Eng King Tan

Summary

Affiliation: Singapore General Hospital
Country: Singapore

Publications

  1. doi request reprint Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease
    Owen A Ross
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Ann Neurol 64:88-92. 2008
  2. pmc Patterns of linkage disequilibrium of LRRK2 across different races: implications for genetic association studies
    Huihua Li
    Health Services Research and Biostatistics Unit, Division of Research, Singapore General Hospital, Singapore, Singapore
    PLoS ONE 8:e75041. 2013
  3. pmc Differentiating non-motor symptoms in Parkinson's disease from controls and hemifacial spasm
    Ming Hui Yong
    Department of Neurology, National Neuroscience Institute, Singapore, Singapore
    PLoS ONE 8:e49596. 2013
  4. pmc Case control polysomnographic studies of sleep disorders in Parkinson's disease
    Ming Hui Yong
    Department of Neurology, National Neuroscience Institute, Singapore
    PLoS ONE 6:e22511. 2011
  5. ncbi request reprint Case-control study of UCHL1 S18Y variant in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 21:1765-8. 2006
  6. ncbi request reprint Case-control study of anxiety symptoms in hemifacial spasm
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 21:2145-9. 2006
  7. ncbi request reprint LRRK2 G2019S founder haplotype in the Chinese population
    Eng King Tan
    Singapore General Hospital, Singapore
    Mov Disord 22:105-7. 2007
  8. ncbi request reprint Clinical features of childhood onset essential tremor
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Eur J Neurol 13:1302-5. 2006
  9. ncbi request reprint Restless legs syndrome and Parkinson's disease: is there an etiologic link?
    Eng King Tan
    Parkinson s Disease and Movement Disorder Program, Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore
    J Neurol 253:VII33-37. 2006
  10. ncbi request reprint Isolated facial myorhythmia
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    J Neurol Sci 252:36-8. 2007

Collaborators

Detail Information

Publications99

  1. doi request reprint Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease
    Owen A Ross
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Ann Neurol 64:88-92. 2008
    ..20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LRRK2 variants in sporadic Parkinson's disease. Ann Neurol 2008...
  2. pmc Patterns of linkage disequilibrium of LRRK2 across different races: implications for genetic association studies
    Huihua Li
    Health Services Research and Biostatistics Unit, Division of Research, Singapore General Hospital, Singapore, Singapore
    PLoS ONE 8:e75041. 2013
    ....
  3. pmc Differentiating non-motor symptoms in Parkinson's disease from controls and hemifacial spasm
    Ming Hui Yong
    Department of Neurology, National Neuroscience Institute, Singapore, Singapore
    PLoS ONE 8:e49596. 2013
    ..This case-control study compared the NMS burden among PD patients, healthy controls and hemifacial spasm (HFS) patients. In addition, we determined the NMS that discriminated between PD and non-PD subjects...
  4. pmc Case control polysomnographic studies of sleep disorders in Parkinson's disease
    Ming Hui Yong
    Department of Neurology, National Neuroscience Institute, Singapore
    PLoS ONE 6:e22511. 2011
    ..The relationship between a number of primary sleep disorders and Parkinson's disease (PD) is still debated. There are limited case control polysomnographic studies in PD and most of these study sample sizes are small...
  5. ncbi request reprint Case-control study of UCHL1 S18Y variant in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 21:1765-8. 2006
    ..Further functional studies of the S18Y variant in both cell and animal models will be of interest...
  6. ncbi request reprint Case-control study of anxiety symptoms in hemifacial spasm
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 21:2145-9. 2006
    ..0 +/- 5.0 vs. 11.0 +/- 6.0; P = 0.001) following appropriate management. As stress and anxiety can aggravate HFS, diagnosis and early management of anxiety symptoms can improve quality of life in these patients...
  7. ncbi request reprint LRRK2 G2019S founder haplotype in the Chinese population
    Eng King Tan
    Singapore General Hospital, Singapore
    Mov Disord 22:105-7. 2007
    ..The haplotype is likely to be more ancient than the G2019S mutation because it is also found in a population with a very low carrier rate...
