Eng King Tan

Summary

Affiliation: Singapore General Hospital
Country: Singapore

Publications

  1. ncbi Restless legs syndrome in an Asian population: A study in Singapore
    E K Tan
    Parkinson s Disease and Movement Disorder Program, Department of Neurology, Singapore General Hospital, Outram Road, Republic of Singapore
    Mov Disord 16:577-9. 2001
  2. pmc Linking restless legs syndrome with Parkinson's disease: clinical, imaging and genetic evidence
    Tasneem Peeraully
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore
    Transl Neurodegener 1:6. 2012
  3. ncbi Alpha synuclein promoter and risk of Parkinson's disease: microsatellite and allelic size variability
    Eng King Tan
    Department of Neurology, National Neuroscience Institute, Parkinson s Disease and Movement Disorder Program, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Neurosci Lett 336:70-2. 2003
  4. ncbi Genetic analysis of DJ-1 in a cohort Parkinson's disease patients of different ethnicity
    Eng King Tan
    Division of Research, SingHealth, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Neurosci Lett 367:109-12. 2004
  5. ncbi Analysis of MDR1 haplotypes in Parkinson's disease in a white population
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Neurosci Lett 372:240-4. 2004
  6. ncbi Case-control study of UCHL1 S18Y variant in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 21:1765-8. 2006
  7. ncbi Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 18:593-5. 2003
  8. doi Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases
    Simon Kang Seng Ting
    Department of Neurology, Singapore General Hospital, Singapore National Neuroscience Institute, Singapore, Singapore
    Neurobiol Aging 34:2441.e7-8. 2013
  9. ncbi Alpha-synuclein mRNA expression in sporadic Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 20:620-3. 2005
  10. ncbi Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 22:1816-8. 2007

