    ..A multidisciplinary approach and commitment to continual professional upgrading are key to surmounting the pathologic challenges brought about by breast screening...
  4. ncbi request reprint Pathology of ductal carcinoma in situ of the breast: a heterogeneous entity in need of greater understanding
    P H Tan
    Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608
    Ann Acad Med Singapore 30:671-6; quiz 677. 2001
    ....
  5. pmc Pathological diagnosis of columnar cell lesions of the breast: are there issues of reproducibility?
    P H Tan
    Histopathology Section, Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608
    J Clin Pathol 58:705-9. 2005
    ..To assess inter/intraobserver variability in the interpretation of a series of digitised images of columnar cell lesions (CCLs) of the breast...
  6. pmc Nuclear morphometry in columnar cell lesions of the breast: is it useful?
    C N Lim
    Department of Pathology, Singapore General Hospital, Singapore
    J Clin Pathol 59:1283-6. 2006
    ..Correlation with follow-up open excision specimens was made...
  7. ncbi request reprint Parafibromin expression in breast cancer: a novel marker for prognostication?
    S Selvarajan
    Department of Pathology, Singapore General Hospital, Singapore
    J Clin Pathol 61:64-7. 2008
    ..Mutations of the HRPT2 gene are common in parathyroid carcinomas, and these exhibit reduced protein expression. Parafibromin expression in breast cancer has not been previously studied...
  8. ncbi request reprint Pathologic-radiologic correlations in screen-detected ductal carcinoma in situ of the breast: findings of the Singapore breast screening project
    P H Tan
    Department of Pathology, Singapore General Hospital, Singapore
    Int J Cancer 90:231-6. 2000
    ..A trend for radiologic crushed stone-like and casting-type calcifications to be associated with DCIS with necrosis and of higher nuclear grade was noted. Int. J. Cancer (Radiat. Oncol. Invest.) 90, 231-236 (2000)...
  9. ncbi request reprint Preoperative and intraoperative diagnosis of low-grade adenosquamous carcinoma of the breast: potential diagnostic pitfalls
    B C S Ho
    Department of Pathology, Singapore General Hospital, Singapore
    Histopathology 49:603-11. 2006
    ..Diagnostic difficulty may be encountered when evaluating breast cytology, core needle biopsy or intraoperative frozen section specimens...
  10. ncbi request reprint Leiomyomatosis-like lymphangioleiomyomatosis of the colon in a female with tuberous sclerosis
    S G Goh
    Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608
    Mod Pathol 14:1141-6. 2001
    ..The patient remained free of complications for the last five years after surgery. Leiomyomatosis-like LAM of the large bowel probably represents another manifestation of the tendency of TSC to be associated with proliferative lesions...
  11. ncbi request reprint Correlation of nuclear morphometry with pathologic parameters in ductal carcinoma in situ of the breast
    P H Tan
    Department of Pathology, Singapore General Hospital, Singapore
    Mod Pathol 14:937-41. 2001
    ..01). No similar relationship was found between pathologic parameters and feret ratio or circle, indicating that nuclear roundness or lack of it did not factor as a significant component in the pathologic assessment...
  12. ncbi request reprint Immunohistochemical expression of hormone receptors in invasive breast carcinoma: correlation of results of H-score with pathological parameters
    A A Thike
    Department of Pathology, Singapore General Hospital, Singapore
    Pathology 33:21-5. 2001
    ....
  13. ncbi request reprint Adenoid cystic carcinoma of the breast
    Y M Law
    Department of Diagnostic Radiology, Singapore General Hospital, Singapore
    Singapore Med J 50:e8-11. 2009
    ..We describe a 63-year-old woman with adenoid cystic carcinoma detected on mammography in our national breast screening programme, the radiological findings at presentation, the surgical management and a review of the literature...
  14. ncbi request reprint Langerhans cell histiocytosis involving the thyroid and parathyroid glands
    W M Yap
    Department of Pathology, Singapore General Hospital, Singapore
    Mod Pathol 14:111-5. 2001
    ....
  15. doi request reprint A right renal angiomyolipoma with IVC thrombus and pulmonary embolism
    Y S Tan
    Department of Urology, Singapore General Hospital, Singapore, Singapore
    Int Urol Nephrol 42:305-8. 2010
    ..One of the rare complications is that of involvement of the lymph nodes and vascular spread via the inferior vena cava. We review the available literature and present a case of invasive AML with fat embolism...