  8. ncbi request reprint Clinical features of childhood onset essential tremor
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Eur J Neurol 13:1302-5. 2006
    ..These observations appear to transcend ethnic and cultural differences and lend further support that gender difference may play a role in the pathogenesis and expression of ET...
  9. ncbi request reprint Restless legs syndrome and Parkinson's disease: is there an etiologic link?
    Eng King Tan
    Parkinson s Disease and Movement Disorder Program, Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore
    J Neurol 253:VII33-37. 2006
    ..Further clinical, imaging, pharmacologic, and genetic studies will be needed to address the many unanswered questions related to the link between RLS and PD...
  10. ncbi request reprint Isolated facial myorhythmia
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    J Neurol Sci 252:36-8. 2007
    ..However, the pathological basis why the facial region was selectively involved in our patient is unclear. Early recognition of the symptoms and signs would facilitate investigations for an underlying cause...
  11. doi request reprint Pathogenicity of LRRK2 P755L variant in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore
    Mov Disord 23:734-6. 2008
    ..Further validation of our findings in other populations would be important...
  12. ncbi request reprint Young onset hemifacial spasm
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Acta Neurol Scand 114:59-62. 2006
    ..If age is a major determinant of the etiology or influences the presentation of HFS, there may be clinical differences between the young and elderly HFS patients...
  13. ncbi request reprint Exploring the relationship between Parkinson's disease and hemifacial spasm
    E K Tan
    Department of Neurology, Singapore, General Hospital, Singapore
    Acta Neurol Scand 113:350-2. 2006
    ..05). Our study demonstrated no significant increased risk of HFS amongst the general PD population and hence HFS symptoms are unlikely to be of clinical importance for most PD patients...
  14. ncbi request reprint Analysis of 14 LRRK2 mutations in Parkinson's plus syndromes and late-onset Parkinson's disease
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 21:997-1001. 2006
    ..We highlight the first case of LRRK2 R1441C mutation in late onset sporadic PD of non-European ancestry. Furthermore, extensive mutational screen found LRRK2 mutations to be rare among patients who presented with PSP, MSA, CBGD, and AP...
  15. ncbi request reprint Botulinum toxin treatment of sialorrhea: comparing different therapeutic preparations
    E K Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Division of Research, SingHealth
    Eur J Neurol 13:60-4. 2006
    ....
  16. ncbi request reprint Impaired transcriptional upregulation of Parkin promoter variant under oxidative stress and proteasomal inhibition: clinical association
    E K Tan
    Department of Neurology, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore
    Hum Genet 118:484-8. 2005
    ..Our clinical and laboratory data provide corroborative evidence that some older individuals who have the -258G variant may have a higher risk of developing PD...
  17. ncbi request reprint Differential expression of splice variant and wild-type parkin in sporadic Parkinson's disease
    E K Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore
    Neurogenetics 6:179-84. 2005
    ..Altered splicing of parkin under cellular stress could lead to changes in gene expression and altered protein activity. The causative role of parkin in sporadic Parkinson's disease (PD) is unknown...
  18. ncbi request reprint Hemidystonia precipitated by acute pontine infarct
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    J Neurol Sci 234:109-11. 2005
    ..Acute dysregulation of pallidal efferents to the pedunculopontine and/or pontine afferents to the thalamus may precipitate hemidystonia...
  19. ncbi request reprint Behind the facial twitch: depressive symptoms in hemifacial spasm
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Outram Road, 169608, Singapore
    Parkinsonism Relat Disord 11:241-5. 2005
    ..Depression impairs psychosocial and occupational functioning and contributes to significant morbidity and mortality. Hemifacial spasm (HFS) causes social embarrassment and visual and verbal disability...
  20. ncbi request reprint Identification of a common genetic risk variant (LRRK2 Gly2385Arg) in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, SingHealth, Singapore
    Ann Acad Med Singapore 35:840-2. 2006
    ..The identification of the LRRK2 Gly2385Arg variant could potentially facilitate the development of clinical, bioimaging, genetic and biological biomarkers, useful in the monitoring and neuroprotective therapy in asymptomatic individuals...
  21. ncbi request reprint DRD3 variant and risk of essential tremor
    E K Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608
    Neurology 68:790-1. 2007
  22. pmc Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Neurology 75:508-12. 2010
    ....