Collaborators

Detail Information

Publications42

  1. ncbi Restless legs syndrome in an Asian population: A study in Singapore
    E K Tan
    Parkinson s Disease and Movement Disorder Program, Department of Neurology, Singapore General Hospital, Outram Road, Republic of Singapore
    Mov Disord 16:577-9. 2001
    ..Based on the IRLSSG criteria, the prevalence of restless leg syndrome (RLS) was 0.6% and 0.1%, respectively...
  2. pmc Linking restless legs syndrome with Parkinson's disease: clinical, imaging and genetic evidence
    Tasneem Peeraully
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore
    Transl Neurodegener 1:6. 2012
    ..In this review, we provide a concise summary of the clinical, imaging and genetic evidence exploring the link between RLS and PD...
  3. ncbi Alpha synuclein promoter and risk of Parkinson's disease: microsatellite and allelic size variability
    Eng King Tan
    Department of Neurology, National Neuroscience Institute, Parkinson s Disease and Movement Disorder Program, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Neurosci Lett 336:70-2. 2003
    ..Variability of the microsatellite region and potential interacting factors that could affect alpha synuclein gene transcription should be further examined...
  4. ncbi Genetic analysis of DJ-1 in a cohort Parkinson's disease patients of different ethnicity
    Eng King Tan
    Division of Research, SingHealth, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Neurosci Lett 367:109-12. 2004
    ..Unlike Parkin, pathogenic DJ-1 mutations appear to be restricted to certain populations and are unlikely to be of clinical importance in our Asian cohort...
  5. ncbi Analysis of MDR1 haplotypes in Parkinson's disease in a white population
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Neurosci Lett 372:240-4. 2004
    ..There was a weak protective effect of the haplotype 2677G-3435C in our white population. However, the MDR1 haplotypes did not generally modulate the risk of PD...
  6. ncbi Case-control study of UCHL1 S18Y variant in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 21:1765-8. 2006
    ..Further functional studies of the S18Y variant in both cell and animal models will be of interest...
  7. ncbi Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 18:593-5. 2003
    ..The Taq1A and Taq1B polymorphisms were in strong linkage disequilibrium. There was, however, no significant association of the two polymorphisms with PD...
  8. doi Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases
    Simon Kang Seng Ting
    Department of Neurology, Singapore General Hospital, Singapore National Neuroscience Institute, Singapore, Singapore
    Neurobiol Aging 34:2441.e7-8. 2013
    ..Our finding suggests that the A673T protective variant is not relevant in our Asian population. Studies in other ethnic populations would clarify whether this variant is specific to specific races/ethnicities. ..
  9. ncbi Alpha-synuclein mRNA expression in sporadic Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 20:620-3. 2005
    ..However, the role of alpha-synuclein mRNA expression in select groups of sporadic PD patients and its interaction with environmental agents need to be further determined...
  10. ncbi Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 22:1816-8. 2007
    ..The relevance of Gly2385Arg as a genetic risk factor may be restricted to selected Asian races, and more studies will be needed to confirm our observations...
  11. ncbi Functional COMT variant predicts response to high dose pyridoxine in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608
    Am J Med Genet B Neuropsychiatr Genet 137:1-4. 2005
    ..Our observational study suggests that the status the functional COMT(L) variant may be potentially useful to select PD patients for high dose pyridoxine therapy...
  12. ncbi "Myorhythmia" slow facial tremor from chronic interferon alpha-2a usage
    Eng King Tan
    Department of Neurology, Singapore General Hospital
    Neurology 61:1302-3. 2003
  13. doi SLC1A2 variant associated with essential tremor but not Parkinson disease in Chinese subjects
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Neurology 80:1618-9. 2013
    ..In addition, we also investigated the variant in patients with Parkinson disease (PD) because the GWAS LINGO1 variant has been implicated in both ET and PD and etiologic links between the conditions have been suggested.(6.)..
  14. ncbi Identification of a common genetic risk variant (LRRK2 Gly2385Arg) in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, SingHealth, Singapore
    Ann Acad Med Singapore 35:840-2. 2006
    ..The identification of the LRRK2 Gly2385Arg variant could potentially facilitate the development of clinical, bioimaging, genetic and biological biomarkers, useful in the monitoring and neuroprotective therapy in asymptomatic individuals...
  15. ncbi Genetic analysis of SCA 2 and 3 repeat expansions in essential tremor and atypical Parkinsonism
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 22:1971-4. 2007
    ..However, in the long-term follow-up of patients who present with an ET phenotype, clinicians should be vigilant for other neurological signs, which may be point to an alternate diagnosis...
  16. ncbi Behind the facial twitch: depressive symptoms in hemifacial spasm
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Outram Road, 169608, Singapore
    Parkinsonism Relat Disord 11:241-5. 2005
    ..Depression impairs psychosocial and occupational functioning and contributes to significant morbidity and mortality. Hemifacial spasm (HFS) causes social embarrassment and visual and verbal disability...
  17. ncbi Effect of MDR1 haplotype on risk of Parkinson disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Arch Neurol 62:460-4. 2005
    ..Specific MDR1 alleles of the 2 SNPs are positively selected among ethnic Chinese but not in the white population...
  18. ncbi Comparing knowledge and attitudes towards genetic testing in Parkinson's disease in an American and Asian population
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    J Neurol Sci 252:113-20. 2007
    ..Recent discoveries of disease-causing genes in Parkinson's disease (PD) have generated considerable interest regarding genetic testing in PD. The attitudes toward genetic testing are largely influenced by knowledge and preconceived notions...
  19. ncbi Impaired motor imagery in patients with essential tremor: a case control study
    Yew Long Lo
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 22:504-8. 2007
    ..The basis for this novel finding is unclear, and further studies are warranted to determine whether it is related to cerebellar or motor cortical dysfunction...
  20. ncbi Isolated facial myorhythmia
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    J Neurol Sci 252:36-8. 2007
    ..However, the pathological basis why the facial region was selectively involved in our patient is unclear. Early recognition of the symptoms and signs would facilitate investigations for an underlying cause...
  21. ncbi Botulinum toxin improves quality of life in hemifacial spasm: validation of a questionnaire (HFS-30)
    Eng King Tan