  16. ncbi request reprint Cytology is useful in breast screening: results and long-term follow-up of the Singapore Breast Screening Pilot Project
    I Chew
    Department of Pathology, Singapore General Hospital, Singapore
    Cytopathology 17:227-32. 2006
    ..The Singapore Breast Screening Pilot Project (SBSPP) was embarked upon (1994-1997) to determine if mammography was useful in early breast cancer detection among Asian women...
  17. pmc An unusual cause of granulomatous inflammation: eosinophilic abscess in Langerhans cell histiocytosis
    H W Tan
    Department of Pathology, Singapore General Hospital
    J Clin Pathol 59:548-9. 2006
    ..Although rare, this case highlights the importance of careful examination of eosinophilic abscess with granulomatous inflammation in order to exclude an underlying neoplasm...
  18. ncbi request reprint Surgical management of angiomyolipoma: nephron-sparing surgery for symptomatic tumour
    S K Yip
    Department of Urology, Singapore General Hospital, Singapore
    Scand J Urol Nephrol 34:32-5. 2000
    ..We conclude that elective nephron-sparing surgery is feasible, even for massive angiomyolipoma or after previous rupture, especially when the diagnosis is made by preoperative imaging and/or intraoperative frozen section...
  19. ncbi request reprint Ductal carcinoma in situ with spindle cells: a potential diagnostic pitfall in the evaluation of breast lesions
    P H Tan
    Department of Pathology, Singapore General Hospital, Singapore
    Histopathology 45:343-51. 2004
    ..The association with neuroendocrine differentiation was also investigated...
  20. ncbi request reprint A rare case of localised AA-type amyloidosis of the ureter with spheroids of amyloid
    Sangeeta Mantoo
    Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608
    Singapore Med J 53:e77-9. 2012
    ..Another interesting finding in this case is the presence of spheroids of amyloid, which to the best of our knowledge, has not been previously reported at this site, and is also unusual at other sites...
  21. pmc Rosai-Dorfman disease of the testis: an unusual entity that mimics testicular malignancy
    S M Fernandopulle
    Department of Pathology, Singapore General Hospital
    J Clin Pathol 59:325-7. 2006
    ....
  22. ncbi request reprint Extramammary Paget's disease of scrotum
    L G Ng
    Department of Urology, Singapore General Hospital, Singapore, Singapore
    Urology 58:105. 2001
    ..Other modes of treatment have been advocated but the efficacy for invasive disease is low. The key to successful control of the disease is therefore a high index of suspicion and early diagnosis...
  23. ncbi request reprint Pseudodicentric (16;12)(q11;p11.2) in a type AB (mixed) thymoma
    S G Goh
    Department of Pathology, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore
    Cancer Genet Cytogenet 131:42-7. 2001
    ..Whether these genes are involved in the pathogenesis of type AB thymoma remain to be clarified and it is currently unclear if cytogenetic studies may eventually play a role in the classification of thymic tumors...
  24. ncbi request reprint 2005 Galloway Memorial Lecture: Breast phyllodes tumours--morphology and beyond
    P H Tan
    Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608
    Ann Acad Med Singapore 34:671-7. 2005
    ....
  25. ncbi request reprint CerbB2 status in breast cancer: pathologic issues
    S C Lian
    Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608
    Ann Acad Med Singapore 31:793-8. 2002
    ..This is a review of the testing methods commonly in use and their applications in the management of breast cancer...
  26. ncbi request reprint Single institution's initial experience with sentinel lymph node biopsy in breast cancer patients
    W S Yong
    Department of Surgery, Singapore General Hospital, Singapore
    ANZ J Surg 73:416-21. 2003
    ..Our aim was to determine the feasibility of detecting the sentinel node in a teaching hospital and whether the sentinel node accurately predicts the axillary status...
  27. ncbi request reprint Intermediate to highly suspicious calcification in breast lesions: a radio-pathologic correlation
    Gary M Tse
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Ngan Shing Street, Shatin, NT, Hong Kong SAR
    Breast Cancer Res Treat 110:1-7. 2008
    ..In a benign biopsy that fails to identify the calcifications visible in the mammography, further evaluation or cutting of the histologic block is recommended to minimize the potential of a false negative investigation...
  28. ncbi request reprint Effect of fixation period on HER2/neu gene amplification detected by fluorescence in situ hybridization in invasive breast carcinoma
    Sathiyamoorthy Selvarajan
    Department of Anatomy, National University of Singapore, Singapore General Hospital, Singapore
    J Histochem Cytochem 50:1693-6. 2002
    ..There was no significant difference in FISH signal detection between the two different fixation protocols in the first two groups. In the third, no signal was detected in 4/6 cases fixed for an extended duration...
  29. ncbi request reprint Correlation of p53 and cerbB2 expression and hormonal receptor status with clinicopathologic parameters in ductal carcinoma in situ of the breast
    Puay Hoon Tan
    Department of Pathology, Singapore General Hospital, Outram Road, S169608, Singapore
    Oncol Rep 9:1081-6. 2002
    ..Immunoexpression for cerbB2, however, seems to correlate with a longer time to recurrence, which is an interesting finding that needs further investigation...
  30. ncbi request reprint Comparison of the effects of differentially sulphated bovine kidney- and porcine intestine-derived heparan sulphate on breast carcinoma cellular behaviour
    Chun Hua Guo
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Int J Oncol 31:1415-23. 2007
    ....
  31. ncbi request reprint Metallothionein 2A expression is associated with cell proliferation in breast cancer
    Rongxian Jin
    Anatomy Department, National University of Singapore, 4 Medical Drive, S117 597 Singapore
    Carcinogenesis 23:81-6. 2002
    ..The finding that MT 2A appears to be the main isoform associated with cell proliferation in invasive ductal breast cancer tissues, may have therapeutic implications...
  32. ncbi request reprint Progressive loss of epidermal growth factor receptor in a subpopulation of breast cancers: implications in target-directed therapeutics
    Lee Yee Choong
    Oncology Research Institute, National University of Singapore, Singapore
    Mol Cancer Ther 6:2828-42. 2007
    ..Although no value of EGFR expression in prognosis was found, our findings are likely to have implications in the design of clinical trials targeting the EGFR family of proteins in breast cancer...
  33. ncbi request reprint Mucinous nonneoplastic cyst of the pancreas: a truly novel pathological entity?
    Brian Kp Goh
    Department of Surgery, Singapore General Hospital, Outram Road, 169610, Singapore
    World J Gastroenterol 11:2045-7. 2005
    ..We also review the literature regarding this "novel" pathological entity and discuss critically its existence and its differential diagnoses...
  34. doi request reprint Treatment for ductal carcinoma in situ in an Asian population: outcome and prognostic factors
    Esther W L Chuwa
    Department of General Surgery, Singapore General Hospital, Singapore
    ANZ J Surg 78:42-8. 2008
    ....
  35. doi request reprint Underestimation of malignancy of atypical ductal hyperplasia diagnosed on 11-gauge stereotactically guided Mammotome breast biopsy: an Asian breast screen experience
    Juliana Teng-Swan Ho
    Department of Oncologic Imaging, National Cancer Centre, 11 Hospital Drive, Singapore 169608, Singapore
    Breast 17:401-6. 2008
    ..503, 0.709, 0.551 respectively). In the absence of residual calcifications, the frequency of underestimation of carcinoma still occurred in 17%...
  36. doi request reprint Expression of basal keratins and vimentin in breast cancers of young women correlates with adverse pathologic parameters
    Maureen Hong Sing Chen
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Mod Pathol 21:1183-91. 2008
    ..Our findings are in concert with reports that expression of basal cytokeratins and vimentin is correlated with adverse pathological parameters...
  37. ncbi request reprint Metallothionein as a prognostic biomarker in breast cancer
    Boon Huat Bay
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 4 Medical Drive, Blk MD 10, Singapore 117 597
    Exp Biol Med (Maywood) 231:1516-21. 2006
    ..Generally, higher MT expression in breast cancers is predictive of worse patient outcomes. The relationship of MT isoforms to histological grade, estrogen receptor (ER) status, and prognosis will also be discussed...
  38. pmc Progesterone induces cellular differentiation in MDA-MB-231 breast cancer cells transfected with progesterone receptor complementary DNA
    Valerie Chun Ling Lin
    Departments of Clinical Research and Pathology, Singapore General Hospital, Singapore
    Am J Pathol 162:1781-7. 2003
    ..We have provided in vitro evidence of the close association of PR with differentiation in breast cancer. It is likely that the Stat 5b protein may play a major role in progesterone-induced differentiation in breast cancer cells...
  39. ncbi request reprint Test and Teach. Recurrent breast lumps in a Chinese woman. Adenomyoepithelioma of the breast
    Hwai Liang Loh
    Histopathology Section, Department of Pathology, Singapore General Hospital, Singapore
    Pathology 36:269-72. 2004
  40. pmc Differential expression of metallothionein 1 and 2 isoforms in breast cancer lines with different invasive potential: identification of a novel nonsilent metallothionein-1H mutant variant
    Siew Kian Tai
    Department of Microbiology, Human Genome Laboratory, Faculty of Medicine, National University of Singapore, 4 Medical Drive, S 117 597 Singapore, Republic of Singapore
    Am J Pathol 163:2009-19. 2003
    ..The observations in this study are relevant to the development of novel approaches to metastatic breast cancer disease, and may herald the search for novel MT mutants and the elucidation of their biological roles...
  41. ncbi request reprint Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death
    Puay Hoon Tan
    Department of Pathology, Singapore General Hospital, Singapore
    Mod Pathol 18:374-81. 2005
    ..Differential regulation of these genes, especially bcl2, may contribute to the biological nature of clinically more aggressive and highly proliferative breast cancers...
  42. ncbi request reprint Y-box binding protein, YB-1, as a marker of tumor aggressiveness and response to adjuvant chemotherapy in breast cancer
    Jingxiang Huang
    Department of Anatomy, Faculty of Medicine, National University of Singapore, Singapore
    Int J Oncol 26:607-13. 2005
    ..024). YB-1 expression in breast cancer may be a potential marker of chemoresistance and could possibly aid in selection of the appropriate adjuvant chemotherapy regime for breast cancers...
  43. ncbi request reprint Phyllodes tumors of the breast: the role of pathologic parameters
    Puay Hoon Tan
    Department of Pathology, Singapore General Hospital, Singapore
    Am J Clin Pathol 123:529-40. 2005
    ..3% and 51.7% respectively. The 7 women who died of disease during follow-up had malignant phyllodes tumor at the outset and experienced recurrences, and death was preceded by distant metastases...
  44. ncbi request reprint Detection of HER2/neu gene amplification in archival paraffin-embedded breast cancer tissues by fluorescence in situ hybridization
    Sathiyamoorthy Selvarajan
    Department of Anatomy, National University of Singapore, Singapore
    Histochem Cell Biol 120:251-5. 2003
    ..There was no significant difference in the detection of FISH signals between microwave oven and routinely fixed specimens...
  45. ncbi request reprint Test and teach. Number fifty-three. Diagnosis: Spindle cell ductal carcinoma in situ with neuroendocrine differentiation
    Ivy Chew
    Department of Pathology, Singapore General Hospital, Singapore
    Pathology 37:76-9. 2005
  46. ncbi request reprint Blue rubber bleb nevus syndrome: a clinical spectrum with correlation between cutaneous and gastrointestinal manifestations
    Chin Ho Wong
    J Gastroenterol Hepatol 18:1000-2. 2003
  47. ncbi request reprint p63 is useful in the diagnosis of mammary metaplastic carcinomas
    Gary M Tse
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong
    Pathology 38:16-20. 2006
    ....
  48. ncbi request reprint Clinicopathological significance of metallothioneins in breast cancer
    Rongxian Jin
    Department of Anatomy, National University of Singapore
    Pathol Oncol Res 10:74-9. 2004
    ..In addition, metallothionein expression may have a potential role in protecting the breast cancer cell from chemotherapeutic threats to survival...
  49. ncbi request reprint Prognostic significance of glutathione S-transferase-pi in invasive breast cancer
    Jingxiang Huang
    Department of Medical Oncology, National Cancer Centre, Singapore
    Mod Pathol 16:558-65. 2003
    ..1). The findings indicate that GST-pi-positive tumors are more aggressive and have a poorer prognosis than do corresponding GST-pi-negative breast cancers...
  50. ncbi request reprint Immunohistochemical expression of heparan sulfate correlates with stromal cell proliferation in breast phyllodes tumors
    Chuay Yeng Koo
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Mod Pathol 19:1344-50. 2006
    ..Stromal 10E4 expression was significantly associated with tumor grade, stromal p53, and MIB1 expression in proliferating cells, suggesting that heparan sulfate may participate in malignant tumor growth...
  51. ncbi request reprint Urothelial carcinoma with an inverted growth pattern can be distinguished from inverted papilloma by fluorescence in situ hybridization, immunohistochemistry, and morphologic analysis
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 31:1861-7. 2007
    ..Morphologic features, as well as immunohistochemical stains (including stains for Ki-67, p53, and cytokeratin 20) and/or UroVysion FISH can help to distinguish inverted papilloma from urothelial carcinoma with an inverted growth pattern...