  23. doi request reprint Clinically reported heterozygous mutations in the PINK1 kinase domain exert a gene dosage effect
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Hum Mutat 30:1551-7. 2009
    ....
  24. doi request reprint CALHM1 variant is not associated with Alzheimer's disease among Asians
    E K Tan
    Department of Neurology, Clinical Research and Health Screening, Singapore General Hospital, Outram Road, 169608 Singapore, Singapore
    Neurobiol Aging 32:546.e11-2. 2011
    ..5% vs 16.7%) and genotype frequency was not significantly different between Alzheimer's disease (AD) and controls. Logistic regression analysis did not reveal any interaction between ApoE4 allele and CALHM1 allele...
  25. doi request reprint Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese
    E K Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore
    Neurobiol Aging 31:2194-6. 2010
    ..99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD...
  26. ncbi request reprint Treatment outcome correlates with knowledge of disease in hemifacial spasm
    Eng King Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Duke NUS Graduate Medical School, Singapore
    Clin Neurol Neurosurg 110:813-7. 2008
    ..We examined the relationship between knowledge of disease with improvement in QOL following botulinum toxin treatment in HFS patients...
  27. doi request reprint Graves disease and isolated orthostatic tremor
    E K Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore
    Neurology 70:1497-8. 2008
  28. doi request reprint Evidence of increased odds of essential tremor in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore
    Mov Disord 23:993-7. 2008
    ..In our Asian population, patients with PD were 5 to 10 times more likely to have ET compared to diseased and healthy controls, suggesting that the association of ET and PD is unlikely to be ethnicity-specific...
  29. doi request reprint Essential tremor and the common LRRK2 G2385R variant
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Parkinsonism Relat Disord 14:569-71. 2008
    ..9%) ET patients compared to 10/247 (4.0%) of controls (odds ratio=0.72, 95% CI 0.24, 2.1, p=0.6). All the Gly2385Arg carriers were heterozygotes. The LRRK2 Gly2385Arg variant is not a significant risk factor for ET in our population...
  30. ncbi request reprint Association between caffeine intake and risk of Parkinson's disease among fast and slow metabolizers
    Eng King Tan
    Departments of Neurology, Singapore General Hospital, Singapore
    Pharmacogenet Genomics 17:1001-5. 2007
    ..Both caffeine and its main metabolite, paraxanthine, may be neuroprotective. The association between caffeine intake and risk of Parkinson's disease (PD) in fast and slow caffeine metabolizers has not been compared...
  31. ncbi request reprint The role of common genetic risk variants in Parkinson disease
    E K Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore
    Clin Genet 72:387-93. 2007
    ..78-2.9). A higher frequency of G2385R carriers has been observed in familial PD when compared with sporadic patients. Based on current evidence, certain common genetic variants are likely to modulate the risk of PD...
  32. ncbi request reprint Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Neurobiol Aging 30:501-2. 2009
    ..3% of AD compared to 4.5% in controls (odds ratio=0.94, 95% CI 0.37-2.42, p=1.0). The Gly2385Arg variant does not appear to modulate the risk of AD in our population...
  33. ncbi request reprint Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 22:1816-8. 2007
    ..The relevance of Gly2385Arg as a genetic risk factor may be restricted to selected Asian races, and more studies will be needed to confirm our observations...
  34. ncbi request reprint Neurovascular compression syndromes and hypertension: clinical relevance
    Eng King Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore
    Nat Clin Pract Neurol 3:416-7. 2007
  35. ncbi request reprint Pathogenic mutations in Parkinson disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Hum Mutat 28:641-53. 2007
    ..Penetrance of some of the recurrent mutations is incomplete and may vary with age. Further research to unravel the etiopathology could identify biochemical or genetic markers for potential neuroprotective trials...
  36. ncbi request reprint Prescribing pattern in Parkinson's disease: are cost and efficacy overriding factors?
    E K Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, SingHealth, National University of Singapore, Singapore
    Int J Clin Pract 59:511-4. 2005
    ..While factors affecting drug usage in PD are well recognised, cost and efficacy of a drug appear to be overriding practical factors in influencing usage pattern in clinical practice...
  37. ncbi request reprint Is hypertension associated with hemifacial spasm?
    E K Tan
    Department of Neurology, Diagnostic Radiology, Singapore General Hospital, Singapore 169608, Republic of Singapore
    Neurology 60:343-4. 2003
  38. ncbi request reprint Restless legs symptoms in thyroid disorders
    E K Tan
    Department of Neurology, Division of Medicine, Singapore General Hospital, Outram Road, Singapore, Singapore 169608
    Parkinsonism Relat Disord 10:149-51. 2004
    ..In conclusion, while RLS-like symptoms were observed in some patients with thyroid disorders, our study demonstrates no significant difference of RLS prevalence between patients with thyroid disorders and euthyroid controls...
  39. ncbi request reprint Alpha-synuclein haplotypes implicated in risk of Parkinson's disease
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Neurology 62:128-31. 2004
    ..0001) with risk of PD after correction for the effects of age, sex, and the other polymorphic loci. Specific four-loci and six-loci haplotypes were significantly associated with an increased or decreased risk of PD...
  40. ncbi request reprint Recurrent jaw dislocation after botulinum toxin treatment for sialorrhoea in amyotrophic lateral sclerosis
    E K Tan
    Department of Neurology, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore
    J Neurol Sci 190:95-7. 2001
    ..Clinicians using BTX to treat sialorrhoea in ALS need to be aware of this potentially serious complication...
  41. ncbi request reprint Restless legs syndrome in Parkinson's disease
    E K Tan
    Parkinson s Disease and Movement Disorder Program, Department of Neurology, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore
    J Neurol Sci 196:33-6. 2002
    ..As RLS responds to dopaminergic medications, an etiologic link between RLS and Parkinson's disease (PD) has been proposed. However, few studies have examined this association...
  42. ncbi request reprint Levodopa-induced oromandibular dystonia in progressive supranuclear palsy
    E K Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Clin Neurol Neurosurg 105:132-4. 2003
    ....
  43. ncbi request reprint Vascular parkinsonism in moyamoya: microvascular biopsy and imaging correlates
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore
    Ann Neurol 54:836-40. 2003
    ..The marked cutaneous arteriolar smooth muscle cell hypertrophy may be a useful surrogate marker for those at risk of developing angiographic moyamoya...
  44. ncbi request reprint "Myorhythmia" slow facial tremor from chronic interferon alpha-2a usage
    Eng King Tan
    Department of Neurology, Singapore General Hospital
    Neurology 61:1302-3. 2003
  45. ncbi request reprint Genetic analysis of Nurr1 haplotypes in Parkinson's disease
    Eng King Tan
    Division of Research, SingHealth, Singapore, Singapore
    Neurosci Lett 347:139-42. 2003
    ..Our study suggests that Nurr1 variability is unlikely to play a major role in the majority of our PD patients...
  46. ncbi request reprint Mitochondrial complex I polymorphism and cigarette smoking in Parkinson's disease
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Neurology 59:1288-9. 2002
  47. ncbi request reprint Reversible choreoathetosis in primary cerebral lymphoma: clinicoradiologic correlation
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore, Singapore
    Eur Neurol 50:53-4. 2003
  48. ncbi request reprint Monoamine oxidase B polymorphism, cigarette smoking and risk of Parkinson's disease: a study in an Asian population
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Am J Med Genet B Neuropsychiatr Genet 120:58-62. 2003
    ..The MAO B G/A genotype frequency in our Asian population was quite different from Caucasians suggesting that ethnicity specific effects need to be considered in evaluating gene-environmental interaction...
  49. ncbi request reprint Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 18:593-5. 2003
    ..The Taq1A and Taq1B polymorphisms were in strong linkage disequilibrium. There was, however, no significant association of the two polymorphisms with PD...
  50. ncbi request reprint Prevalence and ethnic differences of autosomal-dominant cerebellar ataxia in Singapore
    Y Zhao
    Department of Clinical Research, Singapore General Hospital, Singapore
    Clin Genet 62:478-81. 2002
    ..Our findings suggest that SCA 2 is relatively common amongst the Malay race and that priority testing for SCA 3 and SCA 2 for ethnic Chinese, and SCA 2 for ethnic Malay, may be cost effective and relevant for the region...
  51. ncbi request reprint Piribedil-induced sleep attacks in Parkinson's disease
    E K Tan
    Parkinson s Disease and Movement Disorder Programme, Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Fundam Clin Pharmacol 17:117-9. 2003
    ..Here we provide details of the clinical characteristics of Piribedil-induced sleep attacks in these PD patients...
  52. ncbi request reprint Alpha synuclein promoter and risk of Parkinson's disease: microsatellite and allelic size variability
    Eng King Tan
    Department of Neurology, National Neuroscience Institute, Parkinson s Disease and Movement Disorder Program, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Neurosci Lett 336:70-2. 2003
    ..Variability of the microsatellite region and potential interacting factors that could affect alpha synuclein gene transcription should be further examined...
  53. ncbi request reprint Botulinum toxin improves quality of life in hemifacial spasm: validation of a questionnaire (HFS-30)
    Eng King Tan
    Department of Neurology and Clinical Research, Singapore General Hospital, Outram Road, Singapore
    J Neurol Sci 219:151-5. 2004
    ..Hemifacial spasm (HFS) can be disabling and affect quality of life. There is a lack of a validated scale for evaluating botulinum toxin (BTX) response in HFS...
  54. ncbi request reprint Cervical disc prolapse with cord compression presenting with choreoathetosis and dystonia
    E K Tan
    Department of Neurology, Singapore General Hospital
    Neurology 58:661-2. 2002
  55. ncbi request reprint Evaluation of somnolence in Parkinson's disease: comparison with age- and sex-matched controls
    E K Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore
    Neurology 58:465-8. 2002
    ..Epworth Sleepiness Scale scores of > or =10 had 71.4% sensitivity and 88.4% specificity for SA...
  56. ncbi request reprint Alpha-synuclein mRNA expression in sporadic Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 20:620-3. 2005
    ..However, the role of alpha-synuclein mRNA expression in select groups of sporadic PD patients and its interaction with environmental agents need to be further determined...
  57. ncbi request reprint Psychogenic tics: diagnostic value of the placebo test
    Eng King Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, SingHealth Research
    J Child Neurol 19:976-7. 2004
    ..In addition, a concise summary of the clinical phenomenology of tics and the diagnosis and management of psychogenic movement disorders is provided...
  58. ncbi request reprint Restless hand symptoms in carpal tunnel syndrome
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Int J Clin Pract 58:1000-2. 2004
    ..0001). The severity of CTS was not significantly associated with the motor restlessness. Our observations suggest that entrapment syndromes such as CTS can be associated with a form of restlessness in the hands, analogous to RLS...
  59. ncbi request reprint An urge to move with L-thyroxine: clinical, biochemical, and polysomnographic correlation
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 19:1365-7. 2004
    ..RLS symptoms can complicate thyroxine replacement in at-risk hypothyroid patients with low serum ferritin. Early diagnosis and iron replacement could significantly reduce patient morbidity...
  60. ncbi request reprint Effect of MDR1 haplotype on risk of Parkinson disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Arch Neurol 62:460-4. 2005
    ..Specific MDR1 alleles of the 2 SNPs are positively selected among ethnic Chinese but not in the white population...
  61. ncbi request reprint Nurr1 mutational screen in Parkinson's disease
    Eng King Tan
    Division of Research, SingHealth, Singapore
    Mov Disord 19:1503-5. 2004
    ....
  62. ncbi request reprint Fragile X premutation alleles in SCA, ET, and parkinsonism in an Asian cohort
    E K Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608
    Neurology 63:362-3. 2004
    ..These findings suggest that in the absence of other supportive clinical or imaging features, the cost-effectiveness of routine fragile X tremor/ataxia syndrome screening in this Asian cohort with movement disorders was low...
  63. ncbi request reprint Complex movement disorders following bilateral paramedian thalamic and bilateral cerebellar infarcts
    E K Tan
    Department of Neurology, Diagnostic Radiology, Singapore General Hospital, Singapore
    Mov Disord 16:968-70. 2001
    ..This case of a 59-year-old man who developed CMD following bilateral paramedian and bilateral cerebellar infarcts illustrates the lack of anatomic specificity and the diverse pathophysiology which may underlie CMD...
  64. ncbi request reprint Genetic analysis of DJ-1 in a cohort Parkinson's disease patients of different ethnicity
    Eng King Tan
    Division of Research, SingHealth, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Neurosci Lett 367:109-12. 2004
    ..Unlike Parkin, pathogenic DJ-1 mutations appear to be restricted to certain populations and are unlikely to be of clinical importance in our Asian cohort...
  65. ncbi request reprint Clinico-radiologic correlation in unilateral and bilateral hemifacial spasm
    E K Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore 169608, Singapore
    J Neurol Sci 222:59-64. 2004
    ..Clinico-radiologic correlates utilizing advanced imaging techniques have not been systematically examined in bilateral HFS. The prevalence of bilateral HFS in an Asian population has not been clarified...
  66. ncbi request reprint Reversible parkinsonism in systemic lupus erythematosus
    E K Tan
    Department of Neurology, Singapore General Hospital, Outram Road, 169608, Singapore
    J Neurol Sci 193:53-7. 2001
    ....
  67. ncbi request reprint Analysis of LRRK 2 G 2019 S and I 2020 T mutations in Parkinson's disease
    Monika Bialecka
    Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70 111 Szczecin, Poland
    Neurosci Lett 390:1-3. 2005
    ..It can be concluded that the G 2019 S and I 2020 T mutations in exon 41 of LRRK 2 gene are rare causes of Parkinson disease in a Polish population...
  68. ncbi request reprint Glucocerebrosidase mutations and risk of Parkinson disease in Chinese patients
    Eng King Tan
    Arch Neurol 64:1056-8. 2007
  69. ncbi request reprint Autosomal dominant spinocerebellar ataxias: an Asian perspective
    E K Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Can J Neurol Sci 30:361-7. 2003
    ..Researchers have recently provided valuable information on the pathogenesis of the disease and hopefully a cure will be available in the near future...
  70. ncbi request reprint The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications
    Monika Bialecka
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wikp 72, Szczecin, Poland
    Pharmacogenet Genomics 18:815-21. 2008
    ..The role of functional COMT haplotypes in PD susceptibility and treatment response has not been examined...
  71. doi request reprint Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study
    Eng King Tan
    Departments of Neurology, Singapore General Hospital, Singapore
    Hum Mutat 31:561-8. 2010
    ..G2385R and p.R1628P showed higher kinase activity than wild type. We provided the first evidence that multiple LRRK2 variants exert an individual effect and together modulate the risk of PD among Chinese...
  72. ncbi request reprint PINK1 mutations in sporadic early-onset Parkinson's disease
    Eng King Tan
    Division of Research, SingHealth, Singapore
    Mov Disord 21:789-93. 2006
    ..The phenotypic spectrum associated with PINK1-positive patients may be wider than previously reported. Polymorphisms of PINK1 do not appear to modulate risk of PD in our population...
  73. pmc Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila
    Chee Hoe Ng
    National Neuroscience Institute, Singapore
    J Neurosci 29:11257-62. 2009
    ..Together, our results suggest a potential link between LRRK2, parkin, and mitochondria in the pathogenesis of LRRK2-related parkinsonism...
  74. ncbi request reprint Severe bruxism following basal ganglia infarcts: insights into pathophysiology
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore
    J Neurol Sci 217:229-32. 2004
    ..Dysfunction of the efferent and/or afferent thalamic or striatopallidal tracts may play a role in bruxism. Early recognition of bruxism following stroke could reduce unnecessary suffering since the condition can be effectively treated...
  75. doi request reprint Non-synonymous GIGYF2 variants in Parkinson's disease from two Asian populations
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore, Singapore
    Hum Genet 126:425-30. 2009
    ..However, in vivo functional studies and segregation analysis in large pedigrees will be needed to determine if these single heterozygous variants represent rare mutations, risk alleles or benign polymorphisms...
  76. ncbi request reprint Functional COMT variant predicts response to high dose pyridoxine in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608
    Am J Med Genet B Neuropsychiatr Genet 137:1-4. 2005
    ..Our observational study suggests that the status the functional COMT(L) variant may be potentially useful to select PD patients for high dose pyridoxine therapy...
  77. ncbi request reprint Analysis of MDR1 haplotypes in Parkinson's disease in a white population
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    Neurosci Lett 372:240-4. 2004
    ..There was a weak protective effect of the haplotype 2677G-3435C in our white population. However, the MDR1 haplotypes did not generally modulate the risk of PD...
  78. ncbi request reprint Genetic analysis of SCA 2 and 3 repeat expansions in essential tremor and atypical Parkinsonism
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 22:1971-4. 2007
    ..However, in the long-term follow-up of patients who present with an ET phenotype, clinicians should be vigilant for other neurological signs, which may be point to an alternate diagnosis...
  79. ncbi request reprint Comparing knowledge and attitudes towards genetic testing in Parkinson's disease in an American and Asian population
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    J Neurol Sci 252:113-20. 2007
    ..Recent discoveries of disease-causing genes in Parkinson's disease (PD) have generated considerable interest regarding genetic testing in PD. The attitudes toward genetic testing are largely influenced by knowledge and preconceived notions...
  80. ncbi request reprint Case-control study of restless legs syndrome and quality of sleep in Parkinson's disease
    Hui Voon Loo
    Department of Neurology, Singapore General Hospital National Neuroscience Institute SingHealth, Singapore
    J Neurol Sci 266:145-9. 2008
    ..RLS did not play an important role in sleep dysfunction in our PD cohort. A high index of suspicion for sleep problems in advanced PD patients is important as early management could improve their quality of life...
  81. ncbi request reprint Persistent hand spasm: movement disorder or seizure?
    Deidre A De Silva
    Department of Neurology, Singapore General Hospital, Outram Road, 169608, Singapore
    J Neurol Sci 252:185-8. 2007
    ..We report an elderly lady with intractable focal seizure who presented with more than a year of persistent hand spasms. The clinical importance of differentiating epilepsy from movement disorders is discussed...
  82. ncbi request reprint Renin-angiotensin system gene polymorphisms: its impact on IgAN and its progression to end-stage renal failure among Chinese in Singapore
    Yeow Kok Lau
    Department of Renal Medicine, Singapore General Hospital, Singapore
    Nephron Physiol 97:p1-8. 2004
    ..Several studies on Caucasian and Japanese had reported contradicting results. We determined these polymorphisms in 118 Chinese patients with IgAN and 94 healthy Chinese to assess their clinical impact...
  83. ncbi request reprint Validity of family history in essential tremor
    K M Prakash
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore
    Parkinsonism Relat Disord 14:151-3. 2008
    ..001, chi2 14.3). Our study suggests that family history information reported by ET patients was inaccurate, and poorly validated. Clinical and genetic studies in ET should take the limitation of family history data into consideration...
  84. ncbi request reprint Polymorphism of renin-angiotensin system genes in IgA nephropathy
    Keng Thye Woo
    Department of Renal Medicine, Singapore General Hospital, Singapore
    Nephrology (Carlton) 9:304-9. 2004
    ..Several studies on Caucasians and Japanese patients have reported contradictory results. We determined these polymorphisms in 118 Chinese patients with IgAN and 94 healthy Chinese subjects to assess their clinical impact...
  85. ncbi request reprint DYT1 mutations amongst adult primary dystonia patients in Singapore with review of literature comparing East and West
    Roland Dominic G Jamora
    Department of Neurology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
    J Neurol Sci 247:35-7. 2006
    ..While a 3-bp deletion in the DYT1 gene is the most frequent cause of early limb-onset, generalized dystonia, it has also been found in non-generalized forms of sporadic dystonia. An 18-bp deletion in the DYT1 gene has also been reported...
  86. doi request reprint Test-retest repeatability of assessing environmental and lifestyle factors in Parkinson's disease
    Chun Wai Yip
    Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore
    Mov Disord 23:1032-6. 2008
    ....
  87. pmc Differential effects of black versus green tea on risk of Parkinson's disease in the Singapore Chinese Health Study
    Louis C Tan
    Department of Neurology, National Neuroscience Institute, Singapore
    Am J Epidemiol 167:553-60. 2008
    ..Green tea drinking was unrelated to Parkinson's disease risk. Diet had no strong influence on risk. Ingredients of black tea other than caffeine appear to be responsible for the beverage's inverse association with Parkinson's disease...
  88. ncbi request reprint Molecular biology changes associated with LRRK2 mutations in Parkinson's disease
    Yi Wei Lu
    Department of Neurology, Singapore General Hospital, Singapore
    J Neurosci Res 86:1895-901. 2008
    ..Further in vitro and in vivo studies will unravel the role of LRRK2 in cell signaling and its impact on proliferation, differentiation, and survival of neurons...
  89. ncbi request reprint Impaired motor imagery in patients with essential tremor: a case control study
    Yew Long Lo
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 22:504-8. 2007
    ..The basis for this novel finding is unclear, and further studies are warranted to determine whether it is related to cerebellar or motor cortical dysfunction...
  90. ncbi request reprint Acute ataxia, Graves' disease, and stiff person syndrome
    Su Ynn Chia
    Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore
    Mov Disord 22:1969-71. 2007
    ..Initiation of immunosuppressive therapy dramatically improved the patient's Graves' disease within 2 weeks but the neurological symptoms were not alleviated after a follow-up period of 3 years...
  91. ncbi request reprint Genetic testing in Parkinson disease: promises and pitfalls
    Eng King Tan
    Department of Neurology, Singapore General Hospital
    Arch Neurol 63:1232-7. 2006
  92. doi request reprint Case control MR-CISS and 3D TOF MRA imaging study of medullary compression and hypertension in hemifacial spasm
    Ling Ling Chan
    Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Republic of Singapore
    Mov Disord 23:1820-4. 2008
    ..Our case control study provides further support that VLM compression is associated with hypertension in HFS...
  93. ncbi request reprint Valproate-induced Parkinsonism in epilepsy patients
    Dominic Jamora
    Department of Neurology, National Neuroscience Institute, Singapore
    Mov Disord 22:130-3. 2007
    ..Early recognition and switching into another antiepileptic medication may help reduce unnecessary suffering in these patients...
  94. pmc Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect
    Donglai Sheng
    Department of Human Genetics, Genome Institute of Singapore, A STAR, Singapore, Singapore
    PLoS Genet 6:e1000914. 2010
    ..Taken together, our results demonstrate that zLRRK2 is an ortholog of hLRRK2 and that the deletion of WD40 domain of zLRRK2 provides a disease model for PD...
  95. pmc MDPD: an integrated genetic information resource for Parkinson's disease
    Suisheng Tang
    Data Mining Department, Institute for Infocomm Research, Agency for Science, Technology and Research A STAR and Department of Neurology, Singapore General Hospital, Singapore
    Nucleic Acids Res 37:D858-62. 2009
    ..As such, we hope that MDPD will serve as a valuable tool to bridge the gap between genetic analysis and clinical practice. MDPD is publicly accessible at http://datam.i2r.a-star.edu.sg/mdpd/...
  96. ncbi request reprint Emerging therapeutic applications of botulinum toxin
    Zin Soe Thant
    Department of Neurology, Singapore General Hospital, Singapore
    Med Sci Monit 9:RA40-8. 2003
    ..The long-term cost effectiveness of treatment and immunoresistance from repeated injections are also important clinical issues to address...
  97. ncbi request reprint Neurochemistry changes associated with mutations in familial Parkinson's disease
    M M Siddique
    Neuroscience Lab Singapore Health Services Pte Ltd Singapore 169611
    Curr Med Chem 17:4378-91. 2010
    ..Elucidation of the functions of the proteins encoded by the diseasecausing genes will provide an opportunity for identification of specific pathways that could be targeted in neurotherapeutics...
  98. doi request reprint LRRK2 R1628P increases risk of Parkinson's disease: replication evidence
    E K Tan
    Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Outram Road, Singapore, 169608, Singapore
    Hum Genet 124:287-8. 2008
    ..3, 95% CI 1.4- 7.9, P = 0.007). We provided an independent confirmation that the R1628P variant increases the risk of PD among Chinese...