    Department of Neurology and Clinical Research, Singapore General Hospital, Outram Road, Singapore
    J Neurol Sci 219:151-5. 2004
    ..Hemifacial spasm (HFS) can be disabling and affect quality of life. There is a lack of a validated scale for evaluating botulinum toxin (BTX) response in HFS...
  22. ncbi Case-control study of anxiety symptoms in hemifacial spasm
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 21:2145-9. 2006
    ..0 +/- 5.0 vs. 11.0 +/- 6.0; P = 0.001) following appropriate management. As stress and anxiety can aggravate HFS, diagnosis and early management of anxiety symptoms can improve quality of life in these patients...
  23. ncbi Genetic testing in Parkinson disease: promises and pitfalls
    Eng King Tan
    Department of Neurology, Singapore General Hospital
    Arch Neurol 63:1232-7. 2006
  24. doi Clinically reported heterozygous mutations in the PINK1 kinase domain exert a gene dosage effect
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Hum Mutat 30:1551-7. 2009
    ....
  25. doi Transcallosal diffusion tensor abnormalities in predominant gait disorder parkinsonism
    Ling Ling Chan
    Department of Diagnostic Radiology, Singapore General Hospital, Republic of Singapore
    Parkinsonism Relat Disord 20:53-9. 2014
    ..There have been no previous diffusion tensor imaging (DTI) studies comparing Parkinson's disease (PD) with postural instability and gait disorder (PIGD) parkinsonism...
  26. ncbi Vascular parkinsonism in moyamoya: microvascular biopsy and imaging correlates
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore
    Ann Neurol 54:836-40. 2003
    ..The marked cutaneous arteriolar smooth muscle cell hypertrophy may be a useful surrogate marker for those at risk of developing angiographic moyamoya...
  27. pmc Bilateral trapezius hypertrophy with dystonia and atrophy
    Eng King Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore
    CMAJ 176:1702-3. 2007
  28. ncbi An urge to move with L-thyroxine: clinical, biochemical, and polysomnographic correlation
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 19:1365-7. 2004
    ..RLS symptoms can complicate thyroxine replacement in at-risk hypothyroid patients with low serum ferritin. Early diagnosis and iron replacement could significantly reduce patient morbidity...
  29. doi Sleep and Parkinson's disease: a review of case-control polysomnography studies
    Tasneem Peeraully
    National Neuroscience Institute, Department of Neurology, Singapore General Hospital, Singapore, Singapore
    Mov Disord 27:1729-37. 2012
    ..Adequately powered, prospective studies with uniform methodology and healthy controls are needed to further address the association and pathophysiological significance between PD and sleep problems...
  30. ncbi Emerging therapeutic applications of botulinum toxin
    Zin Soe Thant
    Department of Neurology, Singapore General Hospital, Singapore
    Med Sci Monit 9:RA40-8. 2003
    ..The long-term cost effectiveness of treatment and immunoresistance from repeated injections are also important clinical issues to address...
  31. ncbi Severe bruxism following basal ganglia infarcts: insights into pathophysiology
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore
    J Neurol Sci 217:229-32. 2004
    ..Dysfunction of the efferent and/or afferent thalamic or striatopallidal tracts may play a role in bruxism. Early recognition of bruxism following stroke could reduce unnecessary suffering since the condition can be effectively treated...
  32. ncbi Restless legs syndrome and Parkinson's disease: is there an etiologic link?
    Eng King Tan
    Parkinson s Disease and Movement Disorder Program, Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore
    J Neurol 253:VII33-37. 2006
    ..Further clinical, imaging, pharmacologic, and genetic studies will be needed to address the many unanswered questions related to the link between RLS and PD...
  33. ncbi Pathogenic mutations in Parkinson disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Hum Mutat 28:641-53. 2007
    ..Penetrance of some of the recurrent mutations is incomplete and may vary with age. Further research to unravel the etiopathology could identify biochemical or genetic markers for potential neuroprotective trials...
  34. doi Pathogenicity of LRRK2 P755L variant in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore
    Mov Disord 23:734-6. 2008
    ..Further validation of our findings in other populations would be important...
  35. doi Development of Parkinson's disease biomarkers
    Kumar M Prakash
    Singapore General Hospital, Singapore Department of Neurology, Singapore General Hospital, Singapore
    Expert Rev Neurother 10:1811-25. 2010
    ..It is hoped that reliable and well-validated biomarkers will provide critical clues to assist in the diagnosis and management of Parkinson's disease patients in the near future...
  36. ncbi Neurovascular compression syndromes and hypertension: clinical relevance
    Eng King Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore
    Nat Clin Pract Neurol 3:416-7. 2007
  37. ncbi Persistent hand spasm: movement disorder or seizure?
    Deidre A De Silva
    Department of Neurology, Singapore General Hospital, Outram Road, 169608, Singapore
    J Neurol Sci 252:185-8. 2007
    ..We report an elderly lady with intractable focal seizure who presented with more than a year of persistent hand spasms. The clinical importance of differentiating epilepsy from movement disorders is discussed...
  38. doi Dissociative semantic breakdown in Alzheimer's disease: evidence from multiple category fluency test
    Simon Kang Seng Ting
    Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore
    Clin Neurol Neurosurg 115:1049-51. 2013
    ..We re-examine above finding by performing multiple superordinate category verbal fluency test in AD patients...
  39. ncbi Validity of family history in essential tremor
    K M Prakash
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore
    Parkinsonism Relat Disord 14:151-3. 2008
    ..001, chi2 14.3). Our study suggests that family history information reported by ET patients was inaccurate, and poorly validated. Clinical and genetic studies in ET should take the limitation of family history data into consideration...
  40. ncbi Transient paroxysmal dyskinesia associated with focal basal ganglia lesions
    Siew Ju See
    Department of Neurology, Singapore General Hospital, Singapore
    Eur Neurol 50:117-8. 2003
  41. ncbi Psychogenic tics: diagnostic value of the placebo test
    Eng King Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, SingHealth Research
    J Child Neurol 19:976-7. 2004
    ..In addition, a concise summary of the clinical phenomenology of tics and the diagnosis and management of psychogenic movement disorders is provided...
  42. ncbi Acute ataxia, Graves' disease, and stiff person syndrome
    Su Ynn Chia
    Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore
    Mov Disord 22:1969-71. 2007
    ..Initiation of immunosuppressive therapy dramatically improved the patient's Graves' disease within 2 weeks but the neurological symptoms were not alleviated after a follow-up period of 3 